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14501
Modulation of Circulating Cytokine-Chemokine Profile in Patients Affected by Chronic Venous Insufficiency Undergoing Surgical Hemodynamic Correction
Published 2014-01-01“…The expression of proinflammatory cytokines/chemokines has been reported in in vitro/ex vivo settings of chronic venous insufficiency (CVI), but the identification of circulating mediators that might be associated with altered hemodynamic forces or might represent innovative biomarkers is still missing. …”
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14502
Dissecting macrophage heterogeneity and kaempferol in lung adenocarcinoma: a single-cell transcriptomic approach and network pharmacology
Published 2025-01-01“…Methods We conducted single-cell RNA sequencing (scRNA-seq) on LUAD samples, performing an in-depth analysis of macrophage populations and their expression signatures. Network pharmacology was used to identify TCM components with potential TAM-modulatory effects, focusing on Astragalus membranaceus. …”
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14503
Microscopic Observation of Proliferative Membranes in Fibrocontractive Retinal Disorders
Published 2019-01-01“…The cell components found in the ERM specimens, like myofibroblasts, macrophages, and polymorphonuclear cells, were recognized as the expression of cell migration and differentiation that induced an inflammatory process and a fibroproliferative repair process. …”
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14504
Electroacupuncture Zusanli (ST36) Relieves Somatic Pain in Colitis Rats by Inhibiting Dorsal Root Ganglion Sympathetic-Sensory Coupling and Neurogenic Inflammation
Published 2023-01-01“…Furthermore, EA at Zusanli (ST36) activated neurogenic inflammation, characterized by decreased expression of substance P (SP), hyaluronic acid (HA), bradykinin (BK), and prostacyclin (PGI2) in colitis rat skin tissues corresponding to the L6 DRG. …”
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14505
The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism
Published 2021-01-01“…FoxO1, SREBP-1c, FASN, ACLY, ACC, and MAGL expressions in tissue samples were detected by RT-qPCR and WB. …”
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14506
Application of efgartigimod in Chinese patients with myasthenia gravis: a single-center real-world prospective study
Published 2025-01-01“…Within one treatment cycle, 18 (82%) patients showed a reduction of at least 2 points in MG-ADL scores and sustained for at least 4 weeks, and 6 (27%) attained minimal symptom expression (MSE) and sustained for at least 4 weeks. …”
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14507
Effects of synergistic fermentation of tea bee pollen with bacteria and enzymes on growth and intestinal health of Apis cerana cerana
Published 2025-01-01“…Concurrently, the relative expression levels of immune-related genes including Abaecin, PPO, Defensin, and Vg were significantly upregulated. …”
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14508
Anaerobic metabolism promotes breast cancer survival via Histone-3 Lysine-18 lactylation mediating PPARD axis
Published 2025-02-01“…H3K18la promoted the expression of PPARD, which in turn influenced the transcription of AKT, but not ILK. …”
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14509
Differential Regulation of NK Cell Receptors in Acute Lymphoblastic Leukemia
Published 2022-01-01“…Quantitative PCR (q-PCR) further investigated copy number variation (CNV), methylation index (MI), and mRNA expression of significant genes in T-ALL (14 males), NC (12 males and 12 females), and B-ALL samples (N=12 males and 12 females). …”
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14510
Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy
Published 2025-01-01“…Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been identified as key regulators of gene expression, affecting diverse biological processes, notably programmed cell death (PCD). …”
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14511
Prevention of Cyclophosphamide-Induced Immunosuppression in Mice with the Antimicrobial Peptide Sublancin
Published 2018-01-01“…In addition, the mRNA expression of IL-1β, IL-6, and TNF-α in peritoneal macrophages from sublancin- (1.0 mg/kg body weight) administered mice was significantly increased (P<0.05). …”
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14512
Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord
Published 2016-01-01“…Thermal hyperalgesia and mechanical allodynia were measured and used for evaluating level of pain caused by TCI treatment. PKA mRNA expression in dorsal root ganglion (DRG) was detected by RT-PCR. …”
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14513
Prioritization of biological processes based on the reconstruction and analysis of associative gene networks describing the response of plants to adverse environmental factors
Published 2021-09-01“…The prioritization results indicate that fundamental processes, such as gene expression, post-translational modifications, protein degradation, programmed cell death, photosynthesis, signal transmission and stress response play important roles in the common molecular genetic mechanisms for plant response to various adverse factors. …”
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14514
Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction
Published 2025-02-01“…Furthermore, Se@PSN promoted the expression of mitochondrial respiratory complexes, mitigating oxidative phosphorylation damage and preserving mitochondrial function. …”
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14515
Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat
Published 2016-01-01“…We have also examined gene expression and surface marker profiles in a predictive model to identify cells with enhanced chondrogenic potential. …”
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14516
circZNF532 promotes endothelial-to-mesenchymal transition in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD
Published 2024-07-01“…Further data showed that circZNF532 recruited TAF15 to stabilize PIK3CD, thus elevating PIK3CD expression. Following rescue experiments suggested that PIK3CD overexpression partially negated the inhibitory effect of circZNF532 silencing on EndMT, migration, and angiogenesis of HG-treated HRMECs. …”
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14517
Biochemical analysis of miR-217 and miR-532 in patients with fibromyalgia
Published 2025-02-01“…The miR-217 and miR-532 serum expressions were detected using quantitative real-time PCR (qRT-PCR). …”
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14518
Smooth Muscle Cell Alignment and Phenotype Control by Melt Spun Polycaprolactone Fibers for Seeding of Tissue Engineered Blood Vessels
Published 2015-01-01“…The preservation of VSMC contractile phenotype on the aligned scaffold was demonstrated by the retention of α-SMA expression after several days of culture. The effect was assessed on a prototype vascular graft prosthesis fabricated from polylactide caprolactone; VSMCs aligned longitudinally along a fiberless tube, whereas, for the aligned fiber coated tubes, the VSMCs aligned in the required circumferential orientation.…”
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14519
MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway
Published 2025-02-01“…Herein, we revealed for the first time that the migration, invasion, and metastatic abilities of glioma cells decreased significantly after MYH9 expression was downregulated. Moreover, our results suggested that MYH9 regulated the epithelial‒mesenchymal transition (EMT) process in glioma cells via β-catenin. …”
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14520
Effects of Light Spectra on Nutritional Composition in Juvenile Sinonovacula constricta (Lamarck 1818) and Transcriptomic Analysis
Published 2024-01-01“…The results indicate that the light spectrum has a significant impact on the growth, biochemical composition, and gene expression of juvenile S. constricta. Specifically, culturing S. constricta under the yellow light led to improved growth rate (1.09 ± 0.03%/day), higher levels of carbohydrate (26.27% ± 0.49%), crude lipid (11.99% ± 0.23%), energy contents (14,611.34 ± 1,067.01 kJ/kg), and essential amino acids (15.22 ± 0.01 g/kg), as well as increased proportions of polyunsaturated fatty acids (12.38 ± 0.31 µg/mg). …”
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