Thymosin β4 Improves Differentiation and Vascularization of EHTs by Tilman Ziegler, Rabea Hinkel, Andrea Stöhr, Thomas Eschenhagen, Karl-Ludwig Laugwitz, Ferdinand le Noble, Robert David, Arne Hansen, Christian Kupatt

“…We examined the potential impact of Tβ4 to enhance maturation of cardiomyocytes from iPSCs. Assessing the expression of transcription factors associated with cardiac differentiation, we were able to demonstrate the increased generation of cells displaying cardiomyocyte characteristics in vitro. …”
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Agora são elas: a presença das mulheres no público de museus de ciência do Rio de Janeiro by Mônica Santos Dahmouche, Sibele Cazelli, Denise Studart, Vanessa Guimarães, Carla Gruzman

“…Os dados relativos aos 4.606 respondentes foram sistematizados e tratados estatisticamente. Os resultados expressam o potencial de atratividade dos espaços museais, nos quais foi observada a prevalência do “turista cidadão”, que mora e usufrui da cidade, frente ao “turista padrão”. …”
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Genome Analysis of Rhodococcus Sp. DSSKP-R-001: A Highly Effective β-Estradiol-Degrading Bacterium by Hongyan Zhao, Kejian Tian, Qing Qiu, Yu Wang, Hongyan Zhang, Shuang Ma, Shenbao Jin, Hongliang Huo

“…The results showed that there were ten steroid-degrading enzymes distributed in the whole genome of the strain. The existence and expression of estradiol-degrading enzymes were verified by PCR and RTPCR. …”
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Exercise and Omega-3 Polyunsaturated Fatty Acid Supplementation for the Treatment of Hepatic Steatosis in Hyperphagic OLETF Rats by Sarah J. Borengasser, R. Scott Rector, Grace M. Uptergrove, E. Matthew Morris, James W. Perfield, Frank W. Booth, Kevin L. Fritsche, Jamal A. Ibdah, John P. Thyfault

“…Exercise lowers hepatic steatosis through increased complete hepatic FAO, insulin sensitivity, and reduced expression of de novo fatty acid synthesis proteins while n3PUFAs had no effect.…”
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Pulmonary Nuclear protein in Testis (NUT) carcinoma: clinical, molecular characteristics, and treatment strategies by Jingjing Qu, Zhen Chen, Yanping Zhu, JinYan Huang, Qian Shen

“…Immunotherapy demonstrated limited benefit, likely attributable to low PD-L1 expression and an immunologically “cold” tumor microenvironment. …”
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A Novel Version of HPM Coupled with the PSEM Method for Solving the Blasius Problem by Uriel Filobello-Nino, Hector Vazquez-Leal, Jesus Huerta-Chua, Victor Manuel Jimenez-Fernandez, Mario Alberto Sandoval-Hernandez, Enrique Delgado-Alvarado, Victor Manuel Tlapa-Carrera

“…The aim is to obtain an approximate analytical expression that adequately describes the phenomenon considered. …”
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IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network by Ruifen Cao, Qiangsheng Li, Pijing Wei, Yun Ding, Yannan Bin, Chunhou Zheng

“…Interleukin-6 (IL-6) is a potent glycoprotein that plays a crucial role in regulating innate and adaptive immunity, as well as metabolism. The expression and release of IL-6 are closely correlated with the severity of various diseases. …”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…These mechanisms include the expression of various surface molecules that mediate adhesion, motility, and phagocytosis of host cells, as well as the secretion of proteases and other factors that degrade host extracellular matrix and modulate host immune response. …”
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PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling by Qinghui Zhang, Shihao Xiang, Qingqian Liu, Tao Gu, Yongliang Yao, Xiaojie Lu

“…HSCs were exposed to hypoxic environment in the presence or absence of rosiglitazone, and expression of PPARγ and two fibrosis markers, α-SMA and desmin, were measured using western blot and immunofluorescence staining. …”
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Histone lactylation promotes multidrug resistance in hepatocellular carcinoma by forming a positive feedback loop with PTEN by Yuan Zeng, Haoran Jiang, Zhoufeng Chen, Jun Xu, Xiangting Zhang, Weimin Cai, Xianjie Zeng, Peipei Ma, Rong lin, Huilin Yu, Yuanhang He, Huiya Ying, Ruoru Zhou, Xiao Wu, Fujun Yu

“…Mechanistically, active glycolysis induced elevated levels of lactylation, predominantly histone lactylation, with H3K14la playing a key role in regulating gene expression. The ubiquitin E3 ligase NEDD4 was identified as a downstream target of H3K14la. …”
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NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula by Yingbin Luo, Jianchun Wu, Xiaowen Zhu, Chenyuan Gong, Chao Yao, Zhongya Ni, Lixin Wang, Lulu Ni, Yan Li, Shiguo Zhu

“…Furthermore, we found that YPF significantly downregulated the expression of TGF-β, indoleamine 2,3-dioxygenase, and IL-10 in tumor microenvironment. …”
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A thorny pathway of macrophage activating factor (GcMAF): from bench to bedside by A. A. Ostanin, S. S. Kirikovich, E. V. Dolgova, А. S. Proskurina, E. R. Chernykh, S. S. Bogachev

“…Activation results in elevated expression of the specific macrophageal surface receptors involved in the recognition of tumor-associated antigens, as well as in the implementation of direct anticancer activity by inducing the apoptosis or necrosis of tumor cells. …”
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The Proapoptotic Effect of MB-653 Is Associated with the Modulation of Metastasis and Invasiveness-Related Signalling Pathways in Human Colorectal Cancer Cells by Libor Sokoli, Peter Takáč, Mariana Budovská, Radka Michalková, Martin Kello, Natália Nosálová, Ľudmila Balážová, Šimon Salanci, Ján Mojžiš

“…Additionally, MB-653 induces dose-dependent G2/M phase cell cycle arrest, the cause of which could be cyclin B1/CDC2 complex dysfunction and/or a decrease in α-tubulin protein expression. Another important observation was that MB-653 modulated several signalling pathways associated with various cellular activities, including survival, proliferation, tumour invasiveness, metastasis, and epithelial–mesenchymal transition (EMT). …”
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Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder. by Caroline C McGrouther, Aaditya V Rangan, Arianna Di Florio, Jeremy A Elman, Nicholas J Schork, John Kelsoe, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium

“…We find evidence of genetic heterogeneity delineating a statistically significant bicluster comprising a subset of BD cases which exhibits a disease-specific pattern of differential-expression across a subset of SNPs. This disease-specific genetic pattern (i.e., 'genetic subgroup') replicates across the remaining data-sets collected by the PGC containing 5781/8289, 3581/7591, and 6825/9752 cases/controls, respectively. …”
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Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex by Xiaotong Diao, Qinghong Shang, Mengqi Guo, Yubin Huang, Meina Zhang, Xiaoyu Chen, Yinping Liang, Xiangnan Sun, Fan Zhou, Jingjing Zhuang, Shuang-Jiang Liu, Christoph F. A. Vogel, Fraydoon Rastinejad, Dalei Wu

“…Upon ligand binding, AHR translocates from the cytoplasm to nucleus, forming a transcriptionally active complex with aryl hydrocarbon receptor nuclear translocator (ARNT), for DNA binding and initiation of gene expression programs that include cellular detoxification pathways and immune responses. …”
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Implementing a rapid geographic range expansion - the role of behavior changes by Logan, Corina, McCune, Kelsey, LeGrande-Rolls, Christa, Marfori, Zara, Hubbard, Josephine, Lukas, Dieter

“…Our results elucidated that individuals differentially expressing a particular behavior in an edge population could facilitate the rapid geographic range expansion of great-tailed grackles, and we found no support for the importance of several traits that were hypothesized to be involved in such an expansion. …”
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Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Af... by Meng Zhao, Xiaohan Zhang, Ling Gao, Yongfeng Song, Chao Xu, Chunxiao Yu, Shanshan Shao, Jiajun Zhao

“…Upon palmitic acid stimulation, intracellular contents of lipids, as well as the expression and activity of three key molecules in thyroid hormone synthesis (i.e., thyroglobulin, sodium iodide symporter, and thyroperoxidase), were determined in human primary thyrocytes. …”
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Spline approximation of multivalued functions in linear structures routing by D. A. Karpov, V. I. Struchenkov

“…In this case, it is possible to analytically calculate the derivatives of the objective function with respect to the spline parameters in the absence of its analytical expression through these parameters.Results. An algorithm developed for approximating multivalued functions given by a discrete series of points using a spline consisting of arcs of circles conjugated by line segments for solving the first stage of the problem is presented. …”
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Producción y crecimiento de las plantaciones de Prosopis alba Griseb. en la provincia Chaco by Sebastián M. KEES, Paula FERRERE, Ana M. LUPI, Julio F. MICHELA, Juan J. SKOKO

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Effects of Synthetic Astaxanthin on the Growth Performance, Pigmentation, Antioxidant Capacity, and Immune Response in Black Tiger Prawn (Penaeus monodon) by Qiang Chen, Shuting Huang, Jieyu Dai, Congcong Wang, Songming Chen, Yuanxin Qian, Yangyang Gong, Tao Han

“…Moreover, the mRNA expression of immune genes (traf6, relish, and myd88) were inhibited by dietary astaxanthin supplementation. …”
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