Dimethyl Fumarate Protects against Lipopolysaccharide- (LPS-) Induced Sepsis through Inhibition of NF-κB Pathway in Mice by He Fang, Xingtong Wang, Mahendra Damarla, Rongju Sun, Qingli He, Ruojing Li, Pengfei Luo, Jun O. Liu, Zhaofan Xia

“…To further characterize the effect of DMF on LPS signaling, TNF-α, MCP-1, G-CMF, and IL-6 expression levels were determined by using cytokine array panels. …”
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Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition by Jiayu Zhang, Jianmin Peng, Siyu Wang, Li Wang, Yutong Sun, Juan Xia, Bin Cheng, Qinchao Hu

“…OSCC patients with higher PLIN2 expression possessed poorer prognosis and higher sensitivity to chemotherapy drugs (1S,3 R)-RSL3 and ML-210. …”
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Beyond image: evaluating the perceived effectiveness of workplace mental health programs in the insurance sector by Isabel Barbosa, Elizabeth Real de Oliveira

“…Additional key findings included generational differences in program perception, with younger employees expressing more frustration over the lack of follow-through. …”
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miR-486-5p Restrains Extracellular Matrix Production and Oxidative Damage in Human Trabecular Meshwork Cells by Targeting TGF-β/SMAD2 Pathway by Le Xu, Yiming Zhang, Hua Long, Bo Zhou, Haibo Jiang

“…Overexpression of miR-486-5p mitigated H2O2-induced oxidative damage by inhibiting apoptosis, reducing cleaved caspase-3/9 expression, reducing MDA levels, and increasing SOD levels as well as downregulating ECM genes. …”
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Progressive Intramuscular Haematoma in a 12-Year-Old Boy: A Case of Acquired Haemophilia A by Manori Gamage, Sadeepa Weerasinghe, Mohamed Nasoor, A. M. P. W. Karunarathne, Sashi Praba Abeyrathne

“…He had prolonged APPTT level with very high antibody titer against factor VIII. His gene expression for factor VIII was found to be normal. He was managed with FEIBA and recombinant FVII activated complexes and prednisolone 1 m/kg/day regime to control bleeding. …”
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Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland by Sun Eui Kim, Hye Jung Baek, Eun Jung Park, Sung Chul Lim, Sang Soo Kim

“…Further analysis revealed that tumorigenesis was accompanied by the accumulation of cyclin D1 and decreased expression of the cellular oncogenes, c-Myc, c-Jun, and c-Raf. …”
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Formation of gene associations that code for general homeostasis and performance components of durum wheat (Triticum durum Desf.) by P. N. Malchikov, M. G. Myasnikova

“…Dominant genes with additive effects and maximal expression under drought and high temperatures prevailed in the structure of the polygenic system of co-adaptive block of modern cultivars. …”
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Structure elucidation, immunomodulatory activity, antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff by Siyuan Su, Xiang Ding, Yiling Hou, Binbin Liu, Zhouhe Du, Junfeng Liu

“…The protein VEGF and VEGFR expression were significantly reduced under the treatment with BRS-X. …”
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Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids by Cayetano Pleguezuelos-Manzano, Wouter A. G. Beenker, Gijs J. F. van Son, Harry Begthel, Gimano D. Amatngalim, Jeffrey M. Beekman, Hans Clevers, Jeroen den Hertog

“…Bacterial quorum sensing (QS) coordinates virulence factor expression and biofilm formation at population level. …”
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Increased TNF-α Initiates Cytoplasmic Vacuolization in Whole Blood Coculture with Dengue Virus by Rahmat Dani Satria, Tzu-Wen Huang, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yun-Ting Wang, Zhen-Yu Yang, Chung-Hsi Hsing, Chiou-Feng Lin

“…Manipulating TNF-α expression resulted in cytopathogenic effects. These results demonstrate the potential hematological damage caused by ex vivo DENV-induced TNF-α.…”
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Naoxintong Is Involved in the Coagulation Regulation of Warfarin Through the MAPK Pathway by Luo X, Chen L, Xu J, Li J

“…The effect of NXT on warfarin anticoagulation was then tested in rats by analyzing coagulation factors in blood before and after drug administration. The expression of MAPK in the liver tissue was determined by Western blot.Results: The top five components of NXT affecting warfarin anticoagulation degree value were MOL000098, MOL000422, MOL000006, MOL000358, and MOL000449. …”
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Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2 by Bin Ke, Ting Wei, Yuanyuan Huang, Yuxin Gong, Gang Wu, Junfang Liu, Xiaoting Chen, Lin Shi

“…Subsequently, IL-7 enhanced the sensitivity of PI3K/AKT signaling and expressions of ABCG2 to DDP. By inhibiting IL-7 signaling via IL-7R knockdown or activating PI3K/AKT signaling via PI3K activation, the resensitization to DDP by IL-7 was abrogated, and the expression levels of ABCG2, p-PI3K, and p-AKT were found to be significantly higher. …”
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Anti-Inflammatory and Antioxidant Effects of Aqueous Extract on the Liver and Kidney of PCOS Mice by Samah Hachem MS, Miriam Al Battal MD, Hoda Dakdouk MS, Dania El Natour MD, Jamilah Borjac PhD

“…NLRP3 and its associated genes (caspase-1 and ASC) gene expression was assessed. Results The extract restored normal kidney and liver histology post-PCOS induction. …”
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Identification of Protein Kinase C Isoforms Involved in Type 1 Diabetic Encephalopathy in Mice by Jiayin Zheng, Yue Wang, Song Han, Yanlin Luo, Xiuli Sun, Ning Zhu, Li Zhao, Junfa Li

“…In this study, streptozotocin- (STZ-) induced diabetic mice were found to exhibit learning and memory deficits in the Morris water maze test. Meanwhile, the expression of cPKCβII, nPKCε, and cPKCγ did not change in the hippocampus, cortex, and striatum at 2 and 8 weeks after STZ injection. …”
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Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc by Bin Chen, Jing Yu, Qianqian Wang, Yuanyuan Zhao, Li Sun, Changgen Xu, Xiangdong Zhao, Bo Shen, Mei Wang, Wenrong Xu, Wei Zhu

“…Moreover, we found that the c-Myc inhibitor JQ1 and c-Myc siRNA decreased the expression of c-Myc in hBM-MSC-CM-treated tumor cells in vitro. …”
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Role of Lactate in Inflammatory Processes: Friend or Foe by Carolina Manosalva, John Quiroga, John Quiroga, Alejandra I. Hidalgo, Pablo Alarcón, Nicolás Ansoleaga, Nicolás Ansoleaga, María Angélica Hidalgo, Rafael Agustín Burgos

“…Additionally, various targets, including post-translational modifications, G-protein coupled receptor and transcription factor activation such as NF-κB and HIF-1, allow lactate to modulate signaling pathways that control the expression of cytokines, chemokines, adhesion molecules, and several enzymes associated with immune response and metabolism. …”
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Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis by Koichi Tsuneyama, Yen-Chen Chen, Makoto Fujimoto, Yoshiyuki Sasaki, Wataru Suzuki, Tsutomu Shimada, Seiichi Iizuka, Mitsunobu Nagata, Masaki Aburada, Shao-Yuan Chen

“…As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-α expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress.…”
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Biomolecular Triconjugates Formed between Gold, Protamine, and Nucleic Acid: Comparative Characterization on the Nanoscale by Robert K. DeLong, Lisa Cillessen, Chris Reynolds, Adam Wanekaya, Tiffany Severs, Kartik Ghosh, Michael Fisher, Stephanie Barber, John Black, Ashley Schaeffer, Kristin J. Flores

“…Given the intense interest in splice-site switching oligomers (SSOs), we utilized a human tumor cell culture system (HeLa pLuc-705), in which SSO-directed splicing repair upregulates luciferase expression, in order to investigate bioactivity of the bionanoconjugates. …”
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Production Data Analysis and Practical Applications in the Sulige Tight Gas Reservoir, Ordos Basin, China by Minhua Cheng, Wen Xue, Meng Zhao, Guoting Wang, Bo Ning, Guang Ji, Lihua Cheng, Yingying Tian

“…To further improve the accuracy of historical matching of field data such as gas production and bottom-hole pressure during the production process of this type of gas reservoir, in this study, a new expression of wellbore pressure for the uniform flow of vertical fractured wells in Laplace space based on the point sink function model of vertical fractures in tight sandstone gas reservoirs is constructed. …”
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Identification of Pseudoperonospora cubensis RxLR Effector Genes via Genome Sequencing by Rahel Dinsa Guta, Marc Semunyana, Saima Arif, Inyong Jeong, Sun Ha Kim, Jiyoung Min, Sang-Keun Oh

“…Cloning and functional characterization of these effectors were performed through transient expression assays in Nicotiana benthamiana leaves. Subcellular localization of selected effectors was determined using GFP-tagged constructs. …”
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