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11481
Macrophages, Inflammation, and Tumor Suppressors: ARF, a New Player in the Game
Published 2012-01-01“…In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells. …”
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11482
Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
Published 2013-01-01“…RAGE-ligands interaction induces a series of signal transduction cascades and lead to the activation of transcription factor NF-κB as well as increased expression of cytokines, chemokines, and adhesion molecules. …”
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11483
The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage
Published 2024-12-01“…Unrepaired damage can lead to DNA base changes, chromosomal mutations, genomic loss and instability, and disrupted gene and protein expression. Such changes contribute to an increased risk of tumorigenesis, cancer progression, and mortality. …”
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11484
Feminismos para decir, feminismos para vivir. Lenguaje, experiencia y subjetividad política en el feminismo uruguayo contemporáneo
Published 2023-12-01“…L’interpellation profonde de la violence et de la dépossession que les féminismes latino-américains contemporains posent se manifeste par l’articulation créative de multiples formes d’expression. En Uruguay, les féminismes déploient dans l’espace public des pratiques politiques, discursives et linguistiques puissantes qui remettent en question l’ordre patriarcal. …”
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11485
PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition
Published 2020-01-01“…PKM2 is considered a new biomarker of cancer with upregulated expression in tumor tissue. PKM2 participates in the cancer-specific Warburg effect to regulate fast glucose intake consumption. …”
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11486
O CONCEITO DE SOCIEDADE CIVIL: um debate a partir do contexto da Guiné-Bissau
Published 2014-03-01“…O caso de Guiné-Bissau proporciona um entendimento ou insuficiência do conceito de sociedade civil, a partir do qual outras formas de organização têm lugar, a exemplo daquela encontrada nas comunidades étnicas e entre os grupos de Mandjuandade e Djidiu, um movimento de expressão cultural, política e pedagógica de congregação de diferentes etnias e grupos sociais. …”
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11487
Combination of ERG9 Repression and Enzyme Fusion Technology for Improved Production of Amorphadiene in Saccharomyces cerevisiae
Published 2013-01-01“…In our studies, FPP converted to amorphadiene (AD) by expressing heterologous amorphadiene synthase (ADS) in yeast. …”
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11488
Evolution of the Electrical Displacement and Energy Dissipation of Lead Zirconate-Titanate Ceramics under Cyclical Load
Published 2020-01-01“…The total strain of P51 under cyclical loading consists of elastic deformation (εije), immediate ferroelectric domain switching deformation (εijd), and time-dependent deformation (εijc). Thus, an expression for the energy dissipation of P51 can be theoretically derived. …”
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11489
Rock Music and The Political Scripting of Vietnam War: Reading Dispatches by Michael Herr
Published 2024-12-01“…Using Herr’s Dispatches as a case study, it investigates how rock music encapsulates the war’s ambiguous energy, blurring the boundaries between artistic expression and the realities of conflict. The analysis considers the artistic, ideological, and cultural dimensions of the music produced and disseminated during the war, while also reflecting on how the lyrics referenced in Herr’s work reveal the psychological state of soldiers and the growing significance of counter-cultural music as the war progressed.…”
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11490
Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway
Published 2025-01-01“…Further analysis of the underlying mechanism revealed that TMT induced nitrosation stress (RNS), increased NO content and iNOS expression, which in turn activated the NF-κB/NLRP3 pathway and induced pyroptosis. …”
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11491
Practice of relationships between the Prosecutor’s office and the gendarmerie in the investigation of political crimes
Published 2018-12-01“…According to the figurative expression of the former Chairman of the Council of Ministers S. …”
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11492
Dynamics of <i>Nakaseomyces glabratus</i> biofilm formation
Published 2024-09-01“…The system of gene expression coordination (quorum sensing) in the representation of signaling molecules allows regulation of the amount and composition of biofilm populations thus expanding the adaptive capacity of microorganisms. …”
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11493
Organizational climate and interpersonal relationships in helticare: A study of attitudes ane perceptions
Published 2024-01-01“…However, there is room for improvement in encouraging opinion expression (37.30%) and building mutual trust (34.30%). …”
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11494
Research on the Decision Mechanism of University-Enterprise Collaborative Innovation Based on Quantum Cognition
Published 2021-01-01“…Research shows that the internal mechanism of university-enterprise collaborative decision-making is based on its quantum attributes, university-enterprise collaborative decision-making is more inclined to joint decision-making, joint university-enterprise collaborative decision-making is more inclined to quantum cognition incompatibility expression, and the opinions of innovative members will have sequential effects and interference effects on decision makers.…”
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11495
Nonlinear Langevin dynamics via holography
Published 2020-01-01“…This configuration is the linearised solution of the string motion in the doubled black brane geometry which has been proposed as the holographic dual of a thermal Schwinger-Keldysh contour of the CFT. Our expression for the influence phase passes non-trivial consistency conditions arising from the underlying unitarity and thermality of the bath. …”
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11496
Plasmid Gene Therapy for Monogenic Disorders: Challenges and Perspectives
Published 2025-01-01“…However, despite advancements in gene manipulation tools and delivery systems, several challenges remain unresolved, including inefficient delivery, lack of sustained expression, immunogenicity, toxicity, capacity limitations, genomic integration risks, and limited tissue specificity. …”
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11497
Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells
Published 2025-01-01“…This study aims to explore the potential of mealworm-derived protein hydrolysates as novel bioactive materials for promoting adipogenesis and improving adipokine expression, with applications in metabolic health and skin regeneration. …”
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11498
Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity
Published 2009-01-01“…Major contributions were made by experiments using DNA microarray technology, which has been used for the analysis of gene expression patterns in chronic inflammatory and autoimmune diseases, among which were rheumatoid arthritis, systemic lupus erythematosus, psoriasis, systemic sclerosis, multiple sclerosis, and type-1 diabetes. …”
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11499
The value of a metabolic and immune-related gene signature and adjuvant therapeutic response in pancreatic cancer
Published 2025-01-01“…Treatment outcomes exhibit substantial variability across patients, underscoring the urgent need for robust predictive models to effectively estimate survival probabilities and therapeutic responses in PDAC.MethodsMetabolic and immune-related genes exhibiting differential expression were identified using the TCGA-PDAC and GTEx datasets. …”
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11500
Vitamin D Potentiates the Inhibitory Effect of MicroRNA-130a in Hepatitis C Virus Replication Independent of Type I Interferon Signaling Pathway
Published 2015-01-01“…Intriguingly, this potentiating effect of calcitriol on miR-130a was not through upregulating the expression of cellular miR-130a or through increasing the miR-130a-mediated IFNα/β production. …”
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