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11641
Oleuropein Improves Cognitive Dysfunction and Neuroinflammation in Diabetic Rats through the PI3K/Akt/mTOR Pathway
Published 2022-01-01“…Additionally, the malondialdehyde (MDA), myeloperoxidase (MPO) content, superoxide dismutase (SOD) activity, interleukin- (IL-) 1β, tumor necrosis factor (TNF-α), and phosphatidylinositol 3-kinases (PI3K)/threonine-protein kinase (Akt)/mTOR expression levels in rat hippocampus tissues were detected. …”
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11642
Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer
Published 2025-01-01“…Importantly, high tumor expression of a G-protein coupled platelet-activating factor-receptor (PAFR) is associated with increased tumor progression as well as decreased overall survival and poor prognosis in malignancies such as non-small cell lung cancer (NSCLC). …”
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11643
Tangshenning Attenuates High Glucose-Induced Podocyte Injury via Restoring Autophagy Activity through Inhibiting mTORC1 Activation
Published 2022-01-01“…Results showed that TSN treatment enhanced the weakened nephrin expression and autophagic activity of podocytes and inhibited the mTORC1 pathway (p-mTOR, mTOR, p-p70S6K, p70S6K, ULK1, and 4EBP1) under high glucose conditions. …”
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11644
Probabilistic Linguistic Three-Way Multi-Attibute Decision Making for Hidden Property Evaluation of Judgment Debtor
Published 2021-01-01“…Considering the advantages of probabilistic linguistic term sets (PLTSs) expressing the evaluation information and their probabilities on judgment debtor given by expert judges, we extend the three-way decision method to a probabilistic linguistic environment and develop the strict PL3W-MADM model and flexible PL3W-MADM model. …”
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11645
Interplay between Epigenetics and Genetics in Cancer
Published 2013-12-01“…Growing evidence points to an epigenome-wide disruption that involves large-scale DNA hypomethylation but specific hypermethylation of tumor suppressor genes, large blocks of aberrant histone modifications, and abnormal miRNA expression profile. Emerging molecular details regarding the modulation of these epigenetic events in cancer are used to illustrate the alterations of epigenetic molecules, and their consequent malfunctions could contribute to cancer biology. …”
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11646
Everyday Pain in Three- to Five-Year-Old Children in Day Care
Published 1998-01-01“…Intervention by day care staff was strongly associated with children's facial expression of distress: physical and first aid interventions were offered most frequently to children who displayed the greatest facial distress. …”
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11647
Intelligent control algorithms for posture and height control of four-leg hydraulic supports
Published 2025-01-01“…This approach transforms the traditional geometric relationship solutions of the main structure of the hydraulic supports into solutions based on the coordinate relationships of the main hinge points of the support, resulting in a mathematical expression for solving the support posture and height of the hydraulic supports. …”
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11648
In search of prosociality in rodents: A scoping review.
Published 2024-01-01“…Together these results inform future studies on the impact of mediating factors and the importance of behavioral analyses on the expression of prosocial behaviors in rodents.…”
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11649
Males and females’ complimenting behaviour on the celebrities’ Instagram comments
Published 2022-02-01“…A compliment is a sincerely positive comment, remark, utterance, or expression about the speaker’s intention to have a good relationship with others by delivering positive or good values toward someone else. …”
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11650
Semiotic Diagnostics: Methodology for Measuring Education Transformation Efficiency
Published 2020-11-01“…This characteristic makes it possible to implement a procedure for measuring two competitive interactions: the process of selecting the optimal ways to achieve an asymptotically distant goal and the process of the competition of semiotic attractors as an expression of asymptotic goals. The specificity of self-organization mechanisms puts forward requirements for managing these processes. …”
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11651
Dermatology education in U.S. ophthalmology residency: a survey of the program directors
Published 2025-01-01“…Perceptions towards dermatology education varied among PDs, with those from programs with dermatology rotation expressing more favorable opinions.…”
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11652
Neratinib and the Role of Anti‐HER2 Therapy in Salivary Duct Carcinoma
Published 2025-01-01“…ABSTRACT Backgroud Salivary duct carcinoma (SDC) is a rare and aggressive malignancy with a generally dismal prognosis and no standard of care established, despite a known association with epidermal growth factor receptor 2 (HER2) and androgen receptor (AR) over‐expression. Case We report the case of a 64‐year‐old female with extra‐ and intracranial metastases of SDC with evidence of AR and HER2 overexpression. …”
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11653
Evidence for Directed Evolution of Larger Size Motif in Arabidopsis thaliana Genome
Published 2012-01-01“…Transcription control of gene expression depends on a variety of interactions mediated by the core promoter region, sequence specific DNA-binding proteins, and their cognate promoter elements. …”
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11654
A Case of Hepatic Malignant Solitary Fibrous Tumor: A Case Report and Review of the Literature
Published 2023-01-01“…The tumor cells showed strong and diffuse expression of CD34 and STAT6, confirming the diagnosis of malignant solitary fibrous tumor. …”
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11655
Downregulation of TET1 Promotes Glioma Cell Proliferation and Invasion by Targeting Wnt/β-Catenin Pathway
Published 2021-01-01“…RT-qPCR was adopted to detect the RNA level of TET1 and β-catenin; Western blot was taken to determine the expression of proteins. CCK8 assay was used to detect the proliferation of glioma cells. …”
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11656
Política de Assistência Social no período 1988-2018: construção e desmonte
Published 2019-03-01“…Os resultados demonstram que a PAS vinha se consolidando através da estruturação do Sistema Único de Assistência Social, sendo que tal processo sofreu profunda inflexão advinda do Governo Temer, por meio da imposição dos ditames do neoliberalismo expressos nas ações de redução do Estado e destituição de direitos, caracterizados pelo desmonte da seguridade social. …”
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11657
A thermodynamically consistent approach to the energy costs of quantum measurements
Published 2025-01-01“…In practice, this model allows us to perform a quantitative thermodynamic analysis of the measurement process. From the expression of the second law, we show how the minimal required work depends on the energy variation of the system being measured plus information-theoretic quantities characterizing the performance of the measurement – efficiency and completeness. …”
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11658
CEACAM5 exacerbates asthma by inducing ferroptosis and autophagy in airway epithelial cells through the JAK/STAT6-dependent pathway
Published 2025-12-01“…An ovalbumin-sensitized mouse model and an IL-13-stimulated Beas-2B cell model were established for further investigation.Results Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a crucial gene in asthma. CEACAM5 expression was elevated in asthmatic mouse lung tissues and IL-13-stimulated Beas-2B cells, primarily in bronchial epithelial cells. …”
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11659
Pluripotency Factors on Their Lineage Move
Published 2016-01-01“…The balance between these transcription factors greatly influences the integrity of the pluripotency network and latest research suggests that minute changes in their expression can strengthen but also collapse the network. …”
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11660
A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements
Published 2025-01-01“…Relating metal-preferences to metal-availabilities estimated using cellular metal sensors, predicts mis-metalation of MncA with FeII in E. coli. After expression in E. coli, predominantly FeII-bound MncA is isolated experimentally. …”
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