Comprehensive analysis of cuproptosis-related genes in immune infiltration and development of a novel diagnostic model for acute kidney injury by Yajing Li, Yingxue Ding

“…Our study aimed to investigate the involvement of cuproptosis-related genes (CRGs) in AKI.Methods Identification of CRGs was conducted using differential expression analysis, and subsequent Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted using human sequencing profiles. …”
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Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus by Li Qianqian, Shi Li, Liu Yingying, Guan Shimin, Zhang Shuo, Cai Baoguo, Rong Shaofeng

“…A recombinant A. ochraceus strain MF010 with the high expression of CYP monooxygenase was then obtained through homologous recombination. …”
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Enitociclib, a selective CDK9 inhibitor: in vitro and in vivo preclinical studies in multiple myeloma by Son Tran, Patrick Sipila, Melanie M. Frigault, Beatrix Stelte-Ludwig, Amy J. Johnson, Joseph Birkett, Raquel Izumi, Ahmed Hamdy, Ranjan Maity, Nizar J. Bahlis, Paola Neri, Aru Narendran

“…Enitociclib inhibited the phosphorylation of the carboxy-terminal domain (CTD) of RNA polymerase II at Ser2/Ser5 and repressed the protein expression of oncogenes c-Myc, myeloid cell leukemia-1 (Mcl-1), and proliferating cell nuclear antigen (PCNA) in MM cells. …”
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Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells by Huangde Fu, Shengtian Wu, Hechun Shen, Kai Luo, Zhongxiang Huang, Nankun Lu, Yaolin Li, Qian Lan, Yishun Xian

“…In this study, we revealed that DHA significantly inhibits the formation of vasculogenic-like networks, the stemness of C6 glioma stem cells and the growth of glioma by inhibiting the expression of EphA2. Mechanistic investigations indicated that PI3K/Akt pathway at least partly mediated this function, since overexpression of EphA2 reversed the anti-tumor effects of DHA. …”
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Mechanisms of transcriptional regulation of ecdysone response by M. Yu. Mazina, N. E. Vorobyeva

“…The mechanisms of ecdysone-dependent expression have been studied for many decades. Initially, the activation of individual genes under the influence of ecdysone was studied on the model of polythene chromosomes from salivary glands of Drosophila melanogaster. …”
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IDEALIZATION OF REALITY THROUGH PHOTOS IN SOCIAL NETWORKS by Svetlana M. Maltseva, Natalia A. Nikitina, Ekaterina S. Surovegina

“…As we continue to navigate the digital space, it is important to keep in mind how we interact with and interpret visual content, striving for a balance between artistic expression and authentic representation.…”
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Aproximación al Análisis de Dominio (AD) desde la investigación en Bibliotecología y Ciencia de la Información by María Arminda Damus, Gabriela Noemí Acuña

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Measurement of Quality of Life IV. Use of the SEQOL, QOL5, QOL1, and Other Global and Generic Questionnaires by Soren Ventegodt, Joav Merrick, Niels Jorgen Andersen

“…The global quality-of-life concept may help in expressing the objective of the initiatives taken to benefit specific groups. …”
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Uso de los SIG como recurso de innovación docente: Evaluación del conocimiento geoespacial a través de metodologías activas y emergentes by Virginia Alberdi Nieves

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Integrated Network Pharmacology and Gut Microbiota Study on the Mechanism of Huangqin Decoction in Treatment Diabetic Enteritis by Xiaomin Xu, Cheng Fang, Fang Lu, Shumin Liu

“…The results show that Huangqin decoction can inhibit the expression of inflammatory factors and related inflammatory pathways in intestinal epithelial cells, thereby regulating the structure of intestinal flora. …”
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The identification and management of production-living-ecological space from the perspective of land system science: Connection logic and realization path by JI Zhengxin, XU Yueqing, SUN Danfeng, LUN Fei, SUN Qiangqiang, JIAO Xin, CHEN Lu

“…Accordingly, this paper systematically reviews the ideological origin of land system science, elaborates the internal differences and operational structure of the land system, and clarifies the theoretical description and quantitative expression of the land system states. Based on ontological consistency, goal alignment, process relevance, and effect reciprocity, this paper summarizes, this paper summarizes the multi-dimensional interconnected relationship between land system science and the identification and management of PLES, attempts to construct a logical mechanism centered on the land system states between them, sequentially proposes the key solution paths for land system science to support the identification and management of PLES in terms of theoretical foundation, technical channels and practical vision. …”
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DISTANCE ESTIMATION TO THE INTERPHASE-FAULT LOCATION IN THE DISTRIBUTIVE AIR-LINE GRIDS BASED ON ANALYSIS OF THE HARMONIC COMPONENT PARAMETERS OF THE OPERATING EMERGENCY CONDITIONS by E. V. Kalentionok, Ye. O. Yakovchits

“…The algorithm of the present method realization includes: taking down oscillograms of the emergency-mode parameter values (e. g. in doublephase failure – the short-circuit current, the linear voltage between the faulty phases) with necessary discretization interval; expansion of the operating emergency parameters in a Fourier series (realized with a quick Fourier expansion algorithm); estimating the distance to the fault location by the analytical expression; performing the statistical analysis of a row of distance values and finding the most probable distance to the fault location.For effectiveness investigation of the proposed method of trapping harmonic components the paper considers a 10 kV distributive electrical grid feeding nine transformer substations. …”
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SENDEROS DE REPOSICIONAMIENTO A LA COMPLEJIDAD PRAXIOLÓGICA DEL TRABAJO SOCIAL: PATRIMONIO DISCIPLINAR EN CLAVE EXPERIENCIA DE FUSIÓN TEORÍA-PRÁCTICA by Víctor R. Yáñez Pereira

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The Blockade of IL6 Counterparts the Osmolar Stress-Induced Apoptosis in Human Conjunctival Epithelial Cells by Hee-Jung Ju, Yong-Soo Byun, Jee-Won Mok, Choun-Ki Joo

“…Confluent cells were incubated under different osmolarity (290 mOsm and 500 mOsm) with or without neutralizing IL6 antibody (50 ng/mL). The expression of IL6 level was measured in the supernatant of each conditioned medium. …”
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Light quality‐dependent roles of REVEILLE proteins in the circadian system by Cassandra L. Hughes, Yuyan An, Julin N. Maloof, Stacey L. Harmer

“…Here, we further examined light quality‐specific phenotypes of rve mutants and report that rve468 mutants lack the blue light‐specific increase in expression of some circadian clock genes observed in wild type. …”
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La integración de la ciencia, los sistemas locales de innovación y la gestión local de calidad de vida by Nelson Arsenio Castro Perdomo, Jayce Díaz Díaz, Mikhail Benet Rodríguez

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Exploring the role and mechanisms of the PMA gene in Aspergillus fumigatus by Chengrui Tan, Shaojie Jiang, Hongli Zhai, Qingwen Hu, Chenxi Liu, Yi Sun, Lujuan Gao

“…Transcriptome sequencing unveiled revealed a reduced expression of genes associated with ribosome function, the MAPK pathway, endoplasmic reticulum, and the transport and metabolism of fats, sugars, and proteins in ΔAfu-PMA1, highlighting PMA’s regulatory role in growth and adaptation. …”
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DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer by Rashmi R. Joshi, Sk Imran Ali, Amanda K. Ashley

“…Our investigations focused on triple negative breast cancer cells, as, compared to nonbasal breast cancer, LIG4 is frequently amplified, and an increased gene dose is associated with higher Lig4 expression. We depleted Lig4 using siRNA and confirmed our knockdown by qPCR and western blotting. …”
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Systematic Characterization of Splicing Dysregulation in Pan Solid Tumor Transcriptome by Jingru Sui, Dan Guo, Xiao Wen, Lei Zhou, Yue Huang, Haoyu Yu, Jinyu Chen, Zhaoqi Liu

“…Six unique patterns illustrated by ASE‐SF co‐modules are summarized, which involve 1,570 ASEs and altered expression of 170 SFs, covering 40% of TCGA solid tumors. …”
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Therapeutic Effect of Stem Cells on Male Infertility in a Rat Model: Histological, Molecular, Biochemical, and Functional Study by Sally S. Mohammed, Mona F. Mansour, Noha A. Salem

“…Group 2 showed significant histological changes, decreased free testosterone level, decrease in stem cell factor expression, and dysfunction of the oxidation state. …”
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