Glucocorticoid receptor: translocation from the cytoplasm to the nuclei, chromatin and intranuclear chaperone cycles by V. M. Merkulov, N. V. Klimova, T. I. Merkulova

“…Upon ligand binding, GR dissociates from chaperon complex and translocates into the nucleus, where it interacts with specific DNA sequences (GREs) in the regulatory regions of target genes and modulates their expression. Then unliganded GR is exported to the cytoplasm, completing the nuclear-cytoplasmic cycle. …”
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The Active Compound Thymoquinone Alters Chondrogenic Differentiation of Human Mesenchymal Stem Cells via Modulation of Intracellular Signaling by Banu ISKENDER

“…The increase in proinflammatory cytokines in cartilage damage can increase the expression of apoptotic and proinflammatory genes and the matrix degradation enzymes via nuclear factor-κB (NF-κB). …”
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Proceedings of clinical trials on bile tract cancer by XIONG Yichen, YANG Ziyi, SANG Yuer, GONG Wei

“…Along with the advances of tumor molecular diagnostic technology and the in-depth mining of gene expression information of BTC, BTC precision medical research has entered a new era. …”
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Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson’s Disease by Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J. Lithgow, Julie K. Andersen, Shankar J. Chinta

“…Additionally, securinine also inhibited interferon-γ- (IFN-γ-) induced nitric oxide levels and iNOS mRNA expression. Furthermore, conditioned media (CM) from securinine pretreated BV2 cells significantly reduced mesencephalic dopaminergic neurotoxicity compared with CM from LPS stimulated microglia. …”
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Antimalarial Activity of Piperine by Artitaya Thiengsusuk, Phunuch Muhamad, Wanna Chaijaroenkul, Kesara Na-Bangchang

“…Results of real-time PCR showed no effect of piperine on modulating the expression of the three genes associated with antimalarial drug resistance in P. falciparum, i.e., pfcrt, pfmdr1, and pfmrp1. …”
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A Novel Nitrite Reductase from <i>Acinetobacter haemolyticus</i> for Efficient Degradation of Nitrite by Xiao-Yan Yin, Emmanuel Mintah Bonku, Jian-Feng Yuan, Zhong-Hua Yang

“…We constructed a heterologous expression system using <i>E. coli</i> BL21/pET28a-<i>Ah</i>Nir, which exhibited remarkable nitrite reductase enzyme activity of 29 U/mL in the culture broth, substantially higher than that reported for other strains. …”
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A New Case of 13q12.2q13.1 Microdeletion Syndrome Contributes to Phenotype Delineation by Giorgia Mandrile, Eleonora Di Gregorio, Alessandro Calcia, Alessandro Brussino, Enrico Grosso, Elisa Savin, Daniela Francesca Giachino, Alfredo Brusco

“…Clinical features resembling those reported in the literature confirm the existence of a distinct 13q12.3 microdeletion syndrome and provide further evidence that is useful to characterize its phenotypic expression during the 5 years of development.…”
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What Are the Public’s Concerns About ChatGPT? A Novel Self-Supervised Neural Topic Model Tells You by Rui Wang, Xing Liu, Peng Ren, Shuyu Chang, Zhengxin Huang, Haiping Huang, Guozi Sun

“…Both user queries and social media posts have been instrumental in expressing public concerns regarding this advanced dialogue system. …”
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G3DC: A Gene-Graph-Guided Selective Deep Clustering Method for Single Cell RNA-seq Data by Shuqing He, Jicong Fan, Tianwei Yu

“…Single-cell RNA sequencing (scRNA-seq) technology measures the expression of thousands of genes at the cellular level. …”
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MEK1/2 Inhibitor (GDC0623) Promotes Osteogenic Differentiation of Primary Osteoblasts Inhibited by IL-1β through the MEK-Erk1/2 and Jak/Stat3 Pathways by Zeng-Qiao Zhang, Xiao-Shen Hu, Ye-Chen Lu, Jun-Peng Zhang, Wen-Yao Li, Wei-Yang Zhang, Wei Feng, Dao-Fang Ding, Jian-Guang Xu

“…Inhibition of Jak-Stat3 pathway by C188-9 downregulated the expression levels of MMP9 and MMP13, activated MEK-Erk1/2 pathway, and inhibited osteogenic differentiation.…”
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Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in differen... by Jialin Wang, Haodi Yue, Xin Huang, Hongjian Liu, Mengjun Zhang

“…Abstract This study aimed to investigate the anticancer efficacy and underlying mechanism of novel platinum nanoclusters (Pt NCs) in osteosarcoma cell lines exhibiting distinct P53 expression profiles, namely MG-63 (P53−) and U2-OS (P53+). …”
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Laser Capture Microdissection in Dentistry by Uraiwan Chokechanachaisakul, Tomoatsu Kaneko, Takashi Okiji, Reika Kaneko, Hideaki Suda, Jacques E. Nör

“…Laser capture microdissection (LCM) allows for the microscopic procurement of specific cell types from tissue sections that can then be used for gene expression analysis. According to the recent development of the LCM technologies and methodologies, the LCM has been used in various kinds of tissue specimens in dental research. …”
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The "hypnotic state" and eye movements: Less there than meets the eye? by Etzel Cardeña, Barbara Nordhjem, David Marcusson-Clavertz, Kenneth Holmqvist

“…., showing only Highs expressing a particular eye behavior during hypnosis) does not support the claim that eye behaviors (at least as measured with the techniques used) are an indicator of a "hypnotic state." …”
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TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation by Xiang Liu, Jiazichao Tu, Ziqin Zhou, Bingxin Huang, Jianrong Zhou, Jimei Chen

“…Furthermore, TMAO-Exos, but not control-Exos, could significantly promote the mRNA expressions of Tnf, Icam1, Sele, and Cox-2 in the aorta. …”
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Using DIMet for Differential Analysis of Labeled Metabolomics Data: A Step-by-step Guide Showcasing the Glioblastoma Metabolism by Johanna Galvis, Joris Guyon, Thomas Daubon, Macha Nikolski

“…Integrating metabolomics data with gene expression profiles further enriches the analysis, as we demonstrated in our prior study on glioblastoma metabolic symbiosis. …”
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Reconstruction of gene regulatory networks from single cell transcriptomic data by M. A. Rybakov, N. A. Omelyanchuk, E. V. Zemlyanskaya

“…Gene regulatory networks (GRNs) – interpretable graph models of gene expression regulation – are a pivotal tool for understanding and investigating the mechanisms utilized by cells during development and in response to various internal and external stimuli. …”
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Immune regulation is more effective in the U937 inflammation model with mesenchymal stem cell extracellular vesicles stimulated by pro-inflammatory cytokines by Canan Öztürk, Zehra S. Halbutoğullari

“…Flow cytometry, gene expression, and immunofluorescence analyses were performed to investigate the apoptotic and antiproliferative effects of EVs and sEVs in the U937 macrophage inflammation model. …”
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Transforming Children’s Attitudes Toward Insects Through In-School Encounters by Kathleen M. Miller, Dana K. Beegle, Stephanie Blevins Wycoff, Daniel L. Frank

“…Results showed that even after expressing trepidation and fears, students’ knowledge and comfort levels with insects and other arthropods increased as they interacted and learned throughout the program. …”
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PENERAPAN METODE ROLE PLAYING DENGAN MEDIA ORKAS (ORGAN KORAN BEKAS) UNTUK MENINGKATKAN PRESTASI BELAJAR BIOLOGI SISWA KELAS XI IPA MADRASAH MA’ARIF AL-FALAH by Sri Utami, Indah Wijianti, Muh. Waskito Ardhi

“…And courage of students in expressing responses or opinions and experience after playing the role of increased 37.5% (31.25% to 68.75%). …”
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Effect of agarose/gelatin gel addition on the pro-angiogenic potential of polyhydroxybutyrate/chitosan scaffolds by Mária Giretová, Ľubomír Medvecký, Zuzana Demčišáková, Lenka Luptáková, Eva Petrovová, Radoslava Štulajterová

“…Moreover, the upregulation of gene expression responsible for the activation of angiogenic cascade clearly demonstrated a positive effect of the prepared composites on angiogenesis as an essential part of new tissue formation and the regeneration process itself.…”
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