The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…Epigenetics refers to heritable changes in gene expression without altering the DNA sequence, with mechanisms like DNA methylation, histone modification, and non-coding RNA regulation playing critical roles in aging. …”
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Estrategias legales contra la violencia política de género. Las oportunidades de acción by Laura Albaine

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On expansions for nonlinear systems Error estimates and convergence issues by Beauchard, Karine, Le Borgne, Jérémy, Marbach, Frédéric

“…Explicit formulas expressing the solution to non-autonomous differential equations are of great importance in many application domains such as control theory or numerical operator splitting. …”
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Newly Generated Cells in the Dentate Gyrus Differentially Respond to Brief Spatial Exploration and Forced Swim in Adult Female Balb/C Mice by Gerardo Bernabé Ramírez-Rodríguez, María del Ángel Ocaña-Fernández, Leonardo Ortiz-López

“…Here, we investigated the activation of newborn neurons after three (IdU) or six weeks (CldU) postlabelling with the expression of Arc in the same mice but exposed to different environmental stimuli. …”
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A Golgi apparatus‑related subtype and risk signature predicts prognosis and evaluates immunotherapy response in gastric cancer by Ruyue Chen, Zengwu Yao, Lixin Jiang, Jinchen Hu

“…We aimed to decipher the prognostic significance and underlying biological mechanisms of these genes via consistent clustering, differential expression analysis, enrichment analyses, and immune infiltration profiling. …”
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Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model by Sean P. Kessler, Dana R. Obery, Carol de la Motte

“…Developing a temporary targeted therapeutic intervention of HAS3 expression or function in the microcirculation may emerge as a desirable strategy toward tempering colitis in patients undergoing flares of IBD.…”
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Pax6 regulates neuronal migration and cell proliferation via interacting with Wnt3a during cortical development by Bichao Zhang, Meihua Hou, Jiayan Huang, Yunfei Liu, Ciqing Yang, Juntang Lin

“…JASPAR analysis together with the results of qPCR, Western blot, CUT&Tag, and rescue experiments revealed that Pax6 regulates neuronal migration and cell proliferation by indirectly mediating Wnt3a expression. Therefore, we propose that Pax6 participates in corticogenesis via interaction with Wnt3a in regulating neuronal migration and cell proliferation.…”
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L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway by Hao-Ran Li, Xiao-Ming Zheng, Yan Liu, Jing-Hui Tian, Jie-Jian Kou, Jun-Zhuo Shi, Xiao-Bin Pang, Xin-Mei Xie, Yu Yan

“…Biomarkers such as LDH, NT-proBNP, cTnT, and AST, as well as the inflammatory cytokines IL-1β, IL-6, and TNF-α, were decreased in plasma of mice receiving LC treatment after myocardial injury. In addition, the expression of α-SMA as well as the key proteins in the Bax/Bcl-2 signaling pathway in cardiac myocardium were much lower in mice with LC treatment compared to those without after MI. …”
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Computer analysis shows differences between mitochondrial miRNAs and other miRNAs by P. S. Vorozheykin, I. I. Titov

“…A subclass of miRNAs with as yet unknown specific functions is mitomiRs – mitochondrial miRNAs that are mainly derived from nuclear DNA and are imported into mitochondria; moreover, changes in the expression levels of mitomiRs are associated with some diseases. …”
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Development and characterization of a reverse genetics system for the lineage II Chicava strain of Machupo virus in a guinea pig model. by Emily Mantlo, Junki Maruyama, John T Manning, Rachel A Reyna, Cheng Huang, Slobodan Paessler

“…Rescue of the recombinant MACV Chicava strain (rMACV-Chicava) was accomplished by expression of the L protein and nucleoprotein genes of the MACV Carvallo strain in trans in transfected baby hamster kidney (BHK-21) cells. …”
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Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-κB Signaling by Jiangrui Liu, Liangpan Shi, Wenchang Huang, Zhihua Zheng, Xiaohui Huang, Yibin Su

“…HHT alleviated DSS-induced colitis with downregulated TNF-α, IL-1β, IL-6, and CCL2 expression; reduced activation of nuclear factor-kappa B (NF-κB) signaling; and diminished proportion of recruited macrophages in colon tissues. …”
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Markers of Inflammation Associated with Plaque Progression and Instability in Patients with Carotid Atherosclerosis by Enrico Ammirati, Francesco Moroni, Giuseppe Danilo Norata, Marco Magnoni, Paolo G. Camici

“…Atherosclerosis is the focal expression of a systemic disease affecting medium- and large-sized arteries, in which traditional cardiovascular risk factor and immune factors play a key role. …”
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Temas y problemas de los jóvenes colombianos al comenzar el siglo XXI by Germán Muñoz González

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Use of miRNAs as Biomarkers in Sepsis by Raluca Dumache, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Mirela Sarandan, Alina Carmen Cradigati, Marius Papurica, Corina Maria Dumbuleu, Radu Nartita, Dorel Sandesc

“…Following biochemical and physiological imbalances, the expression of miRNAs in blood or other body fluids changes significantly. …”
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“Rights and Liberties” in Pylyp Orlyk’s Constitution through the Prism of Renaissance Interpretations of Justice by S. B. Ivanov

“…It laid down a progressive idea of ​​expressing the aspirations and needs of the whole nation, which shows the high level of legal and philosophical culture of the Ukrainian elite of that time.…”
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Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae by Christie F. Michael, Christopher M. Waters, Kim S. LeMessurier, Amali E. Samarasinghe, Chi Y. Song, Kafait U. Malik, D. Betty Lew

“…In addition, NHBEC treated with SC-MN showed increased expression and activation of Krüppel-like factors (KLFs) 4 and 5, transcription factors important in epithelial cell survival and regulation of epithelial-mesenchymal transition. …”
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Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells by Suh Sung-Suk, Oh Se Kyung, Lee Sung Gu, Kim Il-Chan, Kim Sanghee

“…Pretreatment with porphyra- 334 markedly attenuated the inhibitory effect of UV and induced a dramatic decrease in the apoptotic rate. Expression of active caspase-3 protein was increased in response to UV irradiation, while caspase-3 levels were similar between cells treated with porphyra-334 and the non-irradiated control group. …”
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Modulation of Tyrosine Hydroxylase, Neuropeptide Y, Glutamate, and Substance P in Ganglia and Brain Areas Involved in Cardiovascular Control after Chronic Exposure to Nicotine by Merari F. R. Ferrari, Emerson F. Coelho, Karen L. G. Farizatto, Gerson Chadi, Debora R. Fior-Chadi

“…Immunohistochemical and in situ hybridization data demonstrated increased expression of TH in brain and ganglia related to blood pressure control, preferentially in SHR, after nicotine exposure. …”
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VsMATE1-Mediated Citrate Efflux Is Involved in Al Resistance in Common Vetch (<i>Vicia sativa</i> L.) by Wenhui Yan, Jia Shi, Ling He, Zigang Hou, Zhenfei Guo, Haifeng Zhu

“…Consistently, <i>VsMATE1</i> expression increased faster and to a greater extent in 418 than 426 in response to Al stress. …”
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Role of Epigenetics in Modulating Phenotypic Plasticity against Abiotic Stresses in Plants by Fayaz Ahmad Dar, Naveed Ul Mushtaq, Seerat Saleem, Reiaz Ul Rehman, Tanvir Ul Hassan Dar, Khalid Rehman Hakeem

“…Epigenomic changes in plants through induced methylation of specific genes that lead to changes in their expression can help to overcome various stress conditions. …”
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