Inhibitory Effect of Flavonoid Extract of Lotus Leaf on Alcohol-Induced Gastric Injury by Antioxidant Capacity in Mice by Yi Chen, Qin Li, Zhiping Kuang, Xin Zhao, Ruokun Yi, Xiaowei He, Guangjing Feng

“…The quantitative polymerase chain reaction (qPCR) and Western blot results proved that FELL upregulated the mRNA and protein expressions of SOD1, SOD2, CAT, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), neuronal nitric oxide synthase (nNOS), and endothelial nitric oxide synthase (eNOS) and downregulated the expression of inducible nitric oxide synthase (iNOS) in the gastric tissue of mice with gastric injury. …”
Get full text

Enhanced targeted treatment of cervical cancer using nanoparticle-based doxycycline delivery system by Sadia Anjum, Ayesha Akhtar, Saleh M. Aldaqal, Maisa S. Abduh, Hammad Ahmad, Riaz Mustafa, Faiza Naseer, Maryam Sadia, Tahir Ahmad

“…Cell migration was reduced by 45%, and RT-PCR analysis revealed a 53% downregulation of TNF-α expression, suggesting effective targeting of inflammatory pathways. …”
Get full text

ABOUT THE MORPHOLOGY OF BUD SCALES AND CATAPHYLLS OF ULMUS GLABRA HUDS. (ULMACEAE) by I. S. Antonova, A. S. Popova

“…Specific features of plant development and mechanisms ensuring such processes are expressly linked with the  structure of buds and hence the leaf series formed on lateral shoots.Materials and methods. …”
Get full text

Exploration of the molecular mechanism behind a novel natural genic male-sterile mutation of 1205A in Brassica napus by Lijing Xiao, Jinze Zhang, Shaomin Guo, Hairun Jin, Qingjing Ouyang, Xu Long, Zhongbin Yan, Entang Tian

“…This refinement facilitated the identification of a candidate gene, BnaC03g27700D, through functional and expression analyses. Furthermore, the subcellular localization of BnaC03g27700D was examined. …”
Get full text

Regulatory mechanism of carbohydrate metabolism pathways on oil biosynthesis of oil plant Symplocos paniculata by Wenbin Zeng, Beilei Xie, Yunzhu Chen, Jingzhen Chen, Peiwang Li, Lijuan Jiang, Changzhu Li, Qiang Liu, Yan Yang

“…Whereas, during the fruit maturation stage (from 90 DAF to 170 DAF), the expression of phosphofructokinase 1 (PFK-1), pyruvate kinase (PK) and pyruvate dehydrogenase (PDH) enzyme genes involved in the glycolysis pathway was significantly upregulated, thereby facilitating a rapid and substantial accumulation of oil. …”
Get full text

Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway by Zhengguo Qiu, Jianbing Ma, Xiaqing Zhang, Mingna Jiao, Liqiang Zhi

“…Brain tissue morphology was assessed by HE staining. The expression of various proteins was measured using IF assay and western blot. …”
Get full text

Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system by Shikha Vashisht, Costantino Parisi, Cecilia L. Winata

“…Utilizing heart-specific expression quantitative trait loci data, we further identified a subset of 63 CHD-SNPs with regulatory potential distributed across various cardiac tissues. …”
Get full text

Experimental Study on the Effect of Allogeneic Endothelial Progenitor Cells on Wound Healing in Diabetic Mice by Min Leng, Ying Peng, Manchang Pan, Hong Wang

“…Furthermore, local transplantation of EPCs promoted the expression of SDF-1, CXCR4, and VEGF. We speculated that EPC transplantation may promote wound healing through the SDF-1/CXCR4 axis. …”
Get full text

Attitudes, Awareness, and Willingness of Iranians Toward Using Telemedicine in Post‐COVID Era: A Cross‐Sectional Study by Marsa Gholamzadeh, Hamidreza Abtahi, Reza Safdari, Elham Haghshenas, Mehrnaz Asadi Gharabaghi, Besharat Rahimi

“…Overall, Iranians displayed positive attitudes toward telemedicine, with over two‐thirds expressing a strong willingness to continue using telemedicine post‐pandemic. …”
Get full text

Assessment of different enrichment methods revealed the optimal approach to identify bovine circRnas by Yixin Wang, Jian Wang, Robert J. Gruninger, Tim A. McAllister, Mingzhou Li, Le Luo Guan

“…Although circular RNAs (circRNAs) play important roles in regulating gene expression, the understanding of circRNAs in livestock animals is scarce due to the significant challenge to characterize them from a biological sample. …”
Get full text

Taurine Alleviated the Negative Effects of an Oxidized Lipid Diet on Growth Performance, Antioxidant Properties, and Muscle Quality of the Common Carp (Cyprinus carpio L.) by Dan Liu, Jiali Mi, Xiao Yan, Chaobin Qin, Junli Wang, Guoxing Nie

“…Moreover, taurine supplementation significantly reduced myofiber diameter and increased myofiber density (P<0.05) and enhanced the expression levels of paired box 7 (pax7), myogenic factor 5 (myf5), myogenic differentiation antigen (myod), and myogenic regulatory factor 4 (mrf4) compared with that of the OFO group (P<0.05). …”
Get full text

Hepatic and immune modulatory effectiveness of lactoferrin loaded Selenium nanoparticles on bleomycin induced hepatic injury by Khaled G. Abdel-Wahhab, Mahmoud Ashry, Laila K. Hassan, Marwa H. El-Azma, Ghada M. Elqattan, Mohamed H. A. Gadelmawla, Fathia A. Mannaa

“…Moreover, BLM injection resulted in marked histopathological alterations and severe expression of caspase 3. Post-treatment of BLM-intoxicated rats with LF, SeNPs or LF/SeNPs combination obviously improved the BLM-induced hepatic damages; this was achieved from the marked modulations in the mentioned parameters, besides improving the histopathological hepatic architecture. …”
Get full text

Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes by Miriam Maraslioglu, Elsie Oppermann, Carolin Blattner, Roxane Weber, Dirk Henrich, Christian Jobin, Elke Schleucher, Ingo Marzi, Mark Lehnert

“…Furthermore, LPS and TNF-α stimulated the gene expression of different inflammatory mediators, in part, in a NF-κB-dependent manner.…”
Get full text

Involvement of Proteasome and Macrophages M2 in the Protection Afforded by Telmisartan against the Acute Myocardial Infarction in Zucker Diabetic Fatty Rats with Metabolic Syndrome by C. Di Filippo, C. Rossi, B. Ferraro, R. Maisto, A. De Angelis, F. Ferraraccio, A. Rotondo, M. D’Amico

“…Telmisartan treatment (7 mg/kg and 12 mg/kg) reduced the myocardial infarct size, the expression of proteasome subunits 20S and 26S, and the protein ubiquitin within the heart. …”
Get full text

Artificial Intelligence in Pediatric Epilepsy Detection: Balancing Effectiveness With Ethical Considerations for Welfare by Marina Ramzy Mourid, Hamza Irfan, Malik Olatunde Oduoye

“…Deep learning models, such as CNN‐LSTM, have also enhanced seizure detection from video by capturing subtle movement and expression cues. Non‐EEG sensor‐based methods effectively identified nocturnal seizures, offering promising support for pediatric care. …”
Get full text

Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB by Jeanne Durendale Chiadak, Tatjana Arsenijevic, Kevin Verstrepen, Françoise Gregoire, Nargis Bolaky, Valérie Delforge, Véronique Flamand, Jason Perret, Christine Delporte

“…The aim of this study was to determine the signaling pathway by which Forskolin (FK), a cyclic adenosine monophosphate- (cAMP-) promoting agent causing positive changes in body composition in overweight and obese adult men, affects MCP-1 and GPR120 expression during an inflammatory response induced by lipopolysaccharide (LPS) in adipocytes, such as in an obese state. 3T3-L1 cells differentiated into adipocytes (DC) were stimulated with LPS in the absence or presence of FK and inhibitors of TLR-4 and inhibitor of kappa B (IκBα). …”
Get full text

Anxiety-like behavior and altered hippocampal activity in a transgenic mouse model of Fabry disease by Kai Kummer, Jeiny Luna Choconta, Marie-Luise Edenhofer, Archana Bajpai, Gopuraja Dharmalingam, Theodora Kalpachidou, David A. Collier, Michaela Kress

“…Hippocampus single-cell sequencing further revealed that Gb3 accumulation was associated with differential gene expression in neuronal and non-neuronal cell populations with granule, excitatory and interneurons, as well as microglia and endothelial cells as the main clusters with the most dysregulated genes. …”
Get full text

Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…In this study, an investigation was conducted to map the miRNA and protein expression profiles of EVs derived from septic plasma. …”
Get full text

Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice by Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park

“…Moreover, increased macrophage accumulation and elevated expression of cytokines and chemokines were attenuated by caspase-1 inhibition. …”
Get full text

Toxicological landscape of Fuzi: a comprehensive study on the spatial distribution of toxicants and regional neurotoxicity variability in zebrafish by Xiaoqi Pan, Xiaoqi Pan, Tianyu Liang, Han Feng, Weiying Liu, Qiaoxin Mou, Xiaoyu Yan

“…RNA sequencing analysis further indicated that the amino acid metabolism, ErbB, cGMP-PKG, and p53 signaling pathways-regulated by changes in the expression of Glub, Mao, GAB1, PRKG1B, PSEN2, and BAXα genes were disrupted to varying extents by Fuzi from different origins. …”
Get full text