The role of MRO as an M2 macrophage-associated gene in non-small cell lung cancer: insights into immune infiltration, prognostic significance, and therapeutic implications by Yue Gu, Miaosen Zheng, Jing Xie

“…Single-cell analysis confirmed MRO expression in macrophages. The ESTIMATE algorithm showed positive correlations between MRO expression and immune scores. …”
Get full text

Identification of Crucial lncRNAs for Luminal A Breast Cancer through RNA Sequencing by Xinjian Jia, Hai Lei, Xuemei Jiang, Ying Yi, Xue Luo, Junyan Li, Yu Chen, Sha Liu, Chengcheng Yang

“…The growing body of evidence indicates aberrant expression of long noncoding RNAs (lncRNAs) in breast cancer. …”
Get full text

Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer by Elena Lastraioli, Jessica Iorio, Francesco Piazza, Chiara Capitani, Michele Santillo, Claudia Duranti, Simonetta Bianchi, Icro Meattini, Scott P. Fraser, Mustafa B. A. Djamgoz, Andrea Becchetti, Annarosa Arcangeli

“…The co-expression proteins emerged from the immunohistochemistry analysis. …”
Get full text

Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway by Yue He, Chao Huang, Jingjing Chen, Weizeng Shen

“…Materials and methods: Our study first screened for differentially expressed microRNAs (miRNAs) associated with AS using the Gene Expression Omnibus (GEO) public database at the National Center for Biotechnology Information (NCBI) and R language software. …”
Get full text

Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma by Annika L. Gustafson, Annika L. Gustafson, Annika L. Gustafson, Adam D. Durbin, Kristin B. Artinger, Heide L. Ford, Heide L. Ford, Heide L. Ford

“…Regardless of subtype, RMS resembles embryonic skeletal muscle as it expresses the myogenic regulatory factors (MRFs), MYOD1 and MYOG. …”
Get full text

Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque by Tingfu Du, Shuaiyao Lu, Qinfang Jiang, Yun Li, Kaili Ma

“…Expression change in tryptophan metabolism pathway was also found in this study which may be associations with diabetes. …”
Get full text

MicroRNAs in Autoimmune Sjögren’s Syndrome by Seunghee Cha, Mahmoud Mona, Kyung Eun Lee, Dong Hee Kim, Kyudong Han

“…MicroRNAs (miRNAs), small non-coding RNAs, have been implicated in various diseases and cellular functions as microregulators of gene expression. Although the history of miRNA investigation in autoimmune Sjögren’s syndrome (SjS) is fairly short, a substantial amount of data has already been accumulated. …”
Get full text

Genome-Wide Analyses of MADS-Box Genes Reveal Their Involvement in Seed Development and Oil Accumulation of Tea-Oil Tree (Camellia oleifera) by Xianzhi Zhang, Wenliang He, Xinyi Wang, Yongliang Duan, Yongjuan Li, Yi Wang, Qingbin Jiang, Boyong Liao, Sheng Zhou, Yongquan Li

“…In this study, evolutionary and expression analyses of the MADS-box gene family were performed across the C. oleifera genome for the first time. …”
Get full text

Role of HNF6 in liver homeostasis and pathophysiology by Miaomiao Tian, Weizhen Gao, Shujun Ma, Huiling Cao, Yu Zhang, Fuxiang An, Jianni Qi, Zhen Yang

“…Abstract Background Hepatocyte nuclear factor 6 (HNF6), a member of the HNF family, contains single cleft and homologous domains, which form a DNA-binding region that targets the promoter regions of genes that bind to liver-specific genes and regulate their expression. Furthermore, HNF6 is highly expressed as an HNF in the liver. …”
Get full text

lncRNA PAPPA-AS1 Induces the Development of Hypertrophic Scar by Upregulating TLR4 through Interacting with TAF15 by Pengju Fan, Yongjie Wang, Jingjing Li, Man Fang

“…The expression levels of TLR4, MyD88, TGF-β1, collagen I, collagen III, and α-SMA were greatly elevated in HTsFb cells. …”
Get full text

Combinations of TLR Ligands: A Promising Approach in Cancer Immunotherapy by Saskia Stier, Claudia Maletzki, Ulrike Klier, Michael Linnebacher

“…Toll-like receptors (TLRs), a family of pattern recognition receptors recognizing molecules expressed by pathogens, are typically expressed by immune cells. …”
Get full text

Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics by Simin Luo, Yuhong Zhu, Zhanli Guo, Chuan Zheng, Xi Fu, Fengming You, Xueke Li

“…External datasets confirmed from both mRNA and protein expression levels that low COX11 expression was significantly associated with poor CRC prognosis. …”
Get full text

circSPECC1 Promotes Proliferation and Migration of LNCaP Prostate Cancer Cells by Affecting Their Epithelial-Mesenchymal Transition by Fangmei Xie, Jian Shen, Zeping Han, Wenfeng Luo, Liyin Liao, Jinhua He

“…Stable circSPECC1 shRNA-expressing and circSPECC1-overexpressing LNCaP cell lines were constructed, and relative gene expression levels were determined by RT-PCR. …”
Get full text

Dexmedetomidine Mitigates Microglial Activation Associated with Postoperative Cognitive Dysfunction by Modulating the MicroRNA-103a-3p/VAMP1 Axis by Zhichao Wu, Han Wang, Zuan Shi, Yalan Li

“…Dexmedetomidine treatment markedly inhibited LPS-induced inflammation and the expression of VAMP1, and miR-103a-3p expression reversed this inhibition. …”
Get full text

Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson’s Disease by Wei Quan, Jia Li, Li Liu, Qinghui Zhang, Yidan Qin, Xiaochen Pei, Jiajun Chen

“…We analyzed the differentially expressed genes and function enrichment analysis of the two sets of data and found that the expression of the m6A-modification gene HNRNPC was significantly downregulated in the PD group, and it played an important role in DNA metabolism, RNA metabolism, and RNA processing and may be involved in PD. …”
Get full text

Multiplexed transcriptomic analyzes of the plant embryonic hourglass by Hao Wu, Ruqiang Zhang, Karl J. Niklas, Michael J. Scanlon

“…In contrast, comparisons of embryonic gene expression among different animal phyla describe an inverse hourglass pattern, where expression is correlated during early and late stages but not during mid-embryo development. …”
Get full text

TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma by Sheng Cheng, Jutang Li, Ming Xu, Qun Bao, Jiaoxiang Wu, Peng Sun, Bo Han

“…We analyzed TMEM147 expression in HCC by using the Wilcoxon rank-sum test. …”
Get full text

Construction and Investigation of MicroRNA-mRNA Regulatory Network of Gastric Cancer with Helicobacter pylori Infection by Ping Yang, Junjie Liu, Tianci Yang, Lei Zhang, Peiyou Gong, Boqing Li, Xiuzhi Zhou

“…We identified differentially expressed microRNAs (DEMs) and genes (DEGs) from the Gene Expression Omnibus (GEO) dataset, constructed microRNA-(miRNA-)mRNA expression networks, analyzed the function and signal pathway of cross-genes, analyzed the relations between cross-genes and GC prognosis with the Cancer Genome Atlas (TCGA) data, and verified the expression of cross-genes in patients with H. pylori infection. …”
Get full text

A transcriptional profile of aging in the human kidney. by Graham E J Rodwell, Rebecca Sonu, Jacob M Zahn, James Lund, Julie Wilhelmy, Lingli Wang, Wenzhong Xiao, Michael Mindrinos, Emily Crane, Eran Segal, Bryan D Myers, James D Brooks, Ronald W Davis, John Higgins, Art B Owen, Stuart K Kim

“…In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. …”
Get full text

Ferroptosis-Related Transcriptional Level Changes and the Role of CIRBP in Glioblastoma Cells Ferroptosis by Zijiang Yang, Ting Zhang, Xuanlin Zhu, Xiaobiao Zhang

“…Background/Objective: We aimed to elucidate the roles of ferroptosis-associated differentially expressed genes (DEGs) in glioblastoma and provide a comprehensive resource for researchers in the field of glioblastoma cell ferroptosis. …”
Get full text