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  1. 11621

    Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration by Hui Xu, Lining Cao, Yuxi Chen, Cuiping Zhou, Jie Xu, Zhuolin Zhang, Xiangyu Li, Lihua Liu, Jianfeng Lu

    Published 2025-12-01
    “…Following retinal injury, resting MG1 transitioned into an activated state expressing known reprogramming genes, while resting MG2 gave rise to rod progenitors. …”
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  2. 11622

    Identification of a comprehensive set of transcriptional regulators involved in the long-term survivability of Escherichia coli in soil by Soma Nakamoto, Ikki Kobayashi, Koichi Watanabe, Takeru Kikuta, Sousuke Imamura, Tomohiro Shimada

    Published 2025-02-01
    “…To adapt to environmental changes, bacteria alter their gene expression patterns using transcriptional regulators such as sigma factors. …”
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  3. 11623

    In Silico Evolution of Gene Cooption in Pattern-Forming Gene Networks by Alexander V. Spirov, Marat A. Sabirov, David M. Holloway

    Published 2012-01-01
    “…Starting from a minimal 2-gene network, insufficient for fitting the Drosophila gene expression patterns, we find a general trend of coopting available genes into the GRN, in order to better fit the data. …”
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  4. 11624

    A Severe Case of Overlap of Morphea and Eosinophilic Fasciitis after Burn Injuries by Hania Sami, Faria Sami, Shahzad Ahmed Sami, Abdulqadir J. Nashwan

    Published 2024-01-01
    “…Skin biopsy demonstrated sclerodermoid changes and sclerotic thickening of subcutaneous fibrous septa associated with stromal mucin, dermal perivascular, diffuse lymphoplasmacytic infiltrate with eosinophils, decreased CD34 expression, and increased factor XIIIa. He was subsequently diagnosed with an overlap of generalized morphea and eosinophilic fasciitis. …”
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  5. 11625

    Transplantable Subcutaneous Hepatoma 22a Affects Functional Activity of Resident Tissue Macrophages in Periphery by Ekaterina P. Kisseleva, Andrei V. Krylov, Olga I. Stepanova, Victoria I. Lioudyno

    Published 2011-01-01
    “…Increased inflammatory reactions were not followed by the enhancement of angiogenic potential as assessed by Vascular Endothelial Growth Factor mRNA expression. Phases of macrophage activity corresponded to the stages of tumor growth characterized by high proliferative potential. …”
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  6. 11626

    The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration by Xianxu Zhang, Shicheng Li, Xin Liu, Zhong Ma, Qiang Zhang, Yuji Zhang, Jiangdong An, Zhiqiang Luo

    Published 2025-01-01
    “…This review summarizes the pleiotropic effects of statins and explores their potential mechanisms and actions in IVDD, with particular emphasis on changes in the expression of relevant molecular markers. Furthermore, recent advancements in the application of statins for IVDD treatment are discussed, along with the potential of combining statins with other drugs as part of multi-target therapeutic strategies. …”
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  7. 11627

    Stable Agrobacterium-Mediated Transformation of Maritime Pine Based on Kanamycin Selection by José M. Alvarez, Ricardo J. Ordás

    Published 2013-01-01
    “…Evidence of the stable transgene integration was obtained by polymerase chain reaction for the nptII and uidA genes and expression of the uidA gene. Maturation capacity of the transgenic lines was negatively affected by the transformation process. …”
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  8. 11628

    Integrating Prior Knowledge Using Transformer for Gene Regulatory Network Inference by Guangzheng Weng, Patrick Martin, Hyobin Kim, Kyoung Jae Won

    Published 2025-01-01
    “…By combining LLMs ability to distillate biological knowledge from text and deep learning methodologies capturing complex patterns in gene expression data, GRNPT overcomes the limitations of traditional GRN inference methods and enables more accurate and comprehensive understanding of gene regulatory dynamics.…”
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  9. 11629

    Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt. by Alyssa Hubal, Anusha Vendhoti, Charles N Shaffer, Sarah Vos, Yalitza Lopez Corcino, Carlos S Subauste

    Published 2025-01-01
    “…Epidermal Growth Factor Receptor (EGFR) is a mediator of this survival strategy. However, EGFR expression is limited in the brain and retina, organs affected in toxoplasmosis. …”
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  10. 11630

    PLncWX: A Machine-Learning Algorithm for Plant lncRNA Identification Based on WOA-XGBoost by Fei Guo, Zhixiang Yin, Kai Zhou, Jiasi Li

    Published 2021-01-01
    “…Studies have shown that lncRNAs can regulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels, which are not only closely related to the occurrence, development, and prevention of human diseases, but also can regulate plant flowering and participate in plant abiotic stress responses such as drought and salt. …”
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  11. 11631

    CLIMATE CHANGE AND FARMERS-HERDERS CONFLICT IN NORTHERN NIGERIA by OLUFUNKE .A. MOSES-OJO, ARUYA KINGSLEY JOSEPH, RILWAN ABDULLAHI ALIYU

    Published 2023-08-01
    “…This framework insists that violence is a tragic expression of unmet human needs, implying that all actions undertaken by human beings are attempts to satisfy their needs and means of livelihood. …”
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  12. 11632

    Integrated transcriptomic and metabolomic analyses reveal critical gene regulatory network in response to drought stress in Dendrobium nobile Lindl by Chaoyan Lv, Ya He, Zaiqian Jiang, Wenjia Hu, Mei Zhang

    Published 2025-02-01
    “…We constructed a regulatory network for the drought tolerance of Dendrobium by weighted gene co-expression analysis. Conclusions The results showed that arginine and proline metabolism, glucosinolate biosynthesis and tyrosine metabolism pathways participated in regulating drought stress in D. nobile Lindl. …”
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  13. 11633

    Discrimination of Anti-Donor Response in Allogeneic Transplantation Using an Alloreactive T-Cell Detection Assay by Ryosuke Arata, Naoki Tanimine, Akhmet Seidakhmetov, Kentaro Ide, Yuka Tanaka, Hideki Ohdan

    Published 2025-01-01
    “…After 18 h of one-way mixed lymphocyte reaction (MLR) culture with pre-activated donor-derived stimulators, CD4+ and CD8+ donor-reactive T cells were identified by CD154 and CD137 expression, respectively. Using full MHC mismatched mouse skin transplant models, we observed an increased donor-reactive T-cell proportion by direct presentation with elevated interferon gamma and granzyme B production 7 days post-transplantation, before graft rejection. …”
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  14. 11634

    A Microfluidic-Based Cell-Stretching Culture Device That Allows for Easy Preparation of Slides for Observation with High-Magnification Objective Lenses by Momoko Kato, Kae Sato

    Published 2025-01-01
    “…Stretch stimulation increased integrinβ1 expression and promoted integrin–vinculin complex formation by approximately 1.4-fold in OP9 cells. …”
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  15. 11635

    Altered ERK1/2 Signaling in the Brain of Learned Helpless Rats: Relevance in Vulnerability to Developing Stress-Induced Depression by Yogesh Dwivedi, Hui Zhang

    Published 2016-01-01
    “…In frontal cortex and hippocampus of LH rats, we found that mRNA and protein expressions of ERK1 and ERK2 were significantly reduced, which was associated with their reduced activation and phosphorylation in cytosolic and nuclear fractions, where ERK1 and ERK2 target their substrates. …”
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  16. 11636

    Deformation Mechanism and Control Technology of the Surrounding Rock of the Floor Roadway under the Influence of Mining by Qingchong Zhao, Baojie Fu, Jiadi Yin

    Published 2020-01-01
    “…The floor roadway of the 11123 working face in Pan’er Mine is taken as the research object of this study based on semi-infinite body theory of elastic mechanics to establish a mechanical model along the advancing direction of the working face and derive the stress expression of any point in the affected area of floor mining. …”
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  17. 11637

    Hydrogenotrophic methanogenesis at 7–12 mbar by Methanosarcina barkeri under simulated martian atmospheric conditions by Rachel L. Harris, Andrew C. Schuerger

    Published 2025-01-01
    “…Transcriptomics reveal that low total pressure and temperature did not significantly impact gene expression, highlighting the resilience of M. barkeri. …”
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  18. 11638

    Family Practitioners and Sexually Transmitted Diseases by Marc Steben

    Published 1991-01-01
    “…Assessment of risks for hepatitis B virus infection should include lifestyle indices such as sexual preference, sexual expression, number of partners and alcohol/drug consumption. …”
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  19. 11639

    RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in Helicobacter pylori by Federico D’Agostino, Eva Pinatel, Alexandra Meynhardt, Vincenzo Scarlato, Andrea Vannini, Davide Roncarati

    Published 2025-02-01
    “…We found that RNase Y is membrane-associated and its expression is controlled during bacterial growth and by Fur in response to iron. …”
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  20. 11640

    Local time statistics and permeable barrier crossing: From Poisson to birth-death diffusion equations by Toby Kay, Luca Giuggioli

    Published 2025-01-01
    “…Within this paradigm, we derive the exact expression for the distribution of the number of crossings and find an experimentally measurable statistical definition of permeability. …”
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