H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts by Wilhelm Bouchereau, Hong-Thu Pham, Worawalan Samruan, Van-Hong Vu, Thierry Joly, Marielle Afanassieff, Pierre Savatier, Rangsun Parnpai, Nathalie Beaujean

“…These distinct distribution patterns correlate with high expression levels of methyltransferases (EHMT1, EHMT2, SETDB1) and deacetylases (HDAC1, HDAC2, HDAC5) in expanding blastocysts. …”
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mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections by Lijun Fang, Huaijun Tu, Wei Guo, Shixuan Wang, Ting Xue, Fei Yang, Xiaoyan Zhang, Yazhi Yang, Qian Wan, Zhexin Shi, Xulong Zhan, Jian Li

“…When compared to WT mice, we found higher mortality, greater numbers of bacteria, decreased expression of coactivators in monocytes, increased numbers of Tregs, and decreased numbers of effector T cells in TSC1 KO mice. …”
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Anti-Inflammatory, Antioxidant and Antibacterial Properties of Tomato Skin and Pomegranate Peel Extracts: A Sustainable Approach for Oral Health Care by Alessia Silla, Angela Punzo, Francesca Bonvicini, Matteo Perillo, Marco Malaguti, Antonello Lorenzini, Ismaela Foltran, Dario Mercatante, Mara Mandrioli, Maria Teresa Rodriguez-Estrada, Silvana Hrelia, Cristiana Caliceti

“…After 24 h of treatment with PPE, HP, and MW, significant antioxidant activity and an increased Superoxide Dismutase 1 expression (<i>p</i> < 0.01) were observed. Additionally, the extracts significantly reduced the expression of tumor necrosis factor α (<i>p</i> < 0.05) and Monocyte Chemoattractant Protein 1 (<i>p</i> < 0.001), suggesting an anti-inflammatory role. …”
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Phytochemicals of Vitis vinifera L. var. King Ruby protect mice from benzo(a)pyrene-induced lung injury by Gehad S. Ahmedy, Hend M. Selim, Mona El-Aasr, Souzan M. Ibrahim, Suzy A. El-Sherbeni

“…The anti-inflammatory effects were confirmed by the downregulation of cyclooxygenase-2 (COX-2) and CD34, alongside reduced nuclear factor-kappa B (NF-κB) expression. Antioxidant activity was indicated by decreased malondialdehyde (MDA) levels and inducible nitric oxide synthase (iNOS) expression with the remarkable increase in glutathione (GSH). …”
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Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways by Jing Huang, Lei Li, Liyan Xu, Lixin Feng, Yuxin Wang, Attila Gabor SIK, Meng Jin, Rongchun Wang, Kechun Liu, Xiaobin Li

“…The results showed that MBD could regulate the TLR/NF-κB pathways by inhibiting the mRNA expression of <i>TNF-α</i>, <i>NF-κB</i>, <i>IL-1</i>, <i>IL-1β</i>, <i>IL6</i>, <i>AP1</i>, <i>IFNγ</i>, <i>IKKβ</i>, <i>MyD88</i>, <i>STAT3</i>, <i>TRAF1</i>, <i>TRAF6</i>, <i>NLRP3</i>, <i>NOD2</i>, <i>TLR3</i> and <i>TLR4</i>, and promoting the mRNA expression of <i>IL4</i>, <i>IκBα</i> and <i>Bcl-2.…”
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Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis by Yingjie Li, Xinran Yu, Peng Li, Xin Li, Lushan Wang

“…VaRyhB also functions to inhibit the expression of genes involved in Fe-S assembly and the TCA cycle. …”
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High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells by Hong Feng, Junling Gu, Fang Gou, Wei Huang, Chenlin Gao, Guo Chen, Yang Long, Xueqin Zhou, Maojun Yang, Shuang Liu, Shishi Lü, Qiaoyan Luo, Yong Xu

“…We found that the expression of thioredoxin-interacting protein (TXNIP), NLRP3, and IL-1β was observed by immunohistochemistry in vivo. …”
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Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway by Xiaohong Wang, Yong Han, Jian Liu, Yingzhe Zhang, Kai Cheng, Jiwei Guo, Qingqun Guo, Song Liu, Hongguang Sun, Yitong Hua, Guoqiang Zhang, Shujian Xu, Fengli Guo, Zhenlin Yang

“…The analysis of the exosomal transcriptome expression difference between PCM and normal mammary tissues using RNA-Seq showed the differential genes and enrichment pathways involved in the course of PCM. …”
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Melatonin Rescued Reactive Oxygen Species-Impaired Osteogenesis of Human Bone Marrow Mesenchymal Stem Cells in the Presence of Tumor Necrosis Factor-Alpha by Xianjian Qiu, Xudong Wang, Jincheng Qiu, Yuanxin Zhu, Tongzhou Liang, Bo Gao, Zizhao Wu, Chengjie Lian, Yan Peng, Anjing Liang, Peiqiang Su, Dongsheng Huang

“…In our study, we demonstrate that melatonin can counteract the generation of ROS and the inhibitory osteogenesis of BMSCs induced by TNF-α, by upregulating the expression of antioxidases and downregulating the expression of oxidases. …”
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Composition analysis and mechanism of Guizhi Fuling capsule in anti-cisplatin-resistant ovarian cancer by Lei Dou, Yan Yan, Enting Lu, Fangmei Li, Dongli Tian, Lei Deng, Xue Zhang, Rongjin Zhang, Yin Li, Yi Zhang, Ye Sun

“…Methods: First, differences in cisplatin resistance, PA2G4 gene expression, migration, and invasion in A2780 cells and A2780/DDP cells were analyzed by qRT-PCR, scratch assay, transwell, immunofluorescence, and western blotting. …”
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Ecdysone receptor strongly influences larval–pupal–adult transition and melanization in Tuta absoluta by Xiaodi Wang, Jiajia Wu, Jianyang Guo, Nianwan Yang, Fanghao Wan, Zhichuang Lü, Wanxue Liu

“…Results The full-length cDNA of T. absoluta TaEcR was 1859 bp, and the coding region including the ZnF_C4 and HOLI domains was relatively conserved. The relative expression of EcR in the early pupal stage was substantially higher than that in the other instars. …”
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Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD by Seong Mi Lee, Yura Choi, Dayeon Kim, Ha Jin Jeong, Young Ho Do, Sohee Jung, Bomee Lee, Hyung Jun Choi, Suhyeon Kim, Jung-Min Oh, Songhee Jeon, Jinju Han, Yeni Kim

“…We observed that phosphorylation of SYNAPSIN, PSD95, ERK and CREB, as well as the expression of CDK5, were reduced in the brains of Clcn4 KO mice. …”
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HGF-Modified Dental Pulp Stem Cells Mitigate the Inflammatory and Fibrotic Responses in Paraquat-Induced Acute Respiratory Distress Syndrome by Panpan Geng, Yuning Zhang, Huan Zhang, Xiwen Dong, Yuefeng Yang, XiaoNa Zhu, Chu-Tse Wu, Hua Wang

“…The results showed that MSCs’ supernatant could suppress the expression of proinflammatory and profibrotic cytokines and increase the expression of anti-inflammatory and antifibrotic cytokines in BEAS-2B cells and human pulmonary fibroblast MRC-5. …”
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Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia by Shasha Wu, Tailian Xue, Yilin Li, Weikang Chen, Yan Ren

“…Crossover genes were identified using weighted gene co-expression network analysis (WGCNA) and differential expression genes (DEGs) analysis. …”
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Analysis of MLKL, RIP1 and RIP3 Immunostaining Markers in Human Liver Tissue from Fatal Yellow Fever Cases: Insights into Necroptosis by Vanessa do Socorro Cabral Miranda, Luiz Fabio Magno Falcão, Hellen Thais Fuzii, Marcos Luiz Gaia Carvalho, Jeferson da Costa Lopes, Arnaldo Jorge Martins Filho, Ana Cecilia Ribeiro Cruz, Raimunda do Socorro da Silva Azevedo, Jorge Rodrigues de Sousa, Mayumi Duarte Wakimoto, Pedro Fernando da Costa Vasconcelos, Juarez Antônio Simões Quaresma

“…In this study, we investigated the expression and correlation of necroptosis markers MLKL, RIP1 and RIP3 in human liver tissue from fatal cases of yellow fever (YF) using immunohistochemistry (IHC). …”
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Dairy Foods in a Moderate Energy Restricted Diet Do Not Enhance Central Fat, Weight, and Intra-Abdominal Adipose Tissue Losses nor Reduce Adipocyte Size or Inflammatory Markers in... by Marta D. Van Loan, Nancy L. Keim, Sean H. Adams, Elaine Souza, Leslie R. Woodhouse, Anthony Thomas, Megan Witbracht, Erik R. Gertz, Brian Piccolo, Andrew A. Bremer, Michael Spurlock

“…No diet differences were observed in weight, fat, or IAAT loss; nor SAT mRNA expression of inflammation, circulating cytokines, fasting lipids, glucose, or insulin. …”
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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy by Gao Y, Li L, Zhao F, Cheng Y, Jin M, Xue FS

“…Neurological and sensorimotor function, cerebral infarct volume, histopathological changes, mitochondrial morphological changes, and apoptosis of ischemic brain tissues were assessed in the presence or absence of esketamine and the autophagy inducer rapamycin. The expression of biomarkers related to microglial M1 and M2 phenotypes in the ischemic brain tissues was determined by immunofluorescence staining and RT-qPCR, and the expression of proteins associated with autophagy and the AKT signaling pathway in the ischemic brain tissues was assayed by Western blotting.Results: Esketamine alone and esketamine combined with rapamycin alleviated neurological impairment, improved sensorimotor function, decreased cerebral infarct volume, and mitigated tissue injury in the MCAO rats. …”
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Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites by Yun Teng, Chao Luo, Xiaolan Qiu, Jingyao Mu, Mukesh K. Sriwastva, Qingbo Xu, Minmin Liu, Xin Hu, Fangyi Xu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Maiying Kong, Zhanxu Liu, Xiang Zhang, Raobo Xu, Jun Yan, Michael L. Merchant, Craig J. McClain, Huang-Ge Zhang

“…An increased level of circulating DHA inhibits PD-L1 expression in tumor cells by binding the PD-L1 promoter and subsequently prevents c-myc-initiated transcription of PD-L1. …”
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Atypical Metastases from Prostate Cancer: Alpha-Methylacyl-Coenzyme A Racemase (AMACR) as a Potential Molecular Target in Prostate-Specific Membrane Antigen-Negative Prostate Adeno... by Ilham Badrane, Angelo Castello, Matteo Brunelli, Corrado Cittanti, Sara Adamantiadis, Ilaria Bagni, Noemi Mindicini, Federica Lancia, Massimo Castellani, Licia Uccelli, Mirco Bartolomei, Luca Urso

“…Moreover, 2-deoxy-2-[18F]fluoro-D-glucose ¹⁸F-FDG PET usually shows metastases in the late stages of disease, when dedifferentiated neoplastic clones lose PSMA expression. In some cases, PCa patients may present atypical sites of metastases, with uncommon appearance at PET imaging with different radiotracers. …”
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YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment by Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen

“…Mechanistically, OXA upregulated YTHDF2 expression by activating the cGAS-STING signaling pathway and consequently enhanced the therapeutic outcomes of immunotherapeutic interventions. …”
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