Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness by Sahithi Attaluri, Raghavendra Upadhya, Maheedhar Kodali, Leelavathi N. Madhu, Dinesh Upadhya, Bing Shuai, Ashok K. Shetty

“…CysLT and LTB4 concentrations were elevated in the hippocampus and the cerebral cortex, along with enhanced 5-LOX expression in neurons and microglia. Such changes were also associated with increased proinflammatory cytokine levels in the hippocampus and the cerebral cortex. …”
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Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation by Lei Zhu, Kai X. Zhou, Ming Z. Ma, Lin L. Yao, Yan L. Zhang, Hui Li, Chang Du, Xiao M. Yang

“…We found that TUFT1 can interact with ZYX and inhibit its expression and recruitments to focal complexes in HCC cells. …”
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Criminal protection of sexual integrity of a person: some problematic aspects by T. D. Lysko

“…The terminological shortcomings of this expression are considered, the ways of overcoming such problems are determined. …”
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MicroRNA in Cervical Cancer: OncomiRs and Tumor Suppressor miRs in Diagnosis and Treatment by Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Takashi Iwata, Eiichiro Tominaga, Kyoko Tanaka, Daisuke Aoki

“…MicroRNAs (miRNAs) are implicated in posttranscriptional regulation of gene expression and in the pathogenic mechanisms of cancer, suggesting their importance in diagnosis and treatment. miRNAs may have roles in the pathogenesis of cervical cancer based on the increases or decreases in several specific miRNAs found in patients with this disease. …”
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PROJECT DESIGN OF LEARNING ACTIVITY CYCLE FROM THE PERSPECTIVE OF ACTIVITY AND COMPETENCE APPROACH by E. O. Pokhomchikova

“…The article adduces the basic principles of this approach, namely: the recognition of learning as a pedagogical and educational activity, where the leading role is assigned to learning activity – active self-directed students’ activity aimed at the development of their own competence; practical orientation; the expression of learning outcomes in the ability to successfully operate in various situations, including the professional sphere. …”
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Degraded products generated by iron stent inhibit the vascular smooth muscle cell proliferation by downregulating AP-1 by Jiabing Huang, Bingjian Liu, Chunguang Zhao, Jing Li, Dongxu Qiu

“…The major findings are as follows: 1) The degraded iron stent inhibited the proliferation of VSMCs; 2) The degraded products of the iron stent downregulated the expression of AP-1. In summary, this study demonstrates the inhibitory effect of degraded iron products on VSMC proliferation, implying that such products have the potential to mitigate in-stent restenosis. …”
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Silicate-substituted bovine-derived hydroxyapatite as a bone substitute in regenerative dentistry by Jithendra Ratnayake, Niranjan Ramesh, Maree L Gould, Michael R Mucalo, George J Dias

“…Immunohistochemical analysis revealed a significant increase in osteonectin expression, a key bone matrix protein, after 14 days of incubation under osteogenic conditions. …”
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Innate Immune Signaling in the Pathogenesis of Necrotizing Enterocolitis by David J. Hackam, Amin Afrazi, Misty Good, Chhinder P. Sodhi

“…In seeking to understand the molecular and cellular processes that lead to NEC development, we have identified a critical role for the receptor for bacterial lipopolysaccharide (LPS) toll like receptor 4 (TLR4) in the pathogenesis of NEC, as its activation within the intestinal epithelium of the premature infant leads to mucosal injury and reduced epithelial repair. The expression and function of TLR4 were found to be particularly elevated within the intestinal mucosa of the premature as compared with the full-term infant, predisposing to NEC development. …”
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Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages by Małgorzata Orłowska, Drishtee Barua, Sebastian Piłsyk, Anna Muszewska

“…We analyzed the taxonomic distribution of 85 protein families in Fungi including diverse early diverging fungal lineages. The expression of fucose-related protein-coding genes proteins was validated with the help of transcriptomic data originating from representatives of early diverging fungi. …”
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Large-Scale Plantlet Conversion and Ex Vitro Transplantation Efficiency of Siberian Ginseng by Bioreactor Culture by Jingli Yang, Shicheng Zhao, Changyeon Yu, Chenghao Li

“…TS2 plantlets also showed significantly lower H2O2 content and significantly increased superoxide dismutase (SOD), glutathione peroxidase (GPX), and glutathione transferase (GST) expression levels as compared to HS2 plants when exposure to ex vitro conditions.…”
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Simplified MS2 phage-like particle production including a novel maturation protein internal fusion affinity tag by Enos C. Kline, Rose Duong, Qin Wang, Barry R. Lutz

“…Key developments in PLP controls have enhanced the packing efficiency of RNAs into particles, reduced the complexity of their plasmid expression systems, and shifted purification from ultracentrifugation to affinity chromatography, producing progressively greater yields with higher purity. …”
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Differences and driving factors of leaf functional traits between old tree and mature tree of Pinus tabulaeformis in the Loess Plateau by Yuting Lei, Zimao Feng, Zhong Zhao

“…In addition, by constructing weighted gene co-expression networks analysis WGCNA), this research identified 24 candidate hub genes that regulate leaf functional traits, most of which are related to plant growth and development and the stress response, and can be used for further regulatory mechanism analysis. …”
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5-Aminolevulinic acid activates the MdWRKY71-MdMADS1 module to enhance anthocyanin biosynthesis in apple by Liuzi Zhang, Huihui Tao, Jianting Zhang, Yuyan An, Liangju Wang

“…In this study, we firstly demonstrated that ALA upregulates gene expression of the transcription factor MdMADS1, which in turn directly binds to and activates transcription of the key anthocyanin biosynthetic genes, MdCHS and MdUFGT. …”
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Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture by Olga Schmal, Jan Seifert, Tilman E. Schäffer, Christina B. Walter, Wilhelm K. Aicher, Gerd Klein

“…When seeded as a mixed cell suspension, MSCs segregated into tight spheroids. Despite the high expression of niche-specific extracellular matrix components by spheroid-forming MSCs, HSPCs did not migrate into the spheroids in the initial phase of coculture, indicating strong homotypic interactions of MSCs. …”
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Esophageal submucosal gland duct adenoma: a case report and literature review by Bing Zhou, Jian Zheng, Ling Huang, Hua Hao

“…Immunohistochemical analysis revealed the expression of adenomyoepithelial cytokeratins (CK) CK7, CK5/6, and p63. …”
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A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice by Lifang Sun, Minjie Mao, Zhisheng Yan, Cuiyun Zuo, Xiaojie Zhang

“…In the present study, Qingfei Xieding administration significantly attenuated bleomycin-induced pulmonary fibrosis in mice by reducing lung coefficient, wet/dry, NO, HYP, and MDA as well as the expression of iNOS, CTGF, α-SMA, FN, and DNA damage. …”
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Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners by Katarzyna Popiolek-Barczyk, Anna Piotrowska, Wioletta Makuch, Joanna Mika

“…Using primary microglial cell cultures, we revealed that biphalin did not influence cell viability but diminished NO production and expression of Iba1 in LPS-stimulated cells. Biphalin also diminished MOP receptor level, as well as pronociceptive mediators (iNOS, IL-1β, and IL-18) in an opioid receptor-dependent manner, and it was correlated with diminished p-NF-κB, p-IκB, p-p38MAPK, and TRIF levels. …”
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SIV Env RhmAbs + N-803 at ART initiation prolongs viral decay without disrupting reservoir establishment in SIV-infected infant macaques. by Omotayo Farinre, Tzoalli Anaya, Alexis C King, Kedan Endrias, Anne H Hébert, Alison L Hill, Sherrie Jean, Jennifer S Wood, Stephanie Ehnert, Shan Liang, Gregory M Laird, Rosemarie D Mason, Mario Roederer, Jeffrey T Safrit, Maud Mavigner, Ann Chahroudi

“…Treatment with a single dose of N-803 resulted in increased frequency of Ki67 expressing NK, CD8+, and CD4+ T cells. Levels of intact SIV proviruses in CD4+ T cells from blood, lymph nodes, and rectum at week 48 of ART did not differ across groups. …”
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Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling by Chalystha Yie Qin Lee, Yee Teng Chan, Yi Ying Cheok, Grace Min Yi Tan, Ting Fang Tang, Heng Choon Cheong, Jamuna Vadivelu, Suhailah Abdullah, Chung Yeng Looi, Won Fen Wong

“…Human THP-1 monocytic cells were infected with H. pylori, and the expression levels of human Toll-like receptors (TLRs) were examined. …”
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HIV and the Gut Microbiota, Partners in Crime: Breaking the Vicious Cycle to Unearth New Therapeutic Targets by Kishanda Vyboh, Mohammad-Ali Jenabian, Vikram Mehraj, Jean-Pierre Routy

“…Microbial translocation and their downstream effects such as increased indolamine 2,3-dioxygenase (IDO) enzyme expression and activity create a self-sustaining feedback loop which enhances HIV disease progression and constitute a vicious cycle of inflammation and immune activation combining viral and bacterial factors. …”
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