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12481
A Network-Based Impact Measure for Propagated Losses in a Supply Chain Network Consisting of Resilient Components
Published 2018-01-01“…We obtain an analytical expression for the impact measure under a beta-distributed initial loss (generalizable to any continuous distribution supported on the interval 0,1), under a breakthrough scenario (in which a fraction of the initial production loss reaches a focal company downstream as opposed to containment upstream or at the originating point). …”
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12482
Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention
Published 2025-01-01“…This encompasses the role of the extracellular matrix, altered gene expression, and the formation of persister cells, contributing to the recalcitrance of biofilms to eradication. …”
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12483
Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro
Published 2020-01-01“…In addition, by acting on the GPR109A receptor, NaB regulates the expression of AD-related genes such as APP, NEP, and BDNF. …”
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12484
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12485
β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages
Published 2015-01-01“…Here, we show that βCR expression was mainly in foamy macrophages of atherosclerotic aortas from apolipoprotein E-deficient mice. …”
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12486
Derivation and Implementation of a Non‐Local Term to Improve the Oceanic Convection Representation Within the k–ɛ Parameterization
Published 2025-01-01“…To improve the accuracy of turbulent fluxes, we examine the possibility of adding a non‐local component in their expression in addition to the usual downgradient part. …”
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12487
Characterization of m6A Methylation Modification Patterns in Colorectal Cancer Determines Prognosis and Tumor Microenvironment Infiltration
Published 2022-01-01“…The results indicated that the expression profiles and genetic mutations of 21 genes encoding m6A methylation regulators in CRC were characterized by a high degree of heterogeneity. …”
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12488
Extracellular HMGB1 Induced Glomerular Endothelial Cell Injury via TLR4/MyD88 Signaling Pathway in Lupus Nephritis
Published 2021-01-01“…Additionally, inhibition of extracellular HMGB1 and/or downstream TLR4/MyD88/NF-κB/p65 signaling pathway also alleviated GEC monolayer permeability, reduced the shedding of the glomerular endothelial glycocalyx, improved the intercellular tight junction and cytoskeletal arrangement, and downregulated the NO level and VCAM-1 expression. These results suggested that extracellular HMGB1 might involve in GEC injury by activating the TLR4/MyD88 signaling pathway in LN, which provided novel insights and potential therapeutic target for the treatment of lupus nephritis.…”
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12489
Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects
Published 2025-02-01“…These therapies offer novel strategies for delivering targeted treatments to Nectin-4-expressing cancer cells, enhancing treatment efficacy and minimizing off-target effects. …”
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12490
Identification of a Novel Prognostic Lymphangiogenesis-Related Signature Associated with Tumor Immunity for Guiding Therapy in Lung Adenocarcinoma
Published 2024-01-01“…We confirmed the ectopic expression of lymphangiogenesis-related genes (LRGs) in lung adenocarcinoma (LUAD) cohorts based on the TCGA database. …”
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12491
The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes
Published 2016-01-01“…High-mobility group box 1 (HMGB1), a nonhistone nuclear protein regulating gene expression, was rediscovered as an endogenous danger signal molecule to trigger inflammatory responses when released into extracellular milieu in the late 1990s. …”
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12492
Evaluation of anticancer potency of Cu-isatin-1-(2-pyridyl) piperazine thiosemicarbazone (Cu-Istpypz) against epidermoid carcinoma cell line (A431)
Published 2025-01-01“…RT-PCR and western blot analysis indicated that the compound induced the expression of pro-apoptotic Bax and inhibited anti-apoptotic Bcl-2 and Bcl-xl in a concentration-dependent manner. …”
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12493
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12494
Comparison of the MGISEQ-2000 and Illumina HiSeq 4000 sequencing platforms for RNA sequencing
Published 2019-09-01“…We performed RNA sequencing of four human colon cancer samples with the two platforms, and compared the sequencing quality and expression values. The data produced from the MGISEQ-2000 and HiSeq 4000 showed high concordance, with Pearson correlation coefficients ranging from 0.98 to 0.99. …”
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12495
Species- and strain-specific microbial modulation of interferon, innate immunity, and epithelial barrier in 2D air–liquid interface respiratory epithelial cultures
Published 2025-01-01“…Conclusions Microbial colonization differentially stimulates host gene expression with variations observed across phylogenetically diverse microbes and across different strains of the same species. …”
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12496
High-Performance Optical Fiber Displacement Sensor with Extended Linear Range and Sensitivity
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12497
Old residual mortar as a quality indicator of recycled brick aggregate
Published 2024-12-01“…C-25-grade concrete specimens are prepared using RBA with different RM content and tested for workability, compressive strength, splitting tensile strength, flexural strength, water absorption, bulk density, and voids in hardened concrete. Regression models expressing the change in properties with RM content are presented. …”
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12498
Genome editing using CRISPR/ Cas9 system: a practical guide
Published 2017-02-01“…Nowadays, CRISPR/Cas systems can be used not only to modify genomes, but also to control expression levels of defined genes, visualize loci of interest in the space of living cell nuclei, change methylation status of mammalian CpG sites, and to serve many other purposes. …”
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12499
Coagulase gene and agr complex polymorphism-based genotyping of <i>Staphylococcus aureus</i> isolated from non-human primates
Published 2021-11-01“…The examination was based on typing of coagulase gene and polymorphic locus of arg gene that regulates expression of pathogenicity-associated genes. Structures of coagulase gene (coa) and polymorphic types of regulatory gene (agr) were studied in 145 Staphylococcus aureus isolates recovered from various monkey species. …”
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12500
HIFU-CCL19/21 Axis Enhances Dendritic Cell Vaccine Efficacy in the Tumor Microenvironment
Published 2025-01-01“…This study examines the potential of combining mechanical high-intensity focused ultrasound (M-HIFU) with dendritic cell (DC) vaccines to enhance immune responses against OLFM4-expressing tumors, a CSC marker linked to immune evasion and tumor growth. …”
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