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11621
Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration
Published 2025-12-01“…Following retinal injury, resting MG1 transitioned into an activated state expressing known reprogramming genes, while resting MG2 gave rise to rod progenitors. …”
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11622
Identification of a comprehensive set of transcriptional regulators involved in the long-term survivability of Escherichia coli in soil
Published 2025-02-01“…To adapt to environmental changes, bacteria alter their gene expression patterns using transcriptional regulators such as sigma factors. …”
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11623
In Silico Evolution of Gene Cooption in Pattern-Forming Gene Networks
Published 2012-01-01“…Starting from a minimal 2-gene network, insufficient for fitting the Drosophila gene expression patterns, we find a general trend of coopting available genes into the GRN, in order to better fit the data. …”
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11624
A Severe Case of Overlap of Morphea and Eosinophilic Fasciitis after Burn Injuries
Published 2024-01-01“…Skin biopsy demonstrated sclerodermoid changes and sclerotic thickening of subcutaneous fibrous septa associated with stromal mucin, dermal perivascular, diffuse lymphoplasmacytic infiltrate with eosinophils, decreased CD34 expression, and increased factor XIIIa. He was subsequently diagnosed with an overlap of generalized morphea and eosinophilic fasciitis. …”
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11625
Transplantable Subcutaneous Hepatoma 22a Affects Functional Activity of Resident Tissue Macrophages in Periphery
Published 2011-01-01“…Increased inflammatory reactions were not followed by the enhancement of angiogenic potential as assessed by Vascular Endothelial Growth Factor mRNA expression. Phases of macrophage activity corresponded to the stages of tumor growth characterized by high proliferative potential. …”
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11626
The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration
Published 2025-01-01“…This review summarizes the pleiotropic effects of statins and explores their potential mechanisms and actions in IVDD, with particular emphasis on changes in the expression of relevant molecular markers. Furthermore, recent advancements in the application of statins for IVDD treatment are discussed, along with the potential of combining statins with other drugs as part of multi-target therapeutic strategies. …”
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11627
Stable Agrobacterium-Mediated Transformation of Maritime Pine Based on Kanamycin Selection
Published 2013-01-01“…Evidence of the stable transgene integration was obtained by polymerase chain reaction for the nptII and uidA genes and expression of the uidA gene. Maturation capacity of the transgenic lines was negatively affected by the transformation process. …”
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11628
Integrating Prior Knowledge Using Transformer for Gene Regulatory Network Inference
Published 2025-01-01“…By combining LLMs ability to distillate biological knowledge from text and deep learning methodologies capturing complex patterns in gene expression data, GRNPT overcomes the limitations of traditional GRN inference methods and enables more accurate and comprehensive understanding of gene regulatory dynamics.…”
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11629
Inhibition of Src signaling induces autophagic killing of Toxoplasma gondii via PTEN-mediated deactivation of Akt.
Published 2025-01-01“…Epidermal Growth Factor Receptor (EGFR) is a mediator of this survival strategy. However, EGFR expression is limited in the brain and retina, organs affected in toxoplasmosis. …”
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11630
PLncWX: A Machine-Learning Algorithm for Plant lncRNA Identification Based on WOA-XGBoost
Published 2021-01-01“…Studies have shown that lncRNAs can regulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels, which are not only closely related to the occurrence, development, and prevention of human diseases, but also can regulate plant flowering and participate in plant abiotic stress responses such as drought and salt. …”
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11631
CLIMATE CHANGE AND FARMERS-HERDERS CONFLICT IN NORTHERN NIGERIA
Published 2023-08-01“…This framework insists that violence is a tragic expression of unmet human needs, implying that all actions undertaken by human beings are attempts to satisfy their needs and means of livelihood. …”
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11632
Integrated transcriptomic and metabolomic analyses reveal critical gene regulatory network in response to drought stress in Dendrobium nobile Lindl
Published 2025-02-01“…We constructed a regulatory network for the drought tolerance of Dendrobium by weighted gene co-expression analysis. Conclusions The results showed that arginine and proline metabolism, glucosinolate biosynthesis and tyrosine metabolism pathways participated in regulating drought stress in D. nobile Lindl. …”
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11633
Discrimination of Anti-Donor Response in Allogeneic Transplantation Using an Alloreactive T-Cell Detection Assay
Published 2025-01-01“…After 18 h of one-way mixed lymphocyte reaction (MLR) culture with pre-activated donor-derived stimulators, CD4+ and CD8+ donor-reactive T cells were identified by CD154 and CD137 expression, respectively. Using full MHC mismatched mouse skin transplant models, we observed an increased donor-reactive T-cell proportion by direct presentation with elevated interferon gamma and granzyme B production 7 days post-transplantation, before graft rejection. …”
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11634
A Microfluidic-Based Cell-Stretching Culture Device That Allows for Easy Preparation of Slides for Observation with High-Magnification Objective Lenses
Published 2025-01-01“…Stretch stimulation increased integrinβ1 expression and promoted integrin–vinculin complex formation by approximately 1.4-fold in OP9 cells. …”
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11635
Altered ERK1/2 Signaling in the Brain of Learned Helpless Rats: Relevance in Vulnerability to Developing Stress-Induced Depression
Published 2016-01-01“…In frontal cortex and hippocampus of LH rats, we found that mRNA and protein expressions of ERK1 and ERK2 were significantly reduced, which was associated with their reduced activation and phosphorylation in cytosolic and nuclear fractions, where ERK1 and ERK2 target their substrates. …”
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11636
Deformation Mechanism and Control Technology of the Surrounding Rock of the Floor Roadway under the Influence of Mining
Published 2020-01-01“…The floor roadway of the 11123 working face in Pan’er Mine is taken as the research object of this study based on semi-infinite body theory of elastic mechanics to establish a mechanical model along the advancing direction of the working face and derive the stress expression of any point in the affected area of floor mining. …”
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11637
Hydrogenotrophic methanogenesis at 7–12 mbar by Methanosarcina barkeri under simulated martian atmospheric conditions
Published 2025-01-01“…Transcriptomics reveal that low total pressure and temperature did not significantly impact gene expression, highlighting the resilience of M. barkeri. …”
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11638
Family Practitioners and Sexually Transmitted Diseases
Published 1991-01-01“…Assessment of risks for hepatitis B virus infection should include lifestyle indices such as sexual preference, sexual expression, number of partners and alcohol/drug consumption. …”
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11639
RNase Y mediates posttranscriptional control of the virulence-associated CncR1 small-RNA in Helicobacter pylori
Published 2025-02-01“…We found that RNase Y is membrane-associated and its expression is controlled during bacterial growth and by Fur in response to iron. …”
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11640
Local time statistics and permeable barrier crossing: From Poisson to birth-death diffusion equations
Published 2025-01-01“…Within this paradigm, we derive the exact expression for the distribution of the number of crossings and find an experimentally measurable statistical definition of permeability. …”
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