Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota by Tao Wang, Panpan Wang, Li Yin, Xiuchao Wang, Yuanyuan Shan, Yanglei Yi, Yuan Zhou, Bianfang Liu, Xin Wang, Xin Lü

“…Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. …”
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CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review by M. Guerreiro, F. Príncipe, M. J. Teles, S. Fonseca, A. H. Santos, E. Fonseca, P. Gomes, C. Marques, M. Lima

“…The diagnosis of ANKL is difficult and requires both clinical suspicion and an extensive laboratorial approach. Absence of CD56 expression on the neoplastic NK cells may impose difficulties in the diagnosis, which requires morphological, immunophenotypic, histopathological, immunohistochemical, cytogenetic, and molecular studies.…”
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4-Phenylbutyric Acid Attenuates Pancreatic Beta-Cell Injury in Rats with Experimental Severe Acute Pancreatitis by Yu-pu Hong, Wen-yi Guo, Wei-xing Wang, Liang Zhao, Ming-wei Xiang, Fang-chao Mei, Ablikim Abliz, Peng Hu, Wen-hong Deng, Jia Yu

“…Results showed that 4-PBA attenuated the following: (1) pancreas and islet pathological injuries, (2) serum TNF-α and IL-1β, (3) serum insulin and glucose, (4) beta-cell ultrastructural changes, (5) ER stress markers (BiP, ORP150, and CHOP), Caspase-3, and insulin expression in islet. These results suggested that 4-PBA mitigates pancreatic beta-cell injury and endocrine disorder in SAP, presumably because of its role in inhibiting excessive endoplasmic reticulum stress. …”
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A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs by Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio

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Copper Does Not Induce Tenogenic Differentiation but Promotes Migration and Increases Lysyl Oxidase Activity in Adipose-Derived Mesenchymal Stromal Cells by Marta Milewska, Anna Burdzińska, Katarzyna Zielniok, Katarzyna Siennicka, Sławomir Struzik, Piotr Zielenkiewicz, Leszek Pączek

“…The treatment with CuSO4 did not positively affect the expression of genes associated with tenogenesis (COL1α1, COL3α1, MKX, and SCX). …”
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Comparative transcriptome analysis on candidate genes involved in lipid biosynthesis of developing kernels for three walnut cultivars in Xinjiang by Wenqiang Wang, Hao Wen, Qiang Jin, Wenjun Yu, Gen Li, Minyu Wu, Hongjin Bai, Lirong Shen, Cuiyun Wu

“…Finally, 5 important transcription factors including WRI1, ABI3, FUS3, PKL and VAL1 were identified, and their main regulatory genes might contain ACCase, KASⅡ, LACS, FAD3 and LPAAT which were determined through correlation analysis of expression levels for 27 walnut samples. These findings will provide a comprehensive understanding and valuable information on the genetic engineering and molecular breeding in walnut.…”
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Smokeless tobacco: knowledge, attitudes and usage in Pakistan by Hammad Atif Irshad, Sajjan Raja, Hamzah Jehanzeb, Wamiq Ali Shaikh, Umair Saleem, Shahzil Abdur Rehman Malik, Akmal Shahzad, Mamoon Shaikh, Nousheen Iqbal, Javaid Ahmed Khan

“…About 31% reported to have used the product once, with 69.82% of current users expressing a desire to quit. Conclusions Although adequate knowledge and aligning attitudes exist for SLTs, light is shed in the face of a sustaining public health problem. …”
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Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential by Aseel O. Rataan, Yan Xu, Sean M. Geary, Yousef Zakharia, Eman S. Kamel, Youcef M. Rustum, Aliasger K. Salem

“…This study analyzed their expression in human ccRCC cell lines and patient tumor biopsies. …”
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Optimizing longifolene production in Yarrowia lipolytica via metabolic and protein engineering by Yi-Tong Yao, Xiao Zhang, Chen-Yu Wang, Yu-He Zhang, Da-Wei Li, Wei-Dong Yang, Hong-Ye Li, Li-Gong Zou

“…Subsequently, protein engineering techniques were applied to optimize PsTPS (tPsTPS) for improved catalytic efficiency. Furthermore, co-expression of molecular chaperones was implemented to enhance the synthesis and secretion of PsTPS. …”
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Impact of Obesity on Clinicopathologic Characteristics and Disease Prognosis in Pre- and Postmenopausal Breast Cancer Patients: A Retrospective Institutional Study by Nehad M. Ayoub, Rami J. Yaghan, Nour M. Abdo, Ismail I. Matalka, Laila M. Akhu-Zaheya, Alia H. Al-Mohtaseb

“…No significant association between BMI with expression status of hormone receptors, HER2, lymphovascular invasion, and molecular subtypes was found among patients. …”
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Rapid and Specific Detection of Escherichia coli O157:H7 in Ground Beef Using Immunomagnetic Separation Combined with Loop-Mediated Isothermal Amplification by Qin Yu, Puthiyakunnon Santhosh, Zhang Yiduo, Wu Xianbo, Boddu Swapna, Luo Binde, Fan Hongying

“…Then, EHEC O157:H7 was identified by LAMP assay for amplifying and detecting the rfbE gene, which is highly conserved in all EHEC O157:H7 strains and exhibits strain-specifi c gene expression. The LAMP method results analyzed with real time turbidity measurements showed a high specificity and sensitivity, with a positive detection rate of amplifi cation of EHEC O157:H7 DNA diluted to a minimum equivalent concentration of 1.8 × 101 CFU/mL, which was 10 times more sensitive than the conventional PCR assay. …”
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Gestational diabetes induces autistic-like behaviors in offspring by disrupting the GABAergic system by Xuan-Qi Liu, Tian-li Huang, Shu-Yu Zhang, Yu-Tong Huang, Jia-Ying Mo, Yi-Shang Yan, Yi-Ning Cao, Yue-Ran Cai, Jian-Zhong Sheng, Hong Zhu, He Feng Huang

“…This reduction in GABA was associated with decreased GAD2 expression due to DNA hypermethylation in the GAD2 promoter region.ConclusionThese data suggest that GDM induces autistic-like behaviors, including reduced social novelty and increased stereotypic behaviors, in offspring by affecting the GABAergic system. …”
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Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 by Ya-Hui Wang, Rong-Kun Li, Ying Fu, Jun Li, Xiao-Mei Yang, Yan-Li Zhang, Lei Zhu, Qin Yang, Jian-Ren Gu, Xin Xing, Zhi-Gang Zhang

“…The results showed that EXE attenuated the liver fibrosis by decreasing the collagen deposition and α-SMA expression in vivo and inhibited the activation and proliferation of primary rat HSCs in vitro. …”
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MiR-155-Mediated Deregulation of GPER1 Plays an Important Role in the Gender Differences Related to Inflammatory Bowel Disease by Xiaojuan Shao, Jintao Li, Fumin Xu, Dongfeng Chen, Kaijun Liu

“…The male patients produced more proinflammatory cytokines, and while GPER1 expression was downregulated, miR-155 was upregulated in the patients with IBD. …”
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A comprehensive analysis of molecular characteristics of hot and cold tumor of gastric cancer by Chenxi Lv, Tianwei Chen, Jiangtao Li, Yuqiang Shan, Hong Zhou

“…Methods Consensus clustering was utilized to classify GC patients into distinct immune states, followed by an in-depth analysis of differences in mutation profiles, copy number variations, and DNA methylation patterns. Weighted gene co-expression network analysis (WGCNA) and correlation analysis were applied to identify gene modules underlying the classification of immune “hot” and “cold” tumors. …”
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Age-related changes in DNA methylation in a sample of elderly Brazilians by Hayley Welsh, Caio M. P. F. Batalha, Weili Li, Nadja C. Souza-Pinto, Yeda A. O. Duarte, Michel S. Naslavsky, Esteban J. Parra

“…Abstract Background Age-related changes in DNA methylation (DNAm) play a critical role in regulating gene expression. However, most epigenome-wide association studies have predominantly focused on individuals of European descent. …”
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A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade by Manush Sondhi, Megan Lear, Saleha Dar, Madiha Tariq

“…Mechanisms connecting TIF1 dermatomyositis and cancer involve gene expression dysregulation and chronic inflammation. Anti-TIF1 antibodies are key biomarkers, with IgG2 isotype levels highly predictive of cancer risk. …”
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hCTLA4-Gene-Modified Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMMSCs) Maintain POSTN Secretion to Enhance the Migration Capability of Allogeneic hBMMSCs through the Integ... by Lei Song, Fei Zhang, Rui Zhou, Jun Xiao, Lei He, Fei Dai

“…In the present study, we investigated whether CTLA4-modified hBMMSCs are involved in the migration of allogeneic hBMMSCs (allo-hBMMSCs) by maintaining POSTN secretion. hBMMSCs were isolated from different groups, named hBMMSCs and allo-hBMMSCs. hBMMSCs that were infected with the negative control (NC), empty adenovirus- or recombinant adenovirus-expressing CTLA4, POSTN, or CTLA4 plus the shRNA of POSTN were named NC hBMMSCs, CTLA4-modified hBMMSCs, POSTN-modified hBMMSCs, or CTLA4+shPOSTN-modified hBMMSCs, respectively. …”
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Morphological, Physiological, and Molecular Responses to Heat Stress in Brassicaceae by Iram Batool, Ahsan Ayyaz, Tongjun Qin, Xiaofen Wu, Weiqi Chen, Fakhir Hannan, Zafar Ullah Zafar, Muhammad Shahbaz Naeem, Muhammad Ahsan Farooq, Weijun Zhou

“…While such studies are limited in <i>B. napus</i>, contrasting trends in gene expression have been observed across different species and cultivars, suggesting these genes play a complex role in heat stress tolerance. …”
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Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases by Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu

“…These results highlight reciprocal relationships where certain neurodegenerative diseases influence mitochondrial protein expression levels. These findings underscore the pivotal role of mitochondrial proteins in neurodegenerative diseases, offering critical insights into disease mechanisms and potential therapeutic avenues.…”
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