Development of an Enzyme-Linked Immunosorbent Assay Method for the Detection of Rhein in Rheum officinale by Min Chen, Tie-Gui Nan, Jie Xin, Li Cui, Bo Zhang, Xiao Wang, Bao-Min Wang

“…First, a specific and sensitive monoclonal antibody (mAb) against rhein was produced from a stable hybridoma cell line, 1F8, generated by the fusion of mouse myeloma sp2/0 with spleen cells obtained from a Bal b/c mouse immunized with rhein-BSA. …”
Get full text

Microscopic Defect Detection on Aircraft Engine Blades via Improved YOLOv8 by Yujie Jiang, Ping Li, Bing Lin, Yingying Wang, Tian Li, Hui Xue, Weidong Liu, Zaihu Han, Dan Wang, Junlei Tang

“…Subsequently, we propose an efficient lightweight YOLOv8 framework, incorporating a hierarchical feature fusion module MS-Block for better multi-scale integration, as well as an Efficient Multi-Scale Attention (EMA) and Dilation-wise Residual (DWR) modules to enhance the detection of small targets and replace the loss function with Inner-IoU. …”
Get full text

Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones: A Diagnostic and Therapeutic Challenge by Ambra Di Veroli, Alessandro Micarelli, Mariagiovanna Cefalo, Eleonora Ceresoli, Daniela Nasso, Laura Cicconi, Simone Mauramati, Fabrizio Ottaviani, Adriano Venditti, Sergio Amadori

“…This variety of AML harbors t(8;21) in up to 20–25% of cases (especially in children and black ones of African origin) and, at a molecular level, it is characterized by the generation of a fusion gene known as RUNX1-RUNX1T1. Approximately 10% of M2 AML patients will develop GS, as a consequence, the t(8;21) and the relative transcript represent the most common cytogenetic and molecular abnormalities in GS. …”
Get full text

Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant by Yan Zhou, Ting Zhang, Zhirong Wang, Xuemei Xu

“…We have previously developed an HPV 16 DNA vaccine encoding a modified E7/HSP70 (mE7/HSP70) fusion protein, which demonstrated significant antitumor effects in murine models. …”
Get full text

Numerical Simulations as Tool to Predict Chemical and Radiological Hazardous Diffusion in Case of Nonconventional Events by J.-F. Ciparisse, A. Malizia, L. A. Poggi, O. Cenciarelli, M. Gelfusa, M. C. Carestia, D. Di Giovanni, S. Mancinelli, L. Palombi, C. Bellecci, P. Gaudio

“…The aim of this paper is to show how CFD calculations can help to understand the time evolution of two possible CBRNe (Chemical-Biological-Radiological-Nuclear-explosive) events: (1) hazardous dust mobilization due to the interaction between a jet of air and a metallic powder in case of a LOVA (Loss Of Vacuum Accidents) that is one of the possible accidents that can occur in experimental nuclear fusion plants; (2) toxic gas release in atmosphere. …”
Get full text

Data-Driven Bearing Fault Diagnosis of Microgrid Network Power Device Based on a Stacked Denoising Autoencoder in Deep Learning and Clustering by Fast Search without Data Labels by Fan Xu, Xin Shu, Xin Li, Xiaodi Zhang

“…Therefore, it is necessary to manually select appropriate and sensitive models, such as time-frequency domain indicators and multimodel fusion, to build HIs in multiple steps, which is more complicated because sensitivity characteristics and suitable models are more representatives of bearing degradation trends. …”
Get full text

Constitutive activation of the Src-family kinases Fgr and Hck enhances the tumor burden of acute myeloid leukemia cells in immunocompromised mice by Sherry T. Shu, Li Chen, Giancarlo Gonzalez-Areizaga, Thomas E. Smithgall

“…Methionine substitution of the ‘gatekeeper’ residue (Thr338) also stimulated Hck and Fgr kinase activity and transformed TF-1 cells to GM-CSF independence without CC fusion. TF-1 cells expressing either active form of Hck or Fgr engrafted immunocompromised mice faster and developed more extensive tumors compared to mice engrafted with the parent cell line, resulting in shorter survival. …”
Get full text

Cutting-edge: bionanomaterial solutions in the battle against Severe Acute Respiratory Syndrome Coronavirus 2 by U. Saeed, R. Uppal, M. H. Najmi, I. Fazal, A. A. Khan, Z. Z. Piracha, M. R. Uppal, H. N. Ijaz, D. U. Ozsahin, B. Uzun, I. Ozsahin

“…Nanochemistry, an artful fusion of chemistry and nanoscience, provides a fertile landscape for researchers to craft innovative shields against infection. …”
Get full text

DMPNet: dual-path and multi-scale pansharpening network by Gurpreet Kaur, Manisha Malhotra, Dilbag Singh, Dilbag Singh, Sunita Singhal

“…It consists of three modules: the feature extraction module (FEM), the multi-scale adaptive attention fusion module (MSAAF), and the image reconstruction module (IRM). …”
Get full text

Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Innovative IL-2-based immunotherapeutic approaches include immunotoxins, such as antibody–drug conjugates, immunocytokines, and antibody–cytokine fusion proteins that enhance tumor-specific delivery. …”
Get full text

Multi-scale mechanical properties of Al–Mg–Zr–Sc alloys fabricated by direct metal laser sintering: Towards single-material composites by Dominic Zettel, Piotr Breitkopf, Ludovic Cauvin, Pascal Nicolay, Roland Willmann

“…The results reveal a strong correlation between printing parameters, porosity, and mechanical performance, with average pore areas ranging from 0.037% to 21.161% and varied pore types (spherical pores, keyhole pores, and lack of fusion). Correspondingly, mechanical properties showed a broad range: tensile strength (105.3 MPa–459.0 MPa), Young's modulus (23.38 GPa–69.77 GPa), and yield strength (105.2 MPa–444.8 MPa). …”
Get full text

Osteocondroma cervical y mielopatía en niños: reporte de un caso y revisión de la bibliografía by Santiago Aguer, Javier Dal Lago, Matías Leonardo Cullari, Facundo Aguirre, Eduardo Levy, Ruy Lloyd

“…La paciente fue sometida a una resección del arco posterior de C4 y a descompresión sin fusión. A los 2 años de la cirugía, no había evidencia de recurrencia local ni síntomas neurológicos.…”
Get full text

Exoscope-assisted spine surgery: Current applications and future directions–A short review by Tomas Ferreira, Sakshi Roy, Joecelyn Kirani Tan, Wireko Andrew Awuah, Vallabh Shet, Favour Tope Adebusoye, Adrenito Nicolas, Toufik Abdul-Rahman

“…The application of exoscopes have improved spine surgeries such as spinal fusion procedures, decompression surgeries, instrumentation surgeries, minimally invasive and complex surgeries. …”
Get full text

Prenatal Diagnosis of Penoscrotal Hypospadia in Third Trimester by Two- and Three-Dimensional Ultrasonography: A Case Report by Lívia Teresa Moreira Rios, Edward Araujo Júnior, Luciano Marcondes Machado Nardozza, Liliam Cristine Rolo, Alan Roberto Hatanaka, Antonio Fernandes Moron, Marília da Glória Martins

“…Hypospadia is an abnormal development of the corpus spongiosum, that involves cavernosa urethra, as a result of an inadequate fusion of the urethral folds. The incidence ranges from 0.2 to 4.1 per 1,000 live births. …”
Get full text

Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments by Bruno Rafael Ramos de Mattos, Maellin Pereira Gracindo Garcia, Julia Bier Nogueira, Lisiery Negrini Paiatto, Cassia Galdino Albuquerque, Caique Lopes Souza, Luís Gustavo Romani Fernandes, Wirla Maria da Silva Cunha Tamashiro, Patricia Ucelli Simioni

“…Nowadays, advances in treatments for IBD have included biological therapies, based mainly on monoclonal antibodies or fusion proteins, such as anti-TNF drugs. Notwithstanding the high cost involved, these biological therapies show a high index of remission, enabling a significant reduction in cases of surgery and hospitalization. …”
Get full text

Performance Enhancement of NavIC With Low-Cost MEMS-IMU, Barometer, and Magnetometer by Saraswathi Sirikonda, Laxminarayana Parayitam, Hari B. Hablani

“…Integration of the global navigation satellite systems with the Inertial Navigation System (INS) is a sensor fusion stratagem for continuous and reliable navigation. …”
Get full text

TransDeep: Transformer-Integrated DeepLabV3+ for Image Semantic Segmentation by Tengfei Chai, Zhiguo Xiao, Xiangfeng Shen, Qian Liu, NianFeng Li, Tong Guan, Jia Tian

“…Aiming at problems such as the inability of many image segmentation algorithms to fully capture global context information, low computational efficiency, and insufficient context information fusion. This article integrates the Transformer mechanism and CA mechanism into the DeepLabV3+ network and proposes the TransDeep network. …”
Get full text

Autophagy: An Overview of Molecular Mechanisms and Its Therapeutic Implications for Health and Disease by Hourolein Arab, Mohammad Reza Mofid, Mahboube Rahmati, Elahe Gharehkhani, Armin Mokhtariye, Mohammad Shokrzadeh

“…The autophagy process is tightly regulated by autophagy-related genes (ATG) and consists of several stages: induction, autophagosome formation, fusion with lysosomes, and cargo degradation. Dysfunctional autophagy has been implicated in the development of various diseases, including cancer, neurodegenerative disorders, metabolic diseases, and bacterial or viral infections. …”
Get full text

Audio-visual event localization with dual temporal-aware scene understanding and image-text knowledge bridging by Pufen Zhang, Jiaxiang Wang, Meng Wan, Song Zhang, Jie Jing, Lianhong Ding, Peng Shi

“…This module regulates the ratio between audio-visual fusion features and CLIP’s visual features, thereby bridging the image-text alignment knowledge of CLIP and the audio-visual new knowledge for event category prediction. …”
Get full text

The Physics Case for an Electron-Muon Collider by Meng Lu, Andrew Michael Levin, Congqiao Li, Antonios Agapitos, Qiang Li, Fanqiang Meng, Sitian Qian, Jie Xiao, Tianyi Yang

“…The collision of an electron and muon beam leads to less physics background compared with either an electron-electron or a muon-muon collider, since electron-muon interactions proceed mostly through higher-order vector boson fusion and vector boson scattering processes. The asymmetric collision profile results in collision products that are boosted towards the electron beam side, which can be exploited to reduce beam-induced background from the muon beam to a large extent. …”
Get full text