Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through the PPARγ/eNOS Signaling Pathway by Hua Guo, Qinglan Zhang, Haipo Yuan, Lin Zhou, Fang-fang Li, Sheng-Ming Wang, Gang Shi, Maojuan Wang

“…We analyzed the NO levels in plasma samples from T2DM patients and paired healthy adults by Nitric Oxide Analyzer then measured the expression of inflammatory cytokines (C-reactive protein, heptoglobin, IL-1β, TNF-α, IL-6) in insulin-induced HepG2 cells treated with NO donor or NO scavenger, and the PPARγ, eNOS, C-reactive protein, heptoglobin, IL-1β, TNF-α, and IL-6 levels were detected by RT-PCR and western blot in insulin-induced HepG2 cells transfected with si-PPARγ. …”
Get full text

Optimized “In Vitro” Culture Conditions for Human Rheumatoid Arthritis Synovial Fibroblasts by Claudia Casnici, Donatella Lattuada, Noemi Tonna, Katia Crotta, Claudio Storini, Fabio Bianco, Marcello Claudio Truzzi, Costantino Corradini, Ornella Marelli

“…Spontaneous apoptosis in fibroblasts was also decreased in response to synovial fluid. The expression of proinflammatory cytokines in the presence of synovial fluid was significantly elevated with respect to cells cultured with TNF-alpha or medium, and the overall morphology of cells was also modified. …”
Get full text

Joint Channel and Nonlinearity Estimation for Memoryless Nonlinear Systems by Zahra Mokhtari, Rui Dinis, Sha Hu, Dzevdan Kapetanovic

“…We also derive a closed form expression for the average power of residual distortion in GBD with estimated parameters to see how well this model can characterize the nonlinearity. …”
Get full text

Stromal Derived Factor-1/CXCR4 Axis Involved in Bone Marrow Mesenchymal Stem Cells Recruitment to Injured Liver by Kuai Xiao Ling, Li Peng, Zhang Jian Feng, Cao Wei, Yuan Wei Yan, Shao Nan, Guan Cheng Qi, Wang Zhi Wei

“…We try to investigate the role of SDF-1 signaling in BMSCs migration towards injured liver. The expression of CXCR4 in BMSCs at mRNA level and protein level was confirmed by RT-PCR, flow cytometry, and immunocytochemistry. …”
Get full text

Design and study of valveless piezoelectric pump with streamlined chamber fishtail-type bluff body by Xiaochao Tian, Zhenming Wang, Kai Yang, Yang Bai, Yingyu Dai, Defeng Niu, Zhicheng Zhong

“…First, the three-dimensional model of VPFB is designed and theoretically analyzed based on the piezoelectric inverse effect and fluid dynamics to derive the expression of the relationship affecting the flow rate of the piezoelectric pump. …”
Get full text

Sodium butyrate attenuate hyperglycemia-induced inflammatory response and renal injury in diabetic mice by Yan Man, Zhang Yan-Yan, Xi Yue, Ding Long-Kun, Sun Chang, Qu Li-Juan, Qian Xin, Xu Jing-Wen, Sun Wen, Wu Liang

“…The results showed that high concentration glucose significantly up-regulated the expressions of IL-1β, TNF-α, and NLRP3 in THP-1 cells and mouse spleen, and that NaB could inhibit the overexpression of those genes. …”
Get full text

The electroweak effective field theory from on-shell amplitudes by Gauthier Durieux, Teppei Kitahara, Yael Shadmi, Yaniv Weiss

“…The latter is an all-order expression in the effective-field-theory expansion. …”
Get full text

Psychological Well-Being in Adolescents with Different Types of Socialization by Elena N. Volkova

“…The general level of psychological well-being and the expression of its main domains differ among adolescents with prosocial or asocial types of behaviour. …”
Get full text

Decreased Breg/Th17 Ratio Improved the Prognosis of Patients with Ulcerative Colitis by Xue Bing, Liang Linlang, Chen Keyan

“…The number of Breg cells and Th17 cells, the gene expressions of IL-10 and RORγT, and serum levels of IL-10 and IL-17 all increased in peripheral blood. …”
Get full text

Effect of Muscle Fatigue on Surface Electromyography-Based Hand Grasp Force Estimation by Jinfeng Wang, Muye Pang, Peixuan Yu, Biwei Tang, Kui Xiang, Zhaojie Ju

“…Experiments are conducted in the three cases: (1) pooling training data from all muscle fatigue states with time-domain feature only, (2) employing frequency domain feature for expression of muscle fatigue information based on case 1, and 3) incorporating the quantitative metric of muscle fatigue value as an additional input for estimation model based on case 1. …”
Get full text

Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-κB Signaling Pathway by Quanxin Ma, Kai Wang, Qinqin Yang, Shun Ping, Weichun Zhao, Qiyang Shou, Weimin Zhou, Minli Chen

“…We observed that V. axillare suppressed the mRNA expression of interleukin-1β (IL-1β), IL-6, monocyte chemotactic protein-1 (MCP-1), cyclooxygenase-2 (COX-2), and tumor necrosis factor-α (TNF-α) in RAW264.7 cells challenged with LPS. …”
Get full text

Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy by Ninna Aggerholm-Pedersen, Christina Demuth, Akmal Safwat, Peter Meldgaard, Moustapha Kassem, Boe Sandahl Sorensen

“…However hMSC-TERT20-CE8 exhibited significantly higher expression of the EGFR ligands. EGFR inhibitors such as erlotinib and afatinib alone or in combination with doxorubicin failed to further decrease cell viability of hMSC-TERT20-CE8. …”
Get full text

ANTHROPOLOGICAL DIMENSIONS OF PRAGMATISM AND PERSPECTIVES OF SOCIO-HUMANITARIAN REDESCRIPTION OF ANALYTIC METHODOLOGY by A. S. Synytsia

“…Appealing to science, methodological pluralism, the search for socio-cultural background for thinking and suitable linguistic forms of expression of human experience are the achievements of pragmatism, which are the basis for the socio-humanitarian redescription of analytic methodology.…”
Get full text

Prospective Clinical Trial for Septic Arthritis: Cartilage Degradation and Inflammation Are Associated with Upregulation of Cartilage Metabolites by Hagen Schmal, Anke Bernstein, Matthias J. Feucht, Benjamin Erdle, Jan M. Pestka, That Minh Pham, Eva Johanna Kubosch

“…Infections with Staphylococcus species induced higher IL-1β expression but less cartilage destruction than other bacteria. …”
Get full text

What Factors Influence Patient Measures of Safety Among Adults? by Kim Y, Nam E

“…Additionally, it is significant to facilitate patient expression of safety concerns and establish a patient-centered safety monitoring and feedback system. …”
Get full text

Comparing social stigma of anorexia nervosa, bulimia nervosa, and binge-eating disorder: A quantitative experimental study by Carlye S. Aird, Bennett A. A. Reisinger, Stephanie N. Webb, David H. Gleaves

“…Through further research, a better understanding around the expression of stigma towards specific eating disorders could inform the development of targeted interventions to help reduce the stigma associated with these disorders. …”
Get full text

Understanding Cardiovascular Events With JAK Inhibitors: Tofacitinib Reduces Synovial and Vascular Inflammation but not the Prothrombotic Effects of Inflammatory Cytokines on Endot... by Aliki Zavoriti, Pierre Miossec

“…Shortly after tofacitinib treatment, the expression of EC activation markers, specifically IL‐6, IL‐8, vascular cell adhesion molecule 1 (VCAM‐1), and E‐selectin, and of coagulation, including tissue factor and thrombomodulin, was assessed by real‐time polymerase chain reaction. …”
Get full text

Protection of Corneal Limbus from Riboflavin Prevents Epithelial Stem Cell Loss after Collagen Cross-Linking by Hyo Kyung Lee, Jin Suk Ryu, Hyun Jeong Jeong, Mee Kum Kim, Joo Youn Oh

“…The numbers of BrdU-labelled and p63+ limbal epithelial cells were markedly reduced in the group without a ring, but significantly increased when a ring was used. Robust expression of CK3/12 was observed in the limbal epithelium in the group with a ring. …”
Get full text

Conjugacy of two types of phenotypic variability of small-leaved linden by S. G. Baranov, I. E. Zykov, D. D. Kuznetsova

“…According to the authors, asynchronous growth, competition for light in conditions of high solar activity in 2014–2016 compared to the abnormal wet summer of 2017 led to an increase in FA due to destabilization of mechanisms of growth and regulation of gene expression, which contributed to a decrease in the stability of development. …”
Get full text

Apropiación social del patrimonio culinario. El oficio de la cocina tradicional en Bucaramanga, Santander by Indira Quiroga Dallos, José Hernández Jaimes

Get full text