Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn [ver... by ShamaPrasada K, Reshma Kumarchandra, Vasavi Kumblekar, K Sreedhara Ranganath Pai, Suman Manandhar, Sharada Rai, Rajeshwari Shastry

“…Methods ME.ET was subjected to GC-MS analysis to screen the phytoconstituents, and the identified compounds were docked with protein targets such as extracellular signal-regulated kinases (ERK1), a serine/threonine kinase-1(AKT1), human epidermal growth factor 2 (HER2), estrogen receptor (ER), maternal embryonic leucine zipper kinase (MELK), polo-like kinase-1(PLK1), and protein tyrosine kinase (PTK6). …”
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T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint pr... by Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

“…Our aims were to elucidate whether T cells can induce galectin-9 secretion in human cancer cells derived from solid malignant tumors and whether this soluble form displays higher systemic immunosuppressive activity compared with the cell surface-based protein.Methods A wide range of human cancer cell lines derived from solid tumours, keratinocytes and primary embryonic cells were employed, together with helper and cytotoxic T cell lines and human as well as mouse primary T cells. …”
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Development and nutritional evaluation of pomegranate peel enriched bars. by Rameeza Abbas, Muhammad Aamir, Farhan Saeed, Amar Shankar, Jaspreet Kaur, Rutaba Nadeem, Ashish Singh Chauhan, Ali Imran, Muhammad Afzaal, Abdela Befa Kinki

“…Nutrient rich and ready-made foods are the demand of everyone due to their easy availability and cost effectiveness. …”
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Model Sistem Berbasis Pengetahuan untuk Rekomendasi Aktivitas Pensiun by Dono Catur Prasetyo, Sri Kusumadewi, Isnatin Miladiyah

“…Abstract  Retirement is a period that is sure to come to everyone. When a person enters retirement, there will be an important change in the development of an individual's life, which is marked by changes in circumstances such as financial loss, loss of status, loss of friends/acquaintances, and loss of routine work activities. …”
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L’officier de police, le checkpoint et l’interrogatoire : les spatialités des performances sécuritaires dans le centre-ville du Caire by Laura Monfleur

“…In turn, security performance constructs downtown Cairo as a sensitive zone where police presence, checkpoints and interrogations are all reminders of the social order, a way of telling everyone their place and who has coercive power, but also of a spatial order, a way of signifying to whom downtown belongs.This research is based on various field surveys conducted in Cairo in 2015 and then between 2019 and 2021. …”
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Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4 by Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks

“…Therefore, to identify these novel ubiquitin ligases, we performed high-throughput human siRNA library screen against ubiquitin ligases in clustered regularly interspaced palindromic repeat (CRISPR)-edited E6AP-knockout human embryonic kidney (HEK) 293 cells, stably expressing green fluorescent protein (GFP)-tagged HPV-18E6. …”
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Sprengel deformity: What is the functional outcome of conservative treatment versus surgical correction? by C. Antfang, A. Frommer, G. Gosheger, G. Toporowski, A. Laufer, J. D. Rölfing, R. Roedl, B. Vogt

“…Abstract Background Sprengel deformity is a rare congenital malformation of the scapula defined by malposition during embryonic development. Affected individuals have limited range of motion of the shoulder and torticollis. …”
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Pemanfaatan Aplikasi Pengiriman Makanan Pasca Penurunan Level Pembatasan Kegiatan Masyarakat Akibat Covid-19 Di Indonesia by Wan Ahmad Gazali Kodri, Dwiza Riana, Sri Hadianti

“…Abstract The use of food delivery applications is increasing very quickly, especially during the COVID-19 Pandemic, when people's movements were restricted, making everyone try to use Food Delivery Applications (FDA) to meet their meal needs. …”
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miR-1458 is inhibited by low concentrations of Vitamin B6 and targets TBX6 to promote the formation of spermatogonial stem cells in Rugao Yellow Chicken by Qingqing Geng, Cai Hu, Ziduo Zhao, Zhe Wang, Fufu Cheng, Jing Chen, Qisheng Zuo, Yani Zhang

“…Overall, our findings suggest that miR-1458 is involved in SSCs formation, which is inhibited by low concentrations of Vitamin B6 and subsequently regulates the formation of SSCs by targeting TBX6, an essential gene involved in embryonic stem cell differentiation. Our study demonstrates the critical role of the Vitamin B6-miR-1458-TBX6 regulatory axis in spermatogonial stem cell formation in Rugao Yellow Chicken, providing new insights into the regulatory mechanisms by which miRNAs affect SSCs formation. …”
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Non-formal encounters between Israeli families and African immigrant families foster lifelong learning competence by Michal Ganz Meishar

“…The collaborative atmosphere contributed to the understanding that closeness overpowers distance. Everyone is troubled by similar issues of parenting, enjoyment of children, nutritious food and a shared desire to be good citizens while maintaining tolerance, reciprocity and respect. …”
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Whole-genome resequencing landscape of adaptive evolution in Relict gull (Larus relictus) by Chao Yang, Qingxiong Wang, Kuo Sun, Lei Luo, Hao Yuan, Xuejuan Li, Yuan Huang, Hong Xiao

“…In addition, MED1, CNOT9, NR5A1, and PATZ1 were involved in enhanced male hormone secretion and a high density of candidate genes associated with embryonic development were identified. The findings indicated that the L. relictus population was in a male-biased diffusion mode; the function of the TEKT3 gene showed that males played a dominant role in brooding, which enhanced their attraction to females. …”
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A Model H5N2 Vaccine Strain for Dual Protection Against H5N1 and H9N2 Avian Influenza Viruses by Jin-Ha Song, Seung-Eun Son, Ho-Won Kim, Se-Hee An, Chung-Young Lee, Hyuk-Joon Kwon, Kang-Seuk Choi

“…The productivity of the model vaccine strain (rvH5N2-aM2e-vPB2) in embryonated chicken eggs (ECEs), its potential risk of mammalian infection, and the immunogenicity associated with different inactivation methods (formaldehyde (F/A) vs. binary ethyleneimine (BEI)) were evaluated. …”
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Semen quality and fertility effectiveness of cloned buffalo (Bubalus bubalis) bulls by Manoj Kumar Singh, Smiriti Gupta, Kanika Gandhi, S.S. Lathwal, Naresh L. Selokar

“…The expression pattern of some necessary transcripts and miRNAs associated with spermatogenesis, sperm motility, sperm capacitation, bull fertility, and early embryonic development was almost similar in cloned bulls spermatozoa and parent bulls spermatozoa. …”
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FKBP5 as a key regulator of metabolic processes in birds: Insights from chicken pectoral muscle by Pengfei Du, Xiangli Zhang, Yao Zhu, Ziyang Wang, Xuemeng Si, Huaiyong Zhang, Yanqun Huang, Wen Chen

“…The FKBP5 levels in birds are dramatically modulated during development in insulin-sensitive tissues, with the highest expression observed in striated muscle and liver at embryonic day 19 (E19) (P < 0.01). The basal level of FKBP5 in the pectoral muscle of broilers is higher than that in Silky chickens. …”
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Assessment of Environmental Hazards and Vulnerability of The Rud–E-Shur, Rud-E-Shirin and Rud-E-Minab International Wetland Using the DPSIR Model by Hengameh Safa Eisini, Saber Ghasemi, Afshin Danehkar, Mohsen Dehghani Ghanateghestani, Hossein Parvaresh

“…In order to protect the studied international wetland, it is necessary to promote public information about the ecological characteristics and effects of the wetland in the environment of the province, as well as the threats facing them through public education. Educating everyone about the necessity and method of protecting the environment of wetland and the effects of neglecting its destruction, drafting laws, regulations, criteria and executive standards regarding fuel smuggling, along with the appropriate executive guarantee of the government and finally the organization's forecast. …”
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Genome-wide association study identifies candidate genes affecting body conformation traits of Zhongwei goat by Mingxuan Han, Xinbo Wang, Haidong Du, Yanlong Cao, Zhanqiang Zhao, Shuran Niu, Xuxu Bao, Youjun Rong, Xiaofang Ao, Furong Guo, Qincheng Xia, Fangzheng Shang, Ruijun Wang, Yanjun Zhang

“…Finally, A total of 39 candidate genes are closely related to biological processes such as skeletal muscle development, skeletal formation, carcass quality, and embryonic development, where ADIPOQ, CCDD39, PTPRT, ZNF215, VRTN, ABCD4, DLST, ADAMTS2, ROBO1, AKAP13, AQPI, SOX2, and AHSG were identified as an important component of the genetic framework that may control somatic conformational traits in Zhongwei goats. which warrants further investigation and review. …”
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Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…The acceptable level of emissions is therefore a good to which everybody is entitled a fair share; and this involves everyone being permitted to emit a certain amount of CO2 into the atmosphere. …”
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The role of skill and expertise and organizational resources along with the relevant components in the competitive environment of the organization (case study: Tehran Province Muni... by Mehdi Aghighi, Rashid Zolfegari Zaferani, Behzad Mashali

“…Also, teams and working groups are a pleasant and acceptable mechanism for everyone to perform and complete tasks with more speed and efficiency in organizations (Makandi et al, 2021). …”
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Evaluation of the needs assessment process of the training courses for the staff of the general sports and youth departments by Shahin Hayati, Haleh Fazel, Lora Chapari

“…A detailed needs assessment plan may take care of the least fragmentation, separation, and disintegration in the organization (Gooldstion, 2019). It is clear to everyone that performance can be improved by teaching certain knowledge, attitudes, and skills. …”
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Identifying factors affecting the distribution strategy in the food industry with the attitude of marketing and online sales by solmaz seyedghafouri, Vahid nasehifar, Farid askari

“…The emergence of the internet has made it possible for almost everyone to sell their goods, products or services with just a few clicks from buyers. …”
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