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11581
INFORMATION SUPPORT OF RESEARCH ON TRANSCRIPTIONAL REGULATORY MECHANISMS: AN ONTOLOGICAL APPROACH
Published 2014-12-01“…This paper presents approaches to building knowledge domain ontology, formalized description of the mechanisms of transcriptional regulation and the development of methods for integration of heterogeneous information on the features of the regulation of gene expression on this base. The pilot version of the knowledge base on the transcriptional regulation of eukaryotic genes includes: (1) description of basic terms related to transcription regulation and relationships between them; (2) hierarchical classification of transcription regulators; (3) classification of phases and steps of transcription; (4) a database of transcriptional regulators of three mammalian species (human, mouse, and rat); and (5) dictionaries for molecular processes involved in transcriptional regulation. …”
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11582
Treatment of gouty lumbar spinal stenosis: a case report and bioinformatics analysis
Published 2025-01-01“…In addition, in order to further investigate the deep mechanism of LSS associated with gout, we obtained the intersecting genes of the two diseases based on a machine learning approach by obtaining the dataset GSE113212 related to LSS from the Gene Expression Omnibus (GEO) database, and the genes related to gout from the human gene database. …”
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11583
Study on the Generalized Displacement Boundary and Its Analytical Prediction for Ground Movements Induced by Shield Tunneling
Published 2021-01-01“…Then, a universal pattern of displacement boundary condition around the tunnel cavity is originally introduced, which is solved as the combination of three fundamental deformation modes, namely, uniform convergence, vertical translation, and ovalization. The expression for the above-mentioned displacement boundary condition is derived, by imposing which the analytical solution for ground movements, based on the stress function method, is proposed. …”
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11584
Pathogenic Roles of Macrophage Migration Inhibitory Factor during Dengue Virus Infection
Published 2015-01-01“…Recent evidence indicates that DENV infection induced MIF production and may contribute to vascular hyperpermeability and viral replication during DENV infection. The expression of both adhesion and coagulation molecules on MIF-stimulated monocytes and endothelial cells is also increased, which may contribute to inflammatory and anticoagulatory states during DHF/DSS. …”
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11585
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11586
Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis
Published 2009-01-01“…They could interfere with erythropoietin-mediated signaling pathways, inducing early apoptosis and perturbing the expression and regulation of specific transcription factors involved in the control of erythroid differentiation. …”
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11587
Real-Time Analysis of Endogenous Wnt Signalling in 3D Mesenchymal Stromal Cells
Published 2016-01-01“…Interestingly, endogenous Wnt signalling was only active during 3D differentiation whereas 2D cultures showed no EGFP expression throughout an extended differentiation time-course. …”
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11588
Sample Aging Profoundly Reduces Monocyte Responses in Human Whole Blood Cultures
Published 2018-01-01“…Intracellular cytokine staining revealed that the number of LPS-responding cells was not impacted by sample aging and reduced LPS responsivity could also not be explained by apoptosis or downregulated TLR4 expression. Thus, we speculate that sample aging induces an inhibitory pathway downstream from TLR4 in monocytes. …”
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11589
Optimization of the Coupling Coefficient of the Inductive Link for Wireless Power Transfer to Biomedical Implants
Published 2022-01-01“…This work focuses on the optimization of coupling coefficient (k) of the inductive link for the wireless power transfer (WPT) system to be used in implantable medical devices (IMDs) of centimeter size. The analytic expression of k is presented. Simulations are conducted by using the high-frequency structure simulator (HFSS). …”
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11590
STYLISTIC POTENTIAL OF GERMAN SYNTAX
Published 2013-08-01“…The study sets out to reveal the expressive syntactic means. Disorder of a proper sentence structure makes its expressiveness. …”
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11591
Sargassum plagiophyllum Ethanolic Extract Enhances Wound Healing by Modulating FAK/Src/Akt/p38 and Rac1 Signaling in Keratinocytes HaCaT Cells
Published 2025-01-01“…SPEE increased Rac1 protein expression. Interestingly, hyaluronan synthase (HAS1 and HAS2) as well as collagen type I and elastin were also significantly upregulated when compared with the control upon exposure to SPEE. …”
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11592
MARCAS DA REFORMA UNIVERSITÁRIA DE 1968 E NOVOS DESAFIOS PARA A UNIVERSIDADE BRASILEIRA
Published 2014-03-01“…Busca indicar, ainda, os sentidos prevalecentes que tem sido produzidos, confirmados, ou negociados ao longo do debate sobre universidade no Brasil, entendidos como discursos que expressam um campo de disputa pela hegemonia de projetos de sociedade. …”
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11593
Rational Design for Improving the Thermostability of Saccharomyces cerevisiae Nicotinamide Riboside Kinase 1
Published 2024-12-01“…In order to improve the thermal stability of nicotinamide riboside kinase 1 from Saccharomyces cerevisiae (ScNRK1), six single-point mutants of ScNRK1 were virtually designed using computer-aided technology, and their expression using site-directed mutagenesis and enzymatic characterization were carried out. …”
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11594
Clinical Onset of Celiac Disease after an Episode of Campylobacter jejuni Enteritis
Published 2007-01-01“…The present case suggests that the clinical expression of CD can be unmasked by an acute gastrointestinal infection and supports the hypothesis that environmental factors other than gliadin may play a role in the clinical onset of CD in a genetically susceptible host. …”
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11595
Unmasking The Hidden Clues: Shedding Light On The Potential Of Novel Biomarkers In Endometrial Cancer, Comparing RT-Qpcr And Immunohistochemical Analysis In Clinical Specimens
Published 2025-01-01“…RT-qPCR was performed, and relative gene expressions were calculated using the 2^-ΔΔCt method, with the endogenous control. …”
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11596
Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma
Published 2021-01-01“…Moreover, a correlation between specific effects and expression of somatostatin receptors (SSTRs) was observed in the studied cells. …”
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11597
Les genres littéraires participent de domaines: en relisant Croce, Frye et McLuhan
Published 2024-10-01“…The notion of field – here translated in French by ‘domain’ and specified by the expression ‘domaine de sens’ (field of sense) – enables critics and readers to align views on singularities and similarities, to reject any systematic perspective and to outline literary works’ differences, proximities and conti nuities. …”
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11598
Música, circulación y poesía en las canciones de Pedro Ximénez Abrill Tirado
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11599
The role of KLF4 in human primordial germ cell development
Published 2025-01-01“…Cut-and-run and transcriptomic analyses reveal that KLF4 represses somatic markers involved in neuronal and endodermal differentiation while promoting the expression of genes associated with PGC specification, such as PAX5, and epigenetic regulators, including DNMT3L and REST. …”
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11600
Polymorphonuclear Leukocytes or Hydrogen Peroxide Enhance Biofilm Development of Mucoid Pseudomonas aeruginosa
Published 2018-01-01“…In this study, PMNs and H2O2 promoted alginate production, and biofilms treated with PMNs or H2O2 exhibited higher expression of alginate genes. Additionally, PMNs increased the activity of GDP-mannose dehydrogenase, which is the key enzyme in alginate biosynthesis. …”
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