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10801
Análisis fractal de series de tiempo de anomalías de variables de frijol en México
Published 2015-01-01“…Los valores de dimensión fractal Dv > 1.5 hasta 2 expresan la presencia de variaciones de corto plazo. …”
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10802
CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4–TGFα–EGFR signaling
Published 2025-01-01“…Abstract Background Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated. …”
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10803
Dietary supplementation of mulberry leaf oligosaccharides improves the growth, glucose and lipid metabolism, immunity, and virus resistance in largemouth bass (Micropterus salmoide...
Published 2025-01-01“…In terms of liver health, MLO supplementation significantly up-regulated the relative expression of anti-inflammatory cytokines il-10 and tgf-β, while decreased that of pro-inflammatory cytokines nf-κb, il-8, and tnf-α in the liver tissue (P< 0.05). …”
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10804
Vector‐Free Deep Tissue Targeting of DNA/RNA Therapeutics via Single Capacitive Discharge Conductivity‐Clamped Gene Electrotransfer
Published 2025-01-01“…Proof‐of‐concept studies for “single capacitive discharge conductivity‐clamped gene electrotransfer” (SCD‐CC‐GET) deep tissue delivery of naked DNA and mRNA in the mouse hindlimb skeletal muscle achieve stable (>18 month) expression of luciferase reporter synthetic DNA, and mRNA encoding the reporter yield rapid onset (<3 h) high transient expression for several weeks. …”
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10805
mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy
Published 2025-03-01“…AAV2-shmTOR notably decreased mTOR expression in rMC1 cells under hypoxic conditions, as verified by co-staining for mTOR and glial fibrillary acidic protein (GFAP). …”
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10806
Pro-inflammatory effects of inhaled Great Salt Lake dust particles
Published 2025-01-01“…Dust from the Salton Sea playa (SSD qPM2.5) also stimulated IL6 and IL8 mRNA expression and activated TRPV1 in vitro, but inhibition by TRPV1 and V3 antagonists was dose dependent. …”
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10807
Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function
Published 2025-02-01“…RNA sequencing of T cells from women with TNBC with elevated plasma levels of Gal-3 revealed significantly lower expression of oxidative phosphorylation genes than in T cells from healthy women. …”
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10808
The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications
Published 2025-02-01“…The extract (BEP-03B) caused a significant decrease in the expression of survivin and CCND1 compared to the control GAPDH at its highest dose (12 µg/mL). …”
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10809
Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation
Published 2025-02-01“…However, the mechanisms regulating CKB expression in human white adipocytes remain unclear. …”
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10810
Peripheral mitochondrial transplantation alleviates diabetes-associated cognitive dysfunction by suppressing cuproptosis
Published 2025-03-01“…The findings revealed that in primary neurons exposed to HG/Pal, the expression of copper levels was elevated, and the levels of FDX1, LIAS, and DLAT were reduced. …”
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10811
Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity
Published 2025-02-01“…Results: Our findings revealed that MET boosts plant disease resistance by activating MAPKs, upregulating the expression of downstream defense genes, and fortifying the ROS burst. …”
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10812
Single-cell immunopathology of recurrent acute generalized exanthematous pustulosis associated with vancomycin
Published 2025-05-01“…Single-cell analysis of affected skin showed polyclonal TH17-like cells with gene expression signatures similar to T-cell response during prevalent infectious diseases. …”
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10813
Yeast cell wall polysaccharides accelerate yet in-feed antibiotic delays intestinal development and maturation via modulating gut microbiome in chickens
Published 2025-01-01“…Also, BMD markedly downregulated gene expression levels of β-catenin, lysozyme, occludin and FABP-2 (d 21) and innate immune related genes CD83 and MHC-I mRNA levels (d 42, P < 0.05), and decreased goblet cell counts in the ileum of chickens (d 21 and d 42, P < 0.05). …”
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10814
Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients
Published 2024-04-01“…Clinically, to reach the same tacrolimus concentration-to-dose ratio (CDR), expressors (CYP3A5*1/*1 and *1/*3) require a higher tacrolimus dose than non-expressors (*3/*3). …”
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10815
In Vitro Screening and Transfection Concentration Optimization of Cynomolgus Monkey IκBα-siRNA
Published 2020-01-01“…To seek for a small interfering RNA (siRNA) sequence targeting a cynomolgus monkey inhibitor of nuclear factor kappa B α (IκBα) that can specifically and effectively suppress IκBα gene expression of cynomolgus monkey ciliary muscle (CM) cells and trabecular meshwork (TM) cells in vitro and screen for optimal siRNA transfection concentration. …”
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10816
Modulation of virulence and metabolic profiles in Klebsiella pneumoniae under indole-mediated stress response
Published 2025-02-01“…These findings collectively indicate that indole enhances the intestinal colonization and pathogenicity of K. pneumoniae primarily by modulation of fimbriae expression and metabolic pathway regulation.…”
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10817
Revealing the core suppression effects of various Di (2-ethylhexyl) phthalate exposure on early meiosis progression in postnatal male mice via single-cell RNA sequencing
Published 2025-02-01“…DEHP exposure resulted in a substantial decrease in the expression of the Trp53 gene, which in turn down-regulated three critical downstream genes (Stmn1, Tubb5, and Ccnb1) that are implicated in spindle organization from a mechanistic perspective. …”
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10818
Identification of Inflammatory Biomarkers for Predicting Peripheral Arterial Disease Prognosis in Patients with Diabetes
Published 2024-12-01“…In the discovery phase the cohort was randomly split into a 70:30 ratio, and proteins with a higher mean level of expression in the DM PAD group compared to the DM non-PAD group were identified. …”
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10819
Lignin Metabolism Is Crucial in the Plant Responses to <i>Tambocerus elongatus</i> (Shen) in <i>Camellia sinensis</i> L.
Published 2025-01-01“…Analysis of the expression of related genes indicates that the jasmonate (JA) pathway primarily responds to leafhopper damage. …”
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10820
Descripción clínica y genética de pacientes con enfermedad granulomatosa crónica en un hospital pediátrico
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