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12241
A conspectus of constitutional challenges associated with the dismissal of employees for social media-related misconduct in the South African workplace
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12242
The Role of Plant DNA Methylation in Development, Stress Response, and Crop Breeding
Published 2024-12-01“…We explore how these elements function within the broader epigenetic framework, focusing on their contributions to silencing transposable elements, modulating gene expression, and shaping chromatin architecture. The review also examines the significance of DNA methylation in plant development, particularly its role in adapting to biotic and abiotic stresses. …”
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12243
Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation
Published 2015-12-01“…The main gene for a high predisposition to catalepsy was shown to be associated with the expression of sexual motivation, but not with the hormonal component of sexual arousal (increase in plasma testosterone levels following exposure to a receptive female). …”
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12244
Determination of mutagenicity of chemical compounds, physical factors and environmental pollutants by the Drosophila melanogaster wing somatic mutation and recombination test
Published 2016-03-01“…There are modifications to SMART, based on elevated cytochrome P450 expression, allowing more reliable extrapolation of the test results to mammals. …”
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12245
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12246
Construction of a Cuprotosis-Related Gene-Based Model to Improve the Prognostic Evaluation of Patients with Gastric Cancer
Published 2022-01-01“…The clinical and RNA expression of patients with GC were downloaded from TCGA database. …”
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12247
Immunological Approaches and Different Strategies for Vaccine Development Against SARS-COV-2
Published 2020-12-01“…Moreover, there are different strategies that used by researchers and pharmacological companies to develop vaccines including attenuated or killed viruses, RNA of a spike protein, and vector expressing a particular protein of the virus. The common antibodies have detected to work against SARS-COV-2 in sera of infected or recovered patients are immunoglobin G ( IgG) and immunoglobin M (IgM). …”
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12248
Feature selection in single-cell RNA sequencing data: a comprehensive evaluation
Published 2024-09-01“…Unlike bulk RNA sequencing, scRNA-seq allows for examining gene expression at the individual cell level, revealing cellular heterogeneity and identifying rare cell types. …”
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12249
Inversion of the Main Trends of Digitalization in the Educational Space
Published 2022-12-01“…The appearance of a diffuse identity reinforced by the tendency to glocalization in the socio-political sphere and the transition to a transmedia narrative in the cultural and entertainment sphere, in the digital space of education is transformed into the possibility of self-actualization, self-expression, turning the modern educational space into a mythopoetic “world of all kinds” and anthropological singularity.…”
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12250
Unlocking the Potential of German Smart Cities: Strategy Analysis through Online Content Examination
Published 2024-01-01“…The findings of this study reveal the diversity and richness of German smart city approaches, but also a varying degree of sophistication and transparency of strategic initiatives. As an expression of Germany's federal structure, the cities focus on different aspects, such as mobility, energy efficiency or data-driven administration. …”
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12251
Ligand-Based Pharmacophore Modeling and Virtual Screening of RAD9 Inhibitors
Published 2013-01-01“…Human RAD9 is a key cell-cycle checkpoint protein that participates in DNA repair, activation of multiple cell cycle phase checkpoints, and apoptosis. Aberrant RAD9 expression has been linked to breast, lung, thyroid, skin, and prostate tumorigenesis. …”
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12252
Crotoxin Isolated from Crotalus durissus terrificus Venom Modulates the Functional Activity of Dendritic Cells via Formyl Peptide Receptors
Published 2018-01-01“…Furthermore, CTX and CB inhibited the expression of costimulatory and MHC-II molecules, secretion of proinflammatory cytokines and NF-κBp65 and p38/ERK1/2-MAPK signaling pathways by LPS-incubated DCs. …”
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12253
Characterization of the Escherichia coli Antifungal Protein PPEBL21
Published 2010-01-01“…Results revealed that PPEBL21 inhibited completely the expression of a 16 kDa protein in A. fumigatus. The 16 kDa protein of A. fumigatus targeted by PPEBL21 was identified as a hypothetical protein by peptide mass fingerprinting. …”
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12254
Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome
Published 2013-01-01“…Meanwhile, the chronic inflammation in adipose tissue is regulated by a series of transcription factors, mainly PPARs and C/EBPs, that in conjunction regulate the expression of hundreds of proteins that participate in the metabolism and storage of lipids and, as such, the secretion by adipocytes. …”
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12255
Preparation and Evaluation of Gelatin-Chitosan-Nanobioglass 3D Porous Scaffold for Bone Tissue Engineering
Published 2016-01-01“…GCB 30 scaffold was shown to be noncytotoxic and supported mesenchymal stem cell attachment, proliferation, and differentiation as indicated by MTT assay and RUNX-2 expression. Higher cellular activity was observed in GCB 30 scaffold as compared to GCB 0 scaffold suggesting the fact that 58S bioglass nanoparticles addition into the scaffold promoted better cell adhesion, proliferation, and differentiation. …”
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12256
Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence
Published 2024-12-01“…They have been shown to affect carcinogenesis by modifying the expression of host genes through their functions as enhancers and promoters. …”
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12257
Mitochondrial genome of Cordyceps blackwelliae: organization, transcription, and evolutionary insights into Cordyceps
Published 2023-07-01“…RNA-Seq analysis revealed differential expression of mitochondrial genes and supported annotations resulting from in silico analysis. …”
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12258
Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review
Published 2024-12-01“…Additionally, altered NP2 expression is observed in schizophrenia and bipolar disorder, thus suggesting its involvement in synaptic dysfunction and neurotransmitter imbalance. …”
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12259
Hydroxyapatite Chitosan Gradient Pore Scaffold Activates Oxidative Phosphorylation Pathway to Induce Bone Formation
Published 2025-01-01“…In vitro experiments indicated that the scaffolds had good biocompatibility, promoted the expression of osteogenesis-related genes and proteins, and activated the oxidative phosphorylation pathway to promote bone regeneration. …”
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12260
Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data
Published 2025-01-01“…Abstract Background Imaging-based spatial transcriptomics technologies allow us to explore spatial gene expression profiles at the cellular level. Cell type annotation of imaging-based spatial data is challenging due to the small gene panel, but it is a crucial step for downstream analyses. …”
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