Effects of TGF-β3 on meniscus repair using human amniotic epithelial cells by Yupeng He, Ya Li, Xiaodong Zhi, Yuqiang Zhang, Wei Wang

“…Results Routine transcriptome analysis confirmed that TGF-β3 induced the differentiation of amniotic epithelial cells (hAECs) into fibrochondrocytes through the Wnt signaling pathway. …”
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The effects of obesity on surgical complications and postoperative prognosis of epithelial ovarian cancer: a meta-analysis by Jingjing Sheng, Chu Li, Jiali Zhang, Zujian Jin, Yun Xiao Zhou, Yiping Huang

“…Results 14 studies with 4858 cases of proven epithelial ovarian cancer who underwent extensive surgery were included. …”
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Enhanced Analytical Performance in CYFRA 21-1 Detection Using Lateral Flow Assay with Magnetic Bioconjugates: Integration and Comparison of Magnetic and Optical Registration by Artemiy M. Skirda, Alexey V. Orlov, Juri A. Malkerov, Sergey L. Znoyko, Alexandra S. Rakitina, Petr I. Nikitin

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Constitutive inflammation and epithelial-mesenchymal transition dictate sensitivity to nivolumab in CONFIRM: a placebo-controlled, randomised phase III trial by Dean A. Fennell, Kayleigh Hill, Min Zhang, Charlotte Poile, Sean Ewings, Essa Y. Baitei, Joanna Dzialo, Nada Nusrat, Jan Rogel, Daniel Faulkner, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Kim Mallard, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Liz Darlison, Peter Wells-Jordan, Cathy Richards, James Harber, Aleksandra Bzura, Jake Spicer, Catrin Pritchard, Tamihiro Kamata, Jens C. Hahne, Maymun Jama, Edward J. Hollox, Jason F. Lester, Jin-Li Luo, Zisen Zhou, Hongji Yang, Huiyu Zhou, Astero Klampatsa, Gareth O. Griffiths

“…B-cell infiltration correlated with pro-inflammatory chemokines including IL24 and CCL19. Conversely, epithelial-mesenchymal transition and mitosis were associated with resistance to nivolumab. …”
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Ocular surface changes and corneal epithelial remodeling after cataract surgery in patients with type 2 diabetes: a case-control study by Emilia Koestel, Léa Dormegny, Arnaud Sauer, David Gaucher, Tristan Bourcier

“…Study registration NCT06638424; 2024-10-09 (retrospectively registered).…”
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Robot-assisted versus video-assisted thoracoscopic thymectomy for stage I–II thymic epithelial tumour: a protocol for the first multicentre, randomised controlled clinical trial by Bin Wu, Jian Gao, Yu Qi, Xinyu Yang, Shuai Wang, Lijie Tan, Fei Liang, Yong-Qiang Ao, Junkan Zhu, Zhenguo Sun, Jiahao Jiang, Yuansheng Zheng, Xifei Jiang, Weiming Yue, Jianyong Ding

“…All data and findings will be disseminated and published through peer review.Trial registration number NCT06654830.…”
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Spheroid morphology of lung cancer cell lines correlates with oncological profiles by Kaido Oishi, Keitaro Matsumoto, Shintaro Hashimoto, Fumitake Uchida, Ryosuke Hara, Masato Nishimuta, Takamune Matsumoto, Mayumi Iwatake, Koichi Tomoshige, Ryoichiro Doi, Ryusuke Machino, Tomohiro Obata, Takeshi Nagayasu

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Safety and Proof-of-Concept Study of Oral QLT091001 in Retinitis Pigmentosa Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acylt... by Hendrik P N Scholl, Anthony T Moore, Robert K Koenekoop, Yuquan Wen, Gerald A Fishman, L Ingeborgh van den Born, Ava Bittner, Kristen Bowles, Emily C Fletcher, Frederick T Collison, Gislin Dagnelie, Simona Degli Eposti, Michel Michaelides, David A Saperstein, Ronald A Schuchard, Claire Barnes, Wadih Zein, Ditta Zobor, David G Birch, Janine D Mendola, Eberhart Zrenner, RET IRD 01 Study Group

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Modern trends in diagnostics and prediction of results of anti-vascular endothelial growth factor therapy of pigment epithelial detachment in neovascular agerelated macular degener... by E. V. Kozina, S. N. Sakhnov, V. V. Myasnikova, E. V. Bykova, L. E. Aksenova

“…Modern technologies of spectral optical coherence tomography make it possible to evaluate detailed quantitative parameters of pigment epithelium detachment, such as height, width, maximum linear diameter, area, volume and refl ectivity within the detachment.Groups of Russian and foreign authors identify various biomarkers recorded on optical coherence tomography images. Dynamic registration of such biomarkers expands the ability of clinicians to predict morphological changes in pigment epithelial detachment during anti-VEGF therapy, as well as to optimize treatment regimens to prevent complications in the form of pigment epithelium tear leading to a decrease in visual acuity.Modern methods of deep machine learning and the use of neural networks allow achieving higher accuracy in diff erentiating the types of retinal fluids and automating the quantitative determination of fl uid under the pigment epithelium. …”
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The use of free buccal pad fat graft as a viable therapeutic modality in localized gingival recession: a randomized controlled clinical trial by Reham Abdel-Fatah, Ayman Elkashty, Hesham El-Sharkawy

“…Therefore, this randomized clinical trial (RCT) was conducted to assess the effectiveness of the free buccal fat pad graft (FBPFG) compared to the de-epithelialized free gingival graft (DFGG) in conjunction with coronally advanced flap (CAF) in localized gingival recession treatment. …”
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Bowman’s layer and corneal thickness in health and disease by Yalin Zheng, Vito Romano, Stephen B Kaye, Luca Pagano, Rose Herbert, Alexander Undan, Andrea Madden, Yaochun Shen, Alfredo Borgia, Matteo Posarelli, Tom Sharp

“…The ratio of BT to CCT was independent of diagnosis (CD 0.028, HC 0.030, KC 0.028, p=0.88), age (p=0.23), sex (p=0.67), Kmax (p=0.77) or epithelial thickness (p=0.72).Conclusions Over sample populations of healthy, keratoconic and dystrophic corneas, central BT was consistently associated with corneal thickness and was independent of age, sex, Kmax, and epithelial thickness.Trial registration number ISRCTN40558.…”
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Perceptions of chemoprevention among individuals at high risk of oral cancer: qualitative study within the UK-based SAVER trial by Bridget Young, J Perry, Caroline McCarthy, Stefano Fedele, R Shaw, Frances Sherratt, Albert Jiménez-Tomàs, R Kuruvilla, M W Ho, M Daunt, S Moorhouse

“…We provide recommendations to support staff during recruitment and enhance individuals’ experience of the trial.Trial registration number ISRCTN12448611; Pre-results.…”
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Varenicline Nasal Spray for the Treatment of Dry Eye Disease Following Corneal Collagen Crosslinking by Tanner J. Ferguson, David Durgan, Travis Whitt, Russell J. Swan

“…There was a directional trend toward faster mean change of epithelial healing in the study group, but the difference was not statistically significant at any time point. …”
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Supplementary zinc and vitamin D in management of symptomatic oral lichen planus: a three-arm randomized clinical trial by Alaa Aboushousha, Yasmine Kamal, Shereen Ali

“…Date of Initial Clinical Trial Registration: 4 February 2021.…”
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Effects of Stress, Vagal Nerve Stimulation and Disease Activity on Circulating Cytokines, Quantified by an Ultrasensitive Technique, in Ulcerative Colitis: A Pilot Study by Tamara Mogilevski, Melinda Y. Hardy, Kazuya Takahashi, Rebecca Smith, Anke L. Nguyen, Adam Farmer, James O. Lindsay, Jason A. Tye‐Din, Qasim Aziz, Peter R. Gibson

“…For stress/vagal‐stimulation studies, epithelial injury was quantified by plasma concentrations of intestinal‐type fatty acid‐binding protein. …”
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Evaluating elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta™) for treatment of patients with non-cystic fibrosis bronchiectasis (NCFBE): A clinical study protocol. by Colin E Swenson, William R Hunt, Candela Manfredi, Diana J Beltran, Jeong S Hong, Brian R Davis, Shingo Suzuki, Cristina Barillá, Andras Rab, Cynthia Chico, Joy Dangerfield, Ashleigh Streby, Erin Barton, Elizabeth M Cox, Arlene A Stecenko, Adrianna Westbrook, Rebecca Kapolka, Eric J Sorscher

“…<h4>Trial registration</h4>This trial is registered at clinicaltrials.gov (Identifier: NCT05743946. …”
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Effect of TiO2 Abutment Coatings on Peri-Implant Soft Tissue Behavior: A Systematic Review of In Vivo Studies by Nagat Areid, Faleh Abushahba, Sini Riivari, Timo Närhi

“…Establishing a proper soft tissue adhesion around the implant abutment is essential to prevent microbial invasion, inhibit epithelial downgrowth, and obtain an optimal healing process. …”
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Randomized controlled trial on corneal denervation, neuroinflammation and ocular surface in corneal lenticule extraction for advanced refractive correction (CLEAR) and small incisi... by Mingyi Yu, Chang Liu, Isabelle Xin Yu Lee, Victor Wei-Tse Hsu, Regina Kay Ting Wong, Ansa Anam, Rong Lim, Jodhbir S. Mehta, Yu-Chi Liu

“…Corneal nerve metrics did not restore even at 1 year for both procedures. Trial registration number: ClinicalTrials.gov NCT06774651, registration on 14 January 2025, https://clinicaltrials.gov/study/NCT06774651 .…”
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Effect of high and low molecular weight sodium hyaluronic acid eye drops on corneal recovery after crosslinking in keratoconus patients by Gamze Özkan, Semra Akkaya Turhan, Ebru Toker

“…NI-TBUT was lower in the control group in the 6th and 12th months compared with the other groups.Conclusions The use of artificial tear drops containing HMW-HA may have a therapeutic effect to promote corneal nerve regrowth and support faster functional recovery after CXL.Trial registration number NCT06243991.…”
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A prospective multicenter phase III clinical trial evaluating the efficacy and safety of silk elastin sponge in patients with skin defects by Eiichi Sawaragi, Michiharu Sakamoto, Yasuhiro Katayama, Shingo Kawabata, Satoshi Somamoto, Kazuo Noda, Naoki Morimoto

“…Abstract Silk elastin sponge, a novel recombinant protein used for wound healing, has been shown to be effective in promoting macrophage migration, epithelial growth, granulation, and angiogenesis in both preclinical (in vitro and in vivo) and clinical studies. …”
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