Secretion of One Adipokine Nampt/Visfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells by Yi-Ching Lin, Hui-Chung Wu, Chen-Chung Liao, Yi-Chih Chou, Shwu-Fen Pan, Chi-Ming Chiu

“…Oxidative stress also reduced the Nampt-mediated activation of NF-κB gene expression. In this study, we identify a novel feature of Nampt/visfatin which functions as an adipokine that can be secreted upon cellular stress. …”
Get full text

The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Splicing of pre-messenger RNAs concerns at least 95% of transcripts and constitutes an important mechanism in gene expression regulation. Dysregulation of this process, through variations in spliceosome components, aberrant splicing factors and RNA-binding protein activity, disproportionate regulation of non-coding RNAs, and abnormal mRNA methylation, can contribute to the disruption of AS. …”
Get full text

Nuclear-Targeting Delivery of CRISPRa System for Upregulation of β-Defensin against Virus Infection by Dexamethasone and Phenylalanine Dual-Modified Dendrimer by Mingxiang Zuo, Xiaoxia Li, Shuang Liu, Bin Chen, Du Cheng

“…In vivo experiments demonstrated that the DET- and Phe-modified dendrimer effectively delivered plasmid DNA encoding dCas9 protein into the airway epithelium, inducing β-defensin expression. Delivery of the CRISPR activation system by a dendrimer modified with DET and Phe was a promising approach against viral disease.…”
Get full text

N-Oxalylglycine-Conjugated Hyaluronic Acid as a Macromolecular Prodrug for Therapeutic Angiogenesis by Andrew H. DeMaria, Jeoung Soo Lee, Ken Webb

“…Normal human dermal fibroblasts (NHDFs) cultured with HA-NOG exhibited HIF-1α accumulation in the cell nucleus and dose-dependent increases in mRNA expression levels of three direct HIF transcriptional targets. …”
Get full text

PHILOSOPHICAL-CULTURAL CONCEPTION OF TELEVISION AS A VISUAL PRACTICES OF XX-XXI CENTURY by A. M. Tormakhova

“…Deployment of the author's position within the designated issues is presented as a historical digression – from the first attempts at understanding the phenomenon of television to the newest scientific theories that have found expression in contemporary American philosophical and cultural thought. …”
Get full text

Computer data examination: the essence and procedural order by A. V. Kovalenko

“…The computer data examination is defined as a public investigative (detective) action carried out by the prosecution with the use of electronic computing equipment by means of direct perception of audio-visual expression of computer data in order to obtain information about facts relevant to criminal proceedings.…”
Get full text

Phenotypic and Cytogenetic Characterization of Mesenchymal Stromal Cells in De Novo Myelodysplastic Syndromes by A. J. I. S. Rathnayake, H. W. W. Goonasekera, V. H. W. Dissanayake

“…Cell morphology, differentiation potential, and CD marker expression of MDS-MSCs of all subtypes were comparable to those of control-MSCs. …”
Get full text

Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives by Arash Assadsangabi, Caroline A. Evans, Bernard M. Corfe, Alan Lobo

“…This is because the presence of a given gene mutation does not automatically correspond to changes in its expression or final metabolic or structural effect(s). …”
Get full text

Limitation period and negatory action: review of case law, reflections and problems by O. R. Shyshka

“…It is concluded that acts of judicial interpretation of the Supreme Court, which do not comply with the expression “prescribed by law” and “in accordance with the law”, become the regulator of civil relations, as according to law have binding procedural force before their application in similar cases. …”
Get full text

Serum Concentration and Chemotactic Activity of E-selectin (CD62E) in Inflammatory Bowel Disease by B. Vainerc, O. H. Nielsen

“…E-selectin (CD62E) is an endothelial specific glycoprotein belonging to the selectin family of adhesion molecules. Because a high expression of this molecule at intestinal mucosal surfaces in inflammatory bowel disease (IBD) has been described earlier, the aim was to assess serum levels of E-selectin (sE-selectin) and to correlate it to disease activity, and further to evaluate its chemotactic properties at physiological concentrations. …”
Get full text

Modeling and Data Analysis of Bistatic Bottom Reverberation from a Towed Horizontal Array by Zhaohua Su, Jie Zhuo, Chao Sun

“…Furthermore, we utilize the beam pattern of arrays to incorporate the effects of each scatterer, and derive the expression for bottom reverberation intensity in both the array and beam domains. …”
Get full text

Progress in mentalizing ability among people with psychosis through dialogic literary gatherings by Aitana Fernández-Villardón, Alfonso Sáez de Ibarra, Ana Domínguez-Panchón, Rocío García-Carrión

“…Consistently, patients reported that these dialogues provided a platform for expressing emotions, re-evaluating life perspectives, and achieving greater self-awareness. …”
Get full text

Characterization of a Novel Tc-Carbonyl Complex as a Functional Probe of P-Glycoprotein Transport Activity by Mary Dyszlewski, Helen M. Blake, Julie L. Dahlheimer, Christina M. Pica, David Piwnica-Worms

“…By comparison, net accumulation in control H69 lung tumor cells was 9-fold higher than in MDR-associated protein ( MRP1 )-expressing H69AR cells, indicating only modest transport by MRP1 . …”
Get full text

Aging of Cross-Linked Polyethylene Insulation Cable Lines by I. V. Oleksyuk

“…The paper presents an analytical expression obtained for determining the service life of power electric cables, taking into account the aging of the insulation under the influence of temperature and electric field.…”
Get full text

Research Progress of SGLT2 Inhibitors in Cancer Treatment by Miao X, Zhang J, Huang W, Wang Y, Jin A, Cao J, Zhao Z

“…Recent studies have identified SGLT2 expression in various cancer types, suggesting that SGLT2 inhibition can potentially suppress tumor growth. …”
Get full text

Intervenção precoce em programa de recém-nascidos de risco: um olhar para as famílias by Mariana Sganzella Bambini, Carla Cilene Baptista da Silva, Andrea Perosa Saigh Jurdi

“…Entretanto, as entrevistas semiestruturadas destacaram a expressão de sentimentos de desamparo e a percepção de falta de informação após o parto, resultando em fragilidades e auto culpabilização. …”
Get full text

Fallopian Tube Hemangioma Discovered on Follow-up for Uterine Leiomyoma by Dmitrii SUMTSOV, Georgii SUMTSOV, Natalia HYRIAVENKO, Mykola LYNDIN, Kateryna SIKORA, Volodymyr KOLYSHKIN, Yulia REDKO, Igor GLADCHUK

“…The diagnosis was then confirmed immunohistochemically by CD31 and CD34 expression in the endothelial cells lining the inner surface of the spaces and the low mitotic activity of the tumor cells. …”
Get full text

Molecular Mechanisms Underlying Resistance to <i>Bacillus thuringiensis</i> Cry Toxins in Lepidopteran Pests: An Updated Research Perspective by Deqin Hu, Dongmei Wang, Hongsheng Pan, Xiaoning Liu

“…Extensive research has demonstrated that mutations and alterations in expression patterns of midgut receptor genes are closely associated with <i>Bt</i> resistance. …”
Get full text

The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors by Fernando Cordido, Jesús Garcia-Buela, Susana Sangiao-Alvarellos, Teresa Martinez, Ovidio Vidal

“…These data strongly suggest a role for insulin resistance in the decreased GH secretion of obesity and that the blunted GH secretion of central obesity could be the pituitary expression of the metabolic syndrome.…”
Get full text

Osteoblast-Specific Overexpression of Nucleolar Protein NO66/RIOX1 in Mouse Embryos Leads to Osteoporosis in Adult Mice by Qin Chen, Krishna M. Sinha, Benoit de Crombrugghe, Ralf Krahe

“…Genetic ablation of the NO66 (RIOX1) gene in cells of the Prx1-expressing mesenchymal lineage leads to acceleration of osteochondrogenic differentiation and a larger skeleton in adult mice, whereas mesenchyme-specific overexpression of NO66 inhibits osteochondrogenesis resulting in dwarfism and osteopenia. …”
Get full text