miR-126 and miR-126*: New Players in Cancer by Jeannette Meister, Mirko H. H. Schmidt

“…These affect various signaling cascades during the progression of neoplastic diseases by the regulation of gene expression on the post-transcriptional level. The novel endothelial cell–derived secreted protein epidermal growth factor–like domain 7 (EGFL7) has been suggested to control vascular tubulogenesis. …”
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Codon Usage Bias and Cluster Analysis of the MMP-2 and MMP-9 Genes in Seven Mammals by Tanliang Ouyang, Jincheng Zhong, Zhixin Chai, Jiabo Wang, Ming Zhang, Zhijuan Wu, Jinwei Xin

“…By comparing the content of synonymous codon bases amongst seven mammals, we found that MMP-2 and MMP-9 were low-expression genes in mammals with high codon conservation, and their third codon preferred the G/C base. …”
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Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus by Ping Wang, Huili Liu, Li Chen, Yingli Duan, Qunli Chen, Shoumin Xi

“…The levels of total cholesterol, triglyceride, fasting plasma insulin (FINS), and glucagon (FG) were determined, and an oral glucose tolerance test was performed. The expression patterns of proteins and genes associated with insulin resistance and GK activity were assayed. …”
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A Study Comparing Immunohistochemistry, Fluorescence in situ hybridization, GeneXpert® Breast Cancer STRAT4 Assay for Determining Hormone Receptor, Human Epidermal Growth Factor Re... by Rajaa El Aje, Abdellah Naya, Ayoub Khoaja, Younes Zaid, Mounia Oudghiri, Jodi Weidler, Mehdi Karkouri

“…The Xpert® Breast Cancer STRAT4, an RT-qPCR based system, can be used to classify invasive breast carcinomas based on the assessment of these four biomarkers; Methods: We evaluated ESR1, PGR, ERBB2, and MKi67 mRNA expression by Xpert Breast Cancer STRAT4 and ER, PR, HER2 and Ki67 by IHC (FISH for HER2 IHC 2+) in 200 formalin-fixed paraffin-embedded (FFPE) tissue blocks with invasive breast cancer, collected from the Pathology Department of Casablanca Ibn Rochd University Hospital; Results: Concordance between Xpert ® Breast Cancer STRAT4 and IHC was 93.5% for ER, 83.51% for PR, 95% for HER2 (92% for IHC+FISH), and 81.20% for Ki67 (excluding intermediate IHC Staining 10 ≤ %IHC <20). …”
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The Effect of Serine Protease Inhibitors on Airway Inflammation in a Chronic Allergen-Induced Asthma Mouse Model by Chih-Che Lin, Li-Jen Lin, Shulhn-Der Wang, Chung-Jen Chiang, Yun-Peng Chao, Joseph Lin, Shung-Te Kao

“…At 3 days after the last challenge, mice were sacrificed to assess airway hyperresponsiveness (AHR), remodeling, and inflammation; lung histological features; and cytokine expression profiles. Compared with untreated controls, mice treated with FUT, FOY, and UTI had decreased AHR and goblet cell hyperplasia, decreased eosinophil and neutrophil infiltration, decreased Der p-induced IL-4 levels in serum and IL-5, IL-6, IL-13, and IL-17 levels in bronchoalveolar lavage fluid, and inhibited nuclear factor (NF)-κB activity in lung tissues. …”
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Acoustic Trauma Changes the Parvalbumin-Positive Neurons in Rat Auditory Cortex by Congli Liu, Tao Xu, Xiaopeng Liu, Yina Huang, Haitao Wang, Bin Luo, Jingwu Sun

“…Quantification of Western blotted bands revealed higher expression level of PV protein in the left cortex. These findings of more active PV neurons in noise-exposed rats suggested that a compensatory mechanism might be initiated to maintain a stable state of the brain.…”
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Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice by Victoria E. Shaw, Cassandra Peoples, Sharon Spana, Keyoumars Ashkan, Alim-Louis Benabid, Jonathan Stone, Gary E. Baker, John Mitrofanis

“…The present study explores whether NIr treatment changes the patterns of Fos expression in the subthalamic region, namely, the subthalamic nucleus (STN) and zona incerta (ZI); both cell groups have abnormally overactive cells in parkinsonian cases. …”
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Neuroprotective Effects of Collagen-Glycosaminoglycan Matrix Implantation following Surgical Brain Injury by Jia-Hui Chen, Wei-Cherng Hsu, Kuo-Feng Huang, Chih-Huang Hung

“…Proinflammatory (tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells)) and anti-inflammatory (IL-10 and granulocyte-macrophage colony-stimulating factor (GMCSF)) cytokine expression was evaluated by enzyme-linked immunosorbent assays. …”
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Neuron-Specific Fluorescence Reporter-Based Live Cell Tracing for Transdifferentiation of Mesenchymal Stem Cells into Neurons by Chemical Compound by Do Won Hwang, Hyun Woo Kwon, Jaeho Jang, Hee Jung Jung, Kwang Rok Kim, Dong Soo Lee

“…Two days after NHPDQC treatment, MSCs showed neuron-like phenotype with neurite outgrowth and high expression of neuron-specific markers in more than 95% cells. …”
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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

“…GSEA analysis suggested that the related signaling pathways and biological processes enriched in the high- and low-risk groups may influence the tumor microenvironment (TME) of BRCA. ssGSEA showed the difference in immune cell infiltration, immune pathway activation, and immune checkpoint expression between the two risk groups, with the low-risk group more suitable for immunotherapy. …”
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Clearing the Air on Pollutant Disruptions of the Gut–Brain Axis: Developmental Exposure to Benzo[a]pyrene Disturbs Zebrafish Behavior and the Gut Microbiome in Adults and Subsequen... by Alexandra Alexiev, Ebony Stretch, Kristin D. Kasschau, Lindsay B. Wilson, Lisa Truong, Robyn L. Tanguay, Thomas J. Sharpton

“…Our findings reveal a reticulated axis of association between BaP exposure, developmental AHR2 expression, the zebrafish gut metagenome, and behavior. …”
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Trastuzumab in Esophagogastric Cancer: HER2-Testing and Treatment Reality outside Clinical Studies in Germany by Kirsten Merx, Manuel Barreto Miranda, Lenka Kellermann, Ulrich Mahlknecht, Oliver Lange, Michael Gonnermann, Ralf-Dieter Hofheinz

“…Treatment intensity increased: 49.3% of patients received at least a triplet in 2013 compared to 10.1% in 2006. In cohort 2 HER2 expression was tested in 79.1% of the cases. Still, in 26.9% testing was not done as requested by guidelines. …”
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Las habilidades comunicativas en las carreras de las Ciencias de la Salud by Juan Francisco Tejera Concepcion, Miriam Iglesias León, Manuel Cortés Cortés, Norma Mur Villar, Juan Virgilio López Palacio

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Reading from the Guts: of Text and Disgust by Solveig Dunkel

“…Can there be any “pleasure of the text,” to use Roland Barthes’ expression, in the description of something “so, so unpleasant”? …”
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Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs by Hao-Chih Tai, Xiaocheng Zhu, Yih Jyh Lin, Hidetaka Hara, Mohamed Ezzelarab, Michael Epperley, Mubina A. Quader, David K. C. Cooper

“…The lack of effect may have been related to (i) inadequate depletion of passenger leukocytes, thus not preventing a direct T cell response, (ii) the presence of dead or dying leukocytes (antigens), thus not preventing an indirect T cell response, or (iii) constitutive expression of MHC class II and B7 molecules on the porcine vascular endothelium, activating recipient T cells.…”
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Age-related cerebral ventriculomegaly occurs in patients with primary ciliary dyskinesia by Franziska Eisenhuth, Joy E. Agbonze, Adam M. R. Groh, Jesse M. Klostranec, David A. Rudko, Jo Anne Stratton, Adam J. Shapiro

“…We demonstrated highly specific expression levels of known PCD-related genes in human brain multiciliated ependymal cells (p < 0.0001). …”
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Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3 by Yiting Zhang, Chao Li, Siyi Li, Yiping Lu, Sitong Du, Xinning Zeng, Xi Chen, Jie Chen

“…In this study, DHI treatment of CS-exposed mice reduced the expression of proinflammatory cytokines and the infiltration of immune cells. …”
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Adipokines in Breast Cancer: Decoding Genetic and Proteomic Mechanisms Underlying Migration, Invasion, and Proliferation by Ließem A, Leimer U, Germann GK, Köllensperger E

“…Over a five-day proliferation phase, linear growth was assessed by calculating doubling times and malignancy-associated changes in gene and protein expression were identified using quantitative TaqMan real-time PCR and multiplex protein analysis. …”
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ADULTOS COM DEFICIÊNCIA INTELECTUAL: ASPECTOS DA ALFABETIZAÇÃO E LETRAMENTO by Gizeli Aparecida Ribeiro de Alencar, Cristina Broglia de Feitosa Lacerda

“…Acreditamos que pouca atenção é dada à linguagem escrita como tal, já que, geralmente, o professor começa pelo aspecto técnico e esquece a função social para qual a escrita foi criada, ou seja, para registro, expressão e comunicação, e isso se agrava quando o educando tem DI. …”
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Effects of Rumination and Emotional Regulation on Non-Suicidal Self-Injury Behaviors in Depressed Adolescents in China: A Multicenter Study by He K, Chen L, Fan H, Sun L, Yang T, Liu H, Wang K

“…Cognitive reappraisal and expression inhibition play a significant mediating role in the relationship between rumination and NSSI.Conclusion: Among adolescents with depression, rumination has an impact on the frequency of NSSI behavior, and the relationship between the two is mediated by emotional regulation. …”
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