Loss of SNHG4 Attenuated Spinal Nerve Ligation-Triggered Neuropathic Pain through Sponging miR-423-5p by Xia Pan, Cheng Shen, Yayi Huang, Long Wang, Zhongyuan Xia

“…SNHG4 regulated miR-423-5p expression negatively. As exhibited, the loss of miR-423-5p contributed to neuropathic pain progression, which was rescued by the silence of SNHG4. …”
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Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apo... by Ah Young Yang, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyun Hee Kwon, Jaechan Leem, Eon-Ju Jeon

“…It suppressed cytokine expression and reduced immune cell infiltration, inhibited the activation of the mitogen-activated protein kinase cascade, and alleviated endoplasmic reticulum stress. …”
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Targeted SPP1 Inhibition of Tumor‐Associated Myeloid Cells Effectively Decreases Tumor Sizes by Benan Kartal, Christopher S. Garris, Hyung Shik Kim, Rainer H. Kohler, Jasmine Carrothers, Elias A. Halabi, Yoshiko Iwamoto, Anne‐Gaëlle Goubet, Yuxuan Xie, Pratyaksha Wirapati, Mikaël J. Pittet, Ralph Weissleder

“…Despite this, there is a lack of efficient TAM‐specific therapeutics capable of reducing SPP1 expression. Here, on a phenotypic screen is reported to identify small molecule SPP1 modulators in macrophages. …”
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Current Review of Genetically Modified Lactic Acid Bacteria for the Prevention and Treatment of Colitis Using Murine Models by Alejandra de Moreno de LeBlanc, Silvina del Carmen, Jean-Marc Chatel, Anderson Miyoshi, Vasco Azevedo, Philippe Langella, Luis G. Bermúdez-Humarán, Jean Guy LeBlanc

“…Studies show the efficacy of GM-LAB (using different expression systems) for the prevention and treatment of IBD, highlighting the importance of the bacterial strain selection (with anti-inflammatory innate properties) as a promising alternative. …”
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Liberties of the genome: insertions of mitochondrial DNA fragments into nuclear genome by M. V. Golubenko, V. P. Puzyrev

“…For instance, they may be a source of variability for expression and splicing modulation. The role of NUMTS as a cause of hereditary diseases is negligible, since only a few cases of diseases caused by NUMTS have been described so far. …”
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Calreticulin as an Adjuvant In Vivo to Promote Dendritic Cell Maturation and Enhance Antigen-Specific T Lymphocyte Responses against Melanoma by Zheng Gong, Ming Chen, Jie Miao, Chao-Jie Han, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…OVAp-CRT upregulated CD40, CD80, and CD86 expressions in splenic conventional DCs. Furthermore, OVAp-CRT protected immunized mice against OVA-expressing B16 melanoma cells in vivo. …”
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Perceptions and experiences of directly observed treatment in tuberculosis: insights from a mixed-methods cross-sectional study by Diana Amorim, João Pedro Ramos, Pedro Barbosa, Mariana Vieira, Raquel Duarte

“…There were significant differences between the two groups in their views regarding the impact of DOT on treatment outcomes, with health care professionals perceiving a higher degree of negative effects and patients expressing greater satisfaction. Long travel distances, transportation issues and high costs were some of the challenges mentioned by the patients. …”
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Increased RTN3 phenocopies nonalcoholic fatty liver disease by inhibiting the AMPK–IDH2 pathway by Hao Huang, Shuai Guo, Ya‐Qin Chen, Yu‐Xing Liu, Jie‐Yuan Jin, Yun Liang, Liang‐Liang Fan, Rong Xiang

“…We found an increased expression of RTN3 in NAFLD patients, high‐fat diet mice, and oxidized low‐density lipoprotein‐treated L02 cells. …”
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Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models by Lorenza Mautone, Federica Cordella, Alessandro Soloperto, Silvia Ghirga, Giorgia Di Gennaro, Ylenia Gigante, Silvia Di Angelantonio

“…Our findings reveal that the MAPT mutation leads to delayed retinal cell differentiation and maturation, with tau-mutant disease models exhibiting sustained higher expression of retinal progenitor cell markers and a reduced presence of post-mitotic neurons. …”
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YOLOv8s-Longan: a lightweight detection method for the longan fruit-picking UAV by Jun Li, Jun Li, Jun Li, Kaixuan Wu, Meiqi Zhang, Hengxu Chen, Hengyi Lin, Yuju Mai, Linlin Shi

“…To improve the detection accuracy, a crossstage local network structure VOVGSCSPC module is designed, which can help the model better understand the information of the image through multiscale feature fusion and improve the perception and expression ability of the model. Meanwhile, the novel Inner-SIoU loss function is proposed as the loss function of the target bounding box.Results and discussionThe experimental results show that the proposed algorithm has good detection ability for densely distributed and mutually occluded longan string fruit under complex backgrounds with a mAP@0.5 of 84.3%. …”
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Immune cell profiles and predictive modeling in osteoporotic vertebral fractures using XGBoost machine learning algorithms by Yi-Chou Chen, Hui-Chen Su, Shih-Ming Huang, Ching-Hsiao Yu, Jen-Huei Chang, Yi-Lin Chiu

“…Notably, VF patients exhibited a reduction in Th1 cells and an enrichment of Th17 cells, which promote osteoclastogenesis and bone resorption. Gene expression analysis further highlighted an upregulation of osteoclast-related genes and a downregulation of osteoblast-related genes in VF patients, emphasizing the disrupted balance between bone formation and resorption. …”
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Physiological Response and Comprehensive Evaluation of Cold-Resistant Peach Varieties to Low-Temperature Stress by Ruxuan Niu, Juanjuan Huang, Yiwen Zhang, Falin Wang, Chenbing Wang

“…Soluble sugar (SS) and soluble protein (SP) concentrations peaked at −25 °C and showed a significant negative correlation with semi-lethal temperature (LT50). The expression of free proline varied among different samples. …”
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Biofunctional Characterization of Collagen from Orange-Spotted Grouper, <i>Epinephelus coioides</i>: Maintenance of Cartilage in Aged Zebrafish by Shao-Yang Hu, Chen-Han Tsou, Chung-Chih Tseng, Tai-Wei Han, Chun-Hung Liu

“…After eight weeks of dietary supplementation, zebrafish fed PHC or the combined PHC + GC diets exhibited a significant upregulation of <i>sox9a</i> (<i>jef</i>) expression in spinal tissues, accompanied by a marked downregulation of <i>runx2</i>. …”
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Study on Roof Presplitting Mechanism and Deformation Control of Reused Roadway in Compound Soft Rock by Roof Presplitting Approach by Fuzhou Qi, Dangwei Yang, Xinming Li, Bin Li, Yingying Zhai, Shuisheng Yu

“…According to engineering and geological conditions, an analytic expression of the inertial force, the moment of inertia, and the vertical stress acting on the breakage are obtained by constructing a structural mechanical model of the overlying strata. …”
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Nutritional state-dependent modulation of insulin-producing cells in Drosophila by Rituja S Bisen, Fathima Mukthar Iqbal, Federico Cascino-Milani, Till Bockemühl, Jan M Ache

“…Contrary to IPCs, Diuretic hormone 44-expressing neurons in the pars intercerebralis (DH44PINs) responded to glucose perfusion. …”
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Educational migration from Tajikistan to Russia: trends and consequences by A. Kh. Rakhmonov

“…The main reasons why migrants do not want to return to Tajikistan are not only low wages at home, but also great opportunities abroad, which have not only economic, but also political and social dimensions (freedom of political views, the possibility of self-expression, the possibility of realizing abilities). …”
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Iron metabolism in a mouse model of hepatocellular carcinoma by Dilay Yilmaz, Umesh Tharehalli, Rossana Paganoni, Paul Knoop, Andreas Gruber, Yuexin Chen, Rui Dong, Frank Leithäuser, Thomas Seufferlein, Kerstin Leopold, André Lechel, Maja Vujić Spasić

“…A transcriptome analysis of liver carcinoma was employed to identify p53-dependent gene expression signatures with subsequent in-depth analysis of iron metabolic parameters being conducted locally within liver cancers and at systemic levels. …”
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Falling sex ratios and emerging evidence of sex-selective abortion in Nepal: evidence from nationally representative survey data by Mahesh Puri, Melanie Dawn Frost, Peter Richard Andrew Hinde

“…Changes in the sex ratio at birth since legalisation would suggest an association with legalisation, even though sex-selection is expressly prohibited.Design Analysis of data from four Demographic and Health Surveys, conducted in 1996, 2001, 2006 and 2011.Setting Nepal.Participants 31 842 women aged 15–49.Main outcome measure Conditional sex ratios (CSRs) were calculated, specifically the CSR for second-born children where the first-born was female. …”
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Anti-Inflammatory Effects of Cannabigerol In Vitro and In Vivo Are Mediated Through the JAK/STAT/NFκB Signaling Pathway by Ga Hee Jeong, Ki Chan Kim, Ji Hyun Lee

“…In the cellular model, we confirmed the cytotoxicity of CBG and downregulated the expression of inflammatory markers <i>CCL26</i>, <i>IL1B</i>, <i>IL6</i>, and <i>TNF</i> (<i>p</i> < 0.001). …”
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DNA-mediated self-assembly oxidative damage amplifier combined with copper and MTH1 inhibitor for cancer therapy by Cui Ren, Zhiyong Shi, Xiaowen Zhang, Xueer Yu, Yang Gao, Zhi Qi, Yu Chen, Yong Wang

“…Meanwhile, the released functional nucleic acid G3139 downregulated the expression of Bcl-2, and accelerated the apoptosis of tumor cells. …”
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