Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways by Ciprian Pușcașu, Corina Andrei, Octavian Tudorel Olaru, Anca Zanfirescu

“…GPR40, activated by long-chain fatty acids, exhibits strong anti-inflammatory effects by reducing cytokine expression. Butyrate-activated GPR43 inhibits inflammatory mediators like nitric oxide synthase-2 and cyclooxygenase-2, mitigating inflammation. …”
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Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets by Claire Vinel, James Boot, Weiwei Jin, Nicola Pomella, Alexandra Hadaway, Charles Mein, Nicolae Radu Zabet, Silvia Marino

“…Conclusions We show epigenetic regulation of the expression of genes and related signalling pathways contributing to glioblastoma development. …”
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Linkage Mapping and Identification of Candidate Genes for Cold Tolerance in Rice (Oryza Sativa L.) at the Bud Bursting Stage by Lina Zhang, Fei Wang, Chunhui Liu, Xiaoding Ma, Di Cui, Bing Han, Longzhi Han

“…One candidate gene, LOC_Os07g44410, was identified through gene function annotation, haplotype analysis, and qRT-PCR, with two main haplotypes (Hap1 and Hap2) showing distinct phenotypic differences. qRT-PCR analysis showed that the expression level of LOC_Os07g44410 in cold tolerant lines carrying Hap1 was significantly higher than that in cold sensitive lines carrying Hap2. …”
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Identification and characterization of a novel tetrapeptide from enzymatic hydrolysates of Baijiu byproduct by Qiang Wu, Changqing Zhong, Guirong Zeng, Xu Zhang, Liping Xiang, Chang Wan, Yougui Yu

“…Moreover, it showed no significant cytotoxicity toward human umbilical vein endothelial cells (HUVECs), and significantly induced phosphorylation of endothelial nitric oxide synthase (p-eNOS) and decreased endothelin 1 (END1) expression in angiotensin I (Ang I)-treated HUVECs, demonstrating the potential antihypertensive effect. …”
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A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity by Lanlin Zhang, Jiangyuan Du, Qian Song, Chufan Zhang, Xianghua Wu

“…These effects were closely related to the induction of the expression of distinct ICD hallmarks by RB in both bulk cancer cells and cancer stem cells (CSCs), especially calreticulin (CRT), thus enhancing immune effector cell (i.e., CD4+, CD8+, and memory T cells) infiltration and attenuating the accumulation of immunosuppressive cells (i.e., Tregs, macrophages, and myeloid-derived suppressor cells (MDSCs)) in the TME. …”
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Characterization of the Biochemical Potential of Moroccan Onions (Allium cepa L.) by Amal Brahimi, Mohamed El Ouardi, Amal Kaouachi, Abdelhakim Boudboud, Lhoussain Hajji, Hassan Hajjaj, Hamid Mazouz

“…Onions were collected as seeds from different geographical origins and cultivated in the same environment, to eliminate the influence of the environment on biochemical expression. Moisture, total phenols, flavonoids, antioxidant activity, total and reducing sugars, and sulfur dioxide were the biochemical properties of interest. …”
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La Música Herramienta Efectiva En El Aprendizaje by M.A. Pamela Lilian Calderón Reza, M´´´´´´´´´´Sc. Cristhian Benigno Jara Jimenes, PhD. Lilian Betty Reza Suarez

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Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review by Miguel Fdo. Salazar, Martha Lilia Tena-Suck, Alma Ortiz-Plata, Citlaltepetl Salinas-Lara, Daniel Rembao-Bojórquez

“…Immunolabeling of these showed membrane positivity for GFAP, PS100, and CD99, while Ki-67 expression was null. Ultrastructural examination of retrieved paraffin-embedded tissue showed the presence of scarce microlumina filled with microvilli but failed to demonstrate any content in such optically empty vacuoles as only scant granulofibrillary debris was observed. …”
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Preferential Th1 Cytokine Profile of Phosphoantigen-Stimulated Human Vγ9Vδ2 T Cells by Margaret R. Dunne, Bozgana A. Mangan, Laura Madrigal-Estebas, Derek G. Doherty

“…Cytokine production was not influenced by expression or lack, thereof, of CD4 or CD8. Addition of IL-2 or IL-15 caused expansion of IFN-γ-producing Vγ9Vδ2 T cells, but did not enhance IFN-γ secretion after 24–72 hours. …”
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Mechanisms of bacterial-to-host interaction and their disorders at inflammatory bowel diseases by Ye. A. Poluektova, O. S. Lyashenko, A. V. Korolev, O. S. Shifrin, V. T. Ivashkin

“…The capability of bacteria contact with immune cells is provided by capacity of bacterial cells to adhesion and invasion, competence of mucus layer covering mucosa of gastro-intestinal tract, detaining and fixing microbic cells, competence of intercellular epithelial contacts function, density of signal receptors, level of antimicrobic peptides expression, completeness of autophagy process. Disorder of barrier function of intestine at IBD patients, in combination to prevalence of opportunistic and pathogenic microorganisms in intestinal biome, results in essential overload of innate and adaptive immune system.Conclusion. …”
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Historical traditions of democracy in Ukraine by Stechyshyn A.

“…The main regulatory act regulating the procedure of direct people’s power is the Constitution of Ukraine, which regulates the main forms of expression of the will of the people and spheres of influence. …”
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Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo by Yilai Shu, Yong Tao, Wenyan Li, Jun Shen, Zhengmin Wang, Zheng-Yi Chen

“…We found three adenovirus vectors transduced mouse inner ear cells with different specificities and expression levels, depending on the type of adenoviral vectors and the age of mice. …”
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Performance Analysis of 3D Massive MIMO Cellular Systems with Collaborative Base Station by Xingwang Li, Lihua Li, Ling Xie, Xin Su, Ping Zhang

“…Utilizing this bound, we pursue a “large-system” analysis and provide the asymptotic expression when the number of antennas at the BS grows large, and when the numbers of antennas at transceiver grow large with a fixed ratio. …”
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Stable coding of aversive associations in medial prefrontal populations by Herry, Cyril, Jercog, Daniel

“…While studies at the single-cell level have demonstrated the involvement of this area in various aspects of fear processing, such as the encoding of threat-related cues and fear expression, an increasingly prevalent idea in the systems neuroscience field is that populations of neurons are, in fact, the essential unit of computation in many integrative brain regions such as prefrontal areas. …”
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Antioxidant Protection against Curative and Palliative Doses of Ionizing Irradiation in Human Blood Decreases with Aging by Jelena Kasapović, Vesna Stojiljković, Ljubica Gavrilović, Nataša Popović, Zorka Milićević

“…The aim of this paper was to evaluate the irradiation effects on the activities and expression of AO system in the blood of healthy women during aging. …”
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Daily reference evapotranspiration prediction using empirical and data-driven approaches: A case study of Adana plain by Semin Topaloğlu Paksoy, Deniz Levent Koç

“…The objective of this research was to examine the effectiveness of five different data-driven techniques, including artificial neural networks "multilayer perceptron" (ANN), gene expression programming (GEP), random forest (RF), support vector machine "radial basis function" (SVM), and multiple linear regression (MLR) to model the daily ET0. …”
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Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols by Yue Luo, Jianan Zhang, Chi-Tang Ho, Shiming Li

“…Reduction of carbonyl stress brought alleviation to aging, diabetes, and collagen related diseases or complications through regulation of RAGE expression and subsequent MAPK and TGF-β pathway. Therefore, tea polyphenols can serve as promising natural candidates in the treatment and/or prevention of nephropathy, retinopathy, hepatopathy, hyperglycemia and obesity among others, by their potent antiglycation effect. …”
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Neutral zone closing overvoltage characteristics analysis in traction power supply system for group trains by XIANG Nianwen, XU Chenglin, SHAO Bingbing, YUAN Qiankun, YANG Jin, WANG Zhoulong

“…In order to qualitatively analyze the closing overvoltage characteristics of group trains, the equivalent simplified dynamic circuit of the traction power supply system of group trains is established according to the principle of circuit equivalent simplification. The expression of the train terminal voltage at the moment of closing is solved by reasonable assumptions, which reveals the formation reasons of the closing overvoltage in terms of the qualitative relationship. …”
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Primary school children’s oral hygiene knowledge assessed with different educational methods: a cross-sectional study by Canan Bayraktar Nahir, Alem Coşgun, Necibe Damla şahin, Halenur Altan

“…The animation group (6.73) and the verbal expression group (6.57) had the highest post-training knowledge levels, respectively, while the peer-led reels group had the lowest (5.95) (p < 0.001). …”
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Integrated metabolomics and transcriptomics reveal the role of calcium sugar alcohol in the regulation of phenolic acid biosynthesis in Torreya grandis nuts by Qiandan Xie, Zhengchu Jiang, Chenliang Yu, Qi Wang, Wensheng Dai, Jiasheng Wu, Weiwu Yu

“…Furthermore, the binding of TgAP2-1 to the TgHCT promoter was confirmed using yeast one hybrid and dual-luciferase assays. Furthermore, the expression of TgHCT in Nicotiana enhanced the total flavonoid content. …”
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