Effects of Intravenous Administration of Human Umbilical Cord Blood Stem Cells in 3-Acetylpyridine-Lesioned Rats by Lucía Calatrava-Ferreras, Rafael Gonzalo-Gobernado, Antonio S. Herranz, Diana Reimers, Teresa Montero Vega, Adriano Jiménez-Escrig, Luis Alberto Richart López, Eulalia Bazán

“…In addition, HuUCBMCs upregulated the expression of proteins that are critical for cell survival, such as phospho-Akt and Bcl-2, in the cerebellum and brain stem of 3-AP ataxic rats. …”
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UCH-L1 Inhibitor Alleviates Nerve Damage Caused by Moyamoya Disease by Minghua Xu, Xiaomin Zhao, Jiang Zhao, Zhisheng Tan, Chengshi Zhang, Yun Huang, Huiping Zhong, Meifeng Guo, Chen Zhang, Ping Ye, Wentao Zheng

“…Exosomes were successfully isolated and identified from serum. The expression of GFAP and UCH-L1 was significantly higher in the serum-derived exosomes from MMD patients compared with the healthy controls (P <0.05). …”
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Producción de biomasa, cobertura y calidad forrajera de Chloris gayana y Panicum coloratum en un suelo alcalino sódico de la Depresión del Salado by J. PESQUEIRA, J. OTONDO, M. D. GARCÍA

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How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health by Ayazhan Akhatova, Celine Jones, Kevin Coward, Marc Yeste

“…Abstract Recent studies support the influence of paternal lifestyle and diet before conception on the health of the offspring via epigenetic inheritance through sperm DNA methylation, histone modification, and small non-coding RNA (sncRNA) expression and regulation. Smoking may induce DNA hypermethylation in genes related to anti-oxidation and insulin resistance. …”
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Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management by Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou, Nikolaos Sofikitis, Michael Chrisofos

“…This narrative review integrates current evidence from in vitro studies, animal models, and clinical research to clarify the roles of PDEs in effecting the male reproductive tract, with an emphasis on the mechanistic pathways underlying cyclic nucleotide signaling, the cellular specificity of PDE isoform expression, and the effects of PDE5 inhibitors on Leydig and Sertoli cell functions. …”
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Estrategias de afrontamiento: un programa de entrenamiento para paramédicos de la Cruz Roja by María José Pérez-Molina, Nazareth Rodríguez-Chinchilla

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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“….), and virtual target candidates with varying characteristics (baseline expression, half-life, etc.) to unravel rules for antibody drug candidate selection that achieve favorable drug-target interaction, which is defined by target occupancy (TO) percentage. …”
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Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury by Jeongsoo Han, Minjee Kwon, Myeounghoon Cha, Motomasa Tanioka, Seong-Karp Hong, Sun Joon Bai, Bae Hwan Lee

“…IHC demonstrated that zif268 expression significantly increased in the IC after nerve injury. …”
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Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NF-κB Signaling Pathway following Stimulation... by Junchao Huang, Jialiang Lin, Congbin Li, Bo Tang, Haijun Xiao

“…Therefore, palovarotene may be a novel HO inhibitor, while other drugs or antibodies targeting Smad and NF-κB signaling pathways may also prevent or treat HO. The expressions of Smad5, Id1, P65, and other proteins may predict HO formation.…”
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Modeling the Process of Obtaining Liquid Pyrolysis Products of Plant Biomass Taking into Account the Rate of their Cooling by S. V. Vasilevich, M. V. Malko, D. V. Degterov, A. N. Asadchy

“…The method of calculating the optimal operating parameters (temperature and cooling rate) of the techno-logical process is presented. An expression is proposed to determine the consumption of wood raw materials depending on the temperature of the thermochemical conversion process. …”
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Human Bone Marrow Contains Mesenchymal Stromal Stem Cells That Differentiate In Vitro into Contractile Myofibroblasts Controlling T Lymphocyte Proliferation by Yves Lecarpentier, Olivier Schussler, Antonija Sakic, José Maria Rincon-Garriz, Priscilla Soulie, Marie-Luce Bochaton-Piallat, Vincent Kindler

“…Here we show that medullar MSC cultured in 2D formed an adherent stroma of cells expressing well-organized microfilaments containing α-smooth muscle actin and nonmuscle myosin heavy chain IIA. …”
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Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…Both types of HCM-CMs displayed pathological phenotype of HCM but, more importantly, we found differences between CMs carrying either MYBPC3-Gln1061X or TPM1-Asp175Asn gene mutation in their cellular size, Ca2+ handling, and electrophysiological properties, as well as their gene expression profiles. These findings suggest that even though the clinical phenotypes of the patients carrying either MYBPC3-Gln1061X or TPM1-Asp175Asn gene mutation are similar, the genetic background as well as the functional properties on the cellular level might be different, indicating that the pathophysiological mechanisms behind the two mutations would be divergent as well.…”
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Review of osteokines in spinal cord injury: potential biomarkers during rehabilitation by Jing Liu, Jingyi Yang, Qi Wu, Zixuan Fang, Tong Wang, Zun Wang, Daoming Xu

“…According to previous studies, these treatments could affect the expression levels of osteokines. In conclusion, bone loss and changes in osteokines after SCI are worthy of great attention during the rehabilitation of SCI. …”
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Open-Label Fosmetpantotenate, a Phosphopantothenate Replacement Therapy in a Single Patient with Atypical PKAN by Yiolanda-Panayiota Christou, George A. Tanteles, Elena Kkolou, Annita Ormiston, Kostas Konstantopoulos, Maria Beconi, Randall D. Marshall, Horacio Plotkin, Kleopas A. Kleopa

“…Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder with variable onset, rate of progression, and phenotypic expression. Later-onset, more slowly progressive PKAN often presents with neuropsychiatric as well as motor manifestations that include speech difficulties, progressive dystonia, rigidity, and parkinsonism. …”
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Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats by Md. Iqbal Alam, Naba Sami, Aftab Alam, Sheema Wazib, Neha Dhyani, Sher Afghan, Mairaj Ahmed Ansari

“…In the OVX+E2 group, estrogen treatment considerably improved baroreflex sensitivity and hemodynamic profile while reducing the expression of inflammatory cytokines compared with the OVX group, demonstrating anti-inflammatory actions of estrogen. …”
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Transcription factor KLF2 is associated with the dysfunctional status of NK cells and the prognosis of pediatric B-ALL patients by Fang Wu, Huimin Xu, Benshan Zhang

“…Furthermore, we found that the expression of KLF2 in B-ALL at diagnosis was positively correlated with the percentage of leukemia cells and the positive rate of minimal residual disease (MRD), indicating that KLF2 is a marker of poor prognosis.ConclusionThere are dramatic differences at the single-cell level in the transcriptomics of NK cells between healthy donors and B-ALL patients. …”
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A method for siRNA-mediated knockdown of target genes in RA-induced neurogenesis using P19 cells by Hossein Khodadadi, Hiroaki Taniguchi

“…Validation of the differentiation was performed through quantitative reverse transcription PCR (RT-qPCR) analysis, measuring the expression levels of key neuronal markers, including Map2 and Pax6 along with the pluripotency marker Oct4. …”
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A Chemically Defined Serum-Free Culture System for Spontaneous Human Mesenchymal Stem Cell Spheroid Formation by Yajun Zhao, E. Xiao, Wanqi Lv, Xian Dong, Linhai He, Yixiang Wang, Yi Zhang

“…When reseeded in normal serum-containing medium, the expression level of stemness biomarkers was even higher in spheroid-derived ADSCs than monolayer culture. …”
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IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus by Yitian Song, Fangzhi Wei, Ying Liu, Feng Han, Lihui Ma, Yanping Zhuang, Chengdan Pan, Zhandong Jia, Aimin Gong

“…Similarly, the inhibition of SOX17 expression was followed by downregulation of Ro60 in keratinocytes following IL-33 stimulation. …”
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Percepción de adolescentes a través del dibujo sobre sexualidad by Yuneisys Rodriguez Fajardo, Caridad Dandicourt Thomas, Mailin Cubas Curbelo, Yenima de la Caridad Rodriguez Fajardo, Tania de la Caridad García Castellanos

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