Aberrant methylation of placental development genes in chorionic villi of spontaneous abortions with trisomy 16 by О. Yu. Vasilyeva, E. N. Tolmacheva, A. E. Dmitriev, Ya. A. Darkova, E. A. Sazhenova, T. V. Nikitina, I. N. Lebedev, S. A. Vasilyev

“…Spiral artery remodeling involves the migration of trophoblast cells into the maternal spiral arteries, replacing their endothelium and remodeling to ensure a stable embryonic nutrition and oxygen supply. This is a complex process which depends on many factors from both the embryo and the mother. …”
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Histone Arginine Methylation-Mediated Epigenetic Regulation of Discoidin Domain Receptor 2 Controls the Senescence of Human Bone Marrow Mesenchymal Stem Cells by Zhenyu Xu, Wenming Wu, Fang Shen, Yue Yu, Yue Wang, Charlie Xiang

“…Herein, we compared the gene expression profiles of human embryonic stem cells and human BM-MSCs from donors of different ages. …”
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Exploring the Connectivity Between Education 4.0 and Classroom 4.0: Technologies, Student Perspectives, and Engagement in the Digital Era by Kapil Joshi, Rajesh Kumar, Salil Bharany, Dilip Kumar Jang Bahadur Saini, Rajiv Kumar, Ashraf Osman Ibrahim, Abdelzahir Abdelmaboud, Wamda Nagmeldin, Mohammad Awad Medani

“…The commitment of the democratic welfare government to equitable and quality education is investigated, in line with the Global Agenda SDG 4 goal of ensuring comprehensive and lifelong education for everyone. The modern classroom is witnessing a clash between traditional teaching methods and the digital competency of today’s tech-savvy generation. …”
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Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…Abstract Epithelial-to-mesenchymal transition (EMT) is a critical and complex process involved in normal embryonic development, tissue regeneration, and tumor progression. …”
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The imprinted Igf2-Igf2r axis is critical for exosome biogenesis during the early development of bovine placenta by Kunhua ZHENG, Longfei XIAO, Naihan YUAN, Xihui SHENG, Xiaolong QI, Yingqiu WANG, Chang CHEN, Kaijun GUO, Lin YANG, Bingying LIU, Xiangguo WANG

“…Insulin-like growth factor 2 (IGF2) is essential for cell growth and differentiation and functions through the IGF2 receptor (IGF2R) to regulate embryonic and placental development. Exosomes that are synthesized and released from cells and play important roles in embryogenesis and placental development rely on the IGF2R for sorting and transport. …”
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Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection by Amanda R. Loehr, Dennis M. Timmerman, Michelle Liu, Ad J. M. Gillis, Melia Matthews, Jordana C. Bloom, Peter K. Nicholls, David C. Page, Andrew D. Miller, Leendert H. J. Looijenga, Robert S. Weiss

“…We previously developed a genetically engineered mouse model featuring malignant mixed TGCTs consisting of pluripotent embryonal carcinoma (EC) and differentiated teratoma that, like the corresponding human malignancies, originate in utero and are highly chemosensitive. …”
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Novel Genomic Aberrations in Testicular Germ Cell Tumors by Array-CGH, and Associated Gene Expression Changes by Rolf I. Skotheim, Reija Autio, Guro E. Lind, Sigrid M. Kraggerud, Peter W. Andrews, Outi Monni, Olli Kallioniemi, Ragnhild A. Lothe

“…We analyzed 17 TGCTs, three precursor lesions, and the embryonal carcinoma cell lines, NTERA2 and 2102Ep, by comparative genomic hybridization microarrays (array-CGH), and integrated the data with transcriptome profiles of the same samples. …”
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Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis: Comparison of the Efficacy of Mesenchymal Stem Cells, Neural Stem Cells, and Induced Pluripotent Stem Cells by Lauren Frawley, Noam Tomer Taylor, Olivia Sivills, Ella McPhillamy, Timothy Duy To, Yibo Wu, Beek Yoke Chin, Chiew Yen Wong

“…NSCs, isolated from the fetal spinal cord or brain, demonstrate promise in animal models but face functional integration and ethical challenges. iPSCs, created by reprogramming patient-specific somatic cells, offer a novel approach by potentially replacing or supporting neurons. iPSC therapy addresses ethical issues related to embryonic stem cells but encounters challenges regarding genotoxicity and epigenetic irregularities, somatic cell sources, privacy concerns, the need for extensive clinical trials, and high reprogramming costs. …”
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Morphokinetic Analyses of Fishing Cat–Domestic Cat Interspecies Somatic Cell Nuclear Transfer Embryos Through A Time-Lapse System by Hai-Jun Liu, Serena Jocelyn Wai Yin Oh, Nicole Liling Tay, Christina Yingyan Lim, Chia-Da Hsu, Delia Hwee Hoon Chua, Winnie Koon Lay Teo, Yuin-Han Loh, Soon Chye Ng

“…All earlier time points of embryonic development before the onset of blastulation in the iSCNT embryos were significantly delayed when compared with their IVF counterparts. …”
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Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells by Nuwanka K. Abeysinghe, Ira Thabrew, Sameera R. Samarakoon, Meran K. Ediriweera, Kamani H. Tennekoon, Varuni P. C. Pathiranage, Anuka S. Mendis

“…The present study was designed to determine antiproliferative, apoptotic, autophagic, and antioxidant effects of vernolactone, isolated from V. zeylanica, in human embryonal carcinoma cells (NTERA-2, a cancer stem cell model). …”
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Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro by Fenghua Zhou, Yan Shi, Sujun Tan, Xiaoli Wang, Weicheng Yuan, Shuqi Tao, Ping Xiang, Bin Cong, Chunling Ma, Di Wen

“…In the present study, we aimed to investigate the toxicity and underlying mechanisms of indole SCs JWH-018 and JWH-019 in mice (C57BL/6, male, 6–8 weeks old), zebrafish (AB strain, male, 4–5 months old) and modified human embryonic kidney (HEK) 293 T cells, using behavioral, pharmacokinetic, pharmacological approaches, and molecular docking. …”
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CHALLENGES FOR UNIVERSITIES TO ONLINE TECHNOLOGIES IMPLEMENTATION IN THE CONDITIONS OF WAR IN UKRAINE by Yuliia Sytnykova, Tаtyana Petrenko, Oksana Bezkorovaina, Anastasiia Ptushka

“…The classes were online, and it was difficult to overcome the war stress, but the experience of the pandemic taught everyone to work with online technologies such as Zoom, Meet, and Google Classroom. …”
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Assessment of environmental impacts of heavy metal pollution in rice in Nanning, China by Jing Zhang, Peng Li, Siyan Li, Zhongqi Lyu

“…Rice in southern China is also a staple food for everyone, however, with the development of China’s industrialization model, many industrial areas may be contaminated by heavy metals, leading to contamination of the agricultural areas. …”
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Assessing molecular changes underlying isopropylated phenyl phosphate (IPP)-induced larval sensorimotor response deficits in zebrafish by Sunil Sharma, Alfredo Rojas, Abhishek Gour, Rosemaria Serradimigni, Connor Leong, Abhisheak Sharma, Subham Dasgupta

“…Using zebrafish, our prior whole embryonic RNA-seq data revealed disruption of gene sets enriched for DNA methylation, neurotransmitter synthesis, retinoic acid signaling and eye development. …”
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Real-Time Plant Health Detection Using Deep Convolutional Neural Networks by Mahnoor Khalid, Muhammad Shahzad Sarfraz, Uzair Iqbal, Muhammad Umar Aftab, Gniewko Niedbała, Hafiz Tayyab Rauf

“…In the twenty-first century, machine learning is a significant part of daily life for everyone. Today, it is adopted in many different applications, such as object recognition, object classification, and medical purposes. …”
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Sistem Kontrol Perangkat Inframerah Menggunakan Speech Recognition dengan Spectrogram dan Convolutional Neural Network Berbasis Mikrokontroler by Irfan Muzakky Nurrizqy, Barlian Henryranu Prasetio, Rekyan Regasari Mardi Putri

“…In the present day, where technology advances are rapidly developing all around the world, there have been many things that can help simplify the lives of everyone in the world, especially people with disabilities. …”
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Enhancing maternity healthcare workers’ wellbeing using insider participatory action research by Claire M. Wood, Mary Chambers, Jayne E. Marshall

“…The HEARS wellbeing intervention model (HCW driven, Everyone involved, Ask what makes a person feel good at work, Responses displayed, Steps taken) was developed to frame processes by which HCW participation catalysed impact towards workplace wellbeing. …”
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The Prevalence of Undiagnosed Age-Related Sight-Threatening Diseases in Self-Proclaimed Healthy Individuals by Sophie Lemmens, João Barbosa Breda, Karel Van Keer, Tine Jacobs, Ruben Van Landeghem, Patrick De Boever, Ingeborg Stalmans

“…The frequency of prior ophthalmological examinations does not seem to be relevant to this proportion, meaning that everyone above 55 years old needs a routine ophthalmological evaluation.…”
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Identification and characterization of mRNAs of receptor-like kinases MhyGSO1 and MhyGSO2 in flowering parasitic plant Monotropa hypopitys by A. V. Shchennikova, E. Z. Kochieva, A. V. Beletsky, M. A. Filyushin, O. A. Shulga, N. V. Ravin, K. G. Skryabin

“…In combination with known data about GSO1 and GSO2, it allowed us to assume the redundant activity of MhyGASSHO paralogues in signaling pathways, in particular, in response to exogenous sucrose and in development of reproductive organs and embryonic inflorescences.…”
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Professional propaedeutic council in the university by N. N. Malyarchuk, G. M. Krinitzyna, E. V. Pashchenko, V. V. Pivnenko

“…As a state strategy in higher education, vocational education should be provided for everyone creating equal opportunities. At some large universities, structural divisions are already functioning (resource centers including the defectology faculties and departments), which promote satisfaction of special educational needs of students with disabilities. …”
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