Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility by Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K. Stine V. Bagge, Jennifer R. Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D. Hickson, Andrés López-Contreras, Michael Lisby

“…Moreover, the downregulation of ZGRF1 expression is associated with increased survival in cancer patients. …”
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Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress by Mihai Spiridon-Bodi, Cristina Ros-Carrero, J. Carlos Igual, Mercè Gomar-Alba

“…To control their protein levels, we used dose-dependent β-estradiol-induced expression and auxin-induced degron protein fusions. …”
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Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer by Marco Ragusa, Cristina Barbagallo, Duilia Brex, Angela Caponnetto, Matilde Cirnigliaro, Rosalia Battaglia, Davide Barbagallo, Cinzia Di Pietro, Michele Purrello

“…To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes. …”
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Multigenerational effects of cultivating transgenic maize straw on earthworms: A combined laboratory and field experiment by Li Zhang, Wenjing Shen, Zhixiang Fang, Laipan Liu, Ruizong Jia, Jingang Liang, Biao Liu

“…In this study, the potential effects of cultivating the GM maize variety DBN9936, which exhibits the expression of the Cry1Ab and EPSPS proteins, on earthworms (Eisenia fetida) were evaluated under laboratory and field conditions. …”
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Determinants and impact of calcium oxalate crystal deposition on renal outcomes in acute kidney injury patients by Weiwei Yang, Tao Zhao, Xuejing Chen, Suxia Wang, Yu Wang, Tao Su

“…We assessed factors like urinary oxalate, citrate, urate, electrolytes, pH, tubular calcification index, and SLC26A6 expression, comparing them with creatinine-matched AKI controls without oxalosis. …”
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Effect of Baoshenfang Formula on Podocyte Injury via Inhibiting the NOX-4/ROS/p38 Pathway in Diabetic Nephropathy by Fang-qiang Cui, Long Tang, Yan-bin Gao, Yue-fen Wang, Yuan Meng, Cun Shen, Zi-long Shen, Zhi-qiang Liu, Wen-jing Zhao, Wei Jing Liu

“…BSF treatment increased the nephrin expression, alleviated oxidative cellular damage, and inhibited Bcl-2 family-associated podocyte apoptosis in high-glucose cultured podocytes and/or in diabetic rats. …”
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The Use of Coffee Cherry Pulp Extract as an Alternative to an Antibiotic Growth Promoter in Broiler Diets by Wanaporn Tapingkae, Phatchari Srinual, Pimporn Khamtavee, Naret Pintalerd, Thanongsak Chaiyaso, Mongkol Yachai, Chanidapha Kanmanee, Chompunut Lumsangkul, Orranee Srinual

“…(<i>p</i> < 0.05), and increased the expression of immune-related genes and antioxidant activity in the liver and intestines (<i>p</i> < 0.05). …”
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Integrating transcriptomics, metabolomics, and network pharmacology to investigate multi-target effects of sporoderm-broken spores of Ganoderma lucidum on improving HFD-induced dia... by Lidan Hu, Lili Yu, Zhongkai Cao, Yue Wang, Caifeng Zhu, Yayu Li, Jiazhen Yin, Zhichao Ma, Xuelin He, Ying Zhang, Wunan Huang, Yuelin Guan, Yue Chen, Xue Li, Xiangjun Chen

“…GLP significantly suppressed the inflammations by impacting glucose and energy metabolism-related gene expression (Igfbp1 and Angptl4) and enhanced metabolic biomarkers of 4-Aminocatechol. …”
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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow by Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, Chang-An Geng, Xiaoli Zhao, Huaiyu Wang, Chi-Wai Wong, Kelvin W. K. Yeung, Haobo Pan, William Weijia Lu, Min Guan

“…Mechanistically, adipocyte ESRRA interferes with E2/ESR1 signaling resulting in transcriptional repression of secreted phosphoprotein 1 (Spp1); yet positively modulates leptin expression by binding to its promoter. ESRRA abrogation results in enhanced SPP1 and decreased leptin secretion from both visceral adipocytes and BMAds, concertedly dictating bone marrow stromal stem cell fate commitment and restoring type H vessel formation, constituting a feed-forward loop for bone formation. …”
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100% oxygen mobilizes stem cells and up-regulates MIF and APRIL in humans: a new point on the hormetic dose curve by Kent J. MacLaughlin, Gregory P. Barton, Julia E. MacLaughlin, Jacob J. Lamers, Matthew D. Marcou, Matthew J. O’Brien, Rudolf K. Braun, Marlowe W. Eldridge

“…The cytokines “macrophage migration inhibitory factor” (MIF) and “a proliferation inducing ligand” (APRIL) were significantly upregulated.ConclusionThis study demonstrates that 100% normobaric oxygen mobilizes stem cells and upregulates the expression of the inflammatory cytokines marking a new point on the low dose stimulation phase of the hormetic dose curve of oxygen.…”
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High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy by Meng Zhang, Wei Gao, Xiaotong Cui, Xueting Han, Yamei Xu, Jingmin Zhou, Junbo Ge

“…Abstract Background Apical hypertrophic cardiomyopathy (AHCM) is a subtype of hypertrophic cardiomyopathy (HCM). The expression level of high-sensitive cardiac troponin T (hs-cTNT) and N-terminal pro-BNP (NT-proBNP) in AHCM patients, and these relationships between echocardiography parameters were still unclear. …”
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Convergent evidence for the temperature-dependent emergence of silicification in terrestrial plants by Zhihao Pang, Félix de Tombeur, Sue E. Hartley, Constantin M. Zohner, Miroslav Nikolic, Cyrille Violle, Lidong Mo, Thomas W. Crowther, Dong-Xing Guan, Zhongkui Luo, Yong-Guan Zhu, Yuxiao Wang, Ping Zhang, Hongyun Peng, Caroline A. E. Strömberg, Nina Nikolic, Yongchao Liang

“…Here, we combine experimentation, field studies and analysis of existing databases to test the role of temperature on the expression and emergence of silicification in terrestrial plants. …”
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Multi-omics reveals that ST6GAL1 promotes colorectal cancer progression through LGALS3BP sialylation by Yuanchao Shi, Zhenzhong Pan, Jingwei Duan, Zexing Wang, Yiliang Fang, Bo Tang, Quanlin Guan

“…We found that ST6GAL1 was significantly upregulated in tumor samples than in matched normal samples by analyzing fresh clinical samples from public databases (mean mRNA expression level: tumor vs. normal samples = 0.002712:0.000966, P < 0.05, n = 22). …”
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Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer by Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen

“…During regression in the mouse prostate, all epithelial cells shift their expression profiles toward a proximal periurethral (PrU) state, demonstrating an androgen-dependent plasticity that is restored to normal during androgen restoration and gland regeneration. …”
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Percepções vivenciadas por graduandos de enfermagem em cenário de telessimulação sobre a hipoglicemia neonatal by Nylze Helena Guillarducci Rocha, Gabriella Gomes Lopes Prata, Janaína Aparecida Maia Silva, Rubinéia Stefania da Silva, Maria Paula Custódio Silva, Luciana Mara Monti Fonseca, Divanice Contim

“… Objetivo: Descrever percepções vivenciadas por estudantes de enfermagem no cenário de telessimulação sobre a hipoglicemia neonatal e expressas na autoavaliação. Método: Estudo exploratório, descritivo, de abordagem qualitativa, com 36 graduandos de enfermagem durante uma disciplina eletiva de um curso de graduação em enfermagem de uma universidade pública federal situada no interior do estado de Minas Gerais - Brasil. …”
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Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development by Zhangmin Ke, Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song

“…The regulation of these activities can occur through either the same enzymatic activity acting on different substrates or distinct enzymatic activities targeting the same substrate. Aberrant expression of SIRT5 has been closely linked to tumorigenesis and disease progression; however, its role remains controversial. …”
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Polymorphic variants of the dopamine receptor gene <i>DRD2</i> (rs6277, rs1800497) in adolescents with problematic video game use by S. Yu. Tereshchenko, K. V. Afonicheva, I. V. Marchenko, M. V. Shubina, M. V. Smolnikova

“…The T allele DRD2 (rs6277) is associated with low expression of the dopamine receptor D2 and leads to decreasing the density and affinity of extrastriatal dopamine type 2 receptors, which is associated with impaired social communication as well. …”
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Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction by Jingrun Lin, Xiaoqiu Zhu, Xuan Li, Yu Hong, Yaohui Liang, Siqi Chen, Chenzhuo Feng, Lin Cao

“…Cognitive function was assessed 7–10 days post-surgery using open field, Y-maze, and novel object recognition tests. Hippocampal mRNA expression was analyzed using Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment. …”
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Visual Analysis of Research Progress on the Impact of Cadmium Stress on Horticultural Plants over 25 Years by Zhouli Liu, Benyang Hu, Yi Zhao, Shuyan Zhang, Xiangbo Duan, Hengyu Liu, Luyang Meng

“…Phytoremediation, subcellular distribution and the transcriptome are the world’s emerging topics, while in China, growth and physiological characteristics are still emerging topics. (4) In comparison, China exhibited a lagging development trend, which is reflected in the fact that it began to focus on gene expression and transcriptome research only after the global frontier shifted towards biochar and cadmium co-stress and yield response. …”
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Tp53 determines the spatial dynamics of M1/M2 tumor-associated macrophages and M1-driven tumoricidal effects by Yi-Jing Hsiao, Min-Shu Hsieh, Gee-Chen Chang, Yin-Chen Hsu, Chia-Yu Wang, Yan-Ming Chen, Yi-Ling Chen, Pan-Chyr Yang, Sung-Liang Yu

“…We found that interferons in M1 CM activate JAK1/TYK2 via IFNARs, leading to enhanced STAT1 expression and Y701 phosphorylation. This activation facilitates p53-STAT1 interactions, reduces the interaction between p53 and MDM2, and subsequently decreases p53 ubiquitination. …”
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