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  1. 11581

    INFORMATION SUPPORT OF RESEARCH ON TRANSCRIPTIONAL REGULATORY MECHANISMS: AN ONTOLOGICAL APPROACH by N. L. Podkolodnyy, E. V. Ignatieva, O. A. Podkolodnaya, N. A. Kolchanov

    Published 2014-12-01
    “…This paper presents approaches to building knowledge domain ontology, formalized description of the mechanisms of transcriptional regulation and the development of methods for integration of heterogeneous information on the features of the regulation of gene expression on this base. The pilot version of the knowledge base on the transcriptional regulation of eukaryotic genes includes: (1) description of basic terms related to transcription regulation and relationships between them; (2) hierarchical classification of transcription regulators; (3) classification of phases and steps of transcription; (4) a database of transcriptional regulators of three mammalian species (human, mouse, and rat); and (5) dictionaries for molecular processes involved in transcriptional regulation. …”
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  2. 11582

    Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis by Xiao Zhang, Wenbo Gu, Di Luo, Xi Zhu, Xusheng Li, Haifeng Yuan

    Published 2025-01-01
    “…In addition, in order to further investigate the deep mechanism of LSS associated with gout, we obtained the intersecting genes of the two diseases based on a machine learning approach by obtaining the dataset GSE113212 related to LSS from the Gene Expression Omnibus (GEO) database, and the genes related to gout from the human gene database. …”
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  3. 11583

    Study on the Generalized Displacement Boundary and Its Analytical Prediction for Ground Movements Induced by Shield Tunneling by Qianlong Tang, Fudong Chen, Mingfeng Lei, Binbin Zhu, Limin Peng

    Published 2021-01-01
    “…Then, a universal pattern of displacement boundary condition around the tunnel cavity is originally introduced, which is solved as the combination of three fundamental deformation modes, namely, uniform convergence, vertical translation, and ovalization. The expression for the above-mentioned displacement boundary condition is derived, by imposing which the analytical solution for ground movements, based on the stress function method, is proposed. …”
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  4. 11584

    Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection by Yung-Chun Chuang, Hong-Ru Chen, Trai-Ming Yeh

    Published 2015-01-01
    “…Recent evidence indicates that DENV infection induced MIF production and may contribute to vascular hyperpermeability and viral replication during DENV infection. The expression of both adhesion and coagulation molecules on MIF-stimulated monocytes and endothelial cells is also increased, which may contribute to inflammatory and anticoagulatory states during DHF/DSS. …”
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  5. 11585
  6. 11586

    Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis by F. Morceau, M. Dicato, M. Diederich

    Published 2009-01-01
    “…They could interfere with erythropoietin-mediated signaling pathways, inducing early apoptosis and perturbing the expression and regulation of specific transcription factors involved in the control of erythroid differentiation. …”
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  7. 11587

    Real-Time Analysis of Endogenous Wnt Signalling in 3D Mesenchymal Stromal Cells by Fatima Saleh, Alice Carstairs, S. Leah Etheridge, Paul Genever

    Published 2016-01-01
    “…Interestingly, endogenous Wnt signalling was only active during 3D differentiation whereas 2D cultures showed no EGFP expression throughout an extended differentiation time-course. …”
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  8. 11588

    Sample Aging Profoundly Reduces Monocyte Responses in Human Whole Blood Cultures by H. W. Grievink, M. Moerland

    Published 2018-01-01
    “…Intracellular cytokine staining revealed that the number of LPS-responding cells was not impacted by sample aging and reduced LPS responsivity could also not be explained by apoptosis or downregulated TLR4 expression. Thus, we speculate that sample aging induces an inhibitory pathway downstream from TLR4 in monocytes. …”
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  9. 11589

    Optimization of the Coupling Coefficient of the Inductive Link for Wireless Power Transfer to Biomedical Implants by Jiarui Bao, Shuyan Hu, Zibin Xie, Guangxi Hu, Ye Lu, Lirong Zheng

    Published 2022-01-01
    “…This work focuses on the optimization of coupling coefficient (k) of the inductive link for the wireless power transfer (WPT) system to be used in implantable medical devices (IMDs) of centimeter size. The analytic expression of k is presented. Simulations are conducted by using the high-frequency structure simulator (HFSS). …”
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  10. 11590

    STYLISTIC POTENTIAL OF GERMAN SYNTAX by L. V. Fadeeva

    Published 2013-08-01
    “…The study sets out to reveal the expressive syntactic means. Disorder of a proper sentence structure makes its expressiveness. …”
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  11. 11591

    Sargassum plagiophyllum Ethanolic Extract Enhances Wound Healing by Modulating FAK/Src/Akt/p38 and Rac1 Signaling in Keratinocytes HaCaT Cells by Furoida Moolsup, Wanida Sukketsiri, Wipawadee Sianglum, Jirawat Saetan, Nattakanwadee Khumpirapang, Supita Tanasawet

    Published 2025-01-01
    “…SPEE increased Rac1 protein expression. Interestingly, hyaluronan synthase (HAS1 and HAS2) as well as collagen type I and elastin were also significantly upregulated when compared with the control upon exposure to SPEE. …”
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  12. 11592

    MARCAS DA REFORMA UNIVERSITÁRIA DE 1968 E NOVOS DESAFIOS PARA A UNIVERSIDADE BRASILEIRA by Silke Weber

    Published 2014-03-01
    “…Busca indicar, ainda, os sentidos prevalecentes que tem sido produzidos, confirmados, ou negociados ao longo do debate sobre universidade no Brasil, entendidos como discursos que expressam um campo de disputa pela hegemonia de projetos de sociedade. …”
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  13. 11593

    Rational Design for Improving the Thermostability of Saccharomyces cerevisiae Nicotinamide Riboside Kinase 1 by WANG Yao, SHEN Taisong, LI Sichen, SHI Hongling, YAO Lunguang, TANG Cunduo

    Published 2024-12-01
    “…In order to improve the thermal stability of nicotinamide riboside kinase 1 from Saccharomyces cerevisiae (ScNRK1), six single-point mutants of ScNRK1 were virtually designed using computer-aided technology, and their expression using site-directed mutagenesis and enzymatic characterization were carried out. …”
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  14. 11594

    Clinical Onset of Celiac Disease after an Episode of Campylobacter jejuni Enteritis by EF Verdu, M Mauro, J Bourgeois, D Armstrong

    Published 2007-01-01
    “…The present case suggests that the clinical expression of CD can be unmasked by an acute gastrointestinal infection and supports the hypothesis that environmental factors other than gliadin may play a role in the clinical onset of CD in a genetically susceptible host. …”
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  15. 11595

    Unmasking The Hidden Clues: Shedding Light On The Potential Of Novel Biomarkers In Endometrial Cancer, Comparing RT-Qpcr And Immunohistochemical Analysis In Clinical Specimens by Sampana Fatima, Ayman Sabora, Iqra Anwar, Seher Naeem, Muhammad Abrar

    Published 2025-01-01
    “…RT-qPCR was performed, and relative gene expressions were calculated using the 2^-ΔΔCt method, with the endogenous control. …”
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  16. 11596
  17. 11597

    Les genres littéraires participent de domaines: en relisant Croce, Frye et McLuhan by Jean Bessière

    Published 2024-10-01
    “…The notion of field – here translated in French by ‘domain’ and specified by the expression ‘domaine de sens’ (field of sense) – enables critics and readers to align views on singularities and similarities, to reject any systematic perspective and to outline literary works’ differences, proximities and conti nuities. …”
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  18. 11598
  19. 11599

    The role of KLF4 in human primordial germ cell development by Sun-Min Lee, Merrick Pierson Smela, M. Azim Surani

    Published 2025-01-01
    “…Cut-and-run and transcriptomic analyses reveal that KLF4 represses somatic markers involved in neuronal and endodermal differentiation while promoting the expression of genes associated with PGC specification, such as PAX5, and epigenetic regulators, including DNMT3L and REST. …”
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  20. 11600

    Polymorphonuclear Leukocytes or Hydrogen Peroxide Enhance Biofilm Development of Mucoid Pseudomonas aeruginosa by Qi Tan, Qing Ai, Qi Xu, Fang Li, Jialin Yu

    Published 2018-01-01
    “…In this study, PMNs and H2O2 promoted alginate production, and biofilms treated with PMNs or H2O2 exhibited higher expression of alginate genes. Additionally, PMNs increased the activity of GDP-mannose dehydrogenase, which is the key enzyme in alginate biosynthesis. …”
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