Treatment of Radiation Bone Injury with Transplanted hUCB-MSCs via Wnt/β-Catenin by Yufeng Zhang, Huaxin Deng, Zhiqiang Yang, Zhe Chen, Sheng Zhang, Yufan Zhu, Min Yang, Houcheng Zhong, Fuling Zhou, Yuanlong Xie, Lin Cai

“…Western blot analysis, qRT-PCR, immunohistochemistry, and immunofluorescence staining were used to analyze gene expression and angiogenesis. The apoptosis and migration of osteoblasts were measured by Hoechst staining, scratch test, and transwell. …”
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A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus by Yaping Li, Chenghui Huang, Ming Zhao, Gongping Liang, Rong Xiao, Susan Yung, Tak Mao Chan, Qianjin Lu

“…Furthermore, gene and protein expression of HMGB1 was significantly increased in SLE CD4+ T cells compared to controls, and HMGB1 mRNA was correlated with CD11a and CD70 mRNA. …”
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Potencial Terapêutico da Vortioxetina: Respostas Cardíacas ao Estresse Crônico Moderado Imprevisível em um Modelo de Rato by Ozlem Ozmen, Serife Tasan, Gulin Ozdamar Unal

“…Resultados O grupo ECMI apresentou aumento de hemorragia, edema, degeneração vacuolar e infiltrações de células mononucleares, com redução de troponina e IL-10 e aumento de expressões de caspase-3 e NF-κB em comparação ao grupo controle (p≤0,001). …”
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Levetiracetam Ameliorates L-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats Inducing Critical Molecular Changes in the Striatum by Huan Du, Shuke Nie, Guiqin Chen, Kai Ma, Yan Xu, Zhentao Zhang, Stella M. Papa, Xuebing Cao

“…The effects of levetiracetam were associated with changes in striatal expression of ΔFosB, phosphorylated extracellular signal-regulated kinases 1 and 2 (p-ERK1/2), and phosphorylated cAMP-regulated phosphoprotein of 32 kDa (p-DARPP-32). …”
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A Generic Approach towards Amharic Sign Language Recognition by Netsanet Yigzaw, Million Meshesha, Chala Diriba

“…In terms of orientation and expression, it is separate from written and spoken languages. …”
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Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling by Cheng-Hung Chuang, Yu-An Tai, Ting-Jing Wu, Ying-Jui Ho, Shu-Lan Yeh, Shu-Lan Yeh

“…OQ and IQ also decreased CDDP-induced plasma levels of MCP-1 as well as the mRNA expression of MCP-1 and CCR2 in the brain stem. TAK779 significantly increased grip strength and tended to decrease the cortisol/corticosterone levels in CDDP-exposed mice, indicating the association between the HPA axis and MCP-1 signaling.ConclusionTaken together, the study suggests that quercetin could attenuate CDDP-induced CRF through the mechanisms associated with downregulation of the HPA axis and MCP-1 signaling in mice.…”
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Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma by Dai Zhang, Yu Xing, Lu Liu, Xiaoqing Zhang, Cong Ma, MengYao Xu, Ruiqi Li, HanJing Wei, Yan Zhao, Bingxin Xu, Shuhao Mei

“…Introduction: Mitochondria and angiogenesis play key roles in multiple myeloma (MM) development, but their interrelated genes affecting MM prognosis are under-studied.Methods: We analyzed TCGA_MMRF and GSE4581 datasets to identify four genes – CCNB1, CDC25C, HSP90AA1, and PARP1 – that significantly correlate with MM prognosis, with high expression indicating poor outcomes.Results: A prognostic signature based on these genes stratified patients into high- and low-risk groups, with the latter showing better survival. …”
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Cytoskeletal Interactions at the Nuclear Envelope Mediated by Nesprins by Surayya Taranum, Ilknur Sur, Rolf Müller, Wenshu Lu, R. N. Rashmi, Martina Munck, Sascha Neumann, Iakowos Karakesisoglou, Angelika A. Noegel

“…We show that upon ectopic expression of Nesprin-3 in COS7 cells, which are nearly devoid of Nesprin-3 in vitro, vimentin filaments are recruited to the nucleus and provide evidence for an F-actin interaction of Nesprin-3 in vitro. …”
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Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis by Ying Wang, Lili Wang, Haoyu Yang, Weichang Yuan, Jingyi Ren, Yanping Bai

“…Our results showed both increased frequency and activation (indicated by higher expression of ICOS, PD-1, HLA-DR, and Ki-67 and increased production of IL-21, IL-17, and IFN-γ) of cTfh cells in psoriasis patients. …”
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DESIGN DEVELOPMENT OF THE WATER SUPPLY WELLS AND METHODS OF THEIR CAPITAL REPAIR by V. V. Ivashechkin

“…The energy balance equation for vertical displacement of the water well pipe column results in the computation expression for the hammer striking part weight and its drop height during the capital repair of the water well of improved design.…”
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Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons by Anne-Emilie Allain, Hervé Le Corronc, Alain Delpy, William Cazenave, Pierre Meyrand, Pascal Legendre, Pascal Branchereau

“…In immature brain structures, GABA exerts depolarizing effects mostly contributing to the expression of spontaneous activities that are instructive for the construction of neural networks but GABA also acts as a potent trophic factor. …”
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3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway by Lijie Ma, Yilin Zhao, Ruixuan Wang, Tingting Chen, Wangping Li, Yandong Nan, Xueying Liu, Faguang Jin

“…Further exploration revealed that AC-Rsv and Rsv treatment relieved LPS-induced inhibition on SIRT1 expression and restrained the activation effects of LPS on MAPKs and NF-κB activation both in vitro and in vivo. …”
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Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy by Huaijuan Ren, Yunxia Sang, Fengli Zhang, Zhaoqing Liu, Nianmin Qi, Yantian Chen

“…These differences may be associated with the different expression level of cytokines, including vascular endothelial growth factor, fibroblast growth factor, keratinocyte growth factor, and hepatocyte growth factor in each of the MSCs. …”
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Different Pathological Roles of Toll-Like Receptor 9 on Mucosal B Cells and Dendritic Cells in Murine IgA Nephropathy by Tadahiro Kajiyama, Yusuke Suzuki, Masao Kihara, Hitoshi Suzuki, Satoshi Horikoshi, Yasuhiko Tomino

“…However, cell-type expressing TLR9 in mucosa remains unclear. To address this, we nasally challenged cell-specific CpG DNA ((i): dendritic cell: (DC), (ii): B cell, (iii): both), known as ligand for TLR9, to IgAN prone mice and analyzed disease phenotype of each group. …”
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Whole-Genome Duplication and Purifying Selection Contributes to the Functional Redundancy of Auxin Response Factor (ARF) Genes in Foxtail Millet (Setaria italica L.) by You Chen, Bin Liu, Yujun Zhao, Wenzhe Yu, Weina Si

“…Intrinsic disorder was featured in the middle regions of ARF activators. Finally, expression profiles of SiARFs under hormone and abiotic stress treatment not only revealed their potential function in stress response but also indicate their functional redundancy. …”
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Analysis of whole-genome binding patterns of GAGA and CNC transcription factors during Drosophila melanogaster development by I. I. Brusentsov, D. A. Karagodin, E. M. Baricheva, T. I. Merkulova

“…For an explanation it is proposed that different sets of target genes are regulated by combinations of various GAGA and CNC isoforms, which are characterized by distinct expression patterns during drosophila embryogenesis. …”
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Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues by Francesca Posa, Adriana Di Benedetto, Graziana Colaianni, Elisabetta A. Cavalcanti-Adam, Giacomina Brunetti, Chiara Porro, Teresa Trotta, Maria Grano, Giorgio Mori

“…Our data demonstrate that DBSCs, cultured in an opportune osteogenic medium, differentiate into osteoblast-like cells; Vit D treatment stimulates their osteoblastic features, increasing the expression of typical markers of osteoblastogenesis like RUNX2 and Collagen I (Coll I) and, in a more important way, determining a higher production of mineralized matrix nodules.…”
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La narrativa como método de investigación teológica en una epistemología hermenéutica by John Jairo Pérez-Vargas, Johan Andrés Nieto-Bravo

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Effects of Macromolecular Crowding on Human Adipose Stem Cell Culture in Fetal Bovine Serum, Human Serum, and Defined Xeno-Free/Serum-Free Conditions by Mimmi Patrikoski, Michelle Hui Ching Lee, Laura Mäkinen, Xiu Min Ang, Bettina Mannerström, Michael Raghunath, Susanna Miettinen

“…The ASC immunophenotype was maintained under MMC with significantly higher expression of CD54. However, MMC impaired metabolic activity and differentiation capacity of ASCs in XF/SF conditions. …”
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Using the gene pool of CIMMYT cultivars and lines in spring durum wheat breeding in Western Siberia by V. S. Yusov, М. G. Evdokimov, M. N. Kiriakova, D. A. Glushakov

“…Local cultivars dominated in most of the studied traits, except the stem length, and the length and diameter of the second internode, where short-stemmed cultivars affected the degree of the traits’ expression in hybrids.Conclusion. The result of such activity was the release of cv. …”
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