Effects of Ghrelin on Triglyceride Accumulation and Glucose Uptake in Primary Cultured Rat Myoblasts under Palmitic Acid-Induced High Fat Conditions by Lingling Han, Jia Li, Ying Chen, Wei Wang, Dan Zhang, Guoliang Liu

“…The relative protein expression of p-AMPKα/AMPKα, UCP3, and p-ACC under 0.3 mM PA was significantly reduced compared to controls (all P<0.05), but those in the 10−9 and 10−7 M ghrelin groups were significantly protected from 0.3 mM PA (all P<0.05). …”
Get full text

Determinants Present in the Receptor Carboxy Tail Are Responsible for Differences in Subtype-Specific Coupling of β-Adrenergic Receptors to Phosphoinositide 3-Kinase by Julie Simard, Matthieu Boucher, Rachel Massé, Terence E. Hébert, Guy Rousseau

“…Using transiently transfected HEK 293 cells expressing either β1- or β2-AR, we also observed that in presence of an agonist, β2-AR, but not β1-AR, is able to activate the PI-3K/Akt pathway. …”
Get full text

Effects of Baicalin on Gout Based on Network Pharmacology, Molecular Docking, and in vitro Experiments by Liu C, Liu W, Lu H, Fan Y, Wang A

“…The results of cell experiments suggested that baicalin could reduce the levels of inflammatory cytokines by inhibiting the TLR4/NF-κB signaling pathway in MSU-stimulated THP-1 cells and regulate the expression of these hub targets.Conclusion: These results revealed that baicalin possesses “multitarget, multipathway, multilevel” regulatory effects. …”
Get full text

In the Plots of Neoliberalism: the Impact of AirBnb on Hotel Industry and the Real Estate Market in São Paulo and Rio de Janeiro, Brazil by Rita de Cássia Ariza da Cruz, Cristina Pereira de Araujo, Luciano Muniz Abreu

“…As a theoretical premise, this text considers the relationship between AirBnb, the hotel industry and the real estate market as an expression of neoliberalism in the production of urban spaces in a developing country, based on the construction of a ‘market society’, on the competition between individuals and on their self-entrepreneurship (Andrade; Côrtes; Almeida, 2021). …”
Get full text

Influence of flavonoids’ lipophilicity on platelet aggregation by Babić Ivana, Bojić Mirza, Maleš Željan, Zadro Renata, Gojčeta Koraljka, Duka Ivan, Rimac Hrvoje, Jukić Irena

“…As determined by flow cytometry, the exposition of receptors necessary for the promotion of platelet activation and primary clot formation was diminished, i.e., lowered expression of the activated form of integrin αIIbβ3 was observed in the presence of flavanone. …”
Get full text

Tumor-derived exosomal lncRNA-MIR193BHG promotes bone metastasis of breast cancer by targeting the miR-489-3p/DNMT3A signaling axis in osteoclasts by Xiaoya Liu, Rui Ma, Feng Wei, Maihuan Wang, Yiwei Jiang, Peng Zheng, Zhen Cao

“…Additionally, mechanistic studies revealed that lncRNA-MIR193BHG acted as a competitive endogenous RNA (ceRNA) interacting with miR-489-3p, regulating DNMT3A expression and subsequently affecting osteoclast differentiation. …”
Get full text

Effects of Breast-Conserving Surgery Combined with Sentinel Lymph Node Biopsy on Breast Cosmetic Appearance and Systemic Stress of Patients with Breast Cancer by Jing Ji, Junfeng Shi, Xia Da, Guozhu Wang, Jin Xu

“…No significant difference was observed between the two groups regarding human epidermal growth factor receptor-2 (HER-2) expression (p > 0.05). …”
Get full text

Polymorphism of <i>Sdr</i> genes regulating seed dormancy in <i>Triticum persicum</i> Vav. and <i>Triticum aethiopicum</i> Jakubz. by M. S. Bazhenov, E. D. Guseva, V. S. Rubets

“…Possible effects of the detected polymorphisms on the expression of Sdr genes are discussed.…”
Get full text

The Clinicopathological Characteristics and Prognoses of dMMR Gastric Adenocarcinoma Patients by Jie Wang, Yanfeng Xi, Jian Zhao, Xuetong Rong, Weidong Lu, Yusheng Wang

“…Kaplan–Meier analysis showed that factors related to OS were family history (P=0.048), number of lymph node (LN) metastases (P<0.001), vascular tumor thrombus (P<0.001), HER2 expression status (P=0.025), and clinical stage (P<0.001). …”
Get full text

Lipoprotein(a) and thromboembolism: current state of knowledge and unsolved issues by Małgorzata Konieczyńska, Joanna Natorska, Michał Ząbczyk, Anetta Undas

“…Other prothrombotic mechanisms include increased synthesis of plasminogen activator inhibitor (PAI-1), formation of denser fibrin networks composed of thinner fibers, less susceptible to lysis, increased platelet activation, enhanced oxidation of phospholipids leading to a low-grade proinflammatory state, upregulated tissue factor expression, and suppression of tissue factor pathway inhibitor. …”
Get full text

Interleukin-22 Plays a Protective Role by Regulating the JAK2-STAT3 Pathway to Improve Inflammation, Oxidative Stress, and Neuronal Apoptosis following Cerebral Ischemia-Reperfusio... by Yongfei Dong, Chengyun Hu, Chunxia Huang, Jie Gao, Wanxiang Niu, Di Wang, Yang Wang, Chaoshi Niu

“…IL-22 treatment remarkably reduced the expression of inflammatory cytokines, including IL-1β, monocyte chemotactic protein- (MCP-) 1, and tumor necrosis factor- (TNF-) α, both in serum and the ischemic cerebral cortex. …”
Get full text

Direct immunofluorescence (DIF) versus immunohistochemical (IHC) staining of complements and immunoglobulins (Ig) in pemphigus group by Deepika Rana, Nita Khurana, Shramana Mandal, Bijay Laxmi Sahoo

“…The overall IgG, C3, IgG4, and C4d expression for pemphigus was seen in 88%, 88%, 76.9%, and 61.5% of cases. …”
Get full text

Anti-inflammatory effect of Plantago asiatica crude extract in rat gout arthritis model by Bingjun Qian, Jun Hu, Li Dai, Yue Zhou, Haixia Xu

“…At fixed times after the treatments, assessment of joint swelling ratios and pathological changes in the joints, as well as of select cytokine expression in the blood, was done. RP-HPLC results showed the PAE contained at least 8 ‘active’ ingredients, with plantamajoside, verbascoside, and cymaroside being the most abundant. …”
Get full text

Winery By-Products In Vitro and In Vivo Effects on Atherothrombotic Markers: Focus on Platelet-Activating Factor by Maria Choleva, Smaragdi Antonopoulou, Elizabeth Fragopoulou

“…Evidence from long-term studies shows that consumption may lower total and low density lipoprotein (LDL) cholesterol, improve insulin sensitivity, decrease lipid and protein oxidative damage, enhance antioxidant capacity, and have mild anti-inflammatory action toward reducing cytokine expression and levels. Data from the limited postprandial studies report that the acute consumption of winery by-product extracts improves glycemic response and reduces platelet reactivity to aggregatory stimuli. …”
Get full text

Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes by Rafael L. Simões, Maria Augusta Arruda, Cláudio Canetti, Carlos H. Serezani, Iolanda M. Fierro, Christina Barja-Fidalgo

“…Furthermore, heme induces NF-κB nuclear translocation, iNOS, and also HO-1 expression. Moreover, AM stimulated with free heme show enhanced phagocytic and bactericidal activities. …”
Get full text

Entre rezos y bombos. Aproximación a dos prácticas musicales de la Amazonía de Perú by Korina Grelly Irrazabal Laos, Ricardo López Alcas

“…El presente texto reúne dos expresiones musicales que tienen lugar en diferentes comunidades amazónicas: el ícaro de la comunidad shipibo, correspondiente a una práctica ritualizada y no-abierta, y el movido típico de la localidad de Pucallpa, correspondiente a los contextos festivos y de práctica abierta o colectiva. …”
Get full text

O moderno e a Vila Amaury: by Camila Pescatori Candido da Silva, Átila Rezendo Fialho

Get full text

Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 by Meiyue Wang, Zejie Wu, Xiaoyu Zheng, Yishu Huang, Yizhou Jin, Jiaxin Song, Wanzhen Lei, Hua Liu, Riyue Yu, Haoqing Yang, Runtao Gao

“…Betaine enhanced the expression of WDR81 in SCAPs during chondrogenesis. …”
Get full text

Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer by Sushma Yadav, Claudia M. Kowolik, Daniel Schmolze, Yuan Yuan, Min Lin, Arthur D. Riggs, David A. Horne

“…Approximately 40% of breast cancer tissue exhibited cytoplasmic/membranous localization of p-SMC1A, whereas nuclear expression was observed in normal breast tissues. Moreover, elevated phosphorylation levels were significantly associated with higher tumor grade and metastasis.…”
Get full text

Modified CD15/CD16-CLL1 inhibitory CAR-T cells for mitigating granulocytopenia toxicities in the treatment of acute myeloid leukemia by Rui Zhang, Yifan Zhao, Xiao Chai, Yingshuai Wang, Mohan Zhao, Shujing Guo, Yu Zhang, Mingfeng Zhao

“…Considering the distinct expression levels of CD15/CD16 on neutrophils and AML blasts, we have devised novel modified CD15 /CD16-CLL1 iCAR structures incorporating diverse inhibitory elements. …”
Get full text