Protocol to denoise spatially resolved transcriptomics data utilizing optimal transport-based gene filtering algorithm by Lin Du, Jingmin Kang, Jie Li, Hua Qin, Yong Hou, Hai-Xi Sun

“…Here, we present a protocol for denoising SRT data using SpotGF, an optimal transport-based gene filtering algorithm, without modifying the raw gene expression. We describe steps for data preparation, SpotGF score calculation, filtering threshold determination, denoised data generation, and visualization. …”
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Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson’s Disease by Jianshe Wei, Gilbert Ho, Yoshiki Takamatsu, Eliezer Masliah, Makoto Hashimoto

“…Finally, it is intriguing to predict that increased αS evolvability through suppression of βS expression might protect against autosomal recessive PD. …”
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Diagnostic challenge in chondromyxoid fibroma clinically mimicking neuroma by Aleksandra Izabela Masłowska, Julia Sołek, Paulina Jagodzińska-Mucha, Marcin Braun, Hanna Romańska

“…Using immunohistochemical and genetic analyses focused on the expression of MDM-2 and RB-1, along with an examination for alterations in the GNAS gene, the mass has been finally and conclusively identified as a chondromyxoid fibroma. …”
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An Extension of Taylor’s φ-Circle Method and Some Stability Charts for Submerged Slopes by Ping Li, Luanhua Dong, Xiaowen Gao, Tonglu Li, Xiaokun Hou

“…The critical failure surfaces corresponding to the minimum factor of safety are determined using the computer program proposed by the authors. The general expression of the safety factor of slopes under the following four conditions is derived, namely, (i) partly submerged, (ii) completely submerged, (iii) water sudden drawdown, and (iv) water slow drawdown. …”
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L’Arbre des rues de Mexico : une ressource au-delà de son exploitabilité by Nora Itri

“…From the original design of Mexico City by the altepetl, the Aztec city-state, to the contemporary megalopolis, the ‘‘tree of the street’’ translates the persistent continuity of the natural environment through the city's soil. It is the expression of a form of cultural and conceptual interbreeding, and bears witness to the hybridity that has characterized Mexico City from its foundations. …”
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Potential for Isolation of Immortalized Hepatocyte Cell Lines by Liver-Directed In Vivo Gene Delivery of Transposons in Mice by Masahiro Sato, Issei Saitoh, Emi Inada, Shingo Nakamura, Satoshi Watanabe

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12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation by Alexa R. Lindley, Margaret Crapster-Pregont, Yanjun Liu, Douglas A. Kuperman

“…Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types. 15-lipoxygenase-1 is dramatically elevated in the airways of subjects with asthma. …”
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Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis by Desiré Casares‐Marfil, Amr H. Sawalha

“…Here, we summarize the major findings from GWAS in TAK and provide an in silico functional evaluation of the associated loci (P < 5 × 10−8) and variants in high linkage disequilibrium with them (r2 > 0.8). By exploring gene expression and chromatin interaction data, we identified candidate causal genes in TAK, some of them with well‐known functional implications. …”
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Lidmate se houding teenoor kerkvereniging in die NGK-familie: 'n kruiskulturele ondersoek na enkele veranderlikes by P. Jonch, A. le Roux, P. Verster

“…Although unity is a spiritual reality given by God himself, a comprehensive, visible expression of this essential unity must be achieved. …”
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‘Gall and wormwood’ – The Compositors’ Chronicle (1840–43) as Collaborative Journal by Françoise Baillet

“…It provides three successive highlights on different fields and modes of expression used in the Chronicle, paying attention to the connectedness of printers, within and outside the editorial structure of the journal. …”
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O Espaço Museal e a modelagem na educação: Possibilidades para alfabetização científica by Rosana Maria Luvezute Kripka, Danusa de Lara Bonotto, Luciana Richter, Isabel Cristina Machado de Lara, José Luis Schifino Ferraro

“…Evidencia a emergência de duas categorias: conhecimento; expressão conceitual. Identifica que a atividade propiciou reconstrução, ampliação e integração de conhecimentos, além de reflexões críticas e conscientes sobre a importância do uso do critério ambiental para escolha de combustíveis, além dos critérios de economia e rendimento. …”
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Dynamic Response of Wheel-Rail Interaction at Rail Weld in High-Speed Railway by Boyang An, Ping Wang, Jieling Xiao, Jingmang Xu, Rong Chen

“…These simulation results, combined with Quality Index (QI) method, are used to develop a quantitative expression, which can be easily applied for evaluating rail weld deterioration based on measured rail profiles and axle-box acceleration.…”
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Narrativas da exclusão de migrantes e refugiados na Universidade by Jaqueline Bertoldo, Giuliana Redin

“…Em resumo, a universidade tem mostrado ser um ambiente de reprodução dos mecanismos sociais de exclusão dos não nacionais e que expressam a desigualdade estrutural decorrente da raça e da classe. …”
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Acute Muscle Trauma due to Overexercise in an Otherwise Healthy Patient with Cystic Fibrosis by Henning Neubauer, Clemens Wirth, Katharina Ruf, Helge Hebestreit, Meinrad Beer

“…Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular Ca2+ release dynamics in CFTR-deficient animal models. …”
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Appartenenze ed esclusioni by Frederica Paletti

“…The subjects receiving this copious regulatory production did not correspond to a single legal type, nor did they enjoy the same legal status, since the terms employed by the Venetian and mainland legislation to indicate them were polysemic, the result and expression of different regional historical-social moments and dynamics. …”
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A Novel Approach for Detecting DGA-Based Botnets in DNS Queries Using Machine Learning Techniques by Ali Soleymani, Fatemeh Arabgol

“…Classical approaches that rely heavily on static matching, such as blacklisting or regular expression patterns, may be limited in flexibility or uncertainty in detecting malicious data in system data. …”
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Effectiveness of Polyclonal Antibody Immunoconjugate Treatment with Propamidine Isethionate for Amoebic Keratitis in Golden Hamsters by Manuel Enrique Ávila-Blanco, Sandra Lizbeth Aguilera-Martínez, Javier Ventura-Juarez, Jorge Pérez-Serrano, Elizabeth Casillas-Casillas, Luis Fernando Barba-Gallardo

“…Propamidine isethionate is frequently used for AK treatment, in vivo study we are found IL-1β and IL-10 expression and caspase 3 activity is significantly increased with respect to the group that was inoculated with the amoeba without receiving any treatment, suggesting that it may be an effect of the toxicity of this drug on the corneal tissue. …”
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TWEAK/Fn14 axis may promote vascular smooth muscle cell senescence via p38 signaling pathway: preliminary evidence by Chunyang Wei, Xiaoying Liu, Zhuang Miao, Hua Zhang, Yanfu Wang, Guoxian Qi

“…Additionally, the role of p38 phosphorylation pathway in the effect of TWEAK on VSMCs senescence was assessed.Results Expressions of TWEAK and Fn14 were significantly elevated in senescent VSMCs. …”
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POVERTY AND NATIONAL SECURITY: AN OVERVIEW OF NIGERIA’S FOURTH REPUBLIC by ADAMU MOHAMMED

“…Poverty and weaknesses in national security evolved to the point that the impoverished people took up weapons against the government as a manner of expressing their dissatisfaction, which has taken many forms, including the insurgencies by Boko Haram and the Niger Delta. …”
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Conditional Inactivation of HIF-1 Using Intrabodies by Arjan J. Groot, Eelke H. Gort, Elsken van der Wall, Paul J. van Diest, Marc Vooijs

“…Here we provide a novel approach for HIF-1 targeted therapy using single-domain llama antibodies directed against the HIF-1α oxygen dependent degradation domain which encompass the N-terminal transactivation domain. Conditional expression of HIF intrabodies in mammalian cells interfered with binding to pVHL and inhibited hypoxia induced activation of endogenous target genes. …”
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