Cilostazol Combats Lipopolysaccharide-Induced Hippocampal Injury in Rats: Role of AKT/GSK3β/CREB Curbing Neuroinflammation by Doaa Abou El-ezz, Waleed Aldahmash, Tuba Esatbeyoglu, Sherif M. Afifi, Marawan Abd Elbaset

“…Immunohistochemistry analysis showed a decrease in Iba-1 expression, indicating a reduction in microglial activation in the cilostazol-treated group compared to the LPS group. …”
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Fausses infinitives de but et mirativité by Geneviève Girard-Gillet

“…For the type a) sentences the utterer is expressing his derogatory point of view and giving his personal explanation to what occurred. …”
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Cognitive Feature Extraction of Puns Code-Switching Based on Neural Network Optimization Algorithm by Jing Zhang, Qiaoyun Liao, Lipei Li

“…Broadly speaking, code-switching refers to adjusting one’s language style, appearance, behavior, and expression in order to improve the comfort of others in exchange for fair treatment, quality service, and employment opportunities. …”
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Development and validation of a dynamic nomogram to predict alexithymia in young and middle aged stroke patients by Tinglin Zhang, Feiyang Sun, Xiaodie Ma, Yaoyao Liu, Fangyan Li, Lei Zhang

“…Abstract Alexithymia, characterized by difficulty in expressing and recognizing emotions, is prevalent among young and middle-aged stroke survivors and can significantly impact rehabilitation outcomes. …”
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BMSCs Interactions with Adventitial Fibroblasts Display Smooth Muscle Cell Lineage Potential in Differentiation and Migration That Contributes to Neointimal Formation by Y. Wendan, J. Changzhu, S. Xuhong, C. Hongjing, S. Hong, Y. Dongxia, X. Fang

“…The expressions of TGF-β1, MMP-1, and NF-κB were detected by immunofluorescence staining and Smad3 mRNA was measured by reverse transcription PCR. …”
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Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics by Songting Shou, Ayidana Maolan, Di Zhang, Xiaochen Jiang, Fudong Liu, Yi Li, Xiyuan Zhang, En Geer, Zhenqing Pu, Baojin Hua, Qiujun Guo, Xing Zhang, Bo Pang

“…Furthermore, we suggest that differential expression of telomere and telomerase components at the subcellular level holds promise as a biomarker. …”
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Optogenetic regulation of endogenous gene transcription in mammals by E. S. Omelina, A. V. Pindyurin

“…Despite the rapid development of approaches aimed to precisely control transcription of exogenous genes in time and space, design of systems providing similar tight regulation of endogenous gene expression is much more challenging. However, finding ways to control the activity of endogenous genes is absolutely necessary for further progress in safe and effective gene therapies and regenerative medicine. …”
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RIOK1/2 Negatively Regulates the Antiviral Response by Targeting TBK1 in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) by Kejun Liu, Jiayang Huang, Yuting Gui, Qian Li, Lei Zhang, Shuting Xiong

“…Our findings reveal that the overexpression of PfRIOK1 and PfRIOK2 led to the decreased expression of IFN-related genes and enhanced viral replication in vitro. …”
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Optimization of spline parameters in approximation of multivalued functions by D. A. Karpov, V. I. Struchenkov

“…In this case, it is possible to analytically calculate the derivatives of the objective function with respect to the spline parameters in the absence of its analytical expression.Results. A mathematical model and algorithm were developed to optimize the parameters of a spline as a multivalued function consisting of circular arcs conjugated by line segments. …”
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Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation by Dylan J. Sebo, Irshad Ali, Audrey R. Fetsko, Aubrey A. Trimbach, Michael R. Taylor

“…To further test this concept, we generated a transgenic Tet-On inducible system to drive constitutively active β-catenin expression in neural progenitor cells (NPCs). We found that dose-dependent activation of Wnt/β-catenin in NPCs caused severe deficiency in CNS angiogenesis and BBB development. …”
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Protective Effect and Mechanisms of Radix Astragali Injection on the Intestinal Mucosa of Rats with Obstructive Jaundice by Zhang Xiping, Weng Ke, Yu Yaping, Zhao Hongchan, Cheng Qihui

“…We observed the pathological changes of intestinal mucosa, expression levels of Bax and NF-κB proteins, and apoptosis indexes in intestinal mucosa as well as serum NO, MDA and SOD contents, respectively, on 7d, 14d, 21d and 28d after operation. …”
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Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome) by Majid Alfadhel, Bashayr S. Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S. Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan

“…Furthermore, RT-qPCR revealed a substantial reduction of SPAG9 gene expression at the mRNA level in the affected individuals of both families, thus supporting the pathogenic nature of the identified variant. …”
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Effects of microplastics on microbial community and greenhouse gas emission in soil: A critical review by Guanlin Chen, Saisai Guo, Linan Liu, Wenzhu Zhang, Jingchun Tang

“…Firstly, this review details that MPs alter microbial abundance, structure, activity and gene expression, directly stimulating CO2 and N2O emissions, though their impact on CH4 remains inconclusive. …”
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An Analytical Method for Calculating Short-Term Space Interception Probability by Wenzhe Ding, Xinhong Li, Hong Yang, Zhibin Zhang, Jiping An

“…Then, the Laplace transform and Taylor expansion are used to obtain the exact power series expression and the maximum truncation error of the integral calculation, and the analytical calculation of the short-term space interception probability is realized. …”
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Agresividad cotidiana y aprobación de la violencia extrema by Alexis Romero-Salazar, Raima Rujano Roque, Miguel Ángel Romero Sulbarán

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Genetic Variant of C-5434T REN Enhancer on Serum Renin Levels and Binding Pattern of Signal Transducers and Activators Transcription 3 by Imama Maslahah, Mohammad Saifur Rohman, Nashi Widodo, Agustina Tri Endharti, Didik Utomo

“…This is likely to influence STAT3 activity to stimulate the expression of renin gene in producing renin.…”
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Effects of Low-Intensity Laser Irradiation on Wound Healing in Diabetic Rats by Hui Ma, Ying-xin Li, Hong-li Chen, Mei-ling Kang, Timon Cheng-Yi Liu

“…LISL could obviously promote wound contraction, fibroblasts proliferation, and collagen synthesis, alter bFGF and TGF-β1 expression, and reduce inflammatory reaction in the early and middle phases of chronic wound-healing process. …”
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Antiflammin-2 Activates the Human Formyl-Peptide Receptor Like 1 by Ahmad M. Kamal, Richard P.G. Hayhoe, Anbalakan Paramasivam, Dianne Cooper, Roderick J. Flower, Egle Solito, Mauro Perretti

“…Using HEK-293 cells expressing either human FPR and FPRL-1, and an annexin-A1 peptide as tracer ([125I-Tyr]-Ac2-26), we found that antiflammin-2 competed for binding only at FPRL-1, and not FPR, with an approximate EC50 of 1 μM. …”
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Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease by Junhua Huang, Shuwan Zhang

“…We observed that serum vascular endothelial growth factor (VEGF) levels were increased in KD patients and sera from KD patients upregulated the expression of VEGF receptor 2 (VEGFR2) and neuropilin-1 (NRP1) in human coronary artery endothelial cells (HCAECs). …”
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In vivo Study of the Histone Chaperone Activity of Nucleolin by FRAP by Xavier Gaume, Karine Monier, Françoise Argoul, Fabien Mongelard, Philippe Bouvet

“…Nucleolin possesses, in vitro, chromatin co-remodeler and histone chaperone activities which could explain numerous functions of nucleolin related to the regulation of gene expression. The goal of this report was to investigate the consequences of nucleolin depletion on the dynamics of histones in live cells. …”
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