Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity by Yuming Zhang, Jinghua Lv, Xiaoli Sun, Yiwen Zhang, Menghua Shao, Bingbing Shi, Yajie Zhang, Jihai Gu, Chenchen Zhao, Fengsong Liu

“…To elucidate the toxicity of Sb and its mechanism of action, this study aimed to investigate the adverse effects of Sb on a cosmopolitan insect, housefly (Musca domestica), under a whole life cycle (from embryonic to adult stage) exposure through the examination of a suite of parameters, including biological, physiological, behavioral, and molecular endpoints. …”
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Digit ratio in the common spadefoot toad Pelobates fuscus (Anura: Mesobatrachia: Pelobatidae): patterns and correlations by M. Frątczak, M. Kaczmarski, Ł. Jankowiak, J. Klessa, K. Bielicki, B. Lyskov, P. Tryjanowski

“…Digit ratio (DR or 2D:4D), an indicator based on the relative length of the second and fourth digits, has been linked to embryonic sex hormone levels and is regarded as a biomarker for ontogenetic changes and evolutionary traits across species. …”
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The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine by Zhuoyu Xiao, Sun Liu, Zengguang Li, Jinru Cui, Hailan Wang, Zihan Wang, Qihuan Ren, Laixin Xia, Zhijian Wang, Yuan Li

“…Here, we found that loss of the maternal microbiome altered the expression of m6A writers and erasers, as well as the m6A methylome of the mouse fetal brain and intestine on embryonic day 18. From the m6A profiles, we identified 2,655 and 2,252 m6A modifications regulated by the maternal microbiome in the fetal brain and intestine, respectively, and we demonstrated that these m6A-modified genes were enriched in the neuro/intestinal developmental pathways, such as the Wnt signaling pathway. …”
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Morphology and Immunoexpression of Selenoproteins in Term Placenta of Alpaca (<i>Vicugna pacos</i>) from the Peruvian Andes by Miluska Beatriz Navarrete Zamora, Francisco Acuña, Mônica Duarte da Silva, Thamires Santos-Silva, Matheus Henrique Herminio Garcia, Rodrigo da Silva Nunes Barreto, Alberto Sato Sato, Claudio Gustavo Barbeito, Maria Angelica Miglino

“…South American camelids inhabit high-altitude environments characterized by hypoxia, influencing embryonic, fetal, and placental development. This study examined the term placenta morphology of alpacas (<i>Vicugna pacos</i>, N = 12) and the immunoexpression of antioxidant selenoproteins (SP). …”
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In Vitro Differentiation Potential of Human Placenta Derived Cells into Skin Cells by Ruhma Mahmood, Mahmood S. Choudhery, Azra Mehmood, Shaheen N. Khan, Sheikh Riazuddin

“…Both types of cells were characterized for the expression of embryonic lineage markers and their growth characteristics were determined. …”
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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition by Deniz Gökbuget, Liana Goehring, Ryan M. Boileau, Kayla Lenshoek, Tony T. Huang, Robert Blelloch

“…Using machine learning, we quantify 21 chromatin features predicting local RT and RT changes during differentiation in embryonic stem cells (ESCs). About one-third of the genome shows RT changes during differentiation. …”
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Hydrometeorological Variability of Olive Ridley Sea Turtle (<i>Lepidochelys olivacea</i>) Nesting Beaches: Implications for Conservation Practices by Anatoliy Filonov, Enrique Godínez-Domínguez, Iryna Tereshchenko, Cesar O. Monzon, David Avalos-Cueva, María del Refugio Barba-López

“…Atmospheric parameters were modeled using Newton’s Cooling Law and solved with the finite difference method to estimate heat loss rates from beach sand to its surroundings, shedding light on microclimatic effects on incubation and embryonic development. Meteorological data were gathered from an automatic weather station, while sand temperatures were monitored with thermographs. …”
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Association between Endocrine Disrupting Phenols in Colostrums and Maternal and Infant Health by B. Yi, C. Kim, M. Park, Y. Han, J. Y. Park, M. Yang

“…Study subjects were the lactating mothers who delivered babies within 2 weeks (N=325; 30.67 ± 3.45 years) and their neonates (N=326; embryonic period, 39.1 ± 1.5 weeks). BPA, nonylphenol (NP), and octylphenol (OP) in colostrums were quantified with LC/MS/MS. …”
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Radiological Patterns of Lung Involvement in Inflammatory Bowel Disease by Diletta Cozzi, Chiara Moroni, Gloria Addeo, Ginevra Danti, Monica Marina Lanzetta, Edoardo Cavigli, Massimo Falchini, Fabio Marra, Claudia Lucia Piccolo, Luca Brunese, Vittorio Miele

“…In particular, the spectrum of IBD-associated or related changes in the chest is broad and may mimic other conditions. The common embryonic origin of intestine and lungs from the foregut, autoimmunity, smoking, and bacterial translocation from the colon may all be involved in the pathogenesis of these manifestations in IBD patients. …”
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Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy by Constanza J. Cortes, Kefeng Qin, Eric M. Norstrom, William N. Green, Vytautas P. Bindokas, James A. Mastrianni

“…In autophagy deficient (ATG5−/−) mouse embryonic fibroblasts, or in normal cells treated with the autophagy-inhibitor 3-MA, Mut-PrP colocalization with lysosomes was reduced to a similar extent. …”
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CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production by Emily E. O’Driscoll, Sakshi Arora, Jonathan F. Lang, Beverly L. Davidson, Ophir Shalem

“…Specifically, we performed a CRISPR-based genome-wide knockout (KO) screen in human embryonic kidney (HEK) 293 cells using an antibody specific to intact AAV2 capsids coupled with flow cytometry to identify genes that modulate rAAV production. …”
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Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility by Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K. Stine V. Bagge, Jennifer R. Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D. Hickson, Andrés López-Contreras, Michael Lisby

“…However, at a cellular level, mouse embryonic fibroblasts exhibit sensitivity to ICLs and show elevated levels of the DNA damage marker γH2AX. …”
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Thymosin β4 Improves Differentiation and Vascularization of EHTs by Tilman Ziegler, Rabea Hinkel, Andrea Stöhr, Thomas Eschenhagen, Karl-Ludwig Laugwitz, Ferdinand le Noble, Robert David, Arne Hansen, Christian Kupatt

“…Furthermore, we demonstrated, in a zebrafish model of embryonic vascular development, that Tβ4 is crucial for the proper execution of lymphatic and angiogenic vessel sprouting. …”
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Differential Expression of -Associated Genes in Autosomal Dominant Polycystic Kidney Disease by Yeon Joo Yook, Yu Mi Woo, Moon Hee Yang, Je Yeong Ko, Bo Hye Kim, Eun Ji Lee, Eun Sun Chang, Min Joo Lee, Sunyoung Lee, Jong Hoon Park

“…Previously developed mouse models of PKD1 and PKD2 demonstrated an embryonic lethal phenotype and massive cyst formation in the kidney, indicating that PKD1 and PKD2 probably play important roles during normal renal tubular development. …”
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Identification of Proteins and Genes Associated with Hedgehog Signaling Pathway Involved in Neoplasm Formation Using Text-Mining Approach by Nadezhda Yu. Biziukova, Sergey M. Ivanov, Olga A. Tarasova

“…One of the pathways known to be important for the development of neoplastic diseases and pathological processes is the Hedgehog signaling pathway that normally controls human embryonic development. Systematic accumulation of various types of biological data, including interactions between proteins, regulation of genes transcription, proteomics, and metabolomics experiments results, allows the application of computational analysis of these big data for identification of key molecular mechanisms of certain diseases and pathologies and promising therapeutic targets. …”
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Regarding the update of research infrastructure problems and support for young scientists in the current conditions by S. O. Pogribny, S. V. Bezpalko, I. V. Kritsak, D. Ye. Denischuk

“…The world is moving towards an open research infrastructure, which is a positive trend, after all everyone has an opportunity in free access get acquainted with the authors’ work. …”
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Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells by Vedavathi Madhu, Abhijit S. Dighe, Quanjun Cui, D. Nicole Deal

“…We therefore sought to determine if a simple, one-step, and cost effective method, previously reported to induce neuronal differentiation of embryonic stem cells and induced-pluripotent stem cells, can be applied to adult stem cells. …”
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Knowledge Is (Still) Key: Awareness to Shape Trends in Telemedicine Use during the Pandemic Based on Management Perceptions and Implementation Systems by Nada I. Hawa, Tri E. B. Soesilo, Nuraeni Nuraeni

“…Knowledge is an intellectual property that everyone must have to capitalize on with telemedicine. …”
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Oct4 Gene Expression in Primary Colorectal Cancer Promotes Liver Metastasis by Shiki Fujino, Norikatsu Miyoshi

“…The Oct4 gene plays an important role in undifferentiated embryonic stem cells and regulates stem cell pluripotency. …”
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VOICES-POSITIONS IN DISCOURSES: HOW IS IDENTITY POSSIBLE? by T. V. Podolska

“…The adoption of such an understanding of identity by everyone signifies a high degree of responsibility for self-constructing, which implicitly assumes not just to say “I”, but first of all to define your being as a certain social debt: to another person, to society, its history and everyday life through which we get a chance to be happy.…”
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