A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration by Minkoo Seo, Jin-Chul Kim, Hyung-Ki Kim, Eun wook Choi, Suyeong Jeong, Ki Chang Nam, Mihue Jang

“…In addition, these secretory vesicles could regulate the expression of Wnt-3a, Wnt-10b, and lymphoid enhancer-binding factor-1 (LEF-1), which are related to tissue renewal. …”
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Electrochemical sensors for the detection of immune checkpoint related proteins and their role in cancer companion diagnostics by Louise Barnaby, Andrew G. Watts, Pedro Estrela

“…This review investigates the potential biomarkers relevant to predicting ICI success, as well as the current electrochemical sensors that have been developed to determine the expression levels of these proteins.…”
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HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages by Ting Wang, Huiying Liu, Guan Lian, Song-Yang Zhang, Xian Wang, Changtao Jiang

“…Further results revealed that macrophage M1 polarization, induced by HIF1α overexpression, was via upregulating the mRNA expression of the genes related to the glycolysis metabolism. …”
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Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitors by Zhengyan Kan, Ji Wen, Vinicius Bonato, Jennifer Webster, Wenjing Yang, Vladimir Ivanov, Kimberly Hyunjung Kim, Whijae Roh, Chaoting Liu, Xinmeng Jasmine Mu, Jennifer Lapira-Miller, Jon Oyer, Todd VanArsdale, Paul A. Rejto, Jadwiga Bienkowska

“…The ER independent subgroup, growing from 5% pre-treatment to 21% post-progression, is characterized by down-regulated estrogen signaling and enrichment of resistance markers including TP53 mutations, CCNE1 over-expression and Her2/Basal subtypes. Trajectory inference analyses identify a pseudotime variable strongly correlated with ER independence and disease progression; and revealed bifurcated evolutionary trajectories for ER-independent vs. …”
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Effects of different Lys/Met ratios on the antioxidant capacity, tissue morphology, and fatty acid composition of subcutaneous fat in Tibetan sheep on low-protein diets: a lipidomi... by Rengeerli Sa, Fengshuo Zhang, Xianhua Zhang, Wei Gao, Yu Zhang, Jiacheng Gan, Shengzhen Hou, Linsheng Gui

“…Ultra-High Performance Liquid Chromatography–tandem Mass Spectrometry (UHPLC–MS/MS) was employed to explore the changes in various lipid subclasses in subcutaneous adipose tissue. The expression of genes associated with adipogenesis, antioxidant capacity, and fatty acid metabolism was also examined.ResultsThe results indicated that the 1:1 Lys/Met group exhibited significantly higher antioxidant capacity (glutathione peroxidase, GSH-Px), with more orderly adipocyte arrangement, uniform cell size, and a general increase in unsaturated fatty acid levels. …”
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Inheritance of signs of «many-flowered» common wheat and evaluation of productivity of the spike of F2 hybrids by V. S. Arbuzova, O. B. Dobrovolskaya, P. Martinek, E. V. Chumanova, T. T. Efremova

“…It was shown that «many-flowered» line Skle 123-09 is significantly higher in the number of grains per spike and number of grains per spikelet than varieties N67, S29 and Puza-4, and that the expression of «many-flowering» depends on the environmental conditions and the genetic background. …”
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GATA4 binding to the Sox9 enhancer mXYSRa/Enh13 is critical for testis differentiation in mouse by Yuya Ogawa, Iku Tsuchiya, Shogo Yanai, Takashi Baba, Ken-Ichirou Morohashi, Takehiko Sasaki, Junko Sasaki, Miho Terao, Atsumi Tsuji-Hosokawa, Shuji Takada

“…Abstract In mammals, SOX9/Sox9 expression in embryonic gonads is essential for male gonadal sex determination. …”
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Spatially-implicit modelling of disease-behaviour interactions in the context of non-pharmaceutical interventions by Notice Ringa, Chris T. Bauch

“…We derive a spatially defined expression of the basic reproduction number $R_0$ and we also numerically simulate the model equations. …”
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PPAR-γ Regulates Trophoblast Differentiation in the BeWo Cell Model by Khrystyna Levytska, Sascha Drewlo, Dora Baczyk, John Kingdom

“…We report a novel negative autoregulatory mechanism between PPAR-γ activity and expression and show that blocking PPAR-γ activity induces cell proliferation at the expense of differentiation, while these remain unaltered following treatment with the agonist rosiglitazone. …”
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Acidic Microenvironment Enhances Cisplatin Resistance in Bladder Cancer via Bcl-2 and XIAP by Kaede Hiruma, Vladimir Bilim, Akira Kazama, Yuko Shirono, Masaki Murata, Yoshihiko Tomita

“…A Western blot analysis revealed that the activations of Bcl-2 and XIAP expression appear to inhibit both apoptotic and autophagic cell death. …”
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Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate by Jayalekshmi Haripriyan, Christy Rose Binu, Nitasha D Menon, Muralidharan Vanuopadath, Malavika B. Hari, N Namitha, Kesiya Binoy, Anil Kumar, Bipin G. Nair, Victor Nizet, Geetha B. Kumar

“…Additionally, downregulation of the expression of virulence genes regulated by quorum sensing (QS) and a decrease in levels of the QS signaling molecule, C12-HSL, were also observed. …”
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IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense by Dawn Nyawira Maranga, John Maina Kagira, Christopher Kariuki Kinyanjui, Simon Muturi Karanja, Naomi Wangari Maina, Maina Ngotho

“…Brain immunohistochemical staining revealed an increase in brain glial fibrillary acidic protein expression indicative of reactive astrogliosis in infected animals which were euthanized in late-stage disease. …”
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A review on mechanisms of action of bioactive peptides against glucose intolerance and insulin resistance by Forough Jahandideh, Jianping Wu

“…The recent discoveries of pathways and target cells in the management of glucose and energy metabolism have opened up new opportunities for identification of novel bioactive peptides on enhancing adipocyte differentiation and insulin signaling, glucose uptake, cholecystokinin receptor expression and activation, as well as insulin mimetics and incretin stimulants. …”
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Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition by Suad A Al-Hilu, Wisam H Al-Shujairi

“…Cancer-associated bacteria differ from those in healthy human and are linked with gene-expression profile. We also discuss how live bacteria interact with tumor microenvironments to induce tumor regression through colonization and spread. …”
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Blunting Occam’s razor, or when less is not best: pluralism in the global health care marketplace by Silvia Waisse

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Electroacupuncture-Regulated miR-34a-3p/PDCD6 Axis Promotes Post-Spinal Cord Injury Recovery in Both In Vitro and In Vivo Settings by Lili Ma, Lizhong Ma, Yu Yang, Ting Chen, Limin Wang, Qilong Deng

“…Notably, in the post-SCI rat model, exogenous miR-34a-3p agomir obviously inhibited the expression of PDCD6 at the protein level and promoted neuronal proliferation, motoneurons regeneration, and axonal myelination. …”
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Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1β and Interleukin-18 from Human Monocytes by Kristine Midtbö, Daniel Eklund, Eva Särndahl, Alexander Persson

“…While all downstream responses were strictly dependent on a functional NLRP3 inflammasome, the differences did not depend on the level of gene expression, caspase-1 activity, or pyroptosis. We suggest that the NLRP3 inflammasome response should be considered a dynamic process, which can be described by taking the ratio between IL-1β and IL-18 into account and moving away from an on/off perspective of inflammasome activation.…”
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Narrativas de solidaridad durante el Estallido Social en Chile: Testigos comprometidos durante las protestas en las calles by Ximena Faúndez Abarca, Omar Luis Sagredo Mazuela, Fuad Hatibovich Díaz

“…A través del análisis de contenido, fue posible distinguir diversas expresiones, asociadas no sólo con el momento represivo en que surgen, sino con las urgencias humanas posteriores. …”
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Structural Characterizations and Biological Evaluation of a Natural Polysaccharide from Branches of <i>Camellia oleifera</i> Abel by Shengjia Lu, Yali Zhang, Yanghui Ou, Jianghui Xin, Hongliang Yao, Litao Guan

“…Conclusions: In general, CBP demonstrated significant anti-inflammatory activity with down-regulating the expression of IL-6 and IL-1β in the LPS-induced macrophage RAW264.7 model. …”
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Monitoring and management of adverse effects associated with trastuzumab deruxtecan: a UAE-specific consensus by Emad Dawoud, Fathi Azribi, Aref Chehal, Shaheenah Dawood, Syed Hammad Tirmazy, Dina Hamza, Hassan Jaafar, Hussam Marashi

“…The recognition of “HER2-low” expression as a targetable category has caused a paradigm shift in the management of breast cancer. …”
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