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10641
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10642
Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors
Published 2014-01-01“…We identified the thiazole antibiotics Siomycin A and thiostrepton as inhibitors of transcriptional activity and FOXM1 expression via proteasome inhibition. In addition, we found that all tested proteasome inhibitors target FOXM1. …”
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10643
Enhancing Women’s Participation in Turkey through Digital Storytelling
Published 2012-07-01“…In the resulting dissertation, I examined the potential of Digital Storytelling workshop practice as a means to promote agency and self-expression in a feminist activist organization (such as Amargi Women), focusing in particular on whether or not Digital Storytelling can be used as a change agent – as a tool for challenging the idea of a single public sphere in ways that make it more inclusive of women’s participation. …”
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10644
Nonlinear Dynamic Analysis of Rotor-Bearing System with Cubic Nonlinearity
Published 2021-01-01“…The comprehensive effects of the unbalanced excitation, the internal clearance, the nonlinear Hertzian contact force, the varying compliance vibration, and the nonlinear stiffness of support material are considered. The expression with the linear and the cubic nonlinear terms is adopted to characterize the synthetical nonlinearity of the rotor-bearing system. …”
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10645
Bayesian Network Approach to Customer Requirements to Customized Product Model
Published 2019-01-01“…In order to better meet customer needs, solve the problem of incomplete and inaccurate expression, and improve the correlation between customized product performance and customer demand, a customized product method based on Bayesian network is proposed. …”
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10646
CoTF-reg reveals cooperative transcription factors in oligodendrocyte gene regulation using single-cell multi-omics
Published 2025-02-01“…Next, we train a deep learning model to predict each TG expression using the co-binding TFs’ expressions. Shapley interaction scores reveal high interactions between co-binding TF pairs, such as SOX10-TCF12. …”
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10647
Contributions of Matrix Metalloproteinases to Neural Plasticity, Habituation, Associative Learning and Drug Addiction
Published 2009-01-01“…The premise of this paper is that increased expression of matrix metalloproteinases (MMPs) permits the reconfiguration of synaptic connections (i.e., neural plasticity) by degrading cell adhesion molecules (CAMs) designed to provide stability to those extracellular matrix (ECM) proteins that form scaffolding supporting neurons and glia. …”
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10648
Airline Overbooking Problem with Uncertain No-Shows
Published 2014-01-01“…Finally, the analytic expression of the optimal booking limit is obtained through a numerical example, and the results of sensitivity analysis indicate that the optimal booking limit is affected by flight capacity, discount, confidence level, and parameters of the uncertainty distribution significantly.…”
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10649
Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic β-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1
Published 2016-01-01“…Transgenic mice (Tg mice), ubiquitously expressing mouse CRY1 having a mutation in which cysteine414 (the zinc-binding site of CRY1) being replaced with alanine, display unique phenotypes in their circadian rhythms. …”
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10650
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10651
Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1
Published 2006-01-01“…Most importantly, hemin, an inducer of heme oxygenase expression and activity, recovered the huge number of infiltrated polymorphonuclear leukocytes PMN within the ciliary bodies associated with STZ-hyperglycemic state and EIU damage. …”
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10652
ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells
Published 2020-01-01“…Key events, including cell proliferation, lineage commitment, and MSC differentiation, are ensured by precise gene expression regulation. ATP-dependent chromatin alteration is one form of epigenetic modifications that can regulate the transcriptional level of specific genes by utilizing the energy from ATP hydrolysis to reorganize chromatin structure. …”
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10653
A ilegalidade do Estado e o colapso do neodesenvolvimentismo no Brasil
Published 2017-02-01“… Este artigo tem por objetivo indicar pistas para a investigação da “realidade existente do golpe” no Brasil e seus vínculos com o esgotamento do período ideologicamente chamado de “neodesenvolvimentismo”, tomando como premissa que o ciclo de ascensão e declínio do padrão de desenvolvimento brasileiro e das políticas assistencialistas do Estado, experimentados em pouco menos de uma década, expressam, pois, os impactos da crise estrutural do capital sobre a formação social nacional. …”
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10654
Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system
Published 2024-06-01“…Therefore, GE kinetics of co-ingested water influences the drug release from immediate-release tablets, however, in certain cases, other parameters influencing drug dissolution can partly or fully hinder the expression of this effect.…”
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10656
New phraseological units with word soul (on the material of the social network «Instagram»)
Published 2018-10-01“…The article considers a new linguistic phenomenon, widely spread in social networks — «hashtag». A plan of the expression and a plan of the content of hashtags are analyzed in social networks. …”
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10657
Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications
Published 2015-01-01“…Particular effort has recently been devoted to understanding the functional relationship between chromatin structure regulation and the persistent change in gene expression which is driven by hyperglycaemia and which accounts for long-lasting diabetic complications. …”
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10658
New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis
Published 2011-01-01“…Analysis of molecular alterations of receptor expression in detrusor smooth muscle cells and urothelial integrity is necessary to develop patient-tailored therapeutical concepts. …”
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Research on the Safety Thickness of Tunnel Outburst Prevention in Water-Rich Fault Fracture Zone Based on Janssen’s Theory
Published 2022-01-01“…In this paper, the expression of in situ stress in water-rich fault fracture zone is derived based on Janssen’s theory. …”
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10660
Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways
Published 2022-01-01“…ALA significantly promoted NCM460 and Caco-2 migration, increased mucosal tight junction factors ZO-1 and OCLN expression, and ALA accelerated cell injury repair of both cells in wound healing assay. …”
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