Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study by Martin Wurtele, Camila Coelho, Gloria Gallo, Claudia Campos, Leon Hardy, Yunierkis Perez Castillo, Masamitsu Moriwaki, Mahendra P. Kapoor, Damião Pergentino de Sousa

“…To address the serious challenge of COVID-19, we have performed biochemical inhibition screens with recombinantly expressed SARS-CoV-2 main protease (Mpro). A fluorescent assay was used to identify the flavonoid isoquercitrin as an Mpro inhibitor. …”
Get full text

Rethinking the <i>Unio Mystica</i>: From McGinn to Ibn ʿArabī by Arjun Nair

“…Although this research serves as a promising start to the dialogue among scholars, it has also raised many questions about a “shared moment” that is nevertheless expressed in “irreducibly diverse” and distinct ways in each tradition. …”
Get full text

Treatment of tardive dyskinesia caused by long-term antipsychotic use: case reports and literature review by I. Pabarčiūtė, M. Karnickas

“…A 43-year-old woman with paranoid schizophrenia was hospitalized in 2018 due to constant involuntary movements of the whole body, especially expressed for ~2 years. The patient had been taking antipsychotics for about 20 years, the first dyskinetic movements were observed ~10 years ago (various jerks) and described in 2014 (champing). …”
Get full text

The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions by Ivan Lobov, Natalia Mikhailova

“…Dll4 is most prominently expressed in the endothelium of angiogenic blood vessels and in quiescent arteries and capillaries in all tissues and organs of the mammalian species, and it is the key regulator of blood vessel sprouting. …”
Get full text

Wnt1 Accelerates an Ex Vivo Expansion of Human Cord Blood CD34+CD38− Cells by Kamonnaree Chotinantakul, Patcharee Prasajak, Wilairat Leeanansaksiri

“…The expanded cells exhibited CD34+ CD38− CD133+ CD71low CD33low CD3− CD19− markers, expressed nanog, oct3/4, c-myc, and sox2 genes, and maintained differentiation potential into lymphoid, erythroid and myeloid lineages. …”
Get full text

Nonlinear Radial Consolidation Analysis of Soft Soil with Vertical Drains under Cyclic Loadings by Pyol Kim, Hyong-Sik Kim, Yong-Gun Kim, Chung-Hyok Paek, Song-Nam Oh, Sung-Ryol So, Chang-Son Ok

“…By considering the nonlinear variations of compressibility and permeability expressed by the logarithm relations (e−log σ′ and e−log kh), the governing equation for nonlinear radial consolidation of the soil under equal strain and time-dependent loading is established. …”
Get full text

Discovery of Novel Leaf Rust Responsive microRNAs in Wheat and Prediction of Their Target Genes by Dhananjay Kumar, Dharmendra Singh, Pulkit Kanodia, Kumble Vinod Prabhu, Manish Kumar, Kunal Mukhopadhyay

“…One wheat specific novel miRNA was identified but could not be ascribed or assigned to any known miRNA family. Differentially expressed 22 miRNAs were found between susceptible and resistant wheat near-isogenic lines inoculated with leaf rust pathogen Puccinia triticina and compared with mock inoculated controls. …”
Get full text

A New Prognostic Indicator of Immune Microenvironment and Therapeutic Response in Lung Adenocarcinoma Based on Peroxisome-Related Genes by Zhen Xiong, Liwen Zhang, Wei Fan

“…In this study, we identified 47 differentially expressed peroxisome-related genes (PRGs), including 25 increased and 22 decreased PRGs. …”
Get full text

Need factors for utilisation of institutional delivery services in Nepal: an analysis from Nepal Demographic and Health Survey, 2011 by Vishnu Khanal, Andy H Lee, Rajendra Karkee

“…Similarly, the likelihood for facility delivery increased by 3.4-fold among women who prepared for at least two of the four activities compared to their counterparts who made no preparation (adjusted OR 3.41, 95% CI 2.01 to 5.58).Conclusions The perceived need, as expressed by the frequency of antenatal care visits and birth preparedness activities, plays an important role in institutional delivery service utilisation for Nepali women. …”
Get full text

Farmers and Agricultural Extension Officers Perception of Striga gesnerioides (Willd.) Vatke Parasitism on Cowpea in the Upper East Region of Ghana by Peter Haruna, Aaron T. Asare, Elvis Asare-Bediako, Francis Kusi

“…Both farmers and extension officers had very little knowledge on existence of S. gesnerioides resistant cowpea genotypes for cultivation. Farmers expressed the desire to cultivate Striga-resistant cowpea varieties when made accessible, since it is the most reliable and environmentally friendly method of controlling the parasitic weed.…”
Get full text

Perceptions and expectations of parents regarding their position in a French NICU: quantitative and qualitative approaches by Véronique Thébaud, Jacques Sizun, Magdalini Dargentas

“…In both studies, however, they expressed that they had expected to be better informed about their child’s condition and more involved in medical decision-making. …”
Get full text

Peculiarities of the molecular composition of heterochromatin associated with pronucleoli in mouse embryos by I. O. Bogolyubova, Z. K. Sailau, D. S. Bogolyubov

“…Anti-actin immunocytochemical labeling is most expressed at the two-cell cleavage stage after activation of the embryonic genome. …”
Get full text

Rectal Application of Ozone to Patients with Diabetes Mellitus by Omar Morejón Barroso, Imandra María García Menéndez, Leticia Varela Castro, Ernesto Julio Bernal Valladares

“…The results found were expressed mainly through tables and graphs as the main resources of the statistical language. …”
Get full text

ISLAMIC ECONOMY IN «ISLAMIC STATE»: IS IT POSSIBLE? by R. I. Bekkin

“…Considering the practice of application of Islamic economic principles by the IS, the author of the article develops the thesis expressed in his earlier publications that there is no single universal Islamic economic doctrine that could be applied with some modifications in any society and in any jurisdiction. …”
Get full text

Modifiable Coronary Risk Factors and Global Cardiovascular Risk by Julio Armando Sánchez Delgado, Nailé Edita Sánchez Lara

“…The coexistence of three or more risk factors affected 29 individuals (43.2 %) and expressed a higher risk (RR = 0.76 IC95 % [0.54, 1.07]). …”
Get full text

Amylin: Localization, Effects on Cerebral Arteries and on Local Cerebral Blood Flow in the Cat by Lars Edvinsson, Peter J. Goadsby, Rolf Uddman

“…Immunocytochemistry revealed that numerous nerve cell bodies in the trigeminal ganglion contained CGRP immunoreactivity (-ir); some of these also expressed amylin-ir but none adrenomedullin-ir. There were numerous nerve fibres surrounding cerebral blood vessels that contained CGRP-ir. …”
Get full text

Discrimination perceived by patients being monitored for COVID-19. Tajamar Regalado, Ecuador by Melba Esperanza Narváez Jaramillo, Cinthya Lizeth Pantoja Narváez, Julio Rodrigo Morillo Cano, Sara Ximena Guerrón Enríquez

“…Almost half of the patients expressed having received very bad social support, and 51.68% received bad social support from the authorities in particular.…”
Get full text

Women Architects and Their Works in the Autonomous Region of Madrid, 1978-2008 by María Elia Gutiérrez Mozo, Sofía Parker San José

“…Thirdly, an evaluation based on a qualitative approach of these works, the account of their differential features, and the identification of the very interests that women architects expressed through them. To this end, a methodology is implemented that includes the collection of bibliographic sources, a call to the architects to invite them to submit their projects and field work, by visiting and collecting data from most of the works. …”
Get full text

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach by Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia

“…We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal islets. …”
Get full text

Multidisciplinary and Nonpharmacological Management of Pain in Temporomandibular Disorders (TMDs) by Elżbieta Kubala, Danuta Lietz–Kijak, Paulina Strzelecka, Aneta Wieczorek, Piotr Skomro, Helena Gronwald

“…Treatment using ELF-MF and ELF-MF in combination with LED light in the course of TMD brings about a significant improvement in the subjective pain experience expressed in VAS pain scores. The use of selected physical stimuli and their beneficial effect on pain symptoms during mandibular movements has important implications for patients’ daily life and work. …”
Get full text