Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis by Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor

“…When activated by bioactive compound treatment, Nrf2 translocates to the nucleus and induces the expression of its target genes to exert antioxidant responses. …”
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Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities by de Lima Vazquez Vinicius, Cristovam Scapulatempo, Natalia Martins Perpetuo, Faheez Mohamed, Teóclito Sachetto de Carvalho, Antônio Talvane Torres de Oliveira, José Getúlio Martins Segalla, André Lopes Carvalho

“…A Tissue Microarray was constructed using immunohistochemistry to quantify expression of the HER family, E-cadherins, and podoplanin. …”
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Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections by Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas, Miguel Marcos, Daniel Salete-Granado, Marirene Chacón-Arnaude, María Á. Pérez-Nieto, Ulrike Kemmerling, Juan Luis Concepción, Paul A. M. Michels, Wilfredo Quiñones

“…In humans, where glycolysis occurs mainly in the cytosol, the mislocalization of some glycolytic enzymes in various other subcellular locations, as well as alterations in their expression and regulation, has been associated with the development and progression of various diseases. …”
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Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human u... by Ye Zhu, Junxiu Wei, Xin Yang, Wei Zhu

“…Flow cytometry assessed the apoptotic rate, and Western blotting analysis evaluated the expression levels of ERS-related proteins GRP78 and PERK, and the apoptotic protein marker CHOP. …”
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Nutrient status alters developmental fates via a switch in mitochondrial homeodynamics by Jie Zhang, Suning Liu, Yang Li, Guanfeng Xu, Huimin Deng, Kirst King-Jones, Sheng Li

“…By contrast, post-NRC starvation does not impair mitochondrial homeostasis in PG cells but reduces sit expression and induces moderate autophagy to promote steroidogenesis, leading to precocious metamorphosis. …”
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Idea občana – válečníka a „moderní“ maskulinní identita: modelová studie z dějin Spojených států by Jiří Hutečka

“…This pressure from home community had, thanks to the local character of regiments in both armies and thanks to the “crowded” character of battlefield, an overwhelming tactical implications – the field of battle became the ultimate expression of Bourdieu’s “masculine space” – outward, official, public, short, dangerous, spectacular. …”
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The extraction of effective components and an antioxidant activity study of Tulipa edulis by Doudou Zhang, Dong Xiao, Tingting Yin, Shuangzhi Zhao, Olena Zhur, Xun Xiao, Hailun He, Leilei Chen

“…Meanwhile, the gene expression of heme oxygenase 1 (HO-1), γ-glutamyl cysteine ligase catalytic subunit (GCLC) and NAD(P)H quinone oxidoreductase-1 (NQO1) in HUVEC cells was up-regulated after treated with F2. …”
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Experiences of health information-seeking behaviour in preoperative patients with lung cancer: a qualitative study in China by Wei Li, Lihua Huang, Jie Zhu, Jiayi Guo, Man Ye

“…Eligible participants were patients with lung cancer aged 18 and above, capable of articulate expression, informed about their diagnosis, preparing for surgical intervention and willing to engage voluntarily in the study.Results Four main categories were identified. …”
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Effects of Aerobic Exercise on Rats with Hyperandrogenic Polycystic Ovarian Syndrome by Na Li, Chenghao Yang, Huiyu Xie, Yinghong Liu, Yuanpeng Liao

“…In addition, compared with the NC group, the levels of adiponectin (ADP) were significantly decreased (p<0.05), and the expression of aromatase cytochrome P450 (P450arom) in ovarian tissue was significantly elevated in the PC group (p<0.05). …”
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Mesenchymal stem cell‐derived exosomes mitigate amyloid β‐induced retinal toxicity: Insights from rat model and cellular studies by Amanda Qarawani, Efrat Naaman, Rony Ben‐Zvi Elimelech, Michal Harel, Shahaf Sigal‐Dror, Tali Ben‐Zur, Tamar Ziv, Daniel Offen, Shiri Zayit‐Soudry

“…Similarly, immunostaining highlighted the modulation of α‐crystallin expression in retinal astrocytes by AT‐MSC‐Exosomes. …”
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Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis Display Impaired Function in Inhibiting Th17 Cells by Yue Sun, Wei Deng, Linyu Geng, Lu Zhang, Rui Liu, Weiwei Chen, Genhong Yao, Huayong Zhang, Xuebing Feng, Xiang Gao, Lingyun Sun

“…However, the capacity to inhibit Th17 cell polarization was impaired in RA MSCs, which was related to the low expression of CCL2 in RA MSCs after coculture with CD4+ T cells. …”
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Betacoronaviruses Differentially Activate the Integrated Stress Response to Optimize Viral Replication in Lung-Derived Cell Lines by David M. Renner, Nicholas A. Parenti, Nicole Bracci, Susan R. Weiss

“…Interestingly, genetic ablation of growth arrest and DNA damage-inducible protein (GADD34) expression, an inducible protein phosphatase 1 (PP1)-interacting partner targeting eIF2α for dephosphorylation, did not significantly alter HCoV-OC43 or SARS-CoV-2 replication, while siRNA knockdown of the constitutive PP1 partner, constitutive repressor of eIF2α phosphorylation (CReP), dramatically reduced HCoV-OC43 replication. …”
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Effectiveness of a training program for the acquisition of motor milestones in infants: a randomized clinical trial by Luis Fernández-Sola, Beatriz Cano-Díez, Yessica Pons-Solaz, Begoña Vera-Egido, Sergio Moreno-González

“…Abstract Background In infants, the acquisition of all motor milestones is considered an expression of correct motor development during the first months of life. …”
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Sistemas de labranza y fertilización nitrogenada en trigo bajo distintas historias agrícolas by Soledad M. Santamaría, Guillermo A. Studdert, Hernán E. Echeverría

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Childhood neurodivergent traits, inflammation and chronic disabling fatigue in adolescence: a longitudinal case–control study by Neil A Harrison, Hugo D Critchley, Jessica Eccles, Kevin A Davies, Lisa Quadt, Rod Bond, Jenny Csecs

“…Objectives To test whether inflammatory processes link the expression of childhood neurodivergent traits to chronic disabling fatigue in adolescence.Design Longitudinal case–control study.Setting We analysed data from The Avon Longitudinal Study of Parents and Children (ALSPAC).Participants 8115 and 8036 children of the ALSPAC cohort at ages 7 and 9 years, respectively, 4563 of whom also completed self-report measures at age 18 years.Primary and secondary outcome measures We assessed if children scoring above screening threshold for autism/attention deficit hyperactivity disorder (ADHD) at ages 7 and 9 years had increased risk of chronic disabling fatigue at age 18 years, computing ORs and CIs for effects using binary logistic regression. …”
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Targeted inhibition of ferroptosis in bone marrow mesenchymal stem cells by engineered exosomes alleviates bone loss in smoking-related osteoporosis by Yao Wang, Lin Sun, Zhenglin Dong, Tianyu Zhang, Leining Wang, Yihui Cao, Hui Xu, Chenglei Liu, Bo Chen

“…Using genetic engineering techniques, we introduced α-1,3-fucosyltransferase 6 (Fut6), a key protein involved in prostate cancer bone metastasis, and identified exosomes expressing Fut6 (F6-exo) with bone-targeting capabilities. …”
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Isolation and Characterization of an Adult Stem Cell Population from Human Epidural Fat by Nedaa Al-Jezani, Roger Cho, Anand O. Masson, Brian Lenehan, Roman Krawetz, Frank G. Lyons

“…HEF cells demonstrated MSC surface marker expression. All patient cell lines contracted collagen gels. …”
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The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways by Chunxing Pan, Xiaoying Liu, Yating Zheng, Zejun Zhang, Yongliang Li, Biao Che, Guangrong Liu, Lanyue Zhang, Changzhi Dong, Haji Akber Aisa, Zhiyun Du, Zhengqiang Yuan

“…The treatment by glabridin significantly downregulated both transcriptional and/or protein expression of melanogenesis-related factors including melanocyte stimulating hormone receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), TYR-related protein-1 (TRP-1) and TRP-2 in B16 cells. …”
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Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients by Yanhua Zheng, Zemin Huang, Xianhua Chen, Yi Tian, Jun Tang, Yi Zhang, Xiaomin Zhang, Jijun Zhou, Qing Mao, Bing Ni, Qinghong Wang, Yuzhang Wu

“…No obvious changes were observed in Th1 cell frequencies; although, IFN-γ expression was upregulated in response to telbivudine treatment, suggesting another cell source of IFN-γ in CHB patients. …”
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Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4 by Zhe Huang, Ming Wang, Yitian Chen, Hua Tang, Kuo Tang, Mingkuan Zhao, Wei Yang, Zhengjun Zhou, Junjie Tian, Wei Xiang, Shenjie Li, Qinglian Luo, Luotong Liu, Yanru Zhao, Tao Li, Jie Zhou, Ligang Chen

“…In this study, we observed the presence and formation of migrasomes in GBM cells. We found that expression levels of key migrasome formation factor, tetraspanin 4 (TSPAN4), correlated positively with pathological grade and poor prognosis of GBM based on the databases and clinical samples analysis. …”
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