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12561
Neurobehavioral plasticity in the rodent gustatory system induced by regular consumption of a low-calorie sweetener during adolescence
Published 2025-01-01“…The anterior tongue had fewer fungiform taste papillae, and the circumvallate papillae had a reduced anterior to posterior span and diminished expression of genes involved in sweet reception, sweet and bitter intracellular signaling, fructose transport, and cellular progeneration in the Ace-K-exposed rats. …”
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12562
Reorganisation of chromatin during erythroid differentiation
Published 2019-02-01“…Deciphering the mechanisms that coordinate shifts in gene expression revealed a critical role of three-dimensional chromatin structure in the regulation of gene activity during lineage commitment. …”
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12563
Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors.
Published 2023-01-01“…This long-lasting response was associated with Tumour necrosis factor alpha expression in microglial cells. In vitro, conditioned media from activated BV2 microglial cells increased cell death, decreased Tyrosine hydroxylase-positive cells and induced morphological alterations on human neural stem cells-derived dopaminergic precursors at two differentiation stages: 19 days and 28 days. …”
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12564
Photochemical Treatment of Drosophila APCs Can Eliminate Associated Viruses and Maintain the APC Function for Generating Antigen-Specific CTLs Ex Vivo
Published 2018-01-01“…UVADEX treatment is sufficient to inactivate insect viruses but does not affect the expression of MHC class I molecules and costimulation molecules on Drosophila APCs. …”
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12565
(5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate from Euclea crispa (L.) Inhibits Ovarian Cancer Cell Growth by Controlling Apoptotic and Me...
Published 2022-01-01“…The protein that is responsible for the death of cells (Bcl-2 and Bcl-xL) was reduced (p<0.05), while the protein expression of p53 and caspase-9 was increased (p<0.05) in compound 2-treated HO-8910 cells. …”
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12566
Sargachromenol from Sargassum micracanthum Inhibits the Lipopolysaccharide-Induced Production of Inflammatory Mediators in RAW 264.7 Macrophages
Published 2013-01-01“…It also significantly inhibited the protein expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner in LPS-stimulated macrophage cells. …”
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12567
Engineered CRISPR-Cas9 for Streptomyces sp. genome editing to improve specialized metabolite production
Published 2025-01-01“…Cas9-BD and similarly modified dCas9-BD have been successfully employed for simultaneous biosynthetic gene cluster (BGC) refactoring, multiple BGC deletions, or multiplexed gene expression modulations in Streptomyces. We also demonstrate improved secondary metabolite production using multiplexed genome editing with multiple single guide RNA libraries in several Streptomyces strains. …”
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12568
Gamma Radiation-Induced Damage in the Zinc Finger of the Transcription Factor IIIA
Published 2016-01-01“…These results indicate that the zinc finger motif is a target domain for gamma radiation, which may decrease 5S rRNA expression via impairment of the zinc finger motifs in TFIIIA.…”
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12569
Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro
Published 2020-01-01“…Our results found that SIGIRR negatively regulated TRAF6 ubiquitination and such SIGIRR inhibition could enhance the TRAF6 expression in both alveolar epithelial cells (AECs) and alveolar macrophage cells (AMCs). …”
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12570
Automatic Implementation of Fuzzy Reasoning Spiking Neural P Systems for Diagnosing Faults in Complex Power Systems
Published 2019-01-01“…An FRSN P system offers an intuitive illustration based on a strictly mathematical expression, a good fault-tolerant capacity, a good description for the relationships between protective devices and faults, and an understandable diagnosis model-building process. …”
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12571
Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats
Published 2024-08-01“…We examined the wound closure rate, expression of inflammatory factors, growth factors in addition to the histological analysis. …”
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12572
Beneficial effects of baicalein on a model of allergic rhinitis
Published 2020-03-01“…Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. …”
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12573
SOME CONSIDERATIONS ON THE TYPOLOGY OF PHILOSOPHICAL-ANTHROPOLOGICAL MODELS (TO THE PROBLEM OF VALUE IDENTIFICATIONS OF UKRAINIANS)
Published 2018-12-01“…Originality is in the disclosure of anthropological models that correspond to the value functionality, that is, the determination and expression of the essence of a person. It is shown that certain projects, under the conditions of forced reformatting, by their value reduction are classified as inhuman. …”
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12574
Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats
Published 2019-01-01“…The HCC-induced group showed a significant decrease in the body mass and a significant elevation in the liver weight, alpha-fetoprotein (AFP), liver enzymes, hepatic malondialdehyde (MDA), and p53 protein expression levels as well as genetic mutations in intron 5 of p53 gene in the form of Single-Nucleotide Polymorphisms (SNPs) and insertions. …”
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12575
One-Step Formation of Chondrocytes through Direct Reprogramming via Polysaccharide-Based Gene Delivery
Published 2019-01-01“…The induced chondrocytes were identified through toluidine blue, Safranin O, and the immunostaining. The expression level of collagen II was finally evaluated through western blot. …”
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12576
El zapateo en las tradiciones afrocriollas de la costa peruana: una mirada a lo musical
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12577
Conserved pattern-based classification of human odorant receptor multigene family
Published 2024-11-01“…Furthermore, we found that the CMC correlated with both ligand responses and ectopic expression patterns, highlighting its relevance to OR function. …”
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12578
A Rare Case of Grey Zone Lymphoma Successfully Treated with Brentuximab Vedotin and R-CHP Chemotherapy
Published 2019-01-01“…Given her strong CD30 expression, she underwent 6 cycles of R-BV-CHP (rituximab, brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone) chemotherapy and achieved complete response (CR) both clinically and radiographically. …”
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12579
Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor
Published 2019-01-01“…Positivity for CD45 and CD68 in the larger spindled cells points to an inflammatory pseudotumor subtype and co-expression of CD21, CD23, and CD35 were indicative of follicular dendritic differentiation. …”
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12580
Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application
Published 2025-01-01“…Nonetheless, numerous questions remain regarding the expression of key metabolic genes across different tumors, the regulation of their activities, and the impact of individual KBs on various tumor types. …”
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