Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice by Denis N. Kisakov, Larisa I. Karpenko, Lyubov A. Kisakova, Sergey V. Sharabrin, Mariya B. Borgoyakova, Ekaterina V. Starostina, Oleg S. Taranov, Elena K. Ivleva, Oleg V. Pyankov, Anna V. Zaykovskaya, Elena V. Dmitrienko, Vladimir A. Yakovlev, Elena V. Tigeeva, Irina Alekseevna Bauer, Svetlana I. Krasnikova, Nadezhda B. Rudometova, Andrey P. Rudometov, Artemiy A. Sergeev, Alexander A. Ilyichev

“…<b>Methods:</b> In the first part of the study, the optimal conditions providing low traumatization and high expression of the model mRNA-GFP molecule in the tissues of laboratory animals were determined. …”
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway by Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen

“…Unbiased transcriptional profiling analysis and cellular thermal shift assay suggested that Moscatilin suppresses vascular calcification via binding to interleukin 13 receptor subunit A2 (IL13RA2) and augmenting its expression. Furthermore, IL13RA2 was reduced during HASMC osteogenesis, thus promoting the secretion of inflammatory factors via STAT3. …”
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Post sleeve gastrectomy-enriched gut commensal Clostridia promotes secondary bile acid increase and weight loss by Shaoqian Zhao, Huibin Lin, Wen Li, Xiaoqiang Xu, Qihan Wu, Zhifeng Wang, Juan Shi, Yufei Chen, Lingxia Ye, Liuqing Xi, Lijia Chen, Mingyang Yuan, Junlei Su, Aibo Gao, Jiabin Jin, Xiayang Ying, Xiaolin Wang, Yaorui Ye, Yingkai Sun, Yifei Zhang, Xiaxing Deng, Baiyong Shen, Weiqiong Gu, Guang Ning, Weiqing Wang, Jie Hong, Jiqiu Wang, Ruixin Liu

“…Furthermore, both Clostridia-enriched spore-forming bacteria and GDCA supplementation increased the expression of genes responsible for lipolysis and fatty acid oxidation in adipose tissue and reduced adiposity via Takeda G-protein-coupled receptor 5 (TGR5) signaling. …”
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Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney by Hui Zou, Jie Song, Xianzu Luo, Waseem Ali, Sifan Li, Ling Xiong, Yan Chen, Yan Yuan, Yonggang Ma, Xishuai Tong, Zongping Liu

“…These results indicate that renal function is impaired, oxidative stress and trace element metabolism disorder, nuclear factor-E2 related factor 2 (Nrf2) is activated into the nucleus to induce the expression of related antioxidant proteins (such as HO-1, NQO1). …”
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Blood and Iron: The Rise and Fall of the German Empire 1871 – 1918 by Arzu Melek Ozgumus

“…Initially the writer expresses her hesitations about the character of Wilhelm II, questioning whether he was intelligent and proactive, or merely ignorant and easily influenced by a small circle of advisors. …”
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Evaluation of the needs assessment process of the training courses for the staff of the general sports and youth departments by Shahin Hayati, Haleh Fazel, Lora Chapari

“…Needs assessment is one of the most important topics expressed in the field of human resources and social services, and it is an analysis that identifies two polar situations; Current situation (where we are), and ideal situation (where we should be) (Mustafezian & Lotfi, 2021). …”
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Presenting the entrepreneurship development model in the national oil refining industry with the approach of environmental damage prevention by Jalal Abdi, Reza Yousefi Saeedabadi, Maryam Taghvaee Yazdi

“…Daneshniya et al, (2021) showed that a total of 27 main concepts can be expressed as obstacles to the development of entrepreneurship in Iran; so that 10 concepts of political environment, cultural, legal, educational, technology, government structure, macroeconomic, financial environment, geographical environment and production structure are causal conditions categorized with two categories of institutional and economic factors. 7 concepts of efficiency, opportunism, creativity, risk-taking, need for success, desire for independence, and power-seeking of entrepreneurs were identified with the category of entrepreneurs' characteristics and the background conditions of lack of entrepreneurship development. …”
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Èdè Àyàn: The Language of Àyàn in Yorùbá Art and Ritual of Egúngún by Oláwọlé Fámúlẹ̀

“…As a native speaker with access to Yorùbá philosophy, values and history, and who is fully aware of the fundamental importance of language in African art studies, I aim in this study to examine the mutual relationship existing between the Àyàn and Egúngún from the vantage point of the Yorùbá language, the medium through which the said Yorùbá philosophy, values and history are stored and expressed. It delves into the very root of Egúngún within the Yorùbá cultural context, where traditions and history are preserved and recorded not in the western-type of writing, but rather in the Yorùbá language, ritual performance and ceremonies. …”
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Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease by Maxime Deslande, Francesc Puig-Castellvi, Inés Castro-Dionicio, Romina Pacheco-Tapia, Violeta Raverdy, Robert Caiazzo, Guillaume Lassailly, Audrey Leloire, Petros Andrikopoulos, Yasmina Kahoul, Nawel Zaïbi, Bénédicte Toussaint, Frédérik Oger, Nicolas Gambardella, Philippe Lefebvre, Mehdi Derhourhi, Souhila Amanzougarene, Bart Staels, François Pattou, Philippe Froguel, Amélie Bonnefond, Marc-Emmanuel Dumas

“…Methods: We characterised liver biospies from 318 patients with obesity using RNAseq and metabolomics in liver and plasma to derive associations among hepatic hippurate, hepatic gene expression and MASLD and phenotypes. To test a potential beneficial role for hippurate in hepatic insulin resistance, we profile the metabolome of (IHH) using ultra-high-performance liquid chromatography coupled to high-resolution tandem mass spectrometry (UHPLC-MS/MS), and characterised intracellular triglyceride accumulation and glucose internalisation after a 24 h insulin exposure. …”
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The pattern of elementary teachers' insight in online education, using foundational data theory by reyhaneh bazrafshan delijan, Mohammad Ghafari Mejlej, seyyed javad mortazavi amiri

“…Extended abstract IntroductionThe main expression of this change was a comprehensive and immediate transition to simultaneous distance online teaching and learning. …”
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Duckweed: a starch-hyperaccumulating plant under cultivation with a combination of nutrient limitation and elevated CO2 by Ling Guo, Ling Guo, Yang Fang, Songhu Wang, Yao Xiao, Yanqiang Ding, Yanling Jin, Xueping Tian, Anping Du, Zhihua Liao, Kaize He, Shuang Chen, Yonggui Zhao, Li Tan, Zhuolin Yi, Yuqing Che, Lanchai Chen, Jinmeng Li, Leyi Zhao, Peng Zhang, Zhengbiao Gu, Fangyuan Zhang, Yan Hong, Qing Zhang, Hai Zhao

“…In this study, we integrated whole-genome sequencing, epigenomics, transcriptomics, enzyme activity, and composition variation to elucidate the mechanisms of efficient starch accumulation in duckweed in terms of starch accumulation and carbon partitioning, regulation of the expression of genes in the starch metabolic pathway, and sucrose biosynthesis and transportation.Results and discussionAlthough Landoltia punctata exhibits dramatic gene family contraction, its starch content and productivity reached 72.2% (dry basis) and 10.4 g m-2 d-1, respectively, in 10 days, equivalent to a yield of 38.0 t ha-1 y-1, under nutrient limitation treatment with elevated CO2 levels. …”
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Villa d’époque romaine et habitat médiéval à Mont-Saint-Jean (Sarthe) : bilan des recherches 2008-2020 by Florian Sarreste, Paul-André Besombes, Phaedra Bouvet, Chloé Genies, Étienne Jaffrot, Florian Jedrusiak, Thomas Jubeau, Anthony Ledauphin, Annaïg Le Martret, Christophe Loiseau, Hugo Meunier, Aurore Noël, Sandrine Paradis-Grenouillet, Boris Robin

“…These dates therefore raise questions about the origin of the estate’s establishment and development.Although it is not always possible to reconstruct the exact chronology of the transformations, the development of a monumental dimension to the residence likely continued until the end of the 2nd century. It was mainly expressed through the extension of the pars urbana’s northern pavilions, which were also linked by a gallery measuring over 70 m long.In the agricultural courtyard, the annexes identified are related to cereal farming, with two barns and two possible mills (originally animal-drawn, and subsequently hydraulic). …”
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A Systemic Approach to Inceptive Constructions in Lithuanian by Rolandas Mikulskas

“…Correspondingly, the source constructions of the inceptive constructions headed by these verbs are motion constructions and, importantly, their structural extension with infinitive gives rise to purpose constructions, where the added infinitive expresses the purpose of the motion. The latter could easily be reanalyzed into the corresponding inceptive constructions. …”
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Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes by Peter Vo, Denise M. Imai-Leonard, Benjamin Yang, Andrew Briere, Andy Shao, M. Isabel Casanova, David Adams, Takanori Amano, Oana Amarie, Zorana Berberovic, Lynette Bower, Robert Braun, Steve Brown, Samantha Burrill, Soo Young Cho, Sharon Clementson-Mobbs, Abigail D’Souza, Mary Dickinson, Mohammad Eskandarian, Ann M. Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Jason Heaney, Yann Hérault, Martin Hrabe de Angelis, Chih-Wei Hsu, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Hamid Meziane, Steve Murray, Ki-Hoan Nam, Hyuna Noh, Lauryl M. J. Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jennifer Ryan, Jason Salazar, Zachery Seavey, John Richard Seavitt, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Michelle Stewart, Karen Svenson, Masaru Tamura, Heather Tolentino, Uchechukwu Udensi, Sara Wells, Jacqueline White, Amelia Willett, Janine Wotton, Wolfgang Wurst, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Louise Lanoue, K. C. Kent Lloyd, Brian C. Leonard, Michel J. Roux, Colin McKerlie, Ala Moshiri

“…We also searched publicly available RNAseq data and found that 131 of the total 213 (61.5%) were expressed in adult human corneal tissue. STRING analysis showed several interactions within and between candidate and established CD proteins. …”
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Analyzing the indicators of choosing the appropriate teaching method for Education the principles of accounting (1) using the Meta-synthesis method by Hossein Esmailkhani, Mahmoud Moeinaldin, Forough Heirany

“…In the end, gratitude is expressed to all the people and organizations that played a role in conducting this research and preparing the article.…”
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Factors influencing trust in algorithmic decision-making: an indirect scenario-based experiment by Fernando Marmolejo-Ramos, Rebecca Marrone, Malgorzata Korolkiewicz, Florence Gabriel, George Siemens, Srecko Joksimovic, Yuki Yamada, Yuki Mori, Talal Rahwan, Maria Sahakyan, Belona Sonna, Assylbek Meirmanov, Aidos Bolatov, Bidisha Som, Izuchukwu Ndukaihe, Nwadiogo C. Arinze, Josef Kundrát, Lenka Skanderová, Van-Giang Ngo, Giang Nguyen, Michelle Lacia, Chun-Chia Kung, Meiselina Irmayanti, Meiselina Irmayanti, Abdul Muktadir, Fransiska Timoria Samosir, Marco Tullio Liuzza, Roberto Giorgini, Omid Khatin-Zadeh, Hassan Banaruee, Asil Ali Özdoğru, Kris Ariyabuddhiphongs, Wachirawit Rakchai, Natalia Trujillo, Stella Maris Valencia, Armina Janyan, Armina Janyan, Kiril Kostov, Pedro R. Montoro, Jose Hinojosa, Jose Hinojosa, Kelsey Medeiros, Thomas E. Hunt, Julian Posada, Raquel Meister Ko Freitag, Julian Tejada

“…Algorithms are involved in decisions ranging from trivial to significant, but people often express distrust toward them. Research suggests that educational efforts to explain how algorithms work may help mitigate this distrust. …”
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Sodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic pain by Idy H.T. Ho, Yidan Zou, Kele Luo, Fenfen Qin, Yanjun Jiang, Qian Li, Tingting Jin, Xinyi Zhang, Huarong Chen, Likai Tan, Lin Zhang, Tony Gin, William K.K. Wu, Matthew T.V. Chan, Changyu Jiang, Xiaodong Liu

“…In vivo sodium butyrate supplementation restored oxaliplatin-induced Kcnj9 and Kcnk18 expression and pain-related behaviors in mice for at least 14 days. …”
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Developing and validation of religious education curriculum in preschool by Zeinab Ashrafi Soltan-Ahmadi, Sadegh Maleki Avarsin, Javad Keyhan, jahangir yari

“…The results indicated that special attention should be paid to the exemplary role of the teacher, scientific and religious competence, acceptability and popularity of the teacher for the students, and they also emphasized on expressing religious issues in a simple and understandable way and in the form of specific behaviors and using various educational tools such as books as well as holding attractive ceremonies and competitions.Research methodologyThe research method is applicable in terms of purpose, mixed (qualitative-quantitative) in terms of the type of data, and is a sequential exploratory combined approach. …”
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Reprogramming of iPSCs to NPCEC-like cells by biomimetic scaffolds for zonular fiber reconstruction by Tianhui Chen, Zhongxing Chen, Juan Du, Min Zhang, Zexu Chen, Qingyi Gao, Aodong Chen, Qinghao Meng, Yang Sun, Yan liu, Linghao Song, Xinyue Wang, Pranav Prakash Edavi, Chen Xu, Hongmei Zhang, Jinhai Huang, Yongxiang Jiang

“…Ocular tissue and aqueous humour samples from patients with EL were subjected to RNA sequencing and Olink high-throughput proteomic analysis, revealing the downregulation of pathogenic genes (FBN1, MFAP2) and upregulation of secretory proteins (IL-12, MMP-1). The high expression of FBN1 and MFAP2 in NPCECs suggests their potential as candidates for zonular fiber construction; however, the limited availability of donor sources restricts the feasibility of NPCEC transplantation therapy. …”
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Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor—Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA... by Carla Gaggiano, Antonio Vitale, Laura Obici, Giampaolo Merlini, Alessandra Soriano, Ombretta Viapiana, Marco Cattalini, Maria Cristina Maggio, Giuseppe Lopalco, Davide Montin, Masen Abdel Jaber, Lorenzo Dagna, Raffaele Manna, Antonella Insalaco, Matteo Piga, Francesco La Torre, Virginia Berlengiero, Viviana Gelardi, Luisa Ciarcia, Giacomo Emmi, Piero Ruscitti, Francesco Caso, Rolando Cimaz, José Hernández-Rodríguez, Paola Parronchi, Ludovico Luca Sicignano, Elena Verrecchia, Florenzo Iannone, Jurgen Sota, Salvatore Grosso, Carlo Salvarani, Bruno Frediani, Roberto Giacomelli, Maria Antonietta Mencarelli, Alessandra Renieri, Donato Rigante, Luca Cantarini

“…This study describes one of the widest cohorts of TRAPS patients in the literature, suggesting that the clinical expression of this syndrome is more influenced by the penetrance of the mutation rather than by the age at onset itself. …”
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