Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3K/Akt-Bax/Bcl-2 Pathway by Chenye Wang, Caifei Ding, Zhoujia Hua, Chunyue Chen, Jia Yu

“…Further experiments suggested that CDF improves IR, follicular development, cell apoptosis, and inflammatory microenvironment, and this was associated to the regulation of IGF-1-PI3K/Akt-Bax/Bcl-2 pathway-mediated gene expression. Given that CFD sufficiently suppresses insulin resistance and improves follicular development in this study, exploring these mechanisms might help to optimize the therapeutic treatment of CFD in PCOS patients.…”
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Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs by Jinshuang Bo, Shiya Xie, Yi Guo, Chunli Zhang, Yanming Guan, Chunmei Li, Jianxin Lu, Qing H. Meng

“…It increased reactive oxygen species (ROS) production and apoptosis rate in MIN6 or ISN-1 cells and inhibited mitochondrial membrane potential (MMP) and ATP production. Furthermore, the expression of UCP2, JNK, and P38 as well as the phosphorylation JNK and P38 was increased by MG. …”
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Effect of Centella asiatica Leaf Extract on the Dietary Supplementation in Transgenic Drosophila Model of Parkinson’s Disease by Yasir Hasan Siddique, Falaq Naz, Smita Jyoti, Ambreen Fatima, Saba Khanam, Rahul, Fahad Ali, Syed Faiz Mujtaba, Mohammad Faisal

“…The role of Centella asiatica L. leaf extract was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons. …”
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Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects by Choi SH, Kim YM, Son JY, Ahn DK

“…While prior research has identified dynorphin expression in layers I–II of the dorsal horn across the spinal cord in various pain models, its functional role in trigeminal nociception, including tooth pain, remains underexplored. …”
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Una aproximación a la sociología religiosa de la cultura prehispánica Guane: muerte y prácticas funerarias by Leonardo Moreno Gonzales

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DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model by Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Hölscher

“…In addition, both drugs protected dopaminergic neurons and increased TH expression in the substantia nigra. Furthermore, the level of monomer and aggregated α-synuclein was reduced by the drugs, and insulin resistance as shown in reduced pIRS-1ser312 phosphorylation was also attenuated after drug treatment, with DA5-CH being more effective. …”
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Helicobacter pylori CagA and IL-1β Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model by Haruki Arévalo-Romero, Isaura Meza, Gabriela Vallejo-Flores, Ezequiel M. Fuentes-Pananá

“…We found evidence that both CagA and IL-1β trigger the initiation of the epithelial-to-mesenchymal transition characterized by β-catenin nuclear translocation, increased expression of Snail1 and ZEB1, downregulation of CDH1, and morphological changes during MCF-10A acini formation. …”
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The magnitude of exercise‐induced progenitor cell mobilisation and extravasation is positively associated with cardiorespiratory fitness by Mark Ross, Sarah Aldred, Mark T. Drayson, Jos A. Bosch, James E. Turner

“…V̇O2max was positively associated with the exercise‐induced progenitor cell response and there were statistically significant time × V̇O2max interactions for CD34+, CD34+CD45dim and CD34+CD133+ subpopulations but not VEGFR2‐expressing progenitor cells. There were statistically significant correlations between V̇O2max and ingress (r > 0.70, P < 0.025) and egress (r > −0.77, P < 0.009) of progenitor cell subsets (CD34+, CD34+CD45dim, CD34+CD133+), showing that cardiorespiratory fitness influences the magnitude of progenitor cell mobilisation into the blood and subsequent extravasation. …”
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Microdifferential Pressure Measurement Device for Cellular Microenvironments by Mami Akaike, Jun Hatakeyama, Yoichi Saito, Yoshitaka Nakanishi, Kenji Shimamura, Yuta Nakashima

“…Mechanical forces influence cellular proliferation, differentiation, tissue morphogenesis, and functional expression within the body. To comprehend the impact of these forces on living organisms, their quantification is essential. …”
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Multiple mutations in polyketide synthase led to disruption of Psittacofulvin production across diverse parrot species by Shatadru Ghosh Roy, Jindřich Brejcha, Petr Maršík, Anna Bakhrat, Moty Abdu, Roberto Arbore, Pedro Miguel Araújo, Sandra Afonso, Miguel Carneiro, Iris Grossman-Haham, Uri Abdu

“…Intriguingly, three of the remaining nonsynonymous substitutions reside within the ketoacyl synthase (KS) domain, whereas one at MAT domain. The heterologous expression of these PKS variants in yeast confirmed complete or partial loss of psittacofulvin production. …”
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Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer by A. K. M. Firoj Mahmud, Dina Gamaleldin Mansour Aly, Yelin Zhao, Mikael Benson, Martin Smelik, Oleg Sysoev, Hui Wang, Xinxiu Li

“…The Arp2/3 complex-associated genes were significantly upregulated in PC, suggesting their role in the malignant transformation of pancreatic cysts. Differential expression of these genes was observed across various cell types in PC, indicating their involvement in the tumor microenvironment. …”
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Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…Furthermore, it was demonstrated that DBDCT might promote ROS production, activate NF-κB p65, inhibit Ras and p-ERK1/2 expressions, increase the level of Gal-1, subsequently upregulate the expressions of Bax, p53, Fas, and FasL, and downregulate the expression of Bcl-2. …”
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Transcriptome study on the effect of leaf-fruit ratio on molecular regulation mechanism of Camellia oleifera by Xiaoyan Zhang, Hui Zhang, Xiuzhong Wu, Zhanying Gu, Lingli Wu, Xiaofeng Tan, Ze Li

“…With the decrease of leaf-fruit ratio, the expression of genes related to lignin and flavonoid biosynthesis increased significantly, which promoted the synthesis of lignin and flavonoid. …”
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Evidence That ADAM17 Mediates the Protective Action of CGRP against Angiotensin II-Induced Inflammation in Vascular Smooth Muscle Cells by Si-yu Zeng, Li Yang, Chen-liang Hong, Hui-qin Lu, Qiu-jiang Yan, Yan Chen, Xu-ping Qin

“…Here, we found that CGRP could inhibit inflammation and decrease ADAM17 expression and activation of EGFR and ERK1/2 in VSMCs stimulated with Ang II. …”
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γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies by Eric X. Wei, Vasiliki Leventaki, John K. Choi, Susana C. Raimondi, Elizabeth M. Azzato, Sheila A. Shurtleff, Menchu G. Ong, Diana M. Veillon, James D. Cotelingam, Rodney E. Shackelford

“…Gamma delta (γδ) T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL). …”
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Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes by Annaleise V. Sampey, Paul Hutchinson, Eric F. Morand

“…COX activity and COX2 expression were significantly increased by IL-1β. Annexin I peptide demonstrated no inhibition of constitutive or IL-1β-induced COX activity. …”
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Mast Cells Exert Anti-Inflammatory Effects in an IL10−/− Model of Spontaneous Colitis by E. M. Lennon, L. B. Borst, L. L. Edwards, A. J. Moeser

“…PCR array analyses demonstrated enhanced expression of numerous cytokine and chemokine genes and downregulation of anti-inflammatory genes (e.g., Tgfb2, Bmp2, Bmp4, Bmp6, and Bmp7) in the colonic mucosa of DKO mice. …”
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Glycogen Synthase Kinase-3 Regulates Production of Amyloid-β Peptides and Tau Phosphorylation in Diabetic Rat Brain by Zhong-Sen Qu, Liang Li, Xiao-Jiang Sun, Yu-Wu Zhao, Jin Zhang, Zhi Geng, Jian-Liang Fu, Qing-Guo Ren

“…Streptozotocin injection-induced DM rats displayed an increased GSK-3 activity, decreased activity and expression of Akt. And Aβ40 and Aβ42 were found overproduced and the microtubule-associated protein tau was hyperphosphorylated in the hippocampus. …”
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Leaf Extracts of Moringa oleifera Cultivated in Baghdad: Characterization and Antimicrobial Potential against Endodontic Pathogens by Nada E. Shafiq, Anas F. Mahdee, Zainab Y. Mohammed Hasan

“…Phytochemical screening showed several active ingredients but with higher expression of flavonoids and phenolic compounds. Also, different types of these compounds were detected through TLC and quantified by HPLC. …”
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Formation of the "Self-Made-Man" Idea in the Context of the Christian Middle Ages by V. Y. Antonova, O. M. Korkh

“…All this in historical perspective was found in its radicalized and purified from all sorts of mystical and religious layers of expression in the idea of "Self-made-man".…”
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