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12641
Adult Vascular Wall Resident Multipotent Vascular Stem Cells, Matrix Metalloproteinases, and Arterial Aneurysms
Published 2015-01-01“…The factors and signaling pathways involved in regulating wall resident SC recruitment, survival, proliferation, growth factor production, and differentiation may be also related to selective expression of different MMPs. This review explores the relationship between adult vascular wall resident multipotent vascular SCs, MMPs, and arterial aneurysms.…”
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12642
Overcoming immunotherapy resistance in gastric cancer: insights into mechanisms and emerging strategies
Published 2025-02-01“…This review provides a comprehensive analysis of the mechanisms underlying immunotherapy resistance in GC, including the role of the tumor immune microenvironment, dynamic PD-L1 expression, compensatory activation of other immune checkpoints, and tumor genomic instability. …”
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12643
Clinical case of combined correction of children's psychotraumatic experience and distress in the development of cancer
Published 2020-03-01“…It is shown that the psychotherapeutic techniques used in the framework of the adapted diathesis-stress model (psychosynthesis, short-term analytical psychodrama, cognitive-behavioral psychotherapy) allow us to determine a behavior strategy in overcoming the traumatic situation that occurred in the early stages of childhood, in order to form the skills of the correct expression of our emotions, avoiding this deconstructive "coping" – strategy.…”
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12644
Social contexts and black families' engagement in early childhood programs.
Published 2025-01-01“…Focus group participants described benefits of home visiting while also expressing concerns about being unfairly judged about their parenting practices and the risk of a home visit resulting in child welfare system involvement. …”
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12645
The Student’s Subjective Position as a Condition for Success in Mastering a Profession
Published 2024-06-01“…The student’s subjective position is considered through his or her attitude to educational activities, through his or her achievements at the stage of learning a profession and through his or her expression of readiness for professional activity. The study is based on a survey of students from 20 Russian universities. …”
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12646
Accelerating and decelerating flow of radiatively Casson fluid between two permeable disks under convective boundary conditions
Published 2025-02-01“…Thus, the Jacobi elliptic sine squared function is used to derive the analytical solution of accelerating and decelerating flow. The expression for temperature is also derived analytically. …”
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12647
The effects of the extract of oolong tea and its metabolites from Andraca theae in high fat diet induced obese Wistar rat
Published 2018-06-01“…TE significantly decreased abdominal adipose tissue, especially epididymal fat via increasing preadipocyte factor 1 (Pref-1), SRY (sex determining region Y)-box 9 (SOX-9) and decreasing peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein (C/EBP)β, C/EBPα and C/EBPγ protein expression. Taken together, these results suggest that the content of tea polyphenols in TE play an important role for alleviating abdominal fat. …”
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12648
AS CONEXÕES TEMÁTICAS ENTRE O CORDEL E A INFORMAÇÃO PARA A SAÚDE
Published 2025-02-01“…Nesse sentido, buscou-se identificar em publicações científicas conteúdos que expressam relações entre às duas temáticas, assim como investigar as áreas do conhecimento associadas. …”
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12649
LAMB1 downregulation suppresses glioma progression by inhibiting aerobic glycolysis through regulation of the NF-κB/HK2 axis
Published 2025-02-01“…Western blotting was conducted to monitor the expression of HK1, HK2, PDHA, and PKM. Bioinformatic analysis was employed to investigate the downstream mechanism of LAMB1. …”
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12650
The Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells
Published 2016-01-01“…We found upregulation of MAPT protein expression in human insulinomas when compared to human pancreatic islets of Langerhans and an imbalance between MAPT isoforms in insulinomas tissue. …”
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12651
Opposite roles of serotonin and neuropeptide FMRFamide in the regulation of epigenetic processes involved in the longterm memory formation
Published 2016-05-01“…This may underlie the convergence of the activator and inhibitory pathways involved in the long-term memory formation and underlie following regulation of the expression of genes involved in long-term plasticity.…”
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12652
Etoricoxib–NLC Mitigates Radiation-Induced Ovarian Damage in Rats: Insights into Pro-Inflammatory Cytokines, Antioxidant Activity, and Hormonal Responses
Published 2024-12-01“…Serum levels of estrogen, FSH, and LH were measured, and gene expression analysis for <i>TGF-β</i> and <i>Nrf2</i> was performed using qRT-PCR. …”
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12653
Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance
Published 2012-01-01“…Thus, three main approaches have been undertaken to induce immunological tolerance; delivery of potent immunosuppressive cytokines and other molecules, modification of intracellular signalling pathways in dendritic cells, and de-targeting transgene expression from dendritic cells using microRNA technology. …”
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12654
Prioritization of causal genes from genome-wide association studies by Bayesian data integration across loci.
Published 2025-01-01“…The SigNet method builds on existing methods that focus on individual loci with evidence from gene distance and expression quantitative trait loci (eQTL) by sharing information across loci using protein-protein and gene regulatory interaction network data. …”
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12655
A Novel COL7A1 Mutation in a Patient With Dystrophic Epidermolysis Bullosa. Successful Treatment With Upadacitinib
Published 2025-01-01“…In different DEB subtypes, the severity of the phenotype is associated, to some extent, with the outcome of Type VII collagen caused by mutations in the COL7A1 gene, which may be reduced in expression, remarkably reduced, or completely absent. …”
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12656
Evolutionary analysis of DELLA proteins in sweet potato and related species reveals their roles in development and stress responses
Published 2025-01-01“…Moreover, the DELLA genes in sweet potato display an expression pattern that tends to control the growth and development of either the aerial or below-ground parts, and they are responsive to a range of hormones and abiotic stresses. …”
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12657
Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations.
Published 2025-01-01“…While clinically severe mutations impair neurogenesis, mild mutations have only a modest impact on cell fate. Moreover, expression of severe mutations leads to profound neuronal death. …”
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12658
Locally Delivered Umbilical Cord Mesenchymal Stromal Cells Reduce Chronic Inflammation in Long-Term Nonhealing Wounds: A Randomized Study
Published 2020-01-01“…Mesenchymal stromal cells (MSCs) have been considered a perspective tool for regenerative medicine because of their ability to change the expression and secretory profile under the influence of signals from the microenvironment to perform a regulatory function at the site of tissue damage. …”
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12659
A CONSTRUÇÃO DO “INIMPUTÁVEL PERICULOSO” E O CONTROLE SOCIAL ATRAVÉS DA MEDIDA DE SEGURANÇA // THE CONSTRUCTION OF THE 'DANGEROUS NON-CRIMINALLY RESPONSIBLE' AND SOCIAL CONTROL THR...
Published 2024-06-01“…A análise não se restringe a uma abordagem disciplinar isolada, mas explora a expressão da formação sócio-histórica brasileira enraizada em formas produtivas - não apenas econômicas - da escravização, sustentada pelo racismo e pela colonialidade do poder, do ser e do saber. …”
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12660
Dominance of Sulfur-Oxidizing Bacteria, <i>Thiomicrorhabdus</i>, in the Waters Affected by a Shallow-Sea Hydrothermal Plume
Published 2025-01-01“…In April 2019, we investigated the composition of prokaryotic picoplankton communities, their gene expression profiles, and the dissolved inorganic carbon uptake efficiency. …”
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