The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia by Kai Shen, Chenlu Yang, Jie Huang, Xiao Shuai, Ting Niu, Hongbing Ma

“…It is considered to result from a severe systemic inflammatory response mediated by increased expression of cytokines, chemokines, and adhesion molecules on differentiating blast cells. …”
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Long-Term Dietary Nitrate Supplementation Does Not Prevent Development of the Metabolic Syndrome in Mice Fed a High-Fat Diet by V. B. Matthews, R. Hollingshead, H. Koch, K. D. Croft, N. C. Ward

“…There was no difference in adipose tissue expression of thermogenic proteins or energy expenditure as assessed by the running wheel activity. …”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

“…Molecular analysis revealed significant alterations in the expression of key transcription factors involved in adipogenesis and lipid metabolism, including PPARγ, C/EBPα, ADD-1, Pref-1, IRS-1, GLUT-4, adiponectin, FAS, aP2, ATGL, and HSL. …”
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Ultrastructural studies distinguish skin diversities among Galápagos iguanas by Manuel Scimeca, Rita Bonfiglio, Giuliano Colosimo, Eleonora Candi, Glenn P. Gerber, Gregory A. Lewbart, Alessandro Mauriello, Gerry Melino, Christian Sevilla, Yufang Shi, Ying Wang, Gabriele Gentile

“…The ultrastructural investigation confirmed the absence of iridophores in all analyzed samples. The cytokeratin expression assessed by immunohistochemistry showed stratified epithelium in the epidermis of C. marthae non-black-colored (pink) skin. …”
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Exploring bio-remediation strategies by a novel bacteria Micrococcus sp. strain HX in Cr(VI)-contaminated groundwater from long-term industrial polluted by Yu Xia, Yujuan Wen, Yuesuo Yang, Xiaoming Song, Yunlong Wang, Zhipeng Zhang

“…Transcriptome analyses revealed oxidoreductase activity, ATP binding and the NAD(P) binding region protein-related gene expression were up-regulated. Binding reduction experiments indicated that most of the Cr(III) was detected extracellular, which suggests that the reduction of Cr(VI) by HX was mainly extracellular enzyme-catalyzed.…”
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The preoperative neutrophil‐to‐lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving r... by Zhi Cao, Jin Ji, Chao Zhang, Fubo Wang, Huan Xu, Yongwei Yu, Yinghao Sun

“…Immunohistochemistry was then performed to assess the expression of AR, ERG, PTEN, p‐AKT, Bcl‐2, Beclin‐1, Ki‐67, CD3, CD4, CD8, IFN‐γ and TNF‐α. …”
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Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…Conclusion This study suggests that obese patients defined by BMI may promote the development of allergic asthma by influencing the expression of plasma proteins such as TPST1, ROR1, and DAPK1. …”
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Characterization of pPCP1 Plasmids in Yersinia pestis Strains Isolated from the Former Soviet Union by Chythanya Rajanna, Tamara Revazishvili, Mohammed H. Rashid, Svetlana Chubinidze, Lela Bakanidze, Shota Tsanava, Paata Imnadze, Kimberly A. Bishop-Lilly, Shanmuga Sozhamannan, Henry S. Gibbons, J. Glenn Morris, Alexander Sulakvelidze

“…The FSU strains generally had larger pPCP1 plasmid copy numbers compared to strain CO92. Expression of the plasmid's pla gene was significantly (P≤.05) higher in strain C2944 than in strain CO92. …”
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Simultaneous Determination of Night Effective Constituents and Correlation Analysis of Multiconstituents and Antiplatelet Aggregation Bioactivity In Vitro in Chuanxiong Rhizoma Sub... by Peihua Zhang, Linming Chen, Xiaoxiao Wang, Jinpei Chen, Shungui Xu, Ling Ye, Yixin Yao

“…Senkyunolide H (H) was positively correlated with AAB, senkyunolide I (I) was negatively correlated with AAB, and its expression was AAB = 1.187 ∗ H − 0.199 ∗ I − 0.422. …”
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The book graphics of Vilnius printing houses in XVI-XVII centuries by Jolita Liškevičienė

“…Kazimieras and consisted of 24 emblems (copper engravings) with lemmas expressing the virtue of the saint in one word, and a poem of 12 lines. …”
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TLR4/AP-1-Targeted Anti-Inflammatory Intervention Attenuates Insulin Sensitivity and Liver Steatosis by Xiang Hu, Jing Zhou, Sha-sha Song, Wen Kong, Yan-Chuan Shi, Lu-Lu Chen, Tian-Shu Zeng

“…Intervention of the TLR4 expression regulates macrophage polarization and metabolic inflammation and further alleviates insulin resistance and lipid deposition in hepatocytes.…”
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Book phenomenon in library philosophy and library research by Baiba Sporane

“…The book as a phenomenon in library philosophy could be described as a phenomenon of culture and social environment, maintaining its existence within itself, discovering and expressing itself independently, without merely describing the book outwardly, but explaining it and finding the essential point that determines the significance of the book’s essence. …”
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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis by Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge

“…Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepatocyte-like cells expressing functional drug metabolizing enzymes open up possibilities for novel, more relevant human cell based toxicity models. …”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…Furthermore, our findings indicate that aberrant overexpression of GPN3 is observed in non-small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues, and high expression levels of GPN3 are associated with poor prognosis for NSCLC patients. …”
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Genomic Characterization and Functional Validation of Six <i>cis</i>-Regulatory Sequences in Medicinal Plant <i>Andrographis paniculata</i> by Xingbin Lv, Hua Yang, Yufang Hu, Qi Liang, Shuyun Tian, Lang Yang, Mingkun Huang, Ling Zhang, Yanqin Xu

“…Plant <i>cis</i>-regulatory sequences (CRSs) are essential for gene expression and transcriptional regulation in plants. …”
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Neurological function is restored post-ischemic stroke in zebrafish, with aging exerting a deleterious effect on its pathology by Takamasa Mizoguchi, Ayumi Maki, Yuno Nakase, Mayu Okita, Yuina Minami, Misa Fukunaga, Motoyuki Itoh

“…Furthermore, we observed an escalation in the expression of the neural stem marker gene at 3dpi, followed by an upregulation of the differentiated neuron marker at 7 and 14dpi. …”
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Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2 by Qi Dong, Haoyuan Fu, Wenxiao Li, Xinyu Ji, Yingchao Yin, Yiran Zhang, Yanbo Zhu, Guoqiang Li, Huiyang Jia, Heng Zhang, Haofei Wang, Jinglue Hu, Ganggang Wang, Zhihao Wu, Yingze Zhang, Sujuan Xu, Zhiyong Hou

“…Moreover, activated FXR could directly bind to the Thoc6 promoter, suppressing its expression. The interaction between RUNX2 and Thoc6 was mediated by the Runt domain of RUNX2 and the WD repeat of Thoc6. …”
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Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes by Amrit Chowdhary, Nicholas Jex, Sharmaine Thirunavukarasu, Amanda MacCannell, Natalie Haywood, Altaf Almutairi, Lavanya Athithan, Manali Jain, Thomas Craven, Arka Das, Noor Sharrack, Christopher E. D. Saunderson, Anshuman Sengupta, Lee Roberts, Peter Swoboda, Richard Cubbon, Klaus Witte, John Greenwood, Sven Plein, Eylem Levelt

“…In a cohort of type 2 diabetic (T2D) patients who underwent baseline cardiac magnetic resonance (CMR) and biomarker testing, during a median follow-up of 6 years, we aimed to determine longitudinal changes in the phenotypic expression of heart disease in diabetes, report clinical outcomes, and compare baseline clinical characteristics and CMR findings of patients who experienced major adverse cardiovascular events (MACE) to those remaining MACE free. …”
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L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…Animal studies in lipopolysaccharide-induced models of chorioamnionitis and hyperoxia- and inflammation-induced BPD-PH in rodent lung models revealed that L-CIT supplementation significantly mitigated structural changes in the pulmonary vasculature, preserved alveolar growth, and increased vascular endothelial growth factor gene expression, highlighting the anti-inflammatory and antioxidant effects of L-CIT supplementation. …”
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Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition by Hannah C. Saternos, Kathleen V. Forero, Mahmood A. Meqdad, Raghad Buqaileh, Clare L. Sunderman, Gillian Gallagher, William S. Messer, Ashraf M. Mohieldin, Claudio A. Mucci, Sanjana Kumariya, Islam A. Osman, James P. Burkett, Wissam A. AbouAlaiwi

“…We discovered, for the first time, that CHRM3 was localized to primary cilia of endothelial and cerebrovascular cells, and that CHRM3 expression was downregulated in cilialess cells. Moreover, CHRM3 activation enhanced cilia length and sensory function in terms of eNOS activation. …”
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