Anti-diabetic effect of aloin via JNK-IRS1/PI3K pathways and regulation of gut microbiota by Ruting Zhong, Lanbin Chen, Yuanyuan Liu, Shouxia Xie, Sumei Li, Bin Liu, Chao Zhao

“…Additionally, aloin treatment inhibited the protein expression of c-Jun N-terminal kinases and activated that of IRS1/PI3K/Akt in the liver. …”
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The Role of Naphthaleneacetic Acid and 1-Methylcyclopropene in Preventing Preharvest Berry Dropping in <i>Vitis vinifera</i> L. by Antonio Carlomagno, Claudio Bonghi, Giuseppe Montanaro, Alessandra Ferrandino, Angela Rasori, Vitale Nuzzo, Vittorino Novello

“…Transcript analysis revealed differential gene expression patterns, indicating that NAA affects the ET biosynthesis pathway, while 1-MCP interferes with ET receptor signaling. …”
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Analysis of Non-linear Relationship of PM2.5 Mass Concentration with Aerosol Extinction Coefficient and RH in Hefei, China by Yinan Chen, Shiguo Zhang, Yonghua Wu, Kee Yuan, Jian Huang, Dongfeng Shi, Shunxing Hu

“…Based on Mie scattering theory, we derived a non-linear analytical expression among the PM2.5 mass concentration, aerosol extinction coefficient, and hygroscopic factor. …”
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Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities. by Alok Kafle, Sutas Suttiprapa, Mubarak Muhammad, Jan Clyden B Tenorio, Roshan Kumar Mahato, Norhidayu Sahimin, Shih Keng Loong

“…<h4>Background</h4>Epigenetic modifications, such as DNA methylation and histone modifications, are pivotal in regulating gene expression pathways related to inflammation and cancer. …”
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The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases by Xueyan Zhang, Yihan Yu, Hanyu Lei, Yufeng Cai, Jie Shen, Ping Zhu, Qingnan He, Mingyi Zhao

“…As a regulator of the antioxidant system, it upregulates the expression of HO-1 to reduce oxidative stress. Nrf2/HO-1 also has the ability to modulate calcium levels to prevent ferroptosis, pyroptosis, autophagy, programmed cell necrosis, alkaliptosis, and clockophagy. …”
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HLA-G Dimers in the Prolongation of Kidney Allograft Survival by Maureen Ezeakile, Vera Portik-Dobos, Juan Wu, Daniel D. Horuzsko, Rajan Kapoor, Muralidharan Jagadeesan, Laura L. Mulloy, Anatolij Horuzsko

“…Our study showed that a high level of HLA-G dimers in plasma and increased expression of the membrane-bound form of HLA-G on monocytes are associated with prolongation of kidney allograft survival. …”
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Opposing Roles of Leptin and Ghrelin in the Equine Corpus Luteum Regulation: An In Vitro Study by António Galvão, Angela Tramontano, Maria Rosa Rebordão, Ana Amaral, Pedro Pinto Bravo, Anna Szóstek, Dariusz Skarzynski, Antonio Mollo, Graça Ferreira-Dias

“…Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and GHR on progesterone (P4), prostaglandin (PG) E2 and PGF2α, nitric oxide (nitrite), tumor necrosis factor-α (TNF); macrophage migration inhibitory factor (MIF) secretion, and on angiogenic activity (BAEC proliferation), in equine corpus luteum (CL) from early and mid-luteal stages. LEPR expression was decreased in late CL, while GHR/Ghr-R1A system was increased in the same stage. …”
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New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite by Eman M. Ragab, Doaa M. El Gamal, Fares F. El-najjar, Hager A. Elkomy, Mahmoud A. Ragab, Mariam A. Elantary, Omar M. Basyouni, Sherif M. Moustafa, Shimaa A. EL-Naggar, Abeer S. Elsherbiny

“…These cells are typically identified by the expression of specific cell surface markers. A population of pancreatic cancer stem cells with aberrantly active developmental signaling pathways has been identified in recent studies of human pancreatic tumors. …”
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The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels by Guanglei Zhao, Jinyang Lyu, Xin Huang, Gangyong Huang, Feiyan Chen, Yibing Wei, Siqun Wang, Jun Xia, Jie Chen, Jingsheng Shi

“…The injection of DPSC-exosomes ameliorated destruction of cartilage, promoted matrix synthesis, inhibited cell apoptosis, and decreased the expression of catabolic factors. However, this effect was shown to be almost eliminated when miR-31 antagomir was injected. …”
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Regulation of Recombination between gtfB/gtfC Genes in Streptococcus mutans by Recombinase A by Satoko Inagaki, Kazuyo Fujita, Yukiko Takashima, Kayoko Nagayama, Arifah C. Ardin, Yuki Matsumi, Michiyo Matsumoto-Nakano

“…Determination of the sequences of the gtfB and gtfC genes showed that an approximately 3500 bp region was deleted from the area between them. Furthermore, expression of the recA gene was elevated in those strains as compared to MT8148. …”
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Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis by Fenli Shao, Qianqian Liu, Yuyu Zhu, Zhidan Fan, Wenjun Chen, Shijia Liu, Xiaohui Li, Wenjie Guo, Gen-Sheng Feng, Haiguo Yu, Qiang Xu, Yang Sun

“…A population of CD4-Cre-expressing proliferating chondrocytes was SHP2 deficient, which could differentiate into pre-hypertrophic and hypertrophic chondrocytes. …”
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Desindustrialización y terciarización. El avance hacia una creciente integración servicios-industria by Juan R. Cuadrado-Roura

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Prevalence of the polymorphic H-ficolin (FCN3) genes and mannosebinding lectin-associated serine protease-2 (MASP2) in indigenous populations from the Russian Arctic regions by M. V. Smolnikova, S. Yu. Tereshchenko

“…Lectins, being the main proteins of the lectin pathway activating the complement system, are encoded by polymorphic genes, wherein point mutations cause the protein conformation and expression to change, which turns out to have an effect on the functionality and ability to respond to the pathogen. …”
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Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells by Stefanie Hoyer, Kerstin F. Gerer, Isabell A. Pfeiffer, Sabrina Prommersberger, Sandra Höfflin, Tanushree Jaitly, Luca Beltrame, Duccio Cavalieri, Gerold Schuler, Julio Vera, Niels Schaft, Jan Dörrie

“…None of those RNAs induced changes in the expression of CD25, CD40, CD83, CD86, and CD70 or the secretion of the cytokines IL-8, IL-6, and TNFα of more than 1.5-fold compared to the control condition, while an mRNA encoding an NF-κB-activation protein as positive control induced massive secretion of the cytokines. …”
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Pulsed Electromagnetic Field-Assisting Reduced Graphene Oxide-Incorporated Nanofibers for Osteogenic Differentiation of Human Dental Pulp Stem Cells by Juo Lee, Sungmin Lee, Iksong Byun, Myung Chul Lee, Jungsil Kim, Hoon Seonwoo

“…RGO-NFs exhibited higher osteogenesis-related protein expression than PCL-only scaffolds, further enhanced by pulsed electromagnetic field (PEMF) application. …”
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Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer by Xinhang Xia, Wenhu Pi, Yanli Lan, Xiaomai Wu, Dongqing Lv, Yinnan Meng, Haihua Yang, Wei Wang

“…Western blot showed the decreasing expression of p-Src/p-AKT in the Anlo/5-FU group. Conclusion. …”
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ATP Induces Disruption of Tight Junction Proteins via IL-1 Beta-Dependent MMP-9 Activation of Human Blood-Brain Barrier In Vitro by Fuxing Yang, Kai Zhao, Xiufeng Zhang, Jun Zhang, Bainan Xu

“…Our data demonstrated that exposure to the photoreactive ATP analog, 3′-O-(4-benzoyl)benzoyl adenosine 5′-triphosphate (BzATP), induced a significant decrease in ZO-1 and occludin expression. Meanwhile, the decrease of ZO-1 and occludin was significantly attenuated by P2X7R inhibitors, as well as IL-1R and MMP antagonists. …”
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Chronic Unexpected Mild Stress Destroys Synaptic Plasticity of Neurons through a Glutamate Transporter, GLT-1, of Astrocytes in the Ischemic Stroke Rat by Dafan Yu, Zhenxing Cheng, Abdoulaye Idriss Ali, Jiamin Wang, Kai Le, Enkhmurun Chibaatar, Yijing Guo

“…CUMS evidently reduced the level of astroglial GLT-1 in the hippocampus of the ischemic rats (p<0.05), resulting in smaller amount of glutamate being transported into astrocytes surrounding synapses (p<0.05), and then expression of synaptophysin was suppressed (p<0.05) in hippocampal dentate gyrus. …”
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Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjögren’s Syndrome by Bo Hai, Taeko Shigemoto-Kuroda, Qingguo Zhao, Ryang Hwa Lee, Fei Liu

“…We found that EVs derived from BM-MSCs and iPSC-MSCs suppressed activation of immune cells and expression of proinflammation factors essential for SS progression in vitro and that infusion of iPSC-MSC EVs at the predisease stage decreased the lymphocyte infiltration in salivary glands and serum autoantibody levels in the same way as infusion of BM-MSCs and iPSC-MSCs. …”
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HERVs Endophenotype in Autism Spectrum Disorder: Human Endogenous Retroviruses, Specific Immunoreactivity, and Disease Association in Different Family Members by Marco Bo, Alessandra Carta, Chiara Cipriani, Vanna Cavassa, Elena Rita Simula, Nguyen Thi Huyen, Giang Thi Hang Phan, Marta Noli, Claudia Matteucci, Stefano Sotgiu, Emanuela Balestrieri, Leonardo Antonio Sechi

“…Certain HERV families show unique expression patterns and immune responses in autism spectrum disorder (ASD) patients compared to healthy controls, suggesting their potential as biomarkers. …”
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