Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects by Takashi Kobayashi, Takaomi Kessoku, Michihiro Iwaki, Asako Nogami, Masato Yoneda, Satoru Saito, Yoshie Yamana, Yosuke Nishitani, Hiroshige Kuwahara, Atsushi Nakajima

“…Furthermore, the messenger RNA expression of interleukin-10, an anti-inflammatory cytokine, was upregulated in the small intestine of Lactiplantibacillus plantarum 22 A-3-treated mice. …”
Get full text

Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma by Rui Zhang, Yi Zhang, Hairong Xiao, Qingxi Liu, Mingfeng Zhao

“…These findings suggest that IL4I1 may be a contributing factor to poor prognosis in R/R DLBCL patients. IL4I1 expression enhances immunosuppression via the IDO-AHR-Kyn pathway, inhibiting the effectiveness of PD-1 inhibitors combined with CD19 CAR-T. …”
Get full text

Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production by Katriina Vuolteenaho, Anna Koskinen, Meiju Kukkonen, Riina Nieminen, Unto Päivärinta, Teemu Moilanen, Eeva Moilanen

“…Leptin alone or in combination with IL-1 enhanced the expression of iNOS and COX-2, and production of NO, PGE2, IL-6, and IL-8. …”
Get full text

Machine learning potential predictor of idiopathic pulmonary fibrosis by Chenchun Ding, Quan Liao, Renjie Zuo, Shichao Zhang, Zhenzhen Guo, Junjie He, Ziwei Ye, Weibin Chen, Sunkui Ke

“…Identifying relevant biomarkers for effective early-stage risk prediction is therefore of critical importance.MethodsIn this study, we obtained gene expression profiles and corresponding clinical data of IPF patients from the GEO database. …”
Get full text

Traffic-related-air-pollutant PM2.5 Caused Toxicity on Caenorhabditis elegans with Cotreatment of High-dose Glucose and Tempeh by Jian-He Lu, Ming-Hsien Tsai, Sen-Ting Huang, Jia-De Lee, Ta-Chih Hsiao, Wan Nurdiyana Wan Mansor, How-Ran Chao

“…In addition, tempeh treatment also ameliorated the altered mRNA expression of the antioxidant gene in C. elegans treated with or without TRAP PM2.5 and with or without high-dose glucose diets. …”
Get full text

A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines by Linghong Huang, Xinyuan Sun, Qinhua Zuo, Ting Song, Ning Liu, Zonghua Liu, Wei Xue

“…Degradation of BRD4 can downregulate the expression of ferroptosis-related genes such as GPX4, thereby promoting tumor-specific ferroptosis. …”
Get full text

CBP22, a Novel Bacteriocin Isolated from Clostridium butyricum ZJU-F1, Protects against LPS-Induced Intestinal Injury through Maintaining the Tight Junction Complex by Tenghao Wang, Jie Fu, Xiao Xiao, Zeqing Lu, Fengqin Wang, Mingliang Jin, Yizhen Wang, Xin Zong

“…Moreover, CBP22 treatment increased the expression of the zonula occludens and reduced permeability as well as apoptosis in the jejunum in LPS-treated mice. …”
Get full text

Features of the Surface and Subsurface Waves Application for Ultrasonic Evaluation of Physicomechanical Properties of Solids. Part 2. Strenghtned Inhomogeneous Surface Layer by A. R. Baev, A. L Mayorov, N. V. Levkovich, M. V. Asadchaya

“…Based on the Oulder integral expression. The dependence connecting the wave velocity, its frequency, the depth of the hardened layer and the spatial distribution of hardness represented as a step with a changing slope of its side surface simulating the transition zone of the hardened layer are calculated.Using the pulse method and low-aperture transducers with a frequency of 1−3.8 MHz, the dependences of the surface wave velocity on the cutting height of a layer hardened by HDTV hardening are obtained. …”
Get full text

Antiaging and Antioxidant Bioactivities of Asteraceae Plant Fractions on the Cellular Functions of the Yeast Schizosaccharomyces pombe by Rika Indri Astuti, Muhammad Eka Prastya, Irmanida Batubara, Eka Budiarti, Aulia Ilmiyawati

“…S. nodiflora water fraction has been shown to have antioxidant and antiaging activities in S. pombe, by modulating stress tolerance response, inducing mitochondrial activity, and increasing the ctt1 gene expression. Compounds analysis identified that S. nodiflora water fraction contained some primarily compounds including oxyphyllacinol, valine, and sugiol.…”
Get full text

Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice by Yangwenjie Wang, Yang Xiang, Ruiqi Wang, Xiangning Li, Jianxiong Wang, Siwang Yu, Ying Zhang

“…Importantly, SFN treatment improved antioxidative capacity of skeletal muscle in response to the acute exhaustive exercise by increasing mRNA and nucleoprotein expression of Nrf2 and these genes involved in antioxidant generation and decreasing blood creatine kinase (CK) and 4-hydroxy-2-nonenal (4-HNE)-modified protein levels in the HIIT mice.…”
Get full text

The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis by Katarzyna Kasperkiewicz, Anna S. Świerzko, Marta Przybyła, Janusz Szemraj, Jarosław Barski, Mikael Skurnik, Andrzej Kałużyński, Maciej Cedzyński

“…On the other hand, it seemed to be more hepatotoxic when compared with the other tested endotoxins, while the enlargement of inguinal lymph nodes and drop in hepatic MBL-C expression (at the mRNA level) were independent of LPS chemotype. …”
Get full text

Influenza B virus infection alters the regenerative potential of murine alveolar type 2 pneumocytes by Satoko Nakano, Cait E. Hamele, Aleksandra Tata, Purushothama Rao Tata, Nicholas S. Heaton

“…The impact on the cells that survive viral infection in the distal lung epithelia, however, is much less well-characterized. Utilizing a Cre-expressing influenza B virus (IBV) and a lox-stop-lox tdTomato reporter mouse model, we identified that alveolar type 2 (AT2) pneumocytes, a progenitor cell type in the distal lung, can survive viral infection. …”
Get full text

Conspiracy theories and COVID-19: Coping mechanism or cognitive dissonance? A longitudinal study by Livio TARCHI, Francesco CHIRICO, Eleonora ROSSI, Emanuele CASSIOLI, Kavita BATRA, Pietro CRESCENZO, Amelia RIZZO, Giovanni CASTELLINI, Valdo RICCA

“…Results: At baseline, individuals with a belief in conspiracy theories reported higher Somatization concerns in comparison to the rest of the sample (Hedges’ g -0.424, p 0.023). In turn, those expressing vaccine hesitancy reported higher Obsession-Compulsion in comparison to the rest of the sample (g -0.341, p 0.025). …”
Get full text

Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis by Lingxiao Xu, Qiuyue Peng, Wenhua Xuan, Xiaoke Feng, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wang

“…Furthermore, recombinant IL-29 augmented the mRNA expression of IL-1β, IL-6, IL-8, and matrix-metalloproteinase-3 (MMP-3) in OA FLS and increased cartilage degradation when ex vivo OA cartilage explant was coincubated with OA FLS. …”
Get full text

68Ga-NOTA-RM26 PET/CT in the evaluation of glioma: a pilot prospective study by Yilin Li, Rongxi Wang, Jingci Chen, Zhaohui Zhu, Yu Wang, Wenbin Ma

“…There was a positive correlation (P < 0.01) between GRPR expression level and SUVmax. P53 mutations caused significant differences in SUVmax (P = 0.03). …”
Get full text

The Idea of Education: Development or Service Delivery? by V. E. Ljovkin, A. O. Ljovkina, E. L. Docenko, L. M. Volosnikova

“…It is proved that an established expression “educational services” in modern discourse contributes to destructive transformations of the citizens’ mentality and social space. …”
Get full text

The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes by Anjun Guo, Xueying Li, Lihua Pan, Qiangming Li, Jianping Luo, Xueqiang Zha

“…Consistently, PCP was also found to significantly decrease the phosphorylation of p65, p38, extracellular-regulated kinase 1/2 (ERK1/2) and Akt, and increase the protein expression of inhibitor of NF-κB (IκB) in the aortas of male and female mice induced by HFD. …”
Get full text

Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

“…Antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) are two well-known strategies used to modulate gene expression. RNA-targeted therapy can precisely modulate the function of target RNA with minimal off-target effects and can be rationally designed based on sequence data. …”
Get full text

Concurrent Viewing of H&E and Multiplex Immunohistochemistry in Clinical Specimens by Larry E. Morrison, Tania M. Larrinaga, Brian D. Kelly, Mark R. Lefever, Rachel C. Beck, Daniel R. Bauer

“…<b>Background/Objectives:</b> Performing hematoxylin and eosin (H&E) staining and immunohistochemistry (IHC) on the same specimen slide provides advantages that include specimen conservation and the ability to combine the H&E context with biomarker expression at the individual cell level. We previously used invisible deposited chromogens and dual-camera imaging, including monochrome and color cameras, to implement simultaneous H&E and IHC. …”
Get full text

Genetically-encoded targeted protein degradation technology to remove endogenous condensation-prone proteins and improve crop performance by Ming Luo, Sitao Zhu, Hua Dang, Qing Wen, Ruixia Niu, Jiawei Long, Zhao Wang, Yongjia Tong, Yuese Ning, Meng Yuan, Guoyong Xu

“…Abstract Effective modulation of gene expression in plants is achievable through tools like CRISPR and RNA interference, yet methods for directly modifying endogenous proteins remain lacking. …”
Get full text