Deapioplatycodin D inhibits glioblastoma cell proliferation by inducing BNIP3L-mediated incomplete mitophagy by Yu Sun, Guangze Zhu, Renshuang Zhao, Yaru Li, Hongyang Li, Yunyun Liu, Ningyi Jin, Xiao Li, Yiquan Li, Tiemei Liu

“…Transcriptomics identified differences in mitophagy-related genes, and analysis of the levels of the corresponding proteins indicated that mitophagy in GBM cells was induced mainly through BNIP3L. Increased expression of BNIP3L disrupts the Bcl-2-Beclin-1 complex, thereby releasing Beclin-1 and activating autophagy. …”
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The Critical Role of YAP/BMP/ID1 Axis on Simulated Microgravity‐Induced Neural Tube Defects in Human Brain Organoids by Di Guo, Bin Yao, Wen‐Wei Shao, Jia‐Chen Zuo, Zhe‐Han Chang, Jian‐Xin Shi, Nan Hu, Shuang‐Qing Bao, Meng‐Meng Chen, Xiu Fan, Xiao‐Hong Li

“…SMG impairs N‐cadherin‐based adherens junction formation, leading to neural tube defects associated with dysregulated self‐renewal capacity and neuroepithelial disorganization in human brain organoids. Bulk gene expression analyses reveal that SMG alters Hippo and BMP signaling in brain organoids. …”
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Experimental Study of H-Shaped Honeycombed Stub Columns with Rectangular Concrete-Filled Steel Tube Flanges Subjected to Axial Load by Jing Ji, Maomao Yang, Zhichao Xu, Liangqin Jiang, Huayu Song

“…The axial compression bearing capacity decreases gradually with increasing λs, whereas the ductility increases. An analytical expression for the STHCC short column axial compression bearing capacity is established by introducing a correction function (w), which has good agreement with experimental results. …”
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Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway by Yiyang Wang, Baoshuai Bai, Yanzhu Hu, Haoming Wang, Ningyuan Liu, Yibo Li, Pei Li, Guangdong Zhou, Qiang Zhou

“…The potential mechanism was related to the differential expression of mechanosensing factors in notochordal NP and fibrocartilaginous inner AF, which affects the fate of the cells under hydrostatic pressure. …”
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Real-world use of tafasitamab preceding CD19-directed chimeric antigen receptor T-cell therapy for relapsed or refractory diffuse large B-cell lymphoma by Narendranath Epperla, Loretta J. Nastoupil, Bruce Feinberg, John Galvin, Prathamesh Pathak, Theresa Amoloja, Danielle Gentile, Kim Saverno

“…This small real-world analysis demonstrated disease response to CAR-T therapy and detectable CD19 expression following tafasitamab treatment, adding to literature investigating treatment outcomes associated with sequential use of anti-CD19 therapies in patients with R/R DLBCL.…”
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Verbal Encoding Strategies in Visuo-Spatial Working Memory by Joana Pereira Seabra, Vivien Chopurian, Alessandra S. Souza, Thomas B. Christophel

“…The use of individual spatial words, predicted class 1 cardinal biases in memory (i.e. the observation that cardinal stimuli are more accurately recalled than non-cardinal ones). Conversely, words expressing uncertainty (e.g. ‘slightly’, ‘near’) predicted class 2 cardinal bias (i.e. recall biases away from the cardinal planes). …”
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Das Menschliche in der Musik . August Halms prozessuale Metaphorik im Brennpunkt analysetheoretischer Fragestellungen by Astrid Bolay

“…Der Musiktheoretiker August Halm hat hingegen gerade für die expressiven, dynamischen und prozesshaften Qualitäten von Musik ein reichhaltiges und plastisches Vokabular entwickelt. …”
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The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells by Po-An Tai MD, PhD, Yen-Lin Liu MD, PhD, Ya-Ting Wen MD, Chien-Min Lin MD, PhD, Thanh-Tuan Huynh MD, PhD, Michael Hsiao DVM, PhD, Alexander T. H. Wu PhD, Li Wei MD, PhD

“…We established a CD133 promoter-driven dual reporter, expressing green fluorescent protein (GFP) and firefly luciferase (CD133-LG), capable for in vitro and in vivo imaging of CD133+ GSCs. …”
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Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, C... by Nattaphol Uransilp, Pannawat Chaiyawatthanananthn, Sombat Muengtaweepongsa

“…Previous study showed that simvastatin can reduce oxidative stress and LOX-1 expression. Objectives. To evaluate neurological outcomes and serum sLOX-1 and NO levels in patients with AIS treatment with low dose 10 mg/day and high dose 40 mg/day of simvastatin. …”
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Derivation and Identification of Motor Neurons from Human Urine-Derived Induced Pluripotent Stem Cells by Huan Yi, Bingbing Xie, Ben Liu, Xuan Wang, Li Xu, Jia Liu, Min Li, Xiufeng Zhong, Fuhua Peng

“…Immunofluorescence and PCR confirmed the expression levels of both MN and NMJ markers. The comparison of the ratios of positive labeling for MN markers between urine-iPSCs and B-iPSCs demonstrated that the differentiation potentials of these cells were not significantly different. …”
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Elos entre a precarização laboral e a saúde mental do trabalhador by Laís Maria Germano Canuto Sales, Ana Laís Carvalho de Sousa, Dária Maria Barbosa Dedê, Janne Izabel Alves de Sousa, Renata Guimarães de Carvalho, Camilla Araújo Lopes Vieira

“…Nessa perspectiva, embora tenham sido identificadas correlações entre precarização do trabalho e saúde mental dos trabalhadores, constata-se a necessidade de maior aprofundamento em estudos que possam expressar um maior diagnóstico de nexo causal entre a precarização do trabalho e a saúde mental dos trabalhadores.…”
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INSTINCT: Multi-sample integration of spatial chromatin accessibility sequencing data via stochastic domain translation by Yuyao Liu, Zhen Li, Xiaoyang Chen, Xuejian Cui, Zijing Gao, Rui Jiang

“…Additionally, we highlight the advantages of INSTINCT in spatial domain identification, visualization, spot-type annotation, and various downstream analyses, including motif enrichment analysis, expression enrichment analysis, and partitioned heritability analysis.…”
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Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys by Ayaka Domon, Kentaro Katayama, Yuki Tochigi, Hiroetsu Suzuki

“…Affected males exhibited disorganized architecture of pancreatic islets, decreased numbers of β cells, and markedly decreased expression of insulin, despite no pathological findings of hemorrhage or infiltration of inflammatory cells in the pancreatic islet. …”
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HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast by Katsumi Kito, Toshiharu Maeda, Keiko Ninomiya, Atsuro Sugita, Teiri Sagawa, Kinya Matsuoka, Kousei Kinoshita, Naoki Hyodo, Nagisa Morita, Keizo Furuya

“…Since the spindle cell component was intimately admixed with apocrine carcinoma and had focal cytokeratin expression, we diagnosed it as metaplastic spindle cell carcinoma, which was originated from the apocrine carcinoma. …”
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The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways by Ahmed S. Elshikha, Georges Abboud, Rigena Avdiaj, Laurence Morel, Sihong Song

“…Human AAT also lowered the expressions of interferon signature genes. Western blot analysis showed that hAAT reduced the expression of the active form (cleaved) of TLR9 in DCs, indicating a novel mechanism of hAAT function in the immune system. …”
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Rapamycin Improves Palmitate-Induced ER Stress/NF κ B Pathways Associated with Stimulating Autophagy in Adipocytes by Jiajing Yin, Liping Gu, Yufan Wang, Nengguang Fan, Yuhang Ma, Yongde Peng

“…Furthermore, rapamycin decreased PA-induced nuclear translocation of NFκB P65 subunit, thereby NFκB-dependent inflammatory cytokines MCP-1 and IL-6 expression and secretion. In conclusion, rapamycin attenuated PA-induced ER stress/NFκB pathways to counterbalance adipocytes stress and inflammation. …”
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Deficiency of Dietary Fiber in Slc5a8-Null Mice Promotes Bacterial Dysbiosis and Alters Colonic Epithelial Transcriptome towards Proinflammatory Milieu by Sathish Sivaprakasam, Pramodh K. Ganapathy, Mohd Omar Faruk Sikder, Moamen Elmassry, Sabarish Ramachandran, Kameswara Rao Kottapalli, Vadivel Ganapathy

“…We conclude that absence of fiber in diet in KO mice causes bacterial dysbiosis and alters gene expression in the colon that is conducive for inflammation.…”
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Antitumor effect of a pyrazolone-based-complex [Cu(PMPP-SAL)(EtOH)] against murine melanoma B16 cell in vitro and in vivo by Abula Ayipairi, Zhao Jing, Xu Guancheng, Li Yijie, Sun Surong

“…When challenged C57 BL/6J mice were treated with [Cu(PMPPSAL)(EtOH)], a smaller volume of B16 solid tumors were reported than the control group (p < 0.01), with lower positive expression indices of CD 34, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) (p < 0.01). …”
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Healthcare Workers’ General Health and Its Relation with Anxiety, Anger, and Posttraumatic Stress Disorder during COVID-19 Outbreak in Southeast Iran by Alireza Malakoutikhah, Leila Ahmadi Lari, Pooya Baharloo, Rasmieh Al-Amer, Mohamed Alnaiem, Hossein Khaluei, Mahlagha Dehghan

“…The research tools included the 12-Item General Health Questionnaire (GHQ-12), the Impact of Event Scale-Revised (IES-R), the trait anxiety section of State-Trait Anxiety Inventory (STAI), and the trait anger section of Trait-State Anger Expression Inventory 2 (STAXI-2). Data analysis was done in IBM SPSS Statistics version 25 and using Pearson’s correlation tests, independent t-test, ANOVA, and multivariate linear regression. …”
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KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA by Xiaowei Lu, Kui Hu, Dandan Zhang, Xuefeng Yin, Jifeng Nie, Kai Zhao

“…KLF5 transcription activated PDGFA expression and KLF5 was proved to bind to PDGFA promoter in NOZ cells. …”
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