Genes and light: many years later by A. O. Ruvinsky

“…Georgian white mutation likely causes a low expression of KIT gene. Presented here considerations of KIT protein and its ligand KITLG molecular and cellular interactions suggest a possibility for slow development of W G/W G blastocysts; hence many such blastocysts might be late and miss an opportunity for successful implantation. …”
Get full text

Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA by Daniela Megrian, Mariano Martinez, Pedro M. Alzari, Anne Marie Wehenkel

“…We use phylogenetic inference and protein structure analyses to study its diversity and evolutionary history. Glp-expressing Bacteria have at least two copies of the gene, and analysis of their putative active sites suggests that Glp lost its enzymatic role. …”
Get full text

Stochastic modelling of PTEN regulation in brain tumors: A model for glioblastoma multiforme by Margherita Carletti, Matteo Montani, Valentina Meschini, Marzia Bianchi, Lucia Radici

“…Moreover, the introduction of translational and transcriptional delays offers some interesting insights for the PTEN low expression as observed in brain tumor cells.…”
Get full text

Pausas en la lectura de textos expresivos: métricas de evaluación by Eva Estebas-Vilaplana, Juan María Garrido, María Jesús Machuca

Get full text

Latinoamérica: entre la democracia y el autoritarismo by Jairo García Oñoro

Get full text

Effect of Velocity Slip Boundary Condition on the Flow and Heat Transfer of Cu-Water and TiO2-Water Nanofluids in the Presence of a Magnetic Field by Abdelhalim Ebaid, Fahd Al Mutairi, S. M. Khaled

“…The present paper considers the effect of the velocity slip condition on the flow and heat transfer of the Cu-water and the TiO2-water nanofluids over stretching/shrinking sheets in the presence of a magnetic field. The exact expression for the fluid velocity is obtained in terms of the exponential function, while an effective analytical procedure is suggested and successfully applied to obtain the exact temperature in terms of the generalized incomplete gamma function. …”
Get full text

Endophytes: Colonization, Behaviour, and Their Role in Defense Mechanism by Anteneh Ademe Mengistu

“…Microbes enhance disease resistance through induced systemic resistance (ISR), and Bacillus cereus triggers ISR against Botrytis cinerea through an accumulation of the PR1 protein and activates MAPK signaling and WRKY53 gene expression by the JA/ET signaling pathway. Similarly, Trichoderma arundinaceum produces trichodiene that affects Botrytis cinerea through induction of defense-related genes encoding salicylic acid (SA) and jasmonate (JA). …”
Get full text

Glocalidad y reforma agraria: ¿de nuevo el problema irresuelto de la tierra? by Victor Bretón Solo de Zaldívar

Get full text

Políticas Queer y abyección, o el ano como órgano antinorma by Juliano Felizardo Guimaraes

Get full text

A Case of Special Complication following a Large Amount of Polyacrylamide Hydrogel Injected into the Epicranial Aponeurosis: Leukocytopenia by Li Rong, Shi-Jie Lan, Ying Shao, Zhe Chen, Duo Zhang

“…After receiving PAAG injection for craniofacial contouring, the female patient described herein experienced recurrent swelling, temporal pain (particularly with changes in ambient temperature and facial expression), and ultimately leukocytopenia due to widespread migration of the injected PAAG. …”
Get full text

The United States Supreme Court and Business Elites: Gilded Age Origins of Modern American Liberalism by Paul Kens

“…Furthermore, it consistently held that, because state economic regulations were an expression of popular sovereignty and rights of the community, they should be presumed to be valid. …”
Get full text

Facioscapulohumeral muscular dystrophy: a review of pathogenesis, clinical symptoms, and treatment by T. Mikalauskas, B. Burnytė

“…The phenotypic differences between the two types are not distinct, both resulting from dysregulation of DUX4 expression leading to skeletal muscle toxicity. The first type is characterised by a reduction in D4Z4 repeats, while the second type is characterised by mutations in genes encoding epigenetic regulators such as SMCHD1. …”
Get full text

Electric Drive and Automation of Sampling System for Chimney Fas Analyzer by V. I. Emeliantchikov, E. E. Loikuts, O. F. Opeiko

“…A functional diagram of the control system is proposed, which contains a programmable logic controller for generating the motion mode, as well as a method for calculating parameters and expressions for generating a task signal for continuous sampling mode. …”
Get full text

Early Growth Response Genes Signaling Supports Strong Paracrine Capability of Mesenchymal Stem Cells by Kenichi Tamama, Dominique J. Barbeau

“…EGR2 appears to regulate the expression of immunomodulatory molecules. Chronic nonhealing wounds are ischemic, inflammatory, and often fibrotic, and the hypoxic micro-environment of these wounds may compromise MSCs' wound healing properties in vivo by upregulating the EGR1's fibrogenic effects and downregulating the EGR2's immuno-modulatory effects. …”
Get full text

Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? by Matthieu Sawaf, Hélène Dumortier, Fanny Monneaux

“…In the present review, we give an overview of the aberrant expression and/or function of such key players in lupus, and we highlight their potential as therapeutic targets.…”
Get full text

INVESTIGATION OF THE SPATIAL GENOME ORGANIZATION OF MOUSE SPERM AND FIBROBLASTS BY THE Hi-C METHOD by N. R. Battulin, V. S. Fishman, A. A. Khabarova, M. Yu. Pomaznoy, T. A. Shnaider, D. A. Afonnikov, O. L. Serov

“…The spatial organization of an eukaryotic genome plays an important role in the control of nuclear gene expression. The new Hi-C method allows investigation of the three-dimensional architecture of whole genomes. …”
Get full text

Transition to Circular Economy and Management of Public Services of General Economic Interest by Sandra Antoniazzi

“… Purpose: The aim of this paper is to clarify the topic of the transition to circular economy, an expression of the European “Green New Deal”, which has several application consequences for the SGEI sector. …”
Get full text

La Cultura de Sandino y el hombre nuevo: Alfabetización, música popular y Evangelio. Nicaragua 1979-1980 by Julián David Gutiérrez Ramírez

Get full text

Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking by In Won Lee, Jonghwan Yoon, Gunhee Lee, Minho Lee

“…Apurinic/apyrimidinic endonuclease 1 (APE1) is an enzyme responsible for the initial step in the base excision repair pathway and is known to be a potential drug target for treating cancers, because its expression is associated with resistance to DNA-damaging anticancer agents. …”
Get full text

neutralidade de rede e sua relevância como princípio estruturante da Internet by Alejandro Knaesel Arrabal, Fernanda Koller Borba

“…O artigo aponta para a importância do princípio da Neutralidade de Rede no sentido de garantir as condições estruturais necessárias ao pleno exercício das liberdades de expressão, de comunicação e econômica.…”
Get full text