Loss of Lkb1 cooperates with BrafV600E and ultraviolet radiation, increasing melanoma multiplicity and neural‐like dedifferentiation by Kimberley McGrail, Elena González‐Sánchez, Paula Granado‐Martínez, Roberto Orsenigo, Yuxin Ding, Berta Ferrer, Javier Hernández‐Losa, Iván Ortega, Juan Martín‐Caballero, Eva Muñoz‐Couselo, Vicente García‐Patos, Juan A. Recio

“…Thus, these results suggest that the loss of Lkb1 cooperates with BrafV600E and UVR, impairing the DDR and increasing melanoma multiplicity and neural‐like dedifferentiation.…”
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Impact of Severe Obesity and Weight Loss on Systolic Left Ventricular Function and Morphology: Assessment by 2-Dimensional Speckle-Tracking Echocardiography by Sevda Karimian, Jürgen Stein, Boris Bauer, Claudius Teupe

“…Transthoracic two-dimensional speckle-tracking echocardiography was performed to obtain systolic left ventricular strain before and after weight loss. Body mass index decreased significantly from 38.6±6.2 to 31.5±5.3 kg/m2, and the total percentage fat loss was 19%. …”
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Evaluating the Safety and Usability of an Over-the-Counter Medical Device for Adults With Mild to Moderate Hearing Loss: Formative and Summative Usability Testing by Megan Elizabeth Salwei, Shilo Anders, Carrie Reale, Jason M Slagle, Todd Ricketts, Matthew B Weinger

“… Abstract BackgroundOnly 15% of the nearly 30 million Americans with hearing loss use hearing aids, partly due to high cost, stigma, and limited access to professional hearing care. …”
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Experimental Quantification of Local Pressure Loss at a 90° Bend in Low-Pressure Dilute-Phase Pneumatic Conveying of Coarse Particles by Rui Zhu, Chunsheng Luo, Xin Li, Fei Yan

“…The influences of the local pressure loss versus the gas flow Reynolds number, the solid-gas ratio, and the bending radius ratio are investigated. …”
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Timp2 loss-of-function mutation and TIMP2 treatment in a murine model of NSCLC: Modulation of immunosuppression and oncogenic signaling by David Peeney, Sarvesh Kumar, Tej Pratap Singh, Yueqin Liu, Sandra M. Jensen, Ananda Chowdhury, Sasha Coates-Park, Joshua Rich, Sadeechya Gurung, Yu Fan, Daoud Meerzaman, William G. Stetler-Stevenson

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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study by Helen Blackshaw, Anne GM Schilder, Rishi Mandavia, Gerjon Hannink, Muhammad Nayeem Ahmed, Yaami Premakumar, Timothy Shun Man Chu, Tanjinah Ferdous, Nishchay Mehta, Joseph Manjaly, Maha Khan

“…Introduction The mainstay of treatment for idiopathic sudden sensorineural hearing loss (SSNHL) includes oral steroids, intratympanic steroid injections or a combination of both. …”
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How do health workers build resilience after family loss, covid-19 infection, and social stigma during the pandemic? by Nungky Taniasar, Seger Handoyo, Fendy Suhariadi, Fiona Niska Dinda Nadia

“…This study investigates the resilience-building process of health workers who experienced critical incidents during the COVID-19 pandemic, including family loss, personal infection, and social stigma. Specifically, the research addresses how these factors influence the psychological, emotional, and behavioral resilience of healthcare workers. …”
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Prevalence, Associated Risk Factors, and Economic Loss of Ovine Hemonchosis at Jimma Town Municipal Abattoir, Jimma Zone, Southwestern Ethiopia by Fuad Zenu Abagero, Teshita Edaso Beriso, Tilaye Shibbiru Mengistu

“…Hemonchosis is considered one of the most severe gastrointestinal parasitic diseases in small ruminants due to the blood feeding habits of the parasites, which results in production loss and death of the animals. A cross-sectional study was conducted from December 2022 to March 2023 at the Jimma town municipal abattoir with the objectives of estimating the occurrence of ovine hemonchosis, investigating potential associated risk factors, and assessing economic loss due to the disease. …”
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Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells by Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew J. K. Jones, Yaowu He, John D. Hooper, Nigel A. J. McMillan, Jelena Urosevic, Jamal Saeh, Jon Travers, Daniela Cimini, Jing Chen, Brian Gabrielli

“…We show Aurora B kinase inhibitors efficiently promote polyploidy in many cell types, resulting in the cell cycle exit in RB and p53 functional cells, but hyper-polyploidy in cells with loss of RB and p53 function. These hyper-polyploid cells (>8n DNA content) are viable but have lost long-term proliferative potential in vitro and fail to form tumours in vivo. …”
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Does water rights trading cause economic losses from agricultural water scarcity? Evidence from 264 Chinese cities by Jiajia Liu, Muhammad Umer, Jun Zhao, Qiang Li, Mei Qu

“…Insufficient water in agriculture can constrain production and lead to significant economic losses. Water rights trading (WRT) is a key mechanism for reallocating water resources within and across water-scarce regions and industries. …”
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Clinical and Trichoscopic Evaluations of Topical Finasteride 1%, Topical Spironolactone 5%, and Minoxidil 5% in Female Pattern Hair Loss Treatment by Naglaa Mohamed El Sayed, Eman Hamed Elmorsy, Tarek Mahmoud Hussein, Eman Hassan

“… Introduction: Female pattern hair loss (FPHL) is one of the most common forms of diffuse alopecia in females.. …”
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Investigating the implementation of a new protocol and clinical tool designed to assess the audiological needs of individuals with hearing loss in clinical settings by Mathieu Hotton, Mathieu Hotton, Loonan Chauvette, Sandie Poulin, Jean-Pierre Gagné, Jean-Pierre Gagné

“…Its objective was to assess the implementation of the QAAP-YOA in clinical settings.MethodsAudiologists (n = 5) and adults with hearing loss (n = 29) participated in the study. Audiologists were trained to use the QAAP-YOA. …”
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Nystose attenuates bone loss and promotes BMSCs differentiation to osteoblasts through BMP and Wnt/β-catenin pathway in ovariectomized mice by Qi Zhang, Sijing Hu, Jianjun Wu, Peng Sun, Quanlong Zhang, Yang Wang, Qiming Zhao, Ting Han, Luping Qin, Qiaoyan Zhang

“…The aim of the present study was to investigate the effects of NST on bone loss in ovariectomized mice, and explore the underlying mechanism of NST in promoting differentiation of BMSCs to osteoblasts. …”
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The Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials by Igho Onakpoya, Rohini Terry, Edzard Ernst

“…The purpose of this paper is to assess the efficacy of green coffee extract (GCE) as a weight loss supplement, using data from human clinical trials. …”
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Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant by Livia Victorino de Souza, Vanessa Oliveira, Aline Oliveira Laurindo, DelmaRegına Gomes Huarachı, Paulo Cesar Koch Nogueira, Luciana de Santis Feltran, José Osmar Medina-Pestana, Maria do Carmo Franco

“…We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients’ blood pressure and loss of renal function. The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function. …”
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Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation by Guanying Yao, Xianchao Dou, Xiaozhu Chen, Haolin Qi, Jianling Chen, Peiwei Wu, Jialu Li, Shuang Liang, Zhongjiang Han, Shun Bai, Xu Hu

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Addressing Label Noise in Colorectal Cancer Classification Using Cross-Entropy Loss and pLOF Methods With Stacking-Ensemble Technique by Ishrat Zahan Tani, Kah Ong Michael Goh, Md Nazmul Islam, Md Tarek Aziz, S. M. Hasan Mahmud, Dip Nandi

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Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis by Yao Wang, Lin Sun, Zhenglin Dong, Tianyu Zhang, Leining Wang, Yihui Cao, Hui Xu, Chenglei Liu, Bo Chen

“…F6-(DSS)6-exo enabled the targeted delivery of curcumin, restoring the osteogenic differentiation potential of BMSCs and mitigating bone loss in SROP mouse models. In summary, this study highlights the combination of genetic engineering and hydrophobic diacylglycerol insertion as a novel targeted therapeutic approach for SROP.…”
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The Observed Phase Space of Mass-loss History from Massive Stars Based on Radio Observations of a Large Supernova Sample by Itai Sfaradi, Assaf Horesh, Rob Fender, Lauren Rhodes, Joe Bright, David Williams-Baldwin, Dave A. Green

“…In this work, we study the circumstellar material (CSM) around massive stars, and the mass-loss rates depositing this CSM, using a large sample of radio observations of 325 core-collapse supernovae (CCSNe; only ~22% of them being detected). …”
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SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection by Richard C. Crist, Samar N. Chehimi, Saurabh S. Divakaran, Michael J. Montague, Sébastien Tremblay, Noah Snyder-Mackler, Martin O. Bohlen, Kenneth L. Chiou, Trish M. Zintel, Cayo Biobank Research Unit, Michael L. Platt, Halvor Juul, Guido Silvestri, Matthew R. Hayes, Dennis L. Kolson, Benjamin C. Reiner

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