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10621
Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
Published 2001-01-01“…Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA).…”
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10622
Quantitative Detection of Financial Fraud Based on Deep Learning with Combination of E-Commerce Big Data
Published 2020-01-01“…This method builds a deep neural network model with multiple hidden layers, learns the characteristic expression of the data, and fully depicts the rich internal information of the data, thereby improving the accuracy of financial fraud detection. …”
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10623
Urothelial Cancer Stem Cells
Published 2010-01-01“…This review examines the present knowledge on CSCs in UCCs regarding the similarities between CSCs and the adult urothelial stem cells, potential origin of urothelial CSCs, main regulatory pathways, surface markers expression, and the current state of CSC-targeting therapeutic strategies.…”
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10624
MicroRNAs in Human Pituitary Adenomas
Published 2014-01-01“…MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. …”
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10625
Planar Smooth Path Guidance Law for a Small Unmanned Aerial Vehicle with Parameter Tuned by Fuzzy Logic
Published 2017-01-01“…The guidance law only needs the mathematical expression for the predefined path, the positions, and the velocities of the vehicle in the horizontal inertial frame. …”
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10626
Remaining Useful Life Estimation of Fan Slewing Bearings in Nonlinear Wiener Process with Random Covariate Effect
Published 2022-01-01“…Moreover, the closed expression for the RUL probability density function(PDF) is derived for the random variation of drift coefficients, the individual differences and the random variation of covariates. …”
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10627
Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity
Published 2015-01-01“…Analyzing DA participation in striatal GABAergic plasticity we observed that high frequency stimulation (HFS) of GABAergic interneurons in the presence of DA at a low concentration (200 nM) favored the expression of inhibitory striatal LTD, whereas higher concentration of DA (20 μM) primarily induced LTP. …”
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10628
Safety Evaluation for Highway Geometric Design Based on Spatial Path Properties
Published 2023-01-01“…First, these combinations of horizontal and vertical alignments were categorized into six classifications, each with its own spatial expression in mathematical form. After manipulating the curvature and torsion of the spatial curve algebraically, the correlation between geometric design variables and crash rate was ultimately established. …”
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10629
Pattern Recognition via the Toll-Like Receptor System in the Human Female Genital Tract
Published 2010-01-01“…The available literature regarding the innate immune system of the female genital tract during human reproductive processes was reviewed in order to identify studies specifically related to the expression and function of TLRs under normal as well as pathological conditions. …”
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10630
La correspondance de Charlotte Brontë : coulisses du style et de l’écriture
Published 2008-12-01“…These may allow them to give vent to self-expression, to deliver a testimony of their lives, to speak for themselves when their job places them in a position of mouthpiece for other, fictitious, people’s lives. …”
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10631
Mitochondria as a Therapeutic Target: Focusing on Traumatic Brain Injury
Published 2025-01-01“…Furthermore, mitochondrial metabolism produces signaling molecules such as reactive oxygen species (ROS), regulating calcium levels and controlling the expression profile of intrinsic pro-apoptotic effectors influenced by TBI. …”
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10632
Simultaneous Optimization of Train Timetabling and Platforming Problems for High-Speed Multiline Railway Network
Published 2021-01-01“…The construction of a set of incompatible vertexes and links facilitates the expression of difficult constraints. Finally, example results verify the validity and practicability of our proposed method, which can generate conflict-free train timetables with a station track allocation plan for multiple railway lines at the same time.…”
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10633
Forced to Reimagine: Reflections on the Experience of Leicester Vaughan College Community Benefit Society
Published 2025-01-01“…This response was not only an expression of resistance, but it was an antidote to the neoliberal university system, which all too often undervalues adult education, marginalises adult learners or excludes their education altogether. …”
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10634
Relatos Na e Da Literatura sobre as Barreiras ao Lazer das Mulheres
Published 2025-02-01“…Almeja-se que as conclusões deste estudo possam alimentar discussões e iniciativas que visem a criação de uma realidade mais inclusiva, que verdadeiramente permita que todas as mulheres, nas suas diversidades de possibilidades e expressão, desfrutem de experiências de lazer satisfatórias. …”
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10635
Discriminación y prejuicios de jóvenes sonorenses hacia el migrante indígena
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10636
A luta das mulheres indígenas na América Latina e a crise ambiental
Published 2023-01-01“…A partir de pesquisa bibliográfica (com a priorização dos trabalhos produzidos pelas mulheres indígenas) e documental (em referência aos documentos produzidos pelas diferentes expressões dos movimentos de mulheres indígenas na América Latina), buscamos investigar as contribuições e os caminhos apontados por tais movimentos para a crítica radical ao modelo de desenvolvimento vigente. …”
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10637
Long term efficacy and safety of Lorlatinib in ALK-positive non-small cell lung cancer: A case report
Published 2025-03-01“…Background: Anaplastic lymphoma kinase (ALK) rearrangement is a key oncogenic driver promoting the expression of ALK protein in non-small cell lung cancer (NSCLC). …”
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10638
La ley y el orden. La libertad de imprenta en Buenos Aires durante la década de 1850
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10639
Analyzing the Impact of Ambient Temperature Indicators on Transformer Life in Different Regions of Chinese Mainland
Published 2013-01-01“…The analysis result is applicable to the area where the temperature characteristics are similar to Chinese mainland, and the expressions obtained can be applied to the other locations that are not included in this paper if these three indicators are known.…”
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10640
Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases
Published 2015-01-01“…Most chronic liver diseases (CLDs) are characterized by inflammatory processes with aberrant expressions of various pro- and anti-inflammatory mediators in the liver. …”
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