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  1. 11641

    Oleuropein Improves Cognitive Dysfunction and Neuroinflammation in Diabetic Rats through the PI3K/Akt/mTOR Pathway by Jianru Shang, Shan Che, Mingjie Zhu

    Published 2022-01-01
    “…Additionally, the malondialdehyde (MDA), myeloperoxidase (MPO) content, superoxide dismutase (SOD) activity, interleukin- (IL-) 1β, tumor necrosis factor (TNF-α), and phosphatidylinositol 3-kinases (PI3K)/threonine-protein kinase (Akt)/mTOR expression levels in rat hippocampus tissues were detected. …”
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  2. 11642

    Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer by Anita Thyagarajan, Zaid Sirhan, Ravi P. Sahu

    Published 2025-01-01
    “…Importantly, high tumor expression of a G-protein coupled platelet-activating factor-receptor (PAFR) is associated with increased tumor progression as well as decreased overall survival and poor prognosis in malignancies such as non-small cell lung cancer (NSCLC). …”
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  3. 11643

    Tangshenning Attenuates High Glucose-Induced Podocyte Injury via Restoring Autophagy Activity through Inhibiting mTORC1 Activation by Jiayi Xu, Xiaomeng Shan, Chunwei Chen, Yanbin Gao, Dawei Zou, Xiaolei Wang, Tao Wang, Yimin Shi

    Published 2022-01-01
    “…Results showed that TSN treatment enhanced the weakened nephrin expression and autophagic activity of podocytes and inhibited the mTORC1 pathway (p-mTOR, mTOR, p-p70S6K, p70S6K, ULK1, and 4EBP1) under high glucose conditions. …”
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  4. 11644

    Probabilistic Linguistic Three-Way Multi-Attibute Decision Making for Hidden Property Evaluation of Judgment Debtor by Jinhui He, Huirong Zhang, Zhenyu Zhang, Jiaping Zhang

    Published 2021-01-01
    “…Considering the advantages of probabilistic linguistic term sets (PLTSs) expressing the evaluation information and their probabilities on judgment debtor given by expert judges, we extend the three-way decision method to a probabilistic linguistic environment and develop the strict PL3W-MADM model and flexible PL3W-MADM model. …”
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  5. 11645

    Interplay between Epigenetics and Genetics in Cancer by Jae Duk Choi, Jong-Soo Lee

    Published 2013-12-01
    “…Growing evidence points to an epigenome-wide disruption that involves large-scale DNA hypomethylation but specific hypermethylation of tumor suppressor genes, large blocks of aberrant histone modifications, and abnormal miRNA expression profile. Emerging molecular details regarding the modulation of these epigenetic events in cancer are used to illustrate the alterations of epigenetic molecules, and their consequent malfunctions could contribute to cancer biology. …”
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  6. 11646

    Everyday Pain in Three- to Five-Year-Old Children in Day Care by Carl L von Baeyer, Shannon Baskerville, Patrick J McGrath

    Published 1998-01-01
    “…Intervention by day care staff was strongly associated with children's facial expression of distress: physical and first aid interventions were offered most frequently to children who displayed the greatest facial distress. …”
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  7. 11647

    Intelligent control algorithms for posture and height control of four-leg hydraulic supports by Yihui Pang, Yaoyu Shi

    Published 2025-01-01
    “…This approach transforms the traditional geometric relationship solutions of the main structure of the hydraulic supports into solutions based on the coordinate relationships of the main hinge points of the support, resulting in a mathematical expression for solving the support posture and height of the hydraulic supports. …”
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  8. 11648

    In search of prosociality in rodents: A scoping review. by Valérie Charron, Joey Talbot, Patrick R Labelle, Anne T M Konkle, Hélène Plamondon

    Published 2024-01-01
    “…Together these results inform future studies on the impact of mediating factors and the importance of behavioral analyses on the expression of prosocial behaviors in rodents.…”
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  9. 11649

    Males and females’ complimenting behaviour on the celebrities’ Instagram comments by Muthiara Chairani, Subiyantoro Subiyantoro

    Published 2022-02-01
    “…A compliment is a sincerely positive comment, remark, utterance, or expression about the speaker’s intention to have a good relationship with others by delivering positive or good values toward someone else. …”
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  10. 11650

    Semiotic Diagnostics: Methodology for Measuring Education Transformation Efficiency by N. A. Lyurya

    Published 2020-11-01
    “…This characteristic makes it possible to implement a procedure for measuring two competitive interactions: the process of selecting the optimal ways to achieve an asymptotically distant goal and the process of the competition of semiotic attractors as an expression of asymptotic goals. The specificity of self-organization mechanisms puts forward requirements for managing these processes. …”
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  11. 11651

    Dermatology education in U.S. ophthalmology residency: a survey of the program directors by Winnie Fan, Rojina Nekoonam, Saras Ramanathan, Amanda Twigg

    Published 2025-01-01
    “…Perceptions towards dermatology education varied among PDs, with those from programs with dermatology rotation expressing more favorable opinions.…”
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  12. 11652

    Neratinib and the Role of Anti‐HER2 Therapy in Salivary Duct Carcinoma by Martina Napolitano, Lucia Trudu, Enrica Martinelli, Chiara Santini, Massimo Dominici, Federica Bertolini

    Published 2025-01-01
    “…ABSTRACT Backgroud Salivary duct carcinoma (SDC) is a rare and aggressive malignancy with a generally dismal prognosis and no standard of care established, despite a known association with epidermal growth factor receptor 2 (HER2) and androgen receptor (AR) over‐expression. Case We report the case of a 64‐year‐old female with extra‐ and intracranial metastases of SDC with evidence of AR and HER2 overexpression. …”
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  13. 11653

    Evidence for Directed Evolution of Larger Size Motif in Arabidopsis thaliana Genome by Rajesh Mehrotra, Amit Yadav, Purva Bhalothia, Ratna Karan, Sandhya Mehrotra

    Published 2012-01-01
    “…Transcription control of gene expression depends on a variety of interactions mediated by the core promoter region, sequence specific DNA-binding proteins, and their cognate promoter elements. …”
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  14. 11654

    A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature by Zhiyan Fu, Evita B. Henderson-Jackson, Barbara A. Centeno, Gregory Y. Lauwers, Mihaela Druta, Daniel A. Anaya, Yukihiro Nakanishi

    Published 2023-01-01
    “…The tumor cells showed strong and diffuse expression of CD34 and STAT6, confirming the diagnosis of malignant solitary fibrous tumor. …”
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  15. 11655

    Downregulation of TET1 Promotes Glioma Cell Proliferation and Invasion by Targeting Wnt/β-Catenin Pathway by Jianwen Ji, Qiuxiang You, Jidong Zhang, Yutao Wang, Jing Cheng, Xiangyun Huang, Yundong Zhang

    Published 2021-01-01
    “…RT-qPCR was adopted to detect the RNA level of TET1 and β-catenin; Western blot was taken to determine the expression of proteins. CCK8 assay was used to detect the proliferation of glioma cells. …”
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  16. 11656

    Política de Assistência Social no período 1988-2018: construção e desmonte by Annova Míriam Ferreira Carneiro, Cleonice Correia Araujo, Maria do Socorro Sousa de Araujo

    Published 2019-03-01
    “…Os resultados demonstram que a PAS vinha se consolidando através da estruturação do Sistema Único de Assistência Social, sendo que tal processo sofreu profunda inflexão advinda do Governo Temer, por meio da imposição dos ditames do neoliberalismo expressos nas ações de redução do Estado e destituição de direitos, caracterizados pelo desmonte da seguridade social. …”
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  17. 11657

    A thermodynamically consistent approach to the energy costs of quantum measurements by Camille L Latune, Cyril Elouard

    Published 2025-01-01
    “…In practice, this model allows us to perform a quantitative thermodynamic analysis of the measurement process. From the expression of the second law, we show how the minimal required work depends on the energy variation of the system being measured plus information-theoretic quantities characterizing the performance of the measurement – efficiency and completeness. …”
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  18. 11658

    CEACAM5 exacerbates asthma by inducing ferroptosis and autophagy in airway epithelial cells through the JAK/STAT6-dependent pathway by Si Liu, Li Chen, Yunxiao Shang

    Published 2025-12-01
    “…An ovalbumin-sensitized mouse model and an IL-13-stimulated Beas-2B cell model were established for further investigation.Results Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a crucial gene in asthma. CEACAM5 expression was elevated in asthmatic mouse lung tissues and IL-13-stimulated Beas-2B cells, primarily in bronchial epithelial cells. …”
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  19. 11659

    Pluripotency Factors on Their Lineage Move by Clair E. Weidgang, Thomas Seufferlein, Alexander Kleger, Martin Mueller

    Published 2016-01-01
    “…The balance between these transcription factors greatly influences the integrity of the pluripotency network and latest research suggests that minute changes in their expression can strengthen but also collapse the network. …”
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  20. 11660

    A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements by Sophie E. Clough, Tessa R. Young, Emma Tarrant, Andrew J. P. Scott, Peter T. Chivers, Arthur Glasfeld, Nigel J. Robinson

    Published 2025-01-01
    “…Relating metal-preferences to metal-availabilities estimated using cellular metal sensors, predicts mis-metalation of MncA with FeII in E. coli. After expression in E. coli, predominantly FeII-bound MncA is isolated experimentally. …”
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