TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms by Nicholas L. Calistri, Tiera A. Liby, Zhi Hu, Hongmei Zhang, Mark A. Dane, Sean M. Gross, Laura M. Heiser

“…Analysis of publicly available breast cancer patient data showed that high ELF3 expression was associated with poor prognosis and enrichment in programs associated with cell cycle progression. …”
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Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization by Brenden N Moeun, Florent Lemaire, Alexandra M Smink, Hamid Ebrahimi Orimi, Richard L Leask, Paul de Vos, Corinne A Hoesli

“…Oxygen concentration profiles modeled computationally were analogous to viability gradients observed experimentally through live/dead endpoint measurements and in case I, time-lapse fluorescence imaging was used to monitor the viability of GFP-expressing cells in real time. Intervascular BAPs were cultured under flow for up to 3 days and BAPs without internal flow for up to 7 days, showing glucose-responsive insulin secretion quantified through at-line non-disruptive sampling. …”
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A molecular basis for spine color morphs in the sea urchin Lytechinus variegatus by Maria Wise, Madison Silvia, Gerardo Reyes, Rushane Dunn, Thomas M. Onorato, Cosmo Pieplow, Aidan Furze, El Hebert, Nathalie Oulhen, Dan Ritschoff, David R. McClay, Gary Wessel

“…By confocal microscopy we localized gene expression along and within the spines and learned that genes involved in pigment biosynthesis showed selective distribution along the spine. …”
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Neurotoxic Effect of Myricitrin in Copper-Induced Oxidative Stress Is Mediated by Increased Intracellular Ca²⁺ Levels and ROS/p53/p38 Axis by Ignacija Vlašić, Antonio Krstačić-Galić, Anđela Horvat, Nada Oršolić, Anja Sadžak, Lucija Mandić, Suzana Šegota, Maja Jazvinšćak Jembrek

“…At the protein level, myricitrin upregulated p53 and PUMA expression. The toxic effects of myricitrin were alleviated by the p38 inhibitor SB203580, the intracellular calcium chelator BAPTA-AM, and the NMDA receptor blocker MK-801, highlighting the significant role of the ROS/p53/p38 axis in cell death and the critical involvement of calcium ions in apoptosis induction. …”
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An indole alkaloid from a tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infected mice. by Paromita Bag, Durbadal Ojha, Hemanta Mukherjee, Umesh Chandra Halder, Supriya Mondal, Nidhi S Chandra, Suman Nandi, Ashoke Sharon, Mamta Chawla Sarkar, Sekhar Chakrabarti, Debprasad Chattopadhyay

“…Moreover, Western blot and qRT-PCR assays demonstrated that HM suppressed viral IE gene expression, while the EMSA and co-immunoprecipitation studies showed that HM interfered with the recruitment of LSD-1 by HCF-1. …”
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Inhibiting METTLl3-ATG5 axis-mediated harmful autophagy in macrophages could help reduce airway epithelial inflammation and remodeling in COPD by Chen Guiyang, Xia Zhiwei, Zeng Xianyou, Liu Hanying

“…In a COPD mouse model exposed to cigarette smoke, lung tissues showed increased levels of METTL3, p-p65/ p65, autophagy markers (LC3 and ATG5), inflammatory factors (interleukin-6, IL-8, and TNF-α), and airway remodeling markers (N-cadherin, α-SMA, and Tn-C), while p62 and E-cadherin levels were decreased. Expression of METTL3 and ATG5 was positively correlated. …”
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Flammulina velutipes polysaccharide-iron(III) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters by Chenying Shi, Chen Cheng, Xiaotong Lin, Yanfang Qian, Yufeng Du, Guitang Chen

“…In vivo, FVP1-Fe(III) had a better restorative effect on blood parameters and iron status indicators in rats with IDA as compared with FeSO4 and exerted this effect by downregulating the expression of hepcidin. FVP1-Fe(III) could also regulate gut microbiota dysbiosis in iron deficiency rats by returning the relative abundance of gut microbiota to the normal level. …”
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Prospective analysis of CKM element |Vcd| and D+-meson decay constant from leptonic decays D+ → ℓ+ν by Ya-Xiong Wang, Hai-Jiang Tian, Yin-Long Yang, Tao Zhong, Hai-Bing Fu

“…Consequently, we obtain the QCD sum rule expression for fD+ up to dimension-six condensates, yielding fD+=203.0±1.5MeV. …”
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Effect of glyphosate on renal function: A study integrating epidemiological and experimental evidence by Lin Hu, Mingcong Chen, Xiaoran Xue, Mingyi Zhao, Qingnan He

“…Further zebrafish experiments indicated that zebrafish exposed to 90 μg/mL glyphosate exhibited increased mortality rates, higher fluorescence intensity, up-regulated the havcr1 expression level, and cystic dilatation of the kidney. …”
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Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells by David Schnittker, Karen Kwofie, Ali Ashkar, Bernardo Trigatti, Carl D. Richards

“…When combined, LPS and OSM synergized to increase MCP-1, IL-6, VEGF protein, and mRNA expression as assessed by qRT-PCR, in both HAoAFs and HAoSMCs, while LPS-induced IL-8 levels were reduced. …”
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Comparative Analysis of the Anti-inflammatory Effects of E-MTA, Ketac-E, and Sealapex on Human Periodontal Ligament Stem Cells by Ayesha Imtiaz, Kiran Nayyar, Khadija Akhtar, Muhammad Yousuf Ali, Naresh kumar, Ehsan Ul Haq

“…Three Sealers as commercially available products were used on the cultured hPDLSCs via in-vitro experiments and treated with serial concentrations of 20ul, 40ul, and 60ul respectively to perform MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] cell viability assay. Expression profiling via Real Time-PCR of anti-inflammatory biometers was determined via RNA extract from 24h MTT assay due to its greater reproducibility. …”
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Impacts of Trade Unions on Employees' Welfare in UNATU, Kabale District. by Cyomperwe, Justinah

“…The major problems facing labour unions in Uganda are; casualization of labour which leaves workers at the employers' mercy since their terms and conditions of work are not expressly prescribed, unemployment, and insufficient and inadequate facilitated labour officers Due to the decentralization of labour matters, there is need for the establishment of sufficient, well-funded and staffed branches of industrial courts in Uganda, urgency for the grant of the minimum wage that is appropriate to the services rendered to eliminate oppression at workplace and ensure the enforcement of all privileges and rights granted to the workers.…”
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Portrayal of Men in Damilare Kuku Nearly all Men in Lagos. by Arineitwe, Bridget

“…The novel critiques dominant masculine norms prevalent in Nigerian society, particularly those that dictate behavior, success, and emotional expression among men. Kuku uses humor and satire to expose the absurdity of these stereotypes while simultaneously illustrating how they constrain men’s lives. …”
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Bee Venom—A Potential Complementary Medicine Candidate for SARS-CoV-2 Infections by Keneth Iceland, Kasozi, Simon Peter, Musinguzi

“…Complementary therapies that impact on expression of IgE and IgG antibodies, including administration of bee venom (BV), have efficacy in the management of arthritis, and Parkinson’s disease. …”
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Anxiety, Anger and Depression Amongst Low-Income Earners in Southwestern Uganda During the COVID-19 Total Lockdown by Archibong, Victor, Usman, Ibe Michael, Keneth Iceland, Kasozi, Osamudiamwen, Eric Aigbogun Jr., Josiah, Ifie, Monima, Ann Lemuel, Ssebuufu, Robinson, Chekwech, Gaudencia, Terkimbi, Swase Dominic, Owoisinke, Okon, Mbiydzenyuy, Ngala Elvis, Adeoye, Azeez, Aruwa, oshua Ojodale, Afodun, Adam Moyosore, Odoma, Saidi, Ssempijja, Fred, Ayikobua, Emmanuel Tiyo, Ayuba, John Tabakwot, Nankya, Viola, Onongha, Comfort, Sussan, Henry, Matama, Kevin, Yusuf, Helen, Nalugo, Halima, MacLeod, Ewan, Welburn, Susan Christina

“…Modified generalized anxiety disorder (GAD-7), Spielberger’s State-Trait Anger Expression Inventory-2 (STAXI-2), and Beck Depression Inventory (BDI) tools as appropriate were used to assess anxiety, anger, and depression respectively among our respondents. …”
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Perceived effects of the hidden curriculum of return to entrepreneurship with the mediation of goal orientation by Ahmad KarimiDashtaki, Mohammadbagher Akbarpour Zangalani

“…Goal orientation Goal orientation in the educational situation expresses the individual's motivation to study, and affects the individual's responses in learning situations. …”
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Subgenome asymmetry of gibberellins-related genes plays important roles in regulating rapid growth of bamboos by Ling Mao, Cen Guo, Liang-Zhong Niu, Yu-Jiao Wang, Guihua Jin, Yi-Zhou Yang, Ke-Cheng Qian, Yang Yang, Xuemei Zhang, Peng-Fei Ma, De-Zhu Li, Zhen-Hua Guo

“…Our results showed that gibberellin A1 was important for the rapid shoot growth of the world's largest bamboo, Dendrocalamus sinicus, and indicated that two gibberellins (GAs)-related genes, KAO and SLRL1, were key to the rapid shoot growth and culm size in woody bamboos. The expression of GAs-related genes exhibited significant subgenome asymmetry with subgenomes A and C demonstrating expression dominance in the large-sized woody bamboos while the generally submissive subgenomes B and D dominating in the small-sized species. …”
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Rational design of a triple-type HPV53/56/66 vaccine with one preferable base particle incorporating two identified immunodominant sites by Ciying Qian, Jie Chen, Yurou Yang, Yihan Lu, Tianyu Ren, Yanan Jiang, Yang Huang, Xin Chi, Shuyue Zhang, Chengzong Zhang, Kewei Li, Jingjia Shen, Sibo Zhang, Daning Wang, Lizhi Zhou, Tingting Li, Qingbing Zheng, Hai Yu, Ying Gu, Ningshao Xia, Shaowei Li

“…It introduces an effective method for their soluble expression, as well as that of their mutants, within an Escherichia coli expression system. …”
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HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis by Hong Wang, Dong Qian, Jiabei Wang, Yao Liu, Wenguang Luo, Hongyan Zhang, Jingjing Cheng, Heng Li, Yang Wu, Wuhan Li, Jing Wang, Xia Yang, Tianzhi Zhang, Dong Han, Qinyao Wang, Chris Zhiyi Zhang, Lianxin Liu

“…Methods: Basescope assay was performed to analyze the expression of UPF3B-S mRNA in tissues and cells. RNA immunoprecipitation, and in vitro and in vivo models were used to explore the role of UPF3B-S and the underlying mechanisms. …”
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Integrated physiological and transcriptomic analysis uncovers the mechanism of moderate nitrogen application on promoting the growth and (-)-borneol accumulation of Blumea balsamif... by Yuan Yuan, Wei-Jie Tang, Wei-Jie Tang, Jia-Yuan Cao, Ke Zhong, Ke Zhong, Ze-Jun Mo, Ying Zhou, Yu-Xin Pang, Yu-Xin Pang

“…Comparative transcriptome analysis revealed a total of 6,714 differentially expressed genes (DEGs). Notably, several DEGs associated with auxin signaling and N metabolism were upregulated in the N1 and N2 treatments. …”
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